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    Method of preparing an intravenously administrable immune globulin preparation containing antibodies and preparations produced according to this method
    2.
    发明授权
    Method of preparing an intravenously administrable immune globulin preparation containing antibodies and preparations produced according to this method 失效
    制备含有根据该方法制备的抗体和制剂的静脉内施用的免疫球蛋白制剂的方法

    公开(公告)号：US4276283A

    公开(公告)日：1981-06-30

    申请号：US74257

    申请日：1979-09-10

    申请人： Martha Eibl ,  Otto Schwarz ,  Yendra Linnau

    发明人： Martha Eibl ,  Otto Schwarz ,  Yendra Linnau

    IPC分类号： A61K39/395 ,  C07K16/06 ,  A61K39/00

    CPC分类号： C07K16/065 ,  Y10S530/83

    摘要： A method of preparing an intravenously administrable immune globulin preparation containing antibodies, in which human blood plasma is fractionated and an immune-globulin-containing fraction is freed from undesired protein impurities by a single or repeated precipitation with polyethylene glycol, is characterized in that the immune-globulin-containing fraction is subjected in a first purification step prior to the polyethylene glycol precipitation to a treatment with an aqueous solution of a salt of an inorganic acid, and in that at least one of the following purification steps is carried out with polyethylene glycol in the presence of a soluble carbohydrate or a non-protein-precipitating polyol, whereupon the immune globulin freed from protein impurities is precipitated from the remaining solution by water-soluble polymers and is finished in a known manner to the pharmaceutical preparation.

    摘要翻译： 制备含有抗体的静脉内施用的免疫球蛋白制剂的方法，其中人血浆被分级，并且含有免疫球蛋白的级分通过用聚乙二醇单次或重复沉淀而不含有不需要的蛋白质杂质，其特征在于免疫 含有球蛋白的级分在聚乙二醇沉淀之前的第一纯化步骤中经过无机酸盐的水溶液处理，并且至少一个以下纯化步骤用聚乙二醇 在可溶性碳水化合物或非蛋白沉淀多元醇的存在下，免去蛋白质杂质的免疫球蛋白从剩余的溶液中被水溶性聚合物沉淀，并以已知的方式完成药物制剂。

    Method of producing a factor VIII (AHF) containing fraction
    4.
    发明授权
    Method of producing a factor VIII (AHF) containing fraction 失效
    制备含有因子VIII（AHF）的级分的方法

    公开(公告)号：US4814435A

    公开(公告)日：1989-03-21

    申请号：US108458

    申请日：1987-10-15

    申请人： Otto Schwarz ,  Yendra Linnau

    发明人： Otto Schwarz ,  Yendra Linnau

    IPC分类号： A61K35/14 ,  A61K38/00 ,  A61K38/43 ,  A61P7/04 ,  C07K1/30 ,  C07K14/435 ,  C07K14/745 ,  C07K14/755 ,  A61K35/16 ,  C07K15/14

    CPC分类号： C07K14/755 ,  A61K38/00 ,  Y10S530/83

    摘要： There is disclosed a method of producing a Factor VIII (AHF) containing fraction having a specific activity of at least 2.5 units of Factor VIII/mg protein as well as a portion of immunoglobulin G (IgG) of 10 mg/1000 units of Factor VIII at the most. Its risk of transmission of viral or bacterial infections is to be avoided or largely reduced. The method consists in that undesired proteins are at first precipitated from a Factor VIII (AHF) containing plasma fraction in the presence of SPS. The purified Factor VIII containing solution is treated with suitable salts or salt mixtures in order to obtain a Factor VIII containing precipitate. This precipitate is dissolved, lyophilized and finally heat-treated.

    摘要翻译： 公开了一种生产含有至少2.5单位因子VIII / mg蛋白的比活性的因子VIII（AHF）的部分以及10mg / 1000单位因子VIII的免疫球蛋白G（IgG）的一部分的方法 至多，最多。 其传播病毒或细菌感染的风险是要避免或大大降低。 该方法包括在SPS存在下首先从含有血浆级分的因子VIII（AHF）沉淀不需要的蛋白质。 用合适的盐或盐混合物处理纯化的含Ⅷ因子的溶液，以获得含Ⅷ因子的沉淀物。 将该沉淀溶解，冻干，最后进行热处理。

    Method of producing a factor-VIII(AHF)-high-concentrate
    6.
    发明授权
    Method of producing a factor-VIII(AHF)-high-concentrate 失效
    生产因子VIII（AHF） - 高浓缩物的方法

