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公开(公告)号：US20120263743A1
公开(公告)日：2012-10-18
申请号：US13318099
申请日：2010-04-30
IPC分类号： A61K39/145 , A61P31/16 , A61P37/04 , C07K14/11
CPC分类号： A61K47/6901 , A61K47/646
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and/or prevention of influenza. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is an ectodomain of an influenza virus hemagglutinin protein or a fragment of said ectodomain of an influenza virus hemagglutinin protein. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions efficiently induce immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against influenza virus. Thus, the invention further provides methods of treating, ameliorating and/or preventing influenza virus infection.
摘要翻译： 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明提供用于治疗，改善和/或预防流感的组合物，疫苗组合物和药物组合物。 本发明的组合物，疫苗组合物和药物组合物包含RNA噬菌体和至少一种抗原的病毒样颗粒，其中所述至少一种抗原是流感病毒血凝素蛋白的胞外域或所述胞外域的片段 流感病毒血凝素蛋白。 当给予动物，优选给人时，所述组合物，疫苗组合物和药物组合物有效诱导免疫应答，特别是抗体应答，其中通常且优选所述抗体应答针对流感病毒。 因此，本发明还提供了治疗，改善和/或预防流感病毒感染的方法。
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公开(公告)号：US20100111995A1
公开(公告)日：2010-05-06
申请号：US11922217
申请日：2006-06-14
申请人： Martin F. Bachman , Alain Tissot , Andrea Jegerlehner , Philippe Saudan , Yu Zou , Nicole Schmitz , Adrian Huber , Stephen Martin , Heather Hinton
发明人： Martin F. Bachman , Alain Tissot , Andrea Jegerlehner , Philippe Saudan , Yu Zou , Nicole Schmitz , Adrian Huber , Stephen Martin , Heather Hinton
CPC分类号： A61K39/21 , A61K39/0005 , A61K39/0008 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/57 , A61K2039/6075 , A61K2039/622 , A61K2039/627 , A61K2039/64 , C07K2319/70 , C12N2740/16211 , C12N2740/16234 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen of the invention, wherein said antigen of the invention is CCR5 of the invention, gastrin of the invention, CXCR4 of the invention, CETP of the invention or C5a of the invention. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of diseases in which the antigen of the invention mediates, or contributes to the condition, particularly for the treatment of AIDS, gastrointestinal cancers, coronary heart diseases or inflammatory diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译： 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明提供包含连接至本发明的至少一种抗原的病毒样颗粒（VLP）的组合物，其中本发明的所述抗原是本发明的CCR5，本发明的胃泌素，本发明的CXCR4，本发明的CETP或 C5a。 本发明还提供了一种制备该组合物的方法。 本发明的组合物可用于疫苗的生产，特别是用于治疗其中本发明的抗原介导或有助于该疾病的疾病，特别是用于治疗AIDS，胃肠癌，冠心病或 炎性疾病。 此外，本发明的组合物诱导有效的免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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3.发明申请Methods and compositions for modulating the interaction between adiponectin and its receptor 审中-公开调节脂联素及其受体之间相互作用的方法和组合物公开(公告)号：US20060286035A1
公开(公告)日：2006-12-21
申请号：US10555058
申请日：2004-04-28
申请人： Philippe Saudan , Martin Bachmann
发明人： Philippe Saudan , Martin Bachmann
IPC分类号： A61K49/00 , A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06 , A61K39/395
CPC分类号： G01N33/566 , A61K38/00 , A61K38/2264 , A61K49/0004 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2319/43 , G01N2333/705 , A61K2300/00
摘要： The invention is directed to methods for identifying agents that mimic or modulate the interaction between adiponectin and its receptor. In particular, the invention is directed to methods for mimicking or modulating the adiponectin-T-cadherin interaction in order to treat diseases and disorders associated with a deficiency or overabundance of adiponectin. Such diseases include, e.g., obesity, anorexia nervosa, type I and type II diabetes, coronary artery disease and atherosclerosis. The invention also provides isolated adiponectin-T-cadherin complexes and methods for identifying polypeptides that interact with adiponectin.
摘要翻译： 本发明涉及用于鉴定模拟或调节脂联素及其受体之间相互作用的试剂的方法。 特别地，本发明涉及用于模拟或调节脂连蛋白-T-钙粘蛋白相互作用以便治疗与脂联素缺乏或过量相关的疾病和病症的方法。 这些疾病包括例如肥胖症，神经性厌食症，I型和II型糖尿病，冠状动脉疾病和动脉粥样硬化。 本发明还提供分离的脂联素-T-钙粘蛋白复合物和用于鉴定与脂连蛋白相互作用的多肽的方法。
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公开(公告)号：US20060088550A1
公开(公告)日：2006-04-27
申请号：US11257498
申请日：2005-10-25
申请人： Martin Bachmann , Alma Fulurija , Philippe Saudan
发明人： Martin Bachmann , Alma Fulurija , Philippe Saudan
IPC分类号： A61K39/12 , A61K31/4439 , C12N7/00
CPC分类号： C07K16/26 , A61K39/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2317/34 , C12N7/00 , C12N2730/10122 , C12N2730/10123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a GIP protein or a GIP fragment linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of obesity and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. Accordingly, the invention further provides for methods of treating and/or preventing obesity and other conditions.
