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    Inhibition of stat-1
    4.
    发明申请
    Inhibition of stat-1 失效
    抑制stat-1

    公开(公告)号：US20050037494A1

    公开(公告)日：2005-02-17

    申请号：US10491758

    申请日：2002-10-02

    申请人： Markus Hecker ,  Andreas Wagner

    发明人： Markus Hecker ,  Andreas Wagner

    IPC分类号： A61K45/00 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K38/00 ,  A61K48/00 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P7/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/02 ,  A61P13/12 ,  A61P17/00 ,  A61P17/04 ,  A61P19/00 ,  A61P19/02 ,  A61P19/06 ,  A61P21/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C12N15/113 ,  C12N5/00

    CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/111 ,  C12N2310/13

    摘要： The present invention relates to inhibitors of the transcription factor STAT-1, their use as therapeutic means as well as their use for the prevention or therapy of cardio-vascular complications like restenosis after percutaneous angioplasty or stenosis of venous bypasses, the graft versus host reaction, the ischemia/refusion-related damage in the context of surgical interventions and organ transplantation respectively, immunological hypersensitivity reactions, in particular the allergic rhinitis, the drug and food allergies, in particular urticaria and celiac disease (sprue), contact eczema and the immune complex diseases, in particular alveolitis, arthritis, glomerulonephritis and allergic vasculitis, inflammatory chondro- and osteopathies, in particular arthrosis, gout, ostitis and osteomyelitis, polyneuritis as well as acute and subacute respectively, infection contingent and in particular post-infectious inflammatory diseases, in particular bronchitis, endocarditis, hepatitis, myocarditis, nephritis, pericarditis, peritonitis and pancreatitis, including the septic shock.

    摘要翻译： 本发明涉及转录因子STAT-1的抑制剂，它们作为治疗方法的用途以及它们用于预防或治疗心血管并发症的用途，如经皮血管成形术或静脉旁路狭窄后的再狭窄，移植物抗宿主反应 ，外科手术和器官移植背景下的缺血/重塑相关损伤，免疫超敏反应，特别是过敏性鼻炎，药物和食物过敏症，特别是荨麻疹和乳糜泻（口腔），接触性湿疹和免疫 复杂疾病，特别是肺泡炎，关节炎，肾小球性肾炎和过敏性血管炎，炎性软骨和骨病，特别是关节病，痛风，口鼻炎和骨髓炎，多发性神经炎以及急性和亚急性感染，特别是感染后炎症性疾病， 特别是支气管炎，心内膜炎，肝炎，肌内 心包炎，肾炎，心包炎，腹膜炎和胰腺炎，包括败血性休克。

    Liposomal composition comprising an active ingredient for relaxing smooth muscle, the production of this composition and the therapeutic use thereof
    6.
    发明授权
    Liposomal composition comprising an active ingredient for relaxing smooth muscle, the production of this composition and the therapeutic use thereof 有权
    包含用于松弛平滑肌的活性成分的脂质体组合物，该组合物的制备及其治疗用途

    公开(公告)号：US08524274B2

    公开(公告)日：2013-09-03

    申请号：US11577488

    申请日：2005-10-14

    申请人： Andreas Wagner ,  Karola Vorauer-Uhl ,  Hermann Katinger

    发明人： Andreas Wagner ,  Karola Vorauer-Uhl ,  Hermann Katinger

    IPC分类号： A61K9/127 ,  A61K31/00 ,  A61K31/44 ,  A01N43/42

    CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K9/06 ,  A61K9/1277 ,  A61K9/1278

    摘要： The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.

