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公开(公告)号：US20060104990A1
公开(公告)日：2006-05-18
申请号：US11321475
申请日：2005-12-29
申请人： Martin Hughes , Joseph Santangelo , Jonathan Lane , Robert Feldman , Joanne Moore , Richard Dobson , Paul Everest , Caroline Henwood , Gordon Dougan , Rebecca Wilson
发明人： Martin Hughes , Joseph Santangelo , Jonathan Lane , Robert Feldman , Joanne Moore , Richard Dobson , Paul Everest , Caroline Henwood , Gordon Dougan , Rebecca Wilson
IPC分类号： A61K39/02 , C12Q1/68 , G01N33/554 , C07K14/31
CPC分类号： C12N9/1018 , A61K38/00 , A61K39/00 , C07K14/315 , C07K2319/00 , C12N9/0008 , C12N9/1217 , C12N9/22 , C12N9/92
摘要： According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be located on the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines for the immunization of a patient against microbial infection.
摘要翻译： 根据本发明，在B族链球菌中鉴定出一系列基因，其产物可以位于生物体的外表面上。 基因或其功能片段可用于制备治疗剂，例如， 用于免疫接种微生物感染的患者的疫苗。
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公开(公告)号：US20050131210A1
公开(公告)日：2005-06-16
申请号：US10944521
申请日：2004-09-17
申请人： Martin Glenton Hughes , Joseph Santangelo , Jonathan Lane , Robert Feldman , Joanne Moore , Richard Dobson , Paul Everest , Gordon Dougan , Rebecca Wilson
发明人： Martin Glenton Hughes , Joseph Santangelo , Jonathan Lane , Robert Feldman , Joanne Moore , Richard Dobson , Paul Everest , Gordon Dougan , Rebecca Wilson
IPC分类号： A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N9/04 , C12N9/36 , C12N9/52 , C12N9/90 , C12P21/04 , A61K39/02 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C12N9/2462 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/51 , C07K14/315 , C12N9/0006 , C12N9/52 , C12N9/90
摘要： A protein from Group B Steptococcus is shown to be an outer surface protein and is a useful target for antimicrobial therapy.
摘要翻译： 来自B组细胞周期蛋白的蛋白质显示为外表面蛋白质，是抗微生物治疗的有用靶标。
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公开(公告)号：US07592011B2
公开(公告)日：2009-09-22
申请号：US10944521
申请日：2004-09-17
申请人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
发明人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
CPC分类号： C12N9/2462 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/51 , C07K14/315 , C12N9/0006 , C12N9/52 , C12N9/90
摘要： A protein from Group B Streptococcus is shown to be an outer surface protein and is a useful target for antimicrobial therapy.
摘要翻译： 来自B组链球菌的蛋白质被证明是外表面蛋白质，并且是抗微生物治疗的有用靶标。
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公开(公告)号：US06890539B2
公开(公告)日：2005-05-10
申请号：US10096162
申请日：2002-03-11
申请人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
发明人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
IPC分类号： A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N9/04 , C12N9/36 , C12N9/52 , C12N9/90 , A61K39/09 , A61K39/02 , C07H21/04 , C12N1/20 , C12P21/06
CPC分类号： C12N9/2462 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/51 , C07K14/315 , C12N9/0006 , C12N9/52 , C12N9/90
摘要： A protein from Group B Streptococcus is shown to be an outer surface protein and is a useful target for antimicrobial therapy.
摘要翻译： 来自B组链球菌的蛋白质显示为外表面蛋白质，并且是抗微生物治疗的有用靶标。
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公开(公告)号：US20050142149A1
公开(公告)日：2005-06-30
申请号：US11040661
申请日：2005-01-21
申请人： Helen Crooke , Enda Clarke , Paul Everest , Gordon Dougan , David Holden , Jacqueline Shea , Robert Feldman
发明人： Helen Crooke , Enda Clarke , Paul Everest , Gordon Dougan , David Holden , Jacqueline Shea , Robert Feldman
IPC分类号： G01N33/50 , A61K35/74 , A61K38/00 , A61K39/00 , A61K39/108 , A61K48/00 , A61P31/04 , C07K14/245 , C07K14/345 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , A61K39/02 , C12N15/74
CPC分类号： C07K14/245 , A61K38/00 , A61K39/00 , Y10S436/815 , Y10S930/30 , Y10S930/31
摘要： The present invention is based on the identification of a series of virulence genes in E. coli K1, the products of which may be implicated in the pathogenicity of the organisms. The identification of the genes allows them, or their expressed products, to be used in a number of ways to treat infection.
