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公开(公告)号：US20110166063A1
公开(公告)日：2011-07-07
申请号：US13119297
申请日：2009-09-17
申请人： Mary J. Bossard , Steven O. Roczniak , Harold Zappe , Yujun Wang , Ping Zhang , Dawei Sheng , C. Simone Jude-Fishburn , Elizabeth Louise Minamitani , Xiaofeng Liu , Haim Moskowitz , Dennis G. Fry , Cherie F. Ali , Christine Taylor Brew
发明人： Mary J. Bossard , Steven O. Roczniak , Harold Zappe , Yujun Wang , Ping Zhang , Dawei Sheng , C. Simone Jude-Fishburn , Elizabeth Louise Minamitani , Xiaofeng Liu , Haim Moskowitz , Dennis G. Fry , Cherie F. Ali , Christine Taylor Brew
IPC分类号： A61K38/28 , A61K38/16 , A61K38/08 , A61K38/06 , A61K38/07 , A61K38/10 , C07K5/08 , C07K7/06 , C07K7/08 , C07K14/00 , A61P3/10
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译： 本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110171163A1
公开(公告)日：2011-07-14
申请号：US13119232
申请日：2009-09-17
CPC分类号： C07K14/43504 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110165112A1
公开(公告)日：2011-07-07
申请号：US13119217
申请日：2009-09-17
摘要： The invention provides pro insulin c-peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性寡聚物进行化学修饰的促胰岛素c-肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110171160A1
公开(公告)日：2011-07-14
申请号：US13119211
申请日：2009-09-17
申请人： Elizabeth Louise Minamitani , Harold Zappe , Mary J. Bossard , Steven O. Roczniak , Xiaofeng Liu
发明人： Elizabeth Louise Minamitani , Harold Zappe , Mary J. Bossard , Steven O. Roczniak , Xiaofeng Liu
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110171161A1
公开(公告)日：2011-07-14
申请号：US13119216
申请日：2009-09-17
IPC分类号： A61K38/10 , C08G65/333 , A61P31/00
摘要： The invention provides protegrin that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention has enhanced half-life and/or reduced clearance.
摘要翻译： 本发明提供了通过共价连接水溶性寡聚物进行化学修饰的整合素。 本发明的共轭物具有增强的半衰期和/或减少的间隙。
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公开(公告)号：US20110237524A1
公开(公告)日：2011-09-29
申请号：US13119256
申请日：2009-09-17
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110171165A1
公开(公告)日：2011-07-14
申请号：US13119281
申请日：2009-09-17
IPC分类号： A61K47/48 , C08G65/333 , A61P25/00
CPC分类号： A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20120195847A1
公开(公告)日：2012-08-02
申请号：US13119214
申请日：2009-09-17
申请人： Yujun Wang , Ping Zhang , Mary J. Bossard , Steven O. Roczniak
发明人： Yujun Wang , Ping Zhang , Mary J. Bossard , Steven O. Roczniak
IPC分类号： A61K31/765 , A61K38/08 , A61K31/787 , C08F226/08 , C08F226/06 , C08F216/06 , A61K31/79 , C07K7/06
CPC分类号： C07K5/1016 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110171164A1
公开(公告)日：2011-07-14
申请号：US13119240
申请日：2009-09-17
IPC分类号： A61K47/48 , C08G65/48 , C07K14/575 , A61K38/22
CPC分类号： C07K14/605 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：US20110165113A1
公开(公告)日：2011-07-07
申请号：US13119236
申请日：2009-09-17
申请人： Steven O. Roczniak , Ping Zhang , Haim Moskowitz
发明人： Steven O. Roczniak , Ping Zhang , Haim Moskowitz
CPC分类号： C07K14/4723 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译： 本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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