    公开(公告)号：US4404131A

    公开(公告)日：1983-09-13

    申请号：US287912

    申请日：1981-07-29

    申请人： Otto Schwarz ,  Yendra Linnau

    发明人： Otto Schwarz ,  Yendra Linnau

    IPC分类号： C07K14/745 ,  A61K35/14 ,  A61K38/00 ,  A61K38/16 ,  A61K38/43 ,  C07K14/435 ,  C07K14/755 ,  C07G7/00

    CPC分类号： C07K14/755 ,  A61K38/00 ,  Y10S530/83 ,  Y10S530/831

    摘要： In a method of producing a factor-VIII(AHF)-high-concentrate having a specific activity of at least 2.5 units AHF and a fibrinogen content of less than 0.25 mg/mg protein from human or animal plasma, the plasma is subjected to a multi-step fractionation. The fraction purified by these fractionation measures and enriched in factor VIII (AHF) is subjected to a cryoalcohol precipitation and the resulting precipitate is processed into a stable form.

    摘要翻译： 在生产具有至少2.5单位AHF的比活性和来自人或动物血浆的纤维蛋白原含量小于0.25mg / mg蛋白质的因子VIII（AHF） - 高浓缩物的方法中，将等离子体进行 多步分馏。 通过这些分级测量纯化并富集因子VIII（AHF）的级分进行冷冻醇沉淀，并将所得沉淀物加工成稳定的形式。

    Method of activating prothrombin
    7.
    发明授权
    Method of activating prothrombin 失效
    激活凝血酶原的方法

    公开(公告)号：US5393666A

    公开(公告)日：1995-02-28

    申请号：US34778

    申请日：1993-03-19

    申请人： Yendra Linnau

    发明人： Yendra Linnau

    IPC分类号： C12N9/74 ,  C12N9/64 ,  C12N9/76 ,  C12N11/00 ,  C12N9/00 ,  C12N11/16 ,  A61K37/547

    CPC分类号： C12N9/6429 ,  C12N9/6427 ,  C12N9/647 ,  C12Y304/21005

    摘要： There is disclosed a method of activating prothrombin by means of trypsin, wherein the prothrombin is recovered from a blood or plasma fraction, treated with trypsin immobilized on a water-insoluble carrier, and separated from the immobilized trypsin after activation.

    摘要翻译： 公开了一种通过胰蛋白酶激活凝血酶原的方法，其中从固定在水不溶性载体上的胰蛋白酶处理的血液或血浆级分中回收凝血酶原，并在活化后与固定的胰蛋白酶分离。

    Method of producing lys-plasminogen
    8.
    发明授权
    Method of producing lys-plasminogen 失效
    产生溶酶原纤溶酶原的方法

    公开(公告)号：US5371007A

    公开(公告)日：1994-12-06

    申请号：US41332

    申请日：1993-04-01

    申请人： Yendra Linnau ,  Ernst Hetzl

    发明人： Yendra Linnau ,  Ernst Hetzl

    IPC分类号： A61K38/46 ,  A61P7/02 ,  C12N9/68 ,  C12S3/14 ,  C12P21/00 ,  C12N9/00

    CPC分类号： C12N9/6435 ,  C12Y304/21007

    摘要： To produce lys-plasminogen having a specific activity of at least 17.5 caseinolytic units/mg protein and at least 50 mymoles/g protein nitrogen as well as an electrophoretic purity of at least 90%, plasminogen from plasma, a plasminogen-containing fraction or a tissue culture is adsorbed on immobilized lysine for the purpose of purification, is eluted and is recovered from the eluate by a protein precipitating agent. A solution of the thus purified plasminogen is adjusted to a plasmin activity ranging between 0.005 and 0.2 mymoles/ml min relative to chromogenic substrate H-D-valyl-L-leucyl-L-lysine-p-nitroanilide dihydrochloride, is maintained at a temperature of from +1.degree. C. to +20.degree. C. for a period of from 6 to 60 hours in order to provoke an enzymatic-proteolytic conversion of plasminogen into lys-plasminogen, whereupon the enzymatic action is interrupted and lys-plasminogen is isolated.

    摘要翻译： 为了产生具有至少17.5个酪蛋白分解单位/ mg蛋白和至少50 mymoles / g蛋白质氮的比活性以及至少90％的电泳纯度的溶血纤溶酶原，血浆中的纤溶酶原，含纤溶酶原的级分或 组织培养物被吸附在固定的赖氨酸上用于纯化，被洗脱并通过蛋白质沉淀剂从洗脱液中回收。 将如此纯化的纤溶酶原的溶液调节至相对于显色底物HD-缬氨酰-L-亮氨酰-L-赖氨酸 - 对硝基苯胺二盐酸盐在0.005至0.2 mymoles / ml min范围内的纤溶酶活性维持在 +1℃至+ 20℃，时间为6至60小时，以引起纤溶酶原转化为溶酶原纤维蛋白溶酶原的酶 - 蛋白水解转化，由此中断酶促作用并分离裂解纤溶酶原。