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1.发明申请High affinity human and humanized anti-alpha5beta1 integrin function blocking antibodies with reduced immunogenicity 审中-公开高亲和力人和人源化的抗α5beta1整合蛋白功能阻断具有降低的免疫原性的抗体公开(公告)号：US20090081207A1
公开(公告)日：2009-03-26
申请号：US11802573
申请日：2007-05-23
申请人： ANDREAS MENRAD , JOERG WILLUDA , KLAUS BOSSLET , DIETER ZOPF , HEIKE PETRUL , STEFAN STEIDL , JOSEF PRASSLER , CORINNE PETIT-FRERE
发明人： ANDREAS MENRAD , JOERG WILLUDA , KLAUS BOSSLET , DIETER ZOPF , HEIKE PETRUL , STEFAN STEIDL , JOSEF PRASSLER , CORINNE PETIT-FRERE
IPC分类号： A61K39/395 , C07K16/18 , C12N9/96 , C12N15/11 , C12N15/00 , A61P31/00 , G01N33/574 , C12N5/06 , A01K67/027 , C12P21/04
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21
摘要： The present invention relates to recombinant human or humanized polypeptides which bind to α5β1 integrin with high affinity and blocking function. Further, diagnostic and pharmaceutic applications of the potypeptides are disclosed.
摘要翻译： 本发明涉及以高亲和力和阻断功能结合α5β1整联蛋白的重组人或人源化多肽。 此外，公开了肽的诊断和药物应用。
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公开(公告)号：US20130122024A1
公开(公告)日：2013-05-16
申请号：US13451916
申请日：2012-04-20
申请人： Hans-Georg LERCHEN , Beatrix STELTE-LUDWIG , Sven GOLFIER , Charlotte Christine KOPITZ , Rudolf BEIER , Sherif EL SHEIKH , Iring HEISLER , Axel HARRENGA , Karl-Heinz THIERAUCH , Joachim SCHUHMACHER , Sandra BRUDER , Simone GREVEN , Lars LINDEN , Jörg WILLUDA , Christoph MAHLERT , Heike PETRUL , Hannah JÖRIßEN , Sandra Borkowski
发明人： Hans-Georg LERCHEN , Beatrix STELTE-LUDWIG , Sven GOLFIER , Charlotte Christine KOPITZ , Rudolf BEIER , Sherif EL SHEIKH , Iring HEISLER , Axel HARRENGA , Karl-Heinz THIERAUCH , Joachim SCHUHMACHER , Sandra BRUDER , Simone GREVEN , Lars LINDEN , Jörg WILLUDA , Christoph MAHLERT , Heike PETRUL , Hannah JÖRIßEN , Sandra Borkowski
IPC分类号： C07K16/18 , A61K39/395 , A61K45/06 , C07K7/06
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target mesothelin, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及针对靶间皮素的N，N-二烷基海马素的新粘合剂 - 药物偶联物（ADC），这些ADC的活性代谢物，制备这些ADC的方法，以及使用这些ADC用于治疗和 /或预防疾病，以及使用这些ADC用于制备用于治疗和/或预防疾病的药物，更特别是过度增殖和/或血管生成疾病，例如癌症疾病。 这样的治疗可以作为单一疗法来实施，或者与其它药物组合或进一步的治疗措施。
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公开(公告)号：US20090137002A1
公开(公告)日：2009-05-28
申请号：US12182235
申请日：2008-07-30
申请人： Heike PETRUL , Andreas Menrad , Jorg Willuda , Dieter Zopf , Jens Glienke , Josef Prassler , Andreas Popp , Stefan Steidl , Catrin Pracht
发明人： Heike PETRUL , Andreas Menrad , Jorg Willuda , Dieter Zopf , Jens Glienke , Josef Prassler , Andreas Popp , Stefan Steidl , Catrin Pracht
CPC分类号： C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy.
摘要翻译： 本发明涉及抗体和抗体片段，特异性识别包含轻链和轻链的重链和轻链的EphB4受体及其作为用于治疗病理性血管发生，特别是癌症治疗的药物的用途。
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公开(公告)号：US20140127240A1
公开(公告)日：2014-05-08
申请号：US14113070
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures.
摘要翻译： 本专利申请涉及针对靶表皮生长因子受体（EGFR，基因ID 1956）的N，N-二烷基硫酸锡的新型粘合剂 - 药物共轭物（ADC），这些ADC的有效代谢物，制备这些ADC的方法， 这些ADC用于治疗和/或预防疾病，以及使用这些ADC来制备用于治疗和/或预防疾病，特别是过度增生和/或血管发生疾病例如癌症的药物。 这样的治疗可以作为单一疗法或与其它药物或其他治疗措施组合施用。
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公开(公告)号：US20130066055A1
公开(公告)日：2013-03-14
申请号：US13451950
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
IPC分类号： C07K17/02
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及针对目标C4.4a的N，N-二烷基硫酸钠的新粘合剂 - 药物共轭物（ADC），这些ADC的活性代谢物，制备这些ADC的方法，使用这些ADC 治疗和/或预防疾病，以及使用这些ADC用于制备用于治疗和/或预防疾病的药物，更特别是过度增殖和/或血管生成疾病，例如癌症疾病。 这样的治疗可以作为单一疗法来实施，或者与其它药物组合或进一步的治疗措施。
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