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13 条记录 (耗时 0.034 秒)

    Methods and Agents for Diagnosis and Prevention, Amelioration or Treatment of Goblet Cell-Related Disorders
    2.
    发明申请
    Methods and Agents for Diagnosis and Prevention, Amelioration or Treatment of Goblet Cell-Related Disorders 审中-公开
    用于诊断和预防，改善或治疗杯状细胞相关疾病的方法和药剂

    公开(公告)号：US20080081037A1

    公开(公告)日：2008-04-03

    申请号：US10540818

    申请日：2003-12-23

    申请人： Johannes Grosse ,  Boris Schneider ,  Lutz Zeitlmann ,  Andreas Popp

    发明人： Johannes Grosse ,  Boris Schneider ,  Lutz Zeitlmann ,  Andreas Popp

    IPC分类号： A61K31/70 ,  A01K67/00 ,  A61K39/395 ,  A61P1/00 ,  C07K14/00 ,  C12N1/20 ,  C12N15/00 ,  C12N15/11 ,  C12N5/06 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： C07K14/47 ,  A61K47/6843 ,  A61K51/1093

    摘要： The present invention inter alia relates to methods for the prevention, amelioration or treatment of medical conditions associated with an alteration in normal goblet cell function. It also relates to methods of screening for disease-relevant markers indicative of an increased risk of a subject of developing such a condition. It furthermore relates to an animal model useful for studying said conditions and the molecular mechanisms underlying them, and uses of that animal model, for example for the identification of diagnostic markers or agents useful for the prevention, amelioration, or treatment of a goblet cell-related disorder. Novel agents useful in the above methods, and novel pharmaceutical compositions are likewise provided. The invention further relates to screening methods for agonists and antagonists useful for performing said methods.

    摘要翻译： 本发明尤其涉及用于预防，改善或治疗与正常杯状细胞功能改变相关的医学病症的方法。 它还涉及筛选指示发展这种病症的受试者风险增加的疾病相关标志物的方法。 它还涉及可用于研究所述条件及其基础的分子机制的动物模型，以及该动物模型的用途，例如用于鉴定可用于预防，改善或治疗杯状细胞的诊断标记物或药剂， 相关疾病 在上述方法中有用的新型药剂，以及新的药物组合物。 本发明还涉及用于进行所述方法的激动剂和拮抗剂的筛选方法。

    EXPRESSION OF FULL LENGTH IGG AND SECRETION INTO THE CULTURE MEDIUM OF PROKARYOTIC CELLS
    6.
    发明申请
    EXPRESSION OF FULL LENGTH IGG AND SECRETION INTO THE CULTURE MEDIUM OF PROKARYOTIC CELLS 审中-公开
    表达全长IGG和分泌到原核细胞培养物中

    公开(公告)号：US20100168392A1

    公开(公告)日：2010-07-01

    申请号：US12672859

    申请日：2007-08-10

    申请人： Ralf Ostendorp ,  Andreas Popp ,  Martina Fischer

    发明人： Ralf Ostendorp ,  Andreas Popp ,  Martina Fischer

    IPC分类号： C07K16/00 ,  C12P21/06

    CPC分类号： C07K16/00 ,  C07K2317/10 ,  C07K2319/035

    摘要： A method for the production of an immunoglobulin or a functional fragment thereof in a prokaryotic host cell comprises transforming the host cell with (a) a first nucleic acid molecule comprising a nucleic acid sequence encoding a VL and a CL region and (b) a second nucleic acid molecule comprising a nucleic acid sequence encoding a VH, a CH1, a CH2 and at least a portion of a CH3 region, The host cell is within culture medium. The host cell is cultured under conditions so as to allow the host cell (a) to express (1) the VL and a CL region and (2) the VH, the CH1, the CH2 and the portion of the CH3 region, and (b) to secrete (a)(1) and (a)(2) to the periplasm of the host cell and thereafter to the culture medium of the host cell. Characteristically, (a)(1) and (a)(2) interact to form the immunoglobulin or functional fragment thereof.

