-
公开(公告)号：US20090137002A1
公开(公告)日：2009-05-28
申请号：US12182235
申请日：2008-07-30
申请人： Heike PETRUL , Andreas Menrad , Jorg Willuda , Dieter Zopf , Jens Glienke , Josef Prassler , Andreas Popp , Stefan Steidl , Catrin Pracht
发明人： Heike PETRUL , Andreas Menrad , Jorg Willuda , Dieter Zopf , Jens Glienke , Josef Prassler , Andreas Popp , Stefan Steidl , Catrin Pracht
CPC分类号： C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy.
摘要翻译： 本发明涉及抗体和抗体片段，特异性识别包含轻链和轻链的重链和轻链的EphB4受体及其作为用于治疗病理性血管发生，特别是癌症治疗的药物的用途。
-
2.发明申请Quinoline derivative, its use, production and pharmaceutical agents containing the latter 审中-公开喹啉衍生物，其使用，生产和药剂含有后者公开(公告)号：US20060167035A1
公开(公告)日：2006-07-27
申请号：US11312635
申请日：2005-12-21
申请人： Wolfgang Schwede , Stefan Jaroch , Benjamin Bader , Roman Hillig , Antonius Ter Laak , Dieter Zopf
发明人： Wolfgang Schwede , Stefan Jaroch , Benjamin Bader , Roman Hillig , Antonius Ter Laak , Dieter Zopf
IPC分类号： A61K31/4745 , C07D498/02 , C07D471/02
CPC分类号： C07D221/06 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： This invention relates to a quinoline derivative with general formula A in which R1, R2, R3, X, Y, Z and A are indicated in the description and the claims, the use of the compounds of general formula A for treating various diseases as well as the production of compounds of general formula A.
摘要翻译： 本发明涉及通式A的喹啉衍生物，其中R 1，R 2，R 3，X，Y，Z和A 在说明书和权利要求书中指出，通式A的化合物用于治疗各种疾病以及通式A化合物的制备。
-
公开(公告)号：US5756359A
公开(公告)日：1998-05-26
申请号：US859083
申请日：1997-05-20
申请人： Klaus Habenstein , Dieter Zopf , Winfried Bursch
发明人： Klaus Habenstein , Dieter Zopf , Winfried Bursch
IPC分类号： G01N21/77 , C07C381/12 , C07C391/00 , C07F9/54 , C07F9/72 , C07F9/74 , C12Q1/26 , C12Q1/28 , G01N21/78 , G01N33/48
CPC分类号： C07F9/723 , C07C381/12 , C07C391/00 , C07F9/5456 , C07F9/743 , C12Q1/26 , C12Q1/28 , Y10T436/144444 , Y10T436/148888
摘要： The present invention relates to reagents and processes for the preparation of diagnostics which use a chromogenic redox detection system and whose chromogenic redox detection system essentially remains unaffected by interference from reducing. compounds in the sample material.
摘要翻译： 本发明涉及用于制备诊断的试剂和方法，其使用显色氧化还原检测系统，其显色氧化还原检测系统基本上不受来自还原的干扰的影响。 样品中的化合物。
-
4.发明授权Quinazoline derivatives, their preparation, their use, and medicaments comprising them 失效喹唑啉衍生物，它们的制备方法，用途和包含它们的药物公开(公告)号：US07741333B2
公开(公告)日：2010-06-22
申请号：US11766232
申请日：2007-06-21
申请人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic E. A. Brittain
发明人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic E. A. Brittain
IPC分类号： A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D513/04 , C07D239/70 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a quinazoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹唑啉衍生物：其中R1，R2，X，Y和Z在说明书和权利要求中表示，通式（A）的化合物用于 各种病症的治疗，以及通式（A）的化合物的制备。
-
![3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents](/abs-image/US/2009/01/29/US20090030010A1/abs.jpg.150x150.jpg)
5.发明申请3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents 失效3-氨基 - 吡唑并[3,4b]吡啶作为蛋白酪氨酸激酶的抑制剂，其生产和用作药剂公开(公告)号：US20090030010A1
公开(公告)日：2009-01-29
申请号：US11302307
申请日：2005-12-14
申请人： Wolfgang Schwede , Hermann Kuenzer , Antonius Ter Laak , Benjamin Bader , Roman Hillig , Ursula Moenning , Arndt Schmitz , Dieter Zopf
发明人： Wolfgang Schwede , Hermann Kuenzer , Antonius Ter Laak , Benjamin Bader , Roman Hillig , Ursula Moenning , Arndt Schmitz , Dieter Zopf
IPC分类号： A61K31/496 , C07D471/04 , C07D213/78 , A61K31/437
CPC分类号： C07D471/04 , C07D213/85
摘要： This invention relates to compounds of general formula I in which R1 and R2 are described in this application, the use of the compounds of general formula I as inhibitors of protein tyrosine kinases for treatment of various diseases as well as the compounds of general formulas II and III as intermediate compounds for the production of compounds of general formula I, whereby X, R1a and R2a have the meaning that is described in general formulas II and III.