摘要翻译： 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明尤其提供包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是分别与VLP连接的GIP蛋白或GIP片段。 本发明还提供了一种制备上述组合物的方法。 本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗肥胖症，特别是通过诱导有效的免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。 因此，本发明还提供了治疗和/或预防肥胖症和其他病症的方法。
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公开(公告)号：US20060251620A1
公开(公告)日：2006-11-09
申请号：US10524818
申请日：2003-08-21
申请人： Lidia Ivanova , Wolfgang Renner , Philippe Saudan
发明人： Lidia Ivanova , Wolfgang Renner , Philippe Saudan
CPC分类号： C12N15/86 , A61K48/00 , C12N15/85 , C12N2710/16243 , C12N2800/108 , C12N2840/20
摘要： The present invention relates to compositions and methods that allow the production of polypeptides and untranslated RNA molecules in host cells. More specifically, the invention provides nucleic acid molecules, expression systems, recombinant host cells, methods and kits, which enable the production and/or isolation and/or purification of polypeptides and untranslated RNA molecules. The compositions and methods of the invention can be applied in a regulatable expression system that is transiently transfected into mammalian host cells.
摘要翻译： 本发明涉及允许在宿主细胞中产生多肽和非翻译的RNA分子的组合物和方法。 更具体地，本发明提供能够产生和/或分离和/或纯化多肽和非翻译的RNA分子的核酸分子，表达系统，重组宿主细胞，方法和试剂盒。 本发明的组合物和方法可以应用于瞬时转染入哺乳动物宿主细胞的可调节表达系统中。
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公开(公告)号：US07572451B2
公开(公告)日：2009-08-11
申请号：US11257498
申请日：2005-10-25
IPC分类号： A61K39/385 , A61K39/00 , C12P21/06 , C07H21/04
CPC分类号： C07K16/26 , A61K39/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2317/34 , C12N7/00 , C12N2730/10122 , C12N2730/10123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a GIP protein or a GIP fragment linked to the VLP. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of immunogens, in particular, for the prevention and/or treatment of obesity and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. Accordingly, the invention further provides for methods of treating and/or preventing obesity and other conditions.
摘要翻译： 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明尤其提供包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是GIP蛋白或与VLP连接的GIP片段。 本发明还提供了一种制备上述组合物的方法。 本发明的组合物可用于免疫原的制备，特别是用于预防和/或治疗肥胖症，特别是通过诱导有效的免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。 因此，本发明还提供了治疗和/或预防肥胖症和其他病症的方法。
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公开(公告)号：US07371542B2
公开(公告)日：2008-05-13
申请号：US10888961
申请日：2004-07-12
申请人： Lidia Ivanova , Philippe Saudan
发明人： Lidia Ivanova , Philippe Saudan
IPC分类号： C12P1/02
CPC分类号： C12N15/85 , C07K14/005 , C07K2319/30 , C12N2710/16222 , C12N2800/108 , C12N2830/42 , C12N2830/46 , C12N2840/20
摘要： The present invention relates to nucleic acid molecules and in particular to vectors, comprising at least one gene of interest, at least one scaffold/matrix attached region (S/MAR), at least one origin of replication, and at least one replication initiation factor, cells comprising these, processes for their propagation, and their use, in particular for the high level expression of proteins which can be used as medicaments.
摘要翻译： 本发明涉及核酸分子，特别涉及包含至少一种目的基因，至少一种支架/基质附着区域（S / MAR），至少一种复制起点和至少一种复制起始因子的载体 ，包含它们的细胞，它们的繁殖过程及其用途，特别是可用作药物的蛋白质的高水平表达。
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公开(公告)号：US07959924B2
公开(公告)日：2011-06-14
申请号：US12461206
申请日：2009-08-04
IPC分类号： A61K39/385 , A61K39/00 , C12P21/06 , C07H21/04
CPC分类号： C07K16/26 , A61K39/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2317/34 , C12N7/00 , C12N2730/10122 , C12N2730/10123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a GIP protein or a GIP fragment linked to the VLP respectively.The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of obesity and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. Accordingly, the invention further provides for methods of treating and/or preventing obesity and other conditions.
摘要翻译： 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明尤其提供包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是分别与VLP连接的GIP蛋白或GIP片段。 本发明还提供了一种制备上述组合物的方法。 本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗肥胖症，特别是通过诱导有效的免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。 因此，本发明还提供了治疗和/或预防肥胖症和其他病症的方法。
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公开(公告)号：US20050064467A1
公开(公告)日：2005-03-24
申请号：US10888961
申请日：2004-07-12
申请人： Lidia Ivanova , Philippe Saudan
发明人： Lidia Ivanova , Philippe Saudan
CPC分类号： C12N15/85 , C07K14/005 , C07K2319/30 , C12N2710/16222 , C12N2800/108 , C12N2830/42 , C12N2830/46 , C12N2840/20
摘要： The present invention relates to nucleic acid molecules and in particular to vectors, comprising at least one gene of interest, at least one scaffold/matrix attached region (S/MAR), at least one origin of replication, and at least one replication initiation factor, cells comprising these, processes for their propagation, and their use, in particular for the high level expression of proteins which can be used as medicaments.
摘要翻译： 本发明涉及核酸分子，特别涉及包含至少一种目的基因，至少一种支架/基质附着区域（S / MAR），至少一种复制起点和至少一种复制起始因子的载体 ，包含它们的细胞，它们的繁殖过程及其用途，特别是可用作药物的蛋白质的高水平表达。
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公开(公告)号：US20100143392A1
公开(公告)日：2010-06-10
申请号：US12461206
申请日：2009-08-04
CPC分类号： C07K16/26 , A61K39/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2317/34 , C12N7/00 , C12N2730/10122 , C12N2730/10123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a GIP protein or a GIP fragment linked to the VLP respectively.The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of obesity and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. Accordingly, the invention further provides for methods of treating and/or preventing obesity and other conditions.
摘要翻译： 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明尤其提供包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是分别与VLP连接的GIP蛋白或GIP片段。 本发明还提供了一种制备上述组合物的方法。 本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗肥胖症，特别是通过诱导有效的免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。 因此，本发明还提供了治疗和/或预防肥胖症和其他病症的方法。
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