公开(公告)号：US06335168B1

公开(公告)日：2002-01-01

申请号：US09351198

申请日：1999-07-09

申请人： Mary Jeanne Kreek ,  Karl Steven LaForge ,  Lei Yu ,  Jay A. Tischfield

发明人： Mary Jeanne Kreek ,  Karl Steven LaForge ,  Lei Yu ,  Jay A. Tischfield

IPC分类号： C12Q168

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： Provided herein are variant alleles of a gene encoding a mu opioid receptor, along with cloning vectors for replicating such variant alleles, expressing vectors for expressing the variant alleles to produce variant mu opioid receptors, and antibodies to such variant receptors. Also disclosed are binding characteristics of such variant receptors regarding binding to opioid ligands, and the using of such binding characteristics to diagnose a subjects susceptibility to pain, susceptibility to an addictive disease, selecting an appropriate pain reliever along with a therapeutically effective amount of the reliever to administer to a subject suffering from pain. In addition, diagnostic methods for diagnosing a disease or disorder such as infertility, constipation, diarrhea, decreased immune response relative to a standard, and decreased ability to withstand stress relative to a standard, along with commercial kits for diagnosing such diseases or disorders. Furthermore, the invention is also directed to identification of targeted prevention methods, early therapeutic intervention, and improved treatment of opioid addiction, infertility, constipation, diarrhea, impaired immune responsiveness, and stress.

摘要翻译： 本文提供了编码μ阿片受体的基因的变异等位基因，以及用于复制这种变异等位基因的克隆载体，表达用于表达变体等位基因以产生变体μ阿片样物质受体的载体，以及针对这种变体受体的抗体。 还公开了这样的变体受体关于结合阿片样物质配体的结合特征，以及使用这种结合特征来诊断受试者对疼痛的敏感性，对成瘾性疾病的易感性，选择适当的止痛药以及治疗有效量的缓解剂 给予痛苦的受试者。 此外，用于诊断疾病或病症的诊断方法，例如不育症，便秘，腹泻，相对于标准物的免疫应答降低，以及相对于标准物承受应力的能力降低，以及用于诊断这种疾病或病症的商业试剂盒。 此外，本发明还涉及确定靶向预防方法，早期治疗干预和改善阿片样物质成瘾，不育症，便秘，腹泻，免疫应答受损和应激的治疗。

公开(公告)号：US06337207B1

公开(公告)日：2002-01-08

申请号：US09113426

申请日：1998-07-10

申请人： Mary Jeanne Kreek ,  Karl Steven LaForge ,  Lei Yu ,  Jay A. Tischfield

发明人： Mary Jeanne Kreek ,  Karl Steven LaForge ,  Lei Yu ,  Jay A. Tischfield

IPC分类号： C12N1563

CPC分类号： C12N15/73 ,  C07K14/72 ,  C07K16/28 ,  C12N15/75 ,  C12Q1/6827

摘要： Provided herein are variant alleles of a gene encoding a mu opioid receptor, along with cloning vectors for replicating such variant alleles, expressing vectors for expressing the variant alleles to produce variant mu opioid receptors, and antibodies to such variant receptors. Also disclosed are binding characteristics of such variant receptors regarding binding to opioid ligands, and the using of such binding characteristics to diagnose a subjects susceptibility to pain, susceptibility to an addictive disease, selecting an appropriate pain reliever along with a therapeutically effective amount of the reliever to administer to a subject suffering from pain. In addition, diagnostic methods for diagnosing a disease or disorder such as infertility, constipation, diarrhea, decreased immune response relative to a standard, and decreased ability to withstand stress relative to a standard, along with commercial kits for diagnosing such diseases or disorders.

