公开(公告)号：US4276283A

公开(公告)日：1981-06-30

申请号：US74257

申请日：1979-09-10

申请人： Martha Eibl ,  Otto Schwarz ,  Yendra Linnau

发明人： Martha Eibl ,  Otto Schwarz ,  Yendra Linnau

IPC分类号： A61K39/395 ,  C07K16/06 ,  A61K39/00

CPC分类号： C07K16/065 ,  Y10S530/83

摘要： A method of preparing an intravenously administrable immune globulin preparation containing antibodies, in which human blood plasma is fractionated and an immune-globulin-containing fraction is freed from undesired protein impurities by a single or repeated precipitation with polyethylene glycol, is characterized in that the immune-globulin-containing fraction is subjected in a first purification step prior to the polyethylene glycol precipitation to a treatment with an aqueous solution of a salt of an inorganic acid, and in that at least one of the following purification steps is carried out with polyethylene glycol in the presence of a soluble carbohydrate or a non-protein-precipitating polyol, whereupon the immune globulin freed from protein impurities is precipitated from the remaining solution by water-soluble polymers and is finished in a known manner to the pharmaceutical preparation.

摘要翻译： 制备含有抗体的静脉内施用的免疫球蛋白制剂的方法，其中人血浆被分级，并且含有免疫球蛋白的级分通过用聚乙二醇单次或重复沉淀而不含有不需要的蛋白质杂质，其特征在于免疫 含有球蛋白的级分在聚乙二醇沉淀之前的第一纯化步骤中经过无机酸盐的水溶液处理，并且至少一个以下纯化步骤用聚乙二醇 在可溶性碳水化合物或非蛋白沉淀多元醇的存在下，免去蛋白质杂质的免疫球蛋白从剩余的溶液中被水溶性聚合物沉淀，并以已知的方式完成药物制剂。

公开(公告)号：US5833984A

公开(公告)日：1998-11-10

申请号：US772264

申请日：1996-12-23

申请人： Martha Eibl ,  Hermann Wolf ,  Josef W. Mannhalter ,  Heinz Leibl ,  Yendra Linnau

发明人： Martha Eibl ,  Hermann Wolf ,  Josef W. Mannhalter ,  Heinz Leibl ,  Yendra Linnau

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/08 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07K16/00 ,  C12Q1/02 ,  G01N33/53 ,  C07K16/06

CPC分类号： C07K16/00 ,  A61K39/395 ,  A61K38/00 ,  A61K39/00 ,  Y10S530/861 ,  Y10S530/868

摘要： Inflammation can be treated or prevented altogether by administering a preparation comprising IgA. These preparations also can effect immunomodulation. Preferably, the preparation includes multimeric IgA and is essentially free of IgG in its various forms. Other compounds, such as antibiotics, antiphlogistic agents and antacids, also may be administered. Immunoglobulin A may also be used in vaccines to prevent inflammation. Additionally, an improved assay for evaluating anti-inflammatory activity is provided.

摘要翻译： 通过施用包含IgA的制剂可以完全治疗或预防炎症。 这些制剂也可以实现免疫调节。 优选地，制剂包括多聚体IgA，并且其各种形式基本上不含IgG。 还可以施用其它化合物，例如抗生素，消炎剂和抗酸剂。 免疫球蛋白A也可用于疫苗以预防炎症。 另外，提供了用于评估抗炎活性的改进的测定法。

公开(公告)号：US06646108B1

公开(公告)日：2003-11-11

申请号：US09101430

申请日：1998-07-09

申请人： Heinz Leibl ,  Regine Tomasits ,  Josef Mannhalter ,  Hermann Wolf ,  Martha Eibl

发明人： Heinz Leibl ,  Regine Tomasits ,  Josef Mannhalter ,  Hermann Wolf ,  Martha Eibl

IPC分类号： A61K39395

CPC分类号： C07K16/065 ,  Y10S424/804 ,  Y10S530/861

摘要： A method for the separation of IgG and IgA from an immunoglobulin-containing starting material is described, whereby the method is characterized in that (i) IgG and optionally IgA are adsorbed to a solid inorganic carrier material, (ii) IgA is isolated from the eluate, optionally after selective desorption, whereas IgG remains on the carrier material, and optionally (iii) IgG is isolated from the adsorbate. Furthermore, an IgA preparation is disclosed which demonstrates a low tendency to form aggregates.

摘要翻译： 描述了从含有免疫球蛋白的原料中分离IgG和IgA的方法，其中该方法的特征在于：（i）IgG和任选的IgA被吸附到固体无机载体材料上，（ii）IgA从 洗脱液，任选地在选择性解吸后，而IgG保留在载体材料上，并且任选地（iii）从被吸附物中分离IgG。 此外，公开了表现出形成聚集体的低倾向的IgA制剂。

公开(公告)号：US5808000A

公开(公告)日：1998-09-15

申请号：US500161

申请日：1995-07-10

申请人： Josef W. Mannhalter ,  Heinz Leibl ,  Martha Eibl ,  Regine Tomasits ,  Hermann Wolf

发明人： Josef W. Mannhalter ,  Heinz Leibl ,  Martha Eibl ,  Regine Tomasits ,  Hermann Wolf

IPC分类号： A61K39/395 ,  C07K1/16 ,  C07K1/20 ,  C07K1/22 ,  C07K16/00 ,  C07K16/06

CPC分类号： C07K16/065

摘要： A virus-safe monomeric human IgA is described which is essentially free of IgG. The IgA according to the invention is obtainable according to a process in which (a) an IgA-containing fraction is subjected to a purification such that a monomeric IgA which is essentially free of IgG is obtained and (b) the obtained product is subjected to a process for the inactivation of viruses.

摘要翻译： 描述了基本上不含IgG的病毒安全的单体人IgA。 根据本发明的IgA可以根据以下方法获得：（a）使含IgA的级分进行纯化，使得获得基本上不含IgG的单体IgA，和（b）将所得产物进行 一种灭活病毒的过程。