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公开(公告)号：US20110166063A1
公开(公告)日：2011-07-07
申请号：US13119297
申请日：2009-09-17
申请人： Mary J. Bossard , Steven O. Roczniak , Harold Zappe , Yujun Wang , Ping Zhang , Dawei Sheng , C. Simone Jude-Fishburn , Elizabeth Louise Minamitani , Xiaofeng Liu , Haim Moskowitz , Dennis G. Fry , Cherie F. Ali , Christine Taylor Brew
发明人： Mary J. Bossard , Steven O. Roczniak , Harold Zappe , Yujun Wang , Ping Zhang , Dawei Sheng , C. Simone Jude-Fishburn , Elizabeth Louise Minamitani , Xiaofeng Liu , Haim Moskowitz , Dennis G. Fry , Cherie F. Ali , Christine Taylor Brew
IPC分类号： A61K38/28 , A61K38/16 , A61K38/08 , A61K38/06 , A61K38/07 , A61K38/10 , C07K5/08 , C07K7/06 , C07K7/08 , C07K14/00 , A61P3/10
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译： 本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110165112A1
公开(公告)日：2011-07-07
申请号：US13119217
申请日：2009-09-17
摘要： The invention provides pro insulin c-peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性寡聚物进行化学修饰的促胰岛素c-肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110237524A1
公开(公告)日：2011-09-29
申请号：US13119256
申请日：2009-09-17
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110171164A1
公开(公告)日：2011-07-14
申请号：US13119240
申请日：2009-09-17
IPC分类号： A61K47/48 , C08G65/48 , C07K14/575 , A61K38/22
CPC分类号： C07K14/605 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110171161A1
公开(公告)日：2011-07-14
申请号：US13119216
申请日：2009-09-17
IPC分类号： A61K38/10 , C08G65/333 , A61P31/00
摘要： The invention provides protegrin that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention has enhanced half-life and/or reduced clearance.
摘要翻译： 本发明提供了通过共价连接水溶性寡聚物进行化学修饰的整合素。 本发明的共轭物具有增强的半衰期和/或减少的间隙。
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公开(公告)号：US20110171160A1
公开(公告)日：2011-07-14
申请号：US13119211
申请日：2009-09-17
申请人： Elizabeth Louise Minamitani , Harold Zappe , Mary J. Bossard , Steven O. Roczniak , Xiaofeng Liu
发明人： Elizabeth Louise Minamitani , Harold Zappe , Mary J. Bossard , Steven O. Roczniak , Xiaofeng Liu
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20120195847A1
公开(公告)日：2012-08-02
申请号：US13119214
申请日：2009-09-17
申请人： Yujun Wang , Ping Zhang , Mary J. Bossard , Steven O. Roczniak
发明人： Yujun Wang , Ping Zhang , Mary J. Bossard , Steven O. Roczniak
IPC分类号： A61K31/765 , A61K38/08 , A61K31/787 , C08F226/08 , C08F226/06 , C08F216/06 , A61K31/79 , C07K7/06
CPC分类号： C07K5/1016 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110171163A1
公开(公告)日：2011-07-14
申请号：US13119232
申请日：2009-09-17
CPC分类号： C07K14/43504 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US09861705B2
公开(公告)日：2018-01-09
申请号：US13884901
申请日：2011-11-11
申请人： Mary J. Bossard , Cherie F. Ali , Xiaofeng Liu , Deborah H. Charych , Yujun Wang
发明人： Mary J. Bossard , Cherie F. Ali , Xiaofeng Liu , Deborah H. Charych , Yujun Wang
CPC分类号： A61K47/60 , A61K38/2013 , C07K14/55
摘要： Conjugates of an interleukin-2 (“IL-2”) moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.
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10.发明授权Von willebrand factor- and factor VIII-polymer conjugates having a releasable linkage 有权具有释放键的冯维勒布兰因子和因子VIII-聚合物共轭物公开(公告)号：US09493544B2
公开(公告)日：2016-11-15
申请号：US13620285
申请日：2012-09-14
申请人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
发明人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC分类号： C07K14/755 , C07K14/745 , C07K17/08 , A61K47/48
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
摘要翻译： 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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