Polymer-factor VIII moiety conjugates
    1.
    发明申请
    Polymer-factor VIII moiety conjugates 有权
    聚合物 - 因子VIII部分缀合物

    公开(公告)号:US20080058504A1

    公开(公告)日:2008-03-06

    申请号:US11702302

    申请日:2007-02-05

    IPC分类号: C07K14/755

    CPC分类号: A61K38/37 A61K47/10 A61K47/60

    摘要: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.

    摘要翻译: 提供因子VIII部分和一种或多种水溶性聚合物的共轭物。 通常,水溶性聚合物是聚(乙二醇)或其衍生物。 还提供了包含缀合物的组合物,制备缀合物的方法,以及向患者施用包含缀合物的组合物的方法。

    Motion capture element mount
    2.
    发明授权
    Motion capture element mount 有权
    运动捕捉元件安装

    公开(公告)号:US09033810B2

    公开(公告)日:2015-05-19

    申请号:US13191309

    申请日:2011-07-26

    申请人: Michael Bentley

    发明人: Michael Bentley

    摘要: Enables coupling or retrofitting a golf club with active motion capture electronics that are battery powered, passive or active shot count components, for example a passive RFID, and/or a visual marker on the cap for use with visual motion capture cameras. Does not require modifying the golf club. Electronics package and battery can be easily removed and replaced, for example without any tools. May utilize a weight that is removed when inserting the electronic package in the mount, wherein the weight element may have the same weight as an electronics package, for no net change or minimal change in club weight. May be implemented with a shaft enclosure and expander that may be coupled with a screw aligned along an axis parallel to the axis of the golf club shaft. May utilize non-permanently and/or friction coupling between the mount and golf club shaft. Cap may include a visual marker and/or logo.

    摘要翻译: 使用主动运动捕捉电子设备来耦合或改装高尔夫球杆,这些电动机是电池供电的,被动的或主动的射击计数组件,例如无源RFID,和/或帽子上的视觉标记,用于视觉运动捕捉相机。 不需要修改高尔夫球杆。 电子封装和电池可以方便地拆卸和更换,例如没有任何工具。 可以使用将电子封装插入安装座时被去除的重量,其中重量元件可以具有与电子封装相同的重量,用于没有净变化或者俱乐部重量的最小变化。 可以使用轴壳体和膨胀器来实现,所述轴壳体和膨胀器可以与沿着平行于高尔夫球杆杆轴的轴线对齐的螺钉联接。 可以使用安装座和高尔夫球杆杆之间的非永久和/或摩擦联接。 帽可以包括视觉标记和/或标志。

    Motion capture element mount
    3.
    发明授权
    Motion capture element mount 有权
    运动捕捉元件安装

    公开(公告)号:US09028337B2

    公开(公告)日:2015-05-12

    申请号:US13306869

    申请日:2011-11-29

    申请人: Michael Bentley

    发明人: Michael Bentley

    摘要: Enables coupling or retrofitting a golf club with active motion capture electronics that are battery powered, passive or active shot count components, for example a passive RFID, and/or a visual marker on the cap for use with visual motion capture cameras. Does not require modifying the golf club. Electronics package and battery can be easily removed and replaced, without any tools. May utilize a weight that is removed when inserting the electronic package, wherein the weight element may have the same weight as an electronics package, for no net change or minimal change in club weight. May be implemented with a shaft enclosure and expander that may be coupled with a screw aligned along an axis parallel to the axis of the golf club shaft. May utilize non-permanently and/or friction coupling between the mount and golf club shaft. Cap may include a visual marker and/or logo.

    摘要翻译: 使用主动运动捕捉电子设备来耦合或改装高尔夫球杆,这些电动机是电池供电的,被动的或主动的射击计数组件,例如无源RFID,和/或帽子上的视觉标记,用于视觉运动捕捉相机。 不需要修改高尔夫球杆。 电子封装和电池可以方便地拆卸和更换,无需任何工具。 可以使用在插入电子包装时被去除的重量,其中重量元件可以具有与电子包装件相同的重量,不会发生净变化或者俱乐部重量的最小变化。 可以使用轴壳体和膨胀器来实现,所述轴壳体和膨胀器可以与沿着平行于高尔夫球杆杆轴的轴线对齐的螺钉联接。 可以使用安装座和高尔夫球杆杆之间的非永久和/或摩擦联接。 帽可以包括视觉标记和/或标志。

    Motion capture element
    4.
    发明授权
    Motion capture element 有权
    运动捕捉元素

    公开(公告)号:US08903521B2

    公开(公告)日:2014-12-02

    申请号:US13351429

    申请日:2012-01-17

    摘要: Motion capture element for low power and accurate data capture for use in healthcare compliance, sporting, gaming, military, virtual reality, industrial, retail loss tracking, security, baby and elderly monitoring and other applications for example obtained from a motion capture element and relayed to a database via a mobile phone. System obtains data from motion capture elements, analyzes data and stores data in database for use in these applications and/or data mining, which may be charged for. Enables unique displays associated with the user, such as 3D overlays onto images of the user to visually depict the captured motion data. Ratings, compliance, ball flight path data can be calculated and displayed, for example on a map or timeline or both. Enables performance related equipment fitting and purchase. Includes active and passive identifier capabilities.