摘要翻译： 本文提供了编码μ阿片受体的基因的变异等位基因，以及用于复制这种变异等位基因的克隆载体，表达用于表达变体等位基因以产生变体μ阿片样物质受体的载体，以及针对这种变体受体的抗体。 还公开了这样的变体受体关于结合阿片样物质配体的结合特征，以及使用这种结合特征来诊断受试者对疼痛的敏感性，对成瘾性疾病的易感性，选择适当的止痛药以及治疗有效量的缓解剂 给予痛苦的受试者。 此外，用于诊断疾病或病症的诊断方法，例如不育症，便秘，腹泻，相对于标准物的免疫应答降低，以及相对于标准物承受应力的能力降低，以及用于诊断这些疾病或病症的商业试剂盒。

公开(公告)号：USD936210S1

公开(公告)日：2021-11-16

申请号：US29731563

申请日：2020-04-16

申请人： Lei Yu

设计人： Lei Yu

公开(公告)号：US20160248526A1

公开(公告)日：2016-08-25

申请号：US15146119

申请日：2016-05-04

申请人： Yangbin Wang ,  Lei Yu

发明人： Yangbin Wang ,  Lei Yu

IPC分类号： H04H60/59 ,  H04N21/44 ,  G11B27/22 ,  H04N21/41 ,  H04N21/8358 ,  H04N21/234 ,  H04N21/2187

CPC分类号： H04H60/59 ,  G11B20/00086 ,  G11B20/0021 ,  G11B20/00449 ,  G11B20/00884 ,  G11B27/10 ,  G11B27/22 ,  G11B2220/2562 ,  H04N19/467 ,  H04N21/2187 ,  H04N21/23418 ,  H04N21/2541 ,  H04N21/4122 ,  H04N21/42646 ,  H04N21/44008 ,  H04N21/44236 ,  H04N21/835 ,  H04N21/8358

摘要： Systems and methods are provided for identifying a video object using digital fingerprints. The digital fingerprints are generated from information extracted from the video object including encoded video. The digital fingerprints can be calculated in a manner that permits identification of both the video object and operational characteristics of the video object based on matching calculated digital fingerprints with known fingerprints of known video objects. Systems and methods are described that allow a DVD to be uniquely identified and identify whether the DVD is original, copied or pirated. Systems and methods are described for computing digital fingerprints from strings of bits in which certain additional data is optionally embedded. Systems and methods are described that permit media players to access known signatures of known video objects maintained on one or more databases and to identify video objects presented for playing on the media player. In the parent application, the video object is extended to media content including video and audio, and DVD is extended to media file, network stream and other content mediums. In the present application, the media content is extended to real-time broadcasting signals.

摘要翻译： 提供了使用数字指纹识别视频对象的系统和方法。 从包括编码视频的视频对象提取的信息生成数字指纹。 可以以允许使用已知视频对象的已知指纹匹配的计算出的数字指纹来识别视频对象和视频对象的操作特性的方式来计算数字指纹。 描述允许DVD被唯一标识并识别DVD是原始的，复制的还是盗版的系统和方法。 描述了用于从可选地嵌入某些附加数据的比特串计算数字指纹的系统和方法。 描述的系统和方法允许媒体播放器访问维持在一个或多个数据库上的已知视频对象的已知签名，并且识别呈现用于在媒体播放器上播放的视频对象。 在父应用程序中，将视频对象扩展到包括视频和音频的媒体内容，并将DVD扩展到媒体文件，网络流和其他内容媒体。 在本应用中，媒体内容扩展到实时广播信号。

公开(公告)号：US20160058877A1

公开(公告)日：2016-03-03

申请号：US14786729

申请日：2013-04-26

申请人： Kwok Yin TSANG ,  Hao BAI ,  Yi JIN ,  Lei YU ,  NITTO DENKO CORPORATION

发明人： Kwok Yin Tsang ,  Hao Bai ,  Yi Jin ,  Lei Yu

IPC分类号： A61K47/48 ,  A61K31/337 ,  C08G73/02

CPC分类号： A61K47/645 ,  A61K31/337 ,  A61K47/595 ,  C08G69/10 ,  C08G69/46 ,  C08G69/48

摘要： Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.