    摘要翻译： 本发明涉及由用于局部应用的脂质体中包含的活性成分制成的药物组合物，其中所述脂质体在其内部具有水性介质并且含有其中的至少一种活性成分，其对平滑肌肉组织施加直接或间接的缓解作用， 优选选自前列腺素，腺苷酸环化酶，cAMP，AMP，ATP，NO-合成酶，一氧化氮（NO），NO化合物，硝酸盐，鸟苷酸环化酶，cGMP，GMP，GTP和磷酸二酯酶，特别是西地那非。 本发明进一步涉及用于生产所述组合物的方法，任选地以无菌形式，以及使用支持活性成分的各种盖仑样形式的外源性生物区域用于预防和/或治疗性障碍的用途 男性或女性和/或增加性敏感性。

    LUFFING-JIB TOWER CRANE
    7.
    发明申请
    LUFFING-JIB TOWER CRANE 有权
    LUFFING-JIB塔式起重机

    公开(公告)号：US20130062301A1

    公开(公告)日：2013-03-14

    申请号：US13578951

    申请日：2011-02-16

    申请人： Andreas Wagner

    发明人： Andreas Wagner

    IPC分类号： B66C13/18 ,  B66C23/82

    CPC分类号： B66C23/88 ,  B66C23/82

    摘要： A luffing-jib tower crane, comprising a tower and a jib which is connected to the tower via a joint and is held by a luffing cable, wherein the length of the luffing cable can be changed by a drawing-in unit, by the luffing cable being wound onto or unwound from a cable drum of the drawing-in unit, wherein the angle of the jib with respect to the horizontal plane is measured by a first sensor winch is attached to the jib (first angular value), wherein a measuring device measures the length of the unwound part of the luffing cable, from which length the minimum angle of the jib with respect to the horizontal plane (second angular value) can be calculated, and the first angular value can be compared with the second angular value.

    摘要翻译： 一种起重臂起重机，包括塔架和起重臂，其通过接头连接到塔架并且由变幅缆绳保持，其中变幅缆线的长度可以通过牵引单元通过变幅 电缆从牵引单元的电缆卷筒卷绕或退绕，其中，起重臂相对于水平面的角度由第一传感器绞盘测量，附接到起重臂（第一角度值），其中测量 装置测量变幅电缆的退绕部分的长度，从该长度可以计算起重臂相对于水平面的最小角度（第二角度值），并且可以将第一角度值与第二角度值进行比较 。

    Tank venting device for a fuel tank of a vehicle, and method for venting a fuel tank
    8.
    发明申请
    Tank venting device for a fuel tank of a vehicle, and method for venting a fuel tank 有权
    用于车辆燃料箱的油箱排气装置，以及用于排出燃料箱的方法

    公开(公告)号：US20110284125A1

    公开(公告)日：2011-11-24

    申请号：US13112436

    申请日：2011-05-20

    申请人： HARALD HAGEN ,  Andreas Wagner

    发明人： HARALD HAGEN ,  Andreas Wagner

    IPC分类号： B67D7/04 ,  B67D7/36 ,  G05D7/06 ,  B60K15/035

    CPC分类号： F02M25/089 ,  B60K15/03519 ,  B60K2015/03302 ,  B60K2015/03514 ,  B60K2015/03576 ,  F02M37/0076 ,  Y10T137/264 ,  Y10T137/86324

    摘要： The invention relates to a tank venting system for a fuel tank (12) of a vehicle, having a vent line (14) for discharge of gaseous hydrocarbons from the fuel tank (12) during refueling thereof. Gaseous hydrocarbons originating from the fuel tank (12) can be introduced in a filler pipe (20) of the fuel tank (12) via a recirculation line (24). A control device (34) controls a proportional valve (32) and changes in this way a pass-through cross section of the recirculation line (24). In this way, a load of an activated charcoal filter (16) which is coupled with the vent line (14) can be minimized. The control device (34) can especially determine a pressure in the fuel tank (12). Furthermore, the invention relates to a method of venting a fuel tank (12) during refueling thereof.