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公开(公告)号：US20090274717A1
公开(公告)日：2009-11-05
申请号：US11892024
申请日：2007-08-17
申请人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
发明人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
IPC分类号： A61K39/09 , C07K14/315
CPC分类号： A61K39/092 , A61K39/00 , A61K48/00 , C07K14/315 , G01N33/56944 , Y02A50/401
摘要： According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines to immunize a patient against microbial infection.
摘要翻译： 根据本发明，在B组链球菌中鉴定出一系列基因，其产物可与生物体的外表面相关联。 基因或其功能片段可用于制备治疗剂，例如， 疫苗免疫患者免受微生物感染。
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公开(公告)号：US07419672B2
公开(公告)日：2008-09-02
申请号：US10799072
申请日：2004-03-12
申请人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
发明人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
CPC分类号： A61K39/092 , A61K39/00 , A61K48/00 , C07K14/315 , G01N33/56944 , Y02A50/401
摘要： According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines to immunize a patient against microbial infection.
摘要翻译： 根据本发明，在B组链球菌中鉴定出一系列基因，其产物可与生物体的外表面相关联。 基因或其功能片段可用于制备治疗剂，例如， 疫苗免疫患者免受微生物感染。
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公开(公告)号：US06812021B1
公开(公告)日：2004-11-02
申请号：US09868352
申请日：2001-09-10
申请人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
发明人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
IPC分类号： C12N120
CPC分类号： A61K39/092 , A61K39/00 , A61K48/00 , C07K14/315 , G01N33/56944 , Y02A50/401
摘要： According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vacaccines to immunize a patient against microbial infection.
摘要翻译： 根据本发明，在B组链球菌中鉴定出一系列基因，其产物可能与生物体的外表面相关联。 基因或其功能片段可用于制备治疗剂，例如， 疫苗免疫患者免受微生物感染。
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公开(公告)号：US20080226641A1
公开(公告)日：2008-09-18
申请号：US11892013
申请日：2007-08-17
申请人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Caroline Joanne Henwood , Gordon Dougan , Rebecca Kerry Wilson
发明人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Caroline Joanne Henwood , Gordon Dougan , Rebecca Kerry Wilson
IPC分类号： A61K39/395 , C07K14/315 , C12Q1/68 , A61K38/02 , A61K38/17 , A61P31/04
CPC分类号： C12N9/1018 , A61K38/00 , A61K39/00 , C07K14/315 , C07K2319/00 , C12N9/0008 , C12N9/1217 , C12N9/22 , C12N9/92
摘要： According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be located on the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines for the immunization of a patient against microbial infection.
摘要翻译： 根据本发明，在B族链球菌中鉴定出一系列基因，其产物可以位于生物体的外表面上。 基因或其功能片段可用于制备治疗剂，例如， 用于免疫接种微生物感染的患者的疫苗。
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公开(公告)号：US20080181908A1
公开(公告)日：2008-07-31
申请号：US10799072
申请日：2004-03-12
申请人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
发明人： Martin John Glenton Hughes , Joseph David Santangelo , Jonathan Douglas Lane , Robert Feldman , Joanne Christine Moore , Richard James Dobson , Paul Everest , Gordon Dougan , Rebecca Kerry Wilson
IPC分类号： A61K39/02 , C07H21/04 , C12N1/21 , C12N15/74 , C07K14/315
CPC分类号： A61K39/092 , A61K39/00 , A61K48/00 , C07K14/315 , G01N33/56944 , Y02A50/401
摘要： According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines to immunize a patient against microbial infection.
摘要翻译： 根据本发明，在B组链球菌中鉴定出一系列基因，其产物可与生物体的外表面相关联。 基因或其功能片段可用于制备治疗剂，例如， 疫苗免疫患者免受微生物感染。
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