摘要翻译： 本文描述的是降低聚阴离子聚合物缀合物的内毒素含量的方法。 特别地，本文描述了可以用于多种药物递送应用的聚阴离子聚合物缀合物中降低内毒素含量的方法。

公开(公告)号：US20150237410A1

公开(公告)日：2015-08-20

申请号：US14181683

申请日：2014-02-16

申请人： Lei Yu ,  Yangbin Wang

发明人： Lei Yu ,  Yangbin Wang

IPC分类号： H04N21/81 ,  H04N21/8358 ,  G06Q30/02

CPC分类号： H04N21/812 ,  G06Q30/0251 ,  G06Q30/0269 ,  H04H60/37 ,  H04H60/59 ,  H04H60/66 ,  H04N21/2668 ,  H04N21/437 ,  H04N21/44008 ,  H04N21/8352 ,  H04N21/8358

摘要： A method and system of providing content-aware persistent advertisements comprises the steps of ingesting and collecting VDNA (Video DNA) fingerprints of media contents playing on various network-enabled terminals including Internet browsers, mobile devices, tablets, smart televisions and so on; sending the ingested fingerprints along with other information such as metadata, user's location, etc, to the content identification server via Internet or mobile networks, and selecting accurate advertisements according to the media content and relevant information, then finally pushing the advertisements back to user's terminal. With VDNA fingerprint identification, media contents are identified by content instead of metadata or other surrounding information, so that the result of identification can be considered genuine, and the chosen advertisements based on the media content can be persistent across multiple terminals playing the same media content.

摘要翻译： 提供内容感知持续广告的方法和系统包括以下步骤：摄取和收集在包括因特网浏览器，移动设备，平板电脑，智能电视等的各种启用网络的终端上播放的媒体内容的VDNA（Video DNA）指纹; 将所摄取的指纹与元数据，用户位置等其他信息通过互联网或移动网络发送到内容识别服务器，并根据媒体内容和相关信息选择准确的广告，然后将广告推回用户终端 。 使用VDNA指纹识别，通过内容而不是元数据或其他周围信息来识别媒体内容，使得识别结果可以被认为是真实的，并且基于媒体内容的所选择的广告可以在播放相同媒体内容的多个终端 。

公开(公告)号：US08819794B2

公开(公告)日：2014-08-26

申请号：US13354324

申请日：2012-01-19

申请人： Vadim Eydelman ,  Brian Kress ,  Matthias Leibmann ,  Moustafa Noureddine ,  Lei Yu ,  Haibo Luo

发明人： Vadim Eydelman ,  Brian Kress ,  Matthias Leibmann ,  Moustafa Noureddine ,  Lei Yu ,  Haibo Luo

IPC分类号： G06F15/16

CPC分类号： H04L63/0823 ,  H04L9/321 ,  H04L9/3263 ,  H04L61/3065 ,  H04L61/35 ,  H04L63/062 ,  H04L69/22

摘要： Online and on-premise applications identify trusted authentication providers. The applications are configured with a list of trusted issuers of authentication credentials. When an application receives a request requiring authentication, the application returns a 401 response that includes the trusted issuer list. The requesting application compares the trusted issuer list from the 401 response to its own list of authentication providers. If there is a match between the two lists, then the requesting application creates a self-issued token for the authentication provider. The authentication provider uses the self-issued token to generate an authentication token for the requesting application. The requesting application may also directly create a token for a target partner application, without an authentication provider, if there is a direct trust between the two applications.

