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6 条记录 (耗时 0.019 秒)

    Process for the preparation of asymmetrically substituted ureas, carbamates or thiocarbamates
    1.
    发明授权
    Process for the preparation of asymmetrically substituted ureas, carbamates or thiocarbamates 失效
    制备不对称取代的脲，氨基甲酸酯或硫代氨基甲酸酯的方法

    公开(公告)号：US5248755A

    公开(公告)日：1993-09-28

    申请号：US958155

    申请日：1992-10-09

    申请人： Martin Muller ,  Gerhard Stern ,  Erich Schulz ,  Markus Rossler

    发明人： Martin Muller ,  Gerhard Stern ,  Erich Schulz ,  Markus Rossler

    IPC分类号： C07C273/18 ,  C07C333/04

    CPC分类号： C07C273/1818 ,  C07C273/1827 ,  C07C333/04

    摘要： Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates or substituted isocyanates by reaction of an adduct of isocyanic acid and a tertiary amine with a primary and secondary amine, an alcohol, a thiol or a compound having one or two non-cumulated olefinic double bonds, and a process for the preparation of N-mono- or N,N-disubstituted ureas by reaction of ammonium isocyanate with a primary or secondary amine in a diluent.

    摘要翻译： 通过异氰酸和叔胺的加合物与伯胺和仲胺，醇，硫醇或具有一个或两个非累积烯烃的化合物的反应制备不对称取代的脲，氨基甲酸酯，硫代氨基甲酸酯或取代的异氰酸酯的方法 双键，以及通过异氰酸铵与稀释剂中的伯胺或仲胺反应制备N-单或N，N-二取代脲的方法。

    Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates and substituted isocyanates
    4.
    发明授权
    Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates and substituted isocyanates 失效
    用于制备不对称取代的脲，氨基甲酸酯，硫代氨基甲酸酯和取代的异氰酸酯的方法

    公开(公告)号：US5481035A

    公开(公告)日：1996-01-02

    申请号：US85815

    申请日：1993-07-06

    申请人： Martin Mullner ,  Gerhard Stern ,  Markus Rossler

    发明人： Martin Mullner ,  Gerhard Stern ,  Markus Rossler

    IPC分类号： C07C273/18 ,  C07C333/04

    CPC分类号： C07C273/1818 ,  C07C273/1827 ,  C07C333/04

    摘要： Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates or substituted isocyanates by reaction of an adduct of isocyanic acid and a tertiary amine with a primary and secondary amine, an alcohol, a thiol or a compound having one or two non-cumulated olefinic double bonds, and a process for the preparation of N-mono- or N,N-disubstituted ureas by reaction of ammonium isocyanates with a primary or secondary amine in a diluent.

    摘要翻译： 通过异氰酸和叔胺的加合物与伯胺和仲胺，醇，硫醇或具有一个或两个非累积烯烃的化合物的反应制备不对称取代的脲，氨基甲酸酯，硫代氨基甲酸酯或取代的异氰酸酯的方法 双键，以及通过异氰酸铵与稀释剂中的伯胺或仲胺反应来制备N-单或N，N-二取代的脲的方法。

    Process for Preparing Enantiopure E-(2S)-Alkyl-5-Halopent-4-Enoic Acids and Esters
    6.
    发明申请
    Process for Preparing Enantiopure E-(2S)-Alkyl-5-Halopent-4-Enoic Acids and Esters 审中-公开
    制备对映体（E）（2S） - 烷基-5-卤代-4-烯酸和酯的方法

    公开(公告)号：US20080281125A1

    公开(公告)日：2008-11-13

    申请号：US11885740

    申请日：2006-02-22

    申请人： Markus Rossler ,  Gerhard Steinbauer ,  Peter Pojarliev

    发明人： Markus Rossler ,  Gerhard Steinbauer ,  Peter Pojarliev

    IPC分类号： C07C51/42

    CPC分类号： C07C51/02 ,  C07B2200/07 ,  C07C51/412 ,  C07C51/43 ,  C07C57/52

    摘要： A process for preparing enantiopure E-(2S)-alkyl-5-halopent-4-enoic acids and their esters of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-C4-alkyl and X is chlorine, bromine or iodine, in which the corresponding racemic 2-alkyl-5-halopent-4-enoic acid a) is reacted in a suitable solvent first with (S)-3-Methyl-2-phenylbutylamine, quinine or with N-methyl-D-glucamine, after which b) the corresponding (S)-3-Methyl-2-phenylbutylamine salt, quinine or glucamine salt of the (R)-pentenoic acid is precipitated and removed, and c) the remaining filtrate is mixed with a second chiral base or an inorganic salt, after which the corresponding salt of the (S)-pentenoic acid is precipitated and d) is then converted into the corresponding E-(2S)-alkyl-5-halo-4-pentenoic acid and subsequently where appropriate into the corresponding ester of the formula (I) in which R1 is C1-C4-alkyl.

    摘要翻译： 一种制备对映体育用的E-（2S） - 烷基-5-卤代-4-烯酸及其式（I）的酯的方法，其中R是C 1 -C 6 - 6个 - 烷基，R 1是H或C 1 -C 4 - 烷基，X是氯，溴或碘 其中相应的外消旋的2-烷基-5-卤代-4-烯酸a）在合适的溶剂中首先与（S）-3-甲基-2-苯基丁胺，奎宁或与N-甲基-D-葡萄糖胺 ，然后b）相应的（S）-3-甲基-2-苯基丁胺盐，（R） - 戊烯酸的奎宁或葡糖胺盐沉淀并除去，和c）将剩余的滤液与第二手性碱 或无机盐，然后将（S） - 戊烯酸的相应盐沉淀出来，然后将d）转化成相应的E-（2S） - 烷基-5-卤代-4-戊烯酸，随后适当地加入 其中R 1为C 1 -C 4 - 烷基的式（I）的相应酯。