公开(公告)号：US6075122A

公开(公告)日：2000-06-13

申请号：US466680

申请日：1995-06-06

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K39/00 ,  A61P43/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K17/00 ,  C12N1/21 ,  C12N5/08 ,  C12N7/00 ,  C12N9/12 ,  C12N15/12 ,  C12N15/54 ,  C12N15/86 ,  C12P21/02 ,  G01N33/574

CPC分类号： A61K39/0011 ,  C07K14/4705 ,  C07K14/71 ,  C07K7/06 ,  G01N33/57407 ,  G01N33/57488 ,  A61K38/00 ,  A61K39/00 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

摘要： Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

公开(公告)号：US5869445A

公开(公告)日：1999-02-09

申请号：US625101

申请日：1996-04-01

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K39/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K17/00 ,  C12N5/08 ,  G01N33/574 ,  A61K38/17

CPC分类号： A61K39/0011 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  A61K38/00 ,  A61K39/00 ,  G01N2333/71 ,  G01N2333/82

摘要： Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/neu protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2/neu oncogene is associated.

摘要翻译： 公开了引发或增强对HER-2 / neu蛋白的免疫反应性的化合物和组合物。 化合物包括编码这些肽的多肽和核酸分子。 该化合物可用于预防或治疗HER-2 / neu致癌基因相关的恶性肿瘤。

公开(公告)号：US20100087621A1

公开(公告)日：2010-04-08

申请号：US12629651

申请日：2009-12-02

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： C07K7/06

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  C07K7/06 ,  C07K14/4705 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

摘要： Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

摘要翻译： 公开了检测，监测和治疗其中HER-2 / neu致癌基因相关的恶性肿瘤的方法。 通过体外暴露于HER-2 / neu蛋白来检测特异性T细胞活化（例如，通过测量T细胞的增殖），或检测HER-2 / neu蛋白与体液中抗体之间形成的免疫复合物 允许诊断HER-2 / neu致癌基因相关的恶性肿瘤的存在。 本发明还公开了用于治疗这些恶性肿瘤的方法和组合物，包括肽。

公开(公告)号：US06942862B2

公开(公告)日：2005-09-13

申请号：US09088951

申请日：1998-06-02

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/71 ,  A61K38/17

CPC分类号： A61K39/0005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82

摘要： Methods and compositions to elicit or enhance immunity in humans against self tumor antigens are disclosed. Such immunity is generated by immunization with homologous foreign proteins. Self tumor antigens include protein expression products of overexpressed human oncogenes, such as human HER-2/neu protein, and organ-specific or tissue-specific differentiation antigens, such as PAP or PSA, associated with tumor cells.

摘要翻译： 公开了引发或增强人体免疫自身抗体抗原的方法和组合物。 这种免疫通过用同源外源蛋白免疫产生。 自身肿瘤抗原包括与肿瘤细胞相关的过度表达的人癌基因如人HER-2 / neu蛋白和器官特异性或组织特异性分化抗原如PAP或PSA的蛋白质表达产物。

公开(公告)号：US06953573B1

公开(公告)日：2005-10-11

申请号：US09167516

申请日：1998-10-06

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/71 ,  G01N33/574 ,  A61K35/14 ,  C12N15/85

CPC分类号： C12N15/63 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0011 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82

摘要： Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/neu protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2/neu oncogene is associated.

公开(公告)号：US20100010075A1

公开(公告)日：2010-01-14

申请号：US12554279

申请日：2009-09-04

申请人： Martin A. CHEEVER ,  Mary L. Disis

发明人： Martin A. CHEEVER ,  Mary L. Disis

IPC分类号： A61K31/7088 ,  C07H21/04 ,  C12N15/63

CPC分类号： C12N15/63 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0011 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82

摘要： Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/neu protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2/neu oncogene is associated.

