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公开(公告)号：US06525215B2
公开(公告)日：2003-02-25
申请号：US09885056
申请日：2001-06-21
申请人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07C6532
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： Compounds useful as intermediates in the preparation of HIV protease inhibitors. These compounds have the following general formula:
摘要翻译： 可用作制备HIV蛋白酶抑制剂的中间体的化合物。 这些化合物具有以下通式：
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公开(公告)号：US06693199B2
公开(公告)日：2004-02-17
申请号：US10300638
申请日：2002-11-21
申请人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07D51502
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： A method of making HIV protease inhibitors of general formula (1): These HIV compounds inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other antiviral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译： 制备通式（1）的HIV蛋白酶抑制剂的方法：这些HIV化合物抑制或阻断HIV蛋白酶的生物活性，导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和光学其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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公开(公告)号：US5514802A
公开(公告)日：1996-05-07
申请号：US416568
申请日：1995-04-04
IPC分类号： C07C237/18 , A61K31/16 , A61K31/47 , A61K31/472 , C07C231/14 , C07C237/20 , C07C317/40 , C07C317/50 , C07C323/60 , C07C323/61 , C07C323/63 , C07D215/48 , C07D217/22 , C07D401/12 , C07D217/16
CPC分类号： C07D401/12 , C07C323/60 , C07D215/48
摘要： The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.
摘要翻译： 本发明提供了新的HIV蛋白酶抑制剂，含有这些化合物的药物制剂以及治疗和/或预防HIV感染和/或AIDS的方法。
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公开(公告)号：US5484926A
公开(公告)日：1996-01-16
申请号：US190764
申请日：1994-02-02
申请人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried H. Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried H. Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , C07D217/20
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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公开(公告)号：US5434265A
公开(公告)日：1995-07-18
申请号：US994871
申请日：1992-12-22
IPC分类号： C07C237/18 , A61K31/16 , A61K31/47 , A61K31/472 , C07C231/14 , C07C237/20 , C07C317/40 , C07C317/50 , C07C323/60 , C07C323/61 , C07C323/63 , C07D215/48 , C07D217/22 , C07D401/12 , C07D217/26
CPC分类号： C07D401/12 , C07C323/60 , C07D215/48
摘要： The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating HIV infection.
摘要翻译： 本发明提供了新的HIV蛋白酶抑制剂，含有这些化合物的药物制剂和治疗HIV感染的方法。
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公开(公告)号：US5834467A
公开(公告)日：1998-11-10
申请号：US482504
申请日：1995-06-07
申请人： Vincent J. Kalish , Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriquez
发明人： Vincent J. Kalish , Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriquez
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , A61K31/50
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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7.发明授权Intermediates for inhibitors of HIV protease and method of preparation thereof 失效HIV蛋白酶抑制剂的中间体及其制备方法
公开(公告)号：US5719287A
公开(公告)日：1998-02-17
申请号：US449176
申请日：1995-05-24
申请人： Stephen W. Kaldor , Marlys Hammond
发明人： Stephen W. Kaldor , Marlys Hammond
IPC分类号： A61K31/16 , A61K31/165 , A61K31/47 , A61K38/00 , A61K38/55 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/22 , C07C237/42 , C07C271/22 , C07D209/42 , C07D213/81 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/26 , C07D235/24 , C07D241/42 , C07D241/44 , C07D333/76 , C07D401/12 , C07D405/12 , C07D409/12 , C07K5/02 , C12N15/15 , C07D215/00 , C07C221/00 , C07D309/32 , C07D401/06
CPC分类号： C07D213/81 , C07C237/42 , C07C271/22 , C07D209/42 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/26 , C07D235/24 , C07D241/42 , C07D241/44 , C07D333/76 , C07D401/12 , C07D405/12 , C07D409/12 , C07K5/021 , A61K38/00
摘要： The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of their use.
摘要翻译： 本发明提供新颖的HIV蛋白酶抑制剂，含有这些化合物的药物制剂及其使用方法。
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公开(公告)号：US5827891A
公开(公告)日：1998-10-27
申请号：US478599
申请日：1995-06-07
申请人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , A61K31/16 , C07C233/00
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译： 可通过化学合成获得的HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物活性，导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和任选的其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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公开(公告)号：US5508407A
公开(公告)日：1996-04-16
申请号：US875908
申请日：1992-04-29
申请人： Stephen W. Kaldor , Marlys Hammond
发明人： Stephen W. Kaldor , Marlys Hammond
IPC分类号： A61K38/00 , C07C237/42 , C07C271/22 , C07D209/42 , C07D213/81 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/26 , C07D235/24 , C07D241/42 , C07D241/44 , C07D333/76 , C07D401/12 , C07D405/12 , C07D409/12 , C07K5/02 , A61K31/47
CPC分类号： C07D213/81 , C07C237/42 , C07C271/22 , C07D209/42 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/26 , C07D235/24 , C07D241/42 , C07D241/44 , C07D333/76 , C07D401/12 , C07D405/12 , C07D409/12 , C07K5/021 , A61K38/00
摘要： The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of their use.
摘要翻译： 本发明提供新的HIV蛋白酶抑制剂，含有这些化合物的药物制剂及其使用方法。
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10.发明授权Pharmaceutical compositions containing HIV protease inhibitors and methods of their use 有权含有HIV蛋白酶抑制剂的药物组合物及其使用方法
公开(公告)号：US6162812A
公开(公告)日：2000-12-19
申请号：US283152
申请日：1999-04-01
申请人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译： 可通过化学合成获得的HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物活性，导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和光学其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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