    摘要翻译： 本发明涉及一种用于车辆的燃料箱（12）的罐排放系统，具有用于在其加油期间从燃料箱（12）排出气态烃的排放管线（14）。 源自燃料箱（12）的气态烃可以经由再循环管线（24）引入燃料箱（12）的加注管（20）。 控制装置（34）控制比例阀（32）并以这种方式改变再循环管线（24）的通过横截面。 以这种方式，能够使与排气管线（14）联接的活性炭过滤器（16）的负载最小化。 控制装置（34）可以特别地确定燃料箱（12）中的压力。 此外，本发明涉及一种在加油期间排放燃料箱（12）的方法。

    UNIVERSALLY USABLE ELECTRONIC MANUAL STAMPING DEVICE
    9.
    发明申请
    UNIVERSALLY USABLE ELECTRONIC MANUAL STAMPING DEVICE 审中-公开
    通用电子手动压印装置

    公开(公告)号：US20100128072A1

    公开(公告)日：2010-05-27

    申请号：US12512068

    申请日：2009-07-30

    申请人： Andreas Wagner

    发明人： Andreas Wagner

    IPC分类号： B41J29/38

    CPC分类号： G07B17/00193 ,  B41J3/36 ,  G07B2017/00217

    摘要： A universally usable electronic manual stamping device has an inkjet print head that can be moved back and forth in a print window, the print window being arranged in a base plate facing toward a print medium during the printing. A control unit of the device is connected with a user interface, with an external interface and with an internal interface. The inkjet print head is operationally connected via the internal interface with an actuator to move the inkjet print head and with an internal power source to supply the control unit, the inkjet print head and its actuator, as well as the interfaces. The control unit includes a security processor that possesses at least one transaction module which is provided to implement cryptographic security and certification tasks in connection with the printing of an individually secured stamp imprint. The control unit is programmed to control the printing and a base station onto which the manual stamping device is fashioned to be placed for its maintenance and downloading with data.

    摘要翻译： 普遍可用的电子手动冲压装置具有能够在打印窗口中来回移动的喷墨打印头，打印窗口在打印期间布置在面向打印介质的基板中。 设备的控制单元与用户界面，外部接口和内部接口连接。 喷墨打印头通过内部接口与致动器可操作地连接以移动喷墨打印头和内部电源，以供应控制单元，喷墨打印头及其致动器以及接口。 该控制单元包括一个安全处理器，该安全处理器具有至少一个交易模块，该交易模块被提供以实现与打印单独保密的印记印记有关的加密安全和认证任务。 控制单元被编程为控制打印以及将手动冲压装置制成的基站放置成用于其维护和下载的数据。

    Arrangement for installing a communication unit in an apparatus
    10.
    发明申请
    Arrangement for installing a communication unit in an apparatus 有权
    将通信单元安装在设备中的布置

    公开(公告)号：US20060010000A1

    公开(公告)日：2006-01-12

    申请号：US11172774

    申请日：2005-07-01

    申请人： Joachim Jauert ,  Axel Ortmann ,  Tilmann Schilling ,  Torsten Schlaaff ,  Andreas Wagner ,  Dieter Wolm

    发明人： Joachim Jauert ,  Axel Ortmann ,  Tilmann Schilling ,  Torsten Schlaaff ,  Andreas Wagner ,  Dieter Wolm

    IPC分类号： G06Q99/00

    CPC分类号： G07B17/00193 ,  G07B2017/00233

    摘要： An arrangement for installing a communication unit in an apparatus having a security housing, such as a mail processing apparatus, including a cavity bay located at a non-secure region of the apparatus that is accessible by a cover that is non-destructibly detachable from the security housing. The bay receives a pluggable communication unit that has a connection element connectible by a plug-in movement with a connection element of a motherboard located in the secure region of the apparatus: The cavity has at least one further connection element that is electrically conductively and mechanically connected with a metal chassis part of the apparatus in the security housing. This further connection element protrudes into the cavity and establishes contact with the communication unit for grounding thereof.

    摘要翻译： 一种用于将通信单元安装在具有诸如邮件处理设备的安全壳体的设备中的装置，该设备包括位于设备的非安全区域的空腔，所述空腔可由不可破坏地拆卸的盖可接近 安全住房。 隔间接收可插拔通信单元，该可插拔通信单元具有通过插入式移动连接的连接元件，该连接元件具有位于该设备的安全区域中的主板的连接元件：空腔具有至少一个导电和机械的另外的连接元件 与安全壳体中的装置的金属底盘部分连接。 该另外的连接元件突出到空腔中并与通信单元建立接触，用于接地。