摘要翻译： 公开了引发或增强对HER-2 / neu蛋白的免疫反应性的化合物和组合物。 化合物包括编码这些肽的多肽和核酸分子。 该化合物可用于预防或治疗HER-2 / neu致癌基因相关的恶性肿瘤。

公开(公告)号：US06664370B2

公开(公告)日：2003-12-16

申请号：US09354533

申请日：1999-07-15

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： C07K708

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  C07K7/06 ,  C07K14/4705 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

摘要： Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

摘要翻译： 公开了检测，监测和治疗其中HER-2 / neu致癌基因相关的恶性肿瘤的方法。 通过体外暴露于HER-2 / neu蛋白来检测特异性T细胞活化（例如，通过测量T细胞的增殖），或检测HER-2 / neu蛋白与体液中抗体之间形成的免疫复合物 允许诊断HER-2 / neu致癌基因相关的恶性肿瘤的存在。 本发明还公开了用于治疗这些恶性肿瘤的方法和组合物，包括肽。

公开(公告)号：US5876712A

公开(公告)日：1999-03-02

申请号：US468545

申请日：1995-06-06

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K39/00 ,  A61P43/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K17/00 ,  C12N1/21 ,  C12N5/08 ,  C12N7/00 ,  C12N9/12 ,  C12N15/12 ,  C12N15/54 ,  C12N15/86 ,  C12P21/02 ,  G01N33/574 ,  A61K35/14

CPC分类号： A61K39/0011 ,  C07K14/4705 ,  C07K14/71 ,  C07K7/06 ,  G01N33/57407 ,  G01N33/57488 ,  A61K38/00 ,  A61K39/00 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

摘要： Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

公开(公告)号：US5846538A

公开(公告)日：1998-12-08

申请号：US486348

申请日：1995-06-07

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K39/00 ,  A61P43/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K17/00 ,  C12N1/21 ,  C12N5/08 ,  C12N7/00 ,  C12N9/12 ,  C12N15/12 ,  C12N15/54 ,  C12N15/86 ,  C12P21/02 ,  G01N33/574 ,  A61K38/02

CPC分类号： A61K39/0011 ,  C07K14/4705 ,  C07K14/71 ,  C07K7/06 ,  G01N33/57407 ,  G01N33/57488 ,  A61K38/00 ,  A61K39/00 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

摘要： Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

摘要翻译： 公开了检测，监测和治疗其中HER-2 / neu致癌基因相关的恶性肿瘤的方法。 通过体外暴露于HER-2 / neu蛋白来检测特异性T细胞活化（例如，通过测量T细胞的增殖），或检测HER-2 / neu蛋白与体液中抗体之间形成的免疫复合物 允许诊断HER-2 / neu致癌基因相关的恶性肿瘤的存在。 本发明还公开了用于治疗这些恶性肿瘤的方法和组合物，包括肽。

公开(公告)号：US5801005A

公开(公告)日：1998-09-01

申请号：US414417

申请日：1995-03-31

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K39/00 ,  A61P43/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K17/00 ,  C12N1/21 ,  C12N5/08 ,  C12N7/00 ,  C12N9/12 ,  C12N15/12 ,  C12N15/54 ,  C12N15/86 ,  C12P21/02 ,  G01N33/574 ,  G01N33/53 ,  C07K7/04 ,  C07K14/82

CPC分类号： A61K39/0011 ,  C07K14/4705 ,  C07K14/71 ,  C07K7/06 ,  G01N33/57407 ,  G01N33/57488 ,  A61K38/00 ,  A61K39/00 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

摘要： Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

摘要翻译： 公开了检测，监测和治疗其中HER-2 / neu致癌基因相关的恶性肿瘤的方法。 通过体外暴露于HER-2 / neu蛋白来检测特异性T细胞活化（例如，通过测量T细胞的增殖），或检测HER-2 / neu蛋白与体液中抗体之间形成的免疫复合物 允许诊断HER-2 / neu致癌基因相关的恶性肿瘤的存在。 本发明还公开了用于治疗这些恶性肿瘤的方法和组合物，包括肽。