摘要翻译： 在线和内部部署应用程序标识可信赖的身份验证提供程序。 这些应用程序配置有可信赖的认证凭证发行者列表。 当应用程序接收到需要认证的请求时，应用程序返回包含受信任发行者列表的401响应。 请求应用将可信发行者列表从401响应与其自己的认证提供者列表进行比较。 如果两个列表之间存在匹配，则请求的应用程序将为身份验证提供程序创建自发证券。 认证提供者使用自发证令牌为请求的应用程序生成认证令牌。 如果两个应用程序之间存在直接的信任，请求应用程序也可以直接为目标伙伴应用程序创建令牌，而不需要身份验证提供程序。

公开(公告)号：US08666404B2

公开(公告)日：2014-03-04

申请号：US12735898

申请日：2008-04-18

申请人： Jingxiang Liu ,  Hui Zhang ,  Lei Yu

发明人： Jingxiang Liu ,  Hui Zhang ,  Lei Yu

IPC分类号： H04W4/00

CPC分类号： H04W12/06 ,  H04W68/00 ,  H04W76/34

摘要： A method and an apparatus for quickly unloading a terminal are provided. The method comprises: paging a user terminal which is registered in a mobile switch to unload through a wireless access node after the mobile switch to unload receives a command of unloading the user terminal; the mobile switch to unload detecting whether a paging acknowledgement returned from the user terminal is received, if yes, sending a message to notify that the user terminal is to be unloaded, and then releasing the current signaling connection with the user terminal.

摘要翻译： 提供了一种用于快速卸载终端的方法和装置。 该方法包括：在移动交换机卸载之后，寻呼登记在移动交换机中的用户终端通过无线接入节点卸载接收到卸载用户终端的命令; 移动交换机卸载检测从用户终端返回的寻呼确认是否被接收，如果是，则发送消息以通知用户终端将被卸载，然后释放与用户终端的当前信令连接。

公开(公告)号：US08665988B2

公开(公告)日：2014-03-04

申请号：US13202189

申请日：2009-12-21

申请人： Lei Yu ,  Zheng Wei ,  Laiguo Zhai ,  Zhixin Tong ,  Hongfeng Sun

发明人： Lei Yu ,  Zheng Wei ,  Laiguo Zhai ,  Zhixin Tong ,  Hongfeng Sun

IPC分类号： H04L27/00

CPC分类号： H03M7/40

摘要： The present invention provides a device and method for realizing prefix code construction. The device includes a sort indexer, a generator and a sequence regulator. The sort indexer is used to sort a group of received code lengths to obtain a group of sorted code lengths, and record the position correspondence relationship. The generator receives the sorted code lengths and orderly generates the prefix codes. Except that the first prefix code is preconfigured, the generator generates a current prefix code by adding one to the adjacently previous prefix code and then shifting left by a certain number of bits. The sequence regulator is used to receive the prefix codes corresponding to the sorted code lengths, and regulates the sequence of the prefix codes corresponding to the sorted code lengths according to the position correspondence relationship recorded by the sort indexer to obtain the prefix codes corresponding to the code lengths.

摘要翻译： 本发明提供一种实现前缀码构造的装置和方法。 该设备包括分类索引器，发生器和序列调节器。 分类索引器用于对一组接收到的代码长度进行排序以获得一组排序的代码长度，并记录位置对应关系。 生成器接收排序的代码长度，并有序地生成前缀代码。 除了第一个前缀代码被预先配置之外，生成器通过将相加的前一个前缀代码相加，然后向左移动一定数量的位来生成当前前缀代码。 序列调节器用于接收与分类码长相对应的前缀码，并且根据由分类索引器记录的位置对应关系来调节与分类码长相对应的前缀码序列，以获得对应于 代码长度

公开(公告)号：US20120230917A1

公开(公告)日：2012-09-13

申请号：US13475672

申请日：2012-05-18

申请人： Sang Van ,  Yucheng Song ,  Xinghe Wang ,  Zheng Hou ,  Zhongling Feng ,  Gang Zhao ,  Lei Yu

发明人： Sang Van ,  Yucheng Song ,  Xinghe Wang ,  Zheng Hou ,  Zhongling Feng ,  Gang Zhao ,  Lei Yu

IPC分类号： A61K47/48 ,  A61P35/00 ,  A61K49/00

CPC分类号： B82Y5/00 ,  A61K47/645 ,  A61K47/6925 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/146 ,  A61K49/1824

摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

摘要翻译： 制备包括疏水化合物和聚氨基酸缀合物的各种组合物。 本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。