    摘要翻译: 运动捕捉元件,用于低功率和准确的数据采集,用于医疗保健,体育,游戏,军事,虚拟现实,工业,零售损失跟踪,安全性,婴儿和老年监护以及其他应用,例如从运动捕捉元件获得并传递 通过手机到数据库。 系统从运动捕获元素获取数据,分析数据并将数据存储在数据库中,以用于可能需要支付的这些应用程序和/或数据挖掘中。 启用与用户相关联的独特显示,例如3D覆盖到用户的图像上,以可视地描绘捕获的运动数据。 可以计算和显示评级,合规性,球飞行路径数据,例如在地图或时间轴上或两者上。 使性能相关的设备安装和购买。 包括主动和被动标识符功能。

    Nutritional supplement for osteoarthritis
    6.
    发明授权
    Nutritional supplement for osteoarthritis 有权
    营养补品为骨关节炎

    公开(公告)号:US07910136B2

    公开(公告)日:2011-03-22

    申请号:US12187994

    申请日:2008-08-07

    申请人: Michael Bentley

    发明人: Michael Bentley

    IPC分类号: A61K33/12

    摘要: The present invention relates to a method of treating osteoarthritis by administering a mineral composition in the form of a nutritional supplement, where the mineral composition may contain Smectite, Gypsum, Quartz, Feldspar, Jarosite, Kaolinite and/or Zeolite.

    摘要翻译: 本发明涉及一种通过施用营养补充剂形式的矿物组合物来治疗骨关节炎的方法,其中矿物组合物可以含有蒙皂石,石膏,石英,长石,高铁矿,高岭土和/或沸石。

    NUTRITIONAL SUPPLEMENT FOR OSTEOARTHRITIS
    7.
    发明申请
    NUTRITIONAL SUPPLEMENT FOR OSTEOARTHRITIS 有权
    OSTEOARTHRITIS的营养补充

    公开(公告)号:US20080292730A1

    公开(公告)日:2008-11-27

    申请号:US12187994

    申请日:2008-08-07

    申请人: Michael Bentley

    发明人: Michael Bentley

    IPC分类号: A61K33/06 A61P19/02

    摘要: The present invention relates to a method of treating osteoarthritis by administering a mineral composition in the form of a nutritional supplement, where the mineral composition may contain Smectite, Gypsum, Quartz, Feldspar, Jarosite, Kaolinite and/or Zeolite.

    摘要翻译: 本发明涉及一种通过施用营养补充剂形式的矿物组合物来治疗骨关节炎的方法,其中矿物组合物可以含有蒙皂石,石膏,石英,长石,高铁矿,高岭土和/或沸石。

    Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof
    8.
    发明申请
    Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof 有权
    使用硫代磺酸盐组合物形成水凝胶的方法及其用途

    公开(公告)号:US20080033105A1

    公开(公告)日:2008-02-07

    申请号:US11904985

    申请日:2007-09-27

    IPC分类号: C08F28/02 C08G75/00

    摘要: The present invention provides both crosslinked polymer compositions capable of forming hydrogels upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably multi-arm thiosulfonate polymer derivatives that form a crosslinked polymer composition when exposed to a base without requiring the presence of a second cross-linking reagent, redox catalyst, or radiation. Methods for forming hydrogel compositions, as well as methods for using the hydrogels, are also provided.

    摘要翻译: 本发明提供了能够在暴露于水性环境中形成水凝胶的交联聚合物组合物和形成硫代磺酸盐的水凝胶组分的交联聚合物组合物。 本发明的硫代磺酸盐水凝胶形成成分优选为在不需要存在第二交联剂,氧化还原催化剂或辐射的情况下暴露于碱而形成交联聚合物组合物的多臂硫代磺酸盐聚合物衍生物。 还提供了形成水凝胶组合物的方法以及使用水凝胶的方法。

    Hydrolytically degradable polymers and hydrogels made therefrom
    9.
    发明申请
    Hydrolytically degradable polymers and hydrogels made therefrom 有权
    水解可降解的聚合物和水凝胶

    公开(公告)号:US20060160983A1

    公开(公告)日:2006-07-20

    申请号:US11377973

    申请日:2006-03-17

    IPC分类号: C08G64/00

    摘要: A water soluble polymer is provided having two or more oligomers linked to each other by hydrolytically degradable carbonate linkages. The polymer can be hydrolytically degraded into oligomers (e.g., oligomers of ethylene oxide) under physiological conditions. The polymer can be conjugated to biologically active agents such as proteins or peptides to impart improved water solubility, reduced immunogenicity, reduced rate of renal clearance, and increased stability. The polymer is useful in making hydrolytically degradable hydrogels which can be used in drug delivery and related biomedical applications. On example of the polymer is a poly (ether carbonate) of the formula X—O—[(—CH2CH2-0-)n—CO2—]n—(CH2CH2))n-y where X and Y are independently H, alkyl, alkenyl, aryl, or a reactive moiety, and at least one of X and Y is a reactive moiety.

    摘要翻译: 提供了具有两个或多个通过可水解降解的碳酸酯键相互连接的低聚物的水溶性聚合物。 在生理条件下,聚合物可以水解降解成低聚物(例如环氧乙烷的低聚物)。 聚合物可以与生物活性剂如蛋白质或肽缀合以赋予改善的水溶性,降低的免疫原性,降低的肾清除率和增加的稳定性。 该聚合物可用于制备可用于药物递送和相关生物医学应用的水解可降解水凝胶。 聚合物的实例是式XO的聚(醚碳酸酯) - [( - CH 2 CH 2 -O - ) - N - -CO 2 - - - - - (CH 2 CH 2)) - (CH 2 CH 2) -y其中X和Y独立地是H,烷基,烯基,芳基或反应性部分,X和Y中的至少一个是反应性部分。