摘要翻译： 本发明涉及通式Ⅰ化合物，其中本申请中描述了R1和R2，通式I化合物用作蛋白酪氨酸激酶抑制剂用于治疗各种疾病以及通式II和 III为制备通式I化合物的中间体化合物，其中X，R 1a和R 2a具有通式II和III所述的含义。
-
6.发明授权Cyanoquinoline derivatives, their preparation, their use, and medicaments comprising them 失效氰基喹啉衍生物，它们的制备方法，用途以及包含它们的药物公开(公告)号：US07598263B2
公开(公告)日：2009-10-06
申请号：US11765813
申请日：2007-06-20
申请人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf
发明人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf
IPC分类号： A61K31/435 , C07D215/00
CPC分类号： C07D495/04
摘要： The present invention relates to a quinoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹啉衍生物：其中R1，R2，X，Y和Z在说明书和权利要求中表示，通式（A）的化合物用于 各种病症的治疗，以及通式（A）的化合物的制备。
-
7.发明申请CYANOQUINOLINE DERIVATIVES, THEIR PREPARATION, THEIR USE, AND MEDICAMENTS COMPRISING THEM 失效氰基喹啉衍生物，其制备，其使用和药物包括它们公开(公告)号：US20080108627A1
公开(公告)日：2008-05-08
申请号：US11765813
申请日：2007-06-20
申请人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf
发明人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf
IPC分类号： A61K31/497 , A61P35/00 , A61P25/28 , C07D521/00 , C07D401/14 , A61K31/4365
CPC分类号： C07D495/04
摘要： The present invention relates to a quinoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹啉衍生物：其中R 1，R 2，X，Y和Z在说明书中表示， 权利要求书中，使用通式（A）的化合物治疗各种病症，以及制备通式（A）的化合物。
-
公开(公告)号：US20050159468A1
公开(公告)日：2005-07-21
申请号：US10841825
申请日：2004-05-10
申请人： Arwed Cleve , Volker Schulze , Dieter Zopf , Jens Hoffmann , Andreas Reichel , Karsten Parczyk
发明人： Arwed Cleve , Volker Schulze , Dieter Zopf , Jens Hoffmann , Andreas Reichel , Karsten Parczyk
IPC分类号： A61K31/4178 , A61P35/00 , C07D233/86 , C07D403/06 , C07D43/02
CPC分类号： C07D233/86 , A61K31/4178 , C07D403/06
摘要： This invention relates to anti-androgenic N-[ω-[3-[4-cyano-3-(trifluoromethyl)-phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]alkyl]-substituted pyrrolidines of general formula I, with a strongly pronounced antiproliferative profile of action; process for the production of the compounds of general formula I, pharmaceutical preparations and the use for the production of pharmaceutical agents.
摘要翻译： 本发明涉及抗雄激素N- [3- [4-氰基-3-（三氟甲基） - 苯基] -5,5-二甲基-4-氧代-2-硫代咪唑烷-1-基]烷基] - 通式I的取代吡咯烷，具有强烈显着的抗增殖作用特征; 用于制备通式I化合物，药物制剂和用于生产药剂的用途的方法。
-
公开(公告)号：US06861432B2
公开(公告)日：2005-03-01
申请号：US10301871
申请日：2002-11-22
申请人： Arwed Cleve , Christoph Huwe , Volker Schulze , Helmut Morack , Dieter Zopf , Jens Hoffmann , Andreas Reichel
发明人： Arwed Cleve , Christoph Huwe , Volker Schulze , Helmut Morack , Dieter Zopf , Jens Hoffmann , Andreas Reichel
IPC分类号： C07D207/44 , C07D207/452 , C07D233/86 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/4015
CPC分类号： C07D207/452 , C07D233/86 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14
摘要： This invention relates to new piperazine derivatives of general formula I, in which V, W, n, R, R′, i, j, Y and Z have the meaning that is indicated in the description. The compounds according to the invention are distinguished by a diazacycloalkane substituent. They have at their disposal a special action with respect to the action that destabilizes the androgen receptor and can be used, for example, for treating prostrate cancer.
摘要翻译： 本发明涉及通式I的新的哌嗪衍生物，其中V，W，n，R，R'，i，j，Y和Z具有在说明书中指出的含义。本发明的化合物被区分 通过二氮杂环烷取代基。 他们有权采取行动，使雄激素受体不稳定，并可用于治疗前列腺癌。
-
10.发明授权Sulphoximine-substituted quinoline and quinazoline derivatives as kinase inhibitors 失效磺酰亚胺取代的喹啉和喹唑啉衍生物作为激酶抑制剂公开(公告)号：US08003787B2
公开(公告)日：2011-08-23
申请号：US12126437
申请日：2008-05-23
申请人： Knut Eis , Olaf Prien , Ulrich Lücking , Judith Günther , Dieter Zopf , Dirk Brohm , Verena Vöhringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
发明人： Knut Eis , Olaf Prien , Ulrich Lücking , Judith Günther , Dieter Zopf , Dirk Brohm , Verena Vöhringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
IPC分类号： C07D239/86
CPC分类号： C07D239/86 , C07D215/44 , C07D409/04
摘要： The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹啉或喹唑啉衍生物：其中R3，R4，W，Y和Q在说明书和权利要求中表示，通式（A）的化合物的用途， 用于治疗各种疾病，以及制备通式（A）的化合物。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.042 秒)