    摘要翻译： 用于在原核宿主细胞中产生免疫球蛋白或其功能片段的方法包括用（a）包含编码VL和CL区的核酸序列的第一核酸分子转化宿主细胞，和（b）第二个 核酸分子，其包含编码VH，CH1，CH2和至少部分CH3区的核酸序列。宿主细胞在培养基内。 宿主细胞在条件下培养以允许宿主细胞（a）表达（1）VL和CL区和（2）VH，CH1，CH2和CH3区的部分，和（ b）将（a）（1）和（a）（2）分泌到宿主细胞的周质中，然后到宿主细胞的培养基。 特征地，（a）（1）和（a）（2）相互作用以形成免疫球蛋白或其功能片段。

    Mixtures of polyalkoxylated trimethylolpropane (meth) acrylate
    8.
    发明申请
    Mixtures of polyalkoxylated trimethylolpropane (meth) acrylate 审中-公开
    聚烷氧基化三羟甲基丙烷（甲基）丙烯酸酯的混合物

    公开(公告)号：US20060212011A1

    公开(公告)日：2006-09-21

    申请号：US10551630

    申请日：2004-04-02

    申请人： Andreas Popp ,  Thomas Daniel ,  Jurgen Schroder ,  Thomas Jaworek ,  Rudiger Funk ,  Reinhold Schwalm ,  Matthias Weismantel

    发明人： Andreas Popp ,  Thomas Daniel ,  Jurgen Schroder ,  Thomas Jaworek ,  Rudiger Funk ,  Reinhold Schwalm ,  Matthias Weismantel

    IPC分类号： A61F13/15 ,  C07C69/52 ,  C08F265/02

    CPC分类号： C08F220/06 ,  A61L15/60 ,  C07C67/08 ,  C08F222/1006 ,  C08G65/2609 ,  C08G65/3322 ,  C07C69/54

    摘要： The present invention relates to novel mixtures of (meth)acrylic esters of polyalkoxylated trimethylolpropane of the formula where AO is for each AO independently at each instance EO, PO or BO where EO is O—CH2-CH2- PO is independently at each instance O—CH2-CH(CH3)- or O—CH(CH3)-CH2- BO is independently at each instance O—CH2-CH(CH2-CH3)- or O—CH(CH2-CH3)-CH2- p1+p2+p3 is 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 or 75, R1, R2 and R3 are independently H or CH3, a simplified process for preparing these ester mixtures and the use of reaction mixtures thus obtainable.

    摘要翻译： 本发明涉及下式的聚烷氧基化三羟甲基丙烷的（甲基）丙烯酸酯的新混合物，其中AO在每种情况下各自独立地为每个AO，PO或BO，其中EO为O-CH 2 -CH 2 - ，PO各自独立地为O -CH 2 -CH（CH 3） - 或O-CH（CH 3）-CH 2 - BO在每种情况下独立地为O-CH 2 -CH（CH 2 -CH 3） - 或O-CH（CH 2 -CH 3）-CH 2 - + p3为28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51 ，52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74或75，R1 ，R2和R3独立地为H或CH3，制备这些酯混合物的简化方法以及由此获得的反应混合物的使用。

    Preparations of bacteriorhodopsin variants having increased memory time, and their use
    9.
    发明授权
    Preparations of bacteriorhodopsin variants having increased memory time, and their use 失效
    具有增加的记忆时间的细菌视紫红质变体的制备及其用途

    公开(公告)号：US06274279B1

    公开(公告)日：2001-08-14

    申请号：US08381839

    申请日：1995-02-03

    申请人： Norbert Hampp ,  Andreas Popp ,  Dieter Oesterhelt ,  Christoph Bräuchle

    发明人： Norbert Hampp ,  Andreas Popp ,  Dieter Oesterhelt ,  Christoph Bräuchle

    IPC分类号： G03H118

    CPC分类号： G11B7/244 ,  Y10S430/146

    摘要： Compositions of bacteriorhodopsin variants with increased memory time and their use for reversible optical information recording are disclosed. The compositions are characterized in that the configuration of the retinal of the photoproduct is different from the configuration of the retinal of the initial state and other than 13-cis; the pH value of the composition lies between 3 and 11; the water content of the composition lies between 1 and 30% by weight with respect to the total weight of the composition; and additives for modulating the proton mobility are present in a concentration between 1 and 80% by weight of the mass of purple membrane composition used, and if required matrix materials in a concentration of up to 10% by weight with respect to the total weight of the composition are present. These compositions may be used in reversible information recording systems.

    摘要翻译： 公开了具有增加的记忆时间的细菌视紫红质变体及其可逆光学信息记录的用途的组合物。 组合物的特征在于光产物的视网膜的构型不同于初始状态的视网膜的构型，而不是13-顺式; 组合物的pH值在3和11之间; 组合物的含水量相对于组合物的总重量为1至30重量％; 并且用于调节质子迁移率的添加剂以所使用的紫色膜组合物的质量的1至80重量％的浓度存在，并且如果需要，基质材料的浓度高达10重量％ 该组合物存在。 这些组合物可用于可逆信息记录系统。