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公开(公告)号：US07241873B2
公开(公告)日：2007-07-10
申请号：US10489866
申请日：2002-09-25
申请人： Toshimitsu Uede , Shigeyuki Kon , Nobuchika Yamamoto , Hirofumi Higuchi , Masaharu Torikai , Yoshiyuki Tokieda , Toshihiro Nakashima , Hiroaki Maeda
发明人： Toshimitsu Uede , Shigeyuki Kon , Nobuchika Yamamoto , Hirofumi Higuchi , Masaharu Torikai , Yoshiyuki Tokieda , Toshihiro Nakashima , Hiroaki Maeda
CPC分类号： C07K14/52 , A61K39/00 , A61K2039/505 , C07K16/24 , C07K16/2842 , C07K16/2848 , C07K2317/34
摘要： A recombinant antibody in which at least the constant regions in the heavy chain and the light chain have been converted into human-origin regions and which inhibits the binding of an integrin recognizing the RGD sequence to osteopontin or its fragment and inhibits the binding of an integrin recognizing the SVVYGLR sequence or a sequence corresponding thereto to osteopontin or its fragment. This antibody is useful as a remedy for autoimmune diseases and a remedy for rheumatism or rheumatoid arthritis. Thus, a method of treating autoimmune diseases, rheumatism or rheumatoid arthritis is provided. This osteopontin antibody is useful in a diagnostic for rheumatism and a method of diagnosing rheumatism too.
摘要翻译： 重组抗体，其中至少重链和轻链中的恒定区已转化为人源区，并且抑制识别RGD序列的整联蛋白与骨桥蛋白或其片段的结合并抑制整联蛋白的结合 识别SVVYGLR序列或与骨桥蛋白或其片段相应的序列。 该抗体可用作自身免疫性疾病的补救剂和风湿病或类风湿性关节炎的治疗剂。 因此，提供了治疗自身免疫疾病，风湿病或类风湿性关节炎的方法。 该骨桥蛋白抗体可用于风湿病的诊断和风湿病的诊断方法。
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公开(公告)号：US20110014213A1
公开(公告)日：2011-01-20
申请号：US12810939
申请日：2008-12-26
申请人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译： 本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段， 编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎 其含有抗体或抗体片段。
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公开(公告)号：US20110117602A1
公开(公告)日：2011-05-19
申请号：US12743739
申请日：2008-11-18
申请人： Yuji Ito , Masanori Baba , Naomichi Arima , Yasuo Suda , Toshihiro Nakashima , Masaharu Torikai
发明人： Yuji Ito , Masanori Baba , Naomichi Arima , Yasuo Suda , Toshihiro Nakashima , Masaharu Torikai
CPC分类号： C07K16/005 , C07K16/2833 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , G01N33/57484
摘要： A human antibody that has a specific reactivity with multiple tumor cell lines including ATL cells and possesses both safety and therapeutic efficacy and a fragment of said antibody are provided. A human antibody and a fragment of said antibody that may recognize HLA-DR β chain expressed on the surface of tumor cells were obtained. In particular, it was found that a dimer of scFv (diabody) of said antibody may induce potent apoptosis in cells expressing the HLA-DR β chain. The antibody and a fragment of said antibody obtained in accordance with the present invention are useful for a detection reagent, a diagnostic and a medicament for protection or treatment of cancers including ATL and/or viral infectious diseases.
摘要翻译： 提供了与多种肿瘤细胞系（包括ATL细胞）具有特异性反应性并具有安全性和治疗功效以及所述抗体片段的人类抗体。 可以识别HLA-DR和bgr的人抗体和所述抗体的片段; 获得在肿瘤细胞表面表达的链。 特别地，发现所述抗体的scFv（双抗体）的二聚体可能在表达HLA-DR和bgr的细胞中诱导有效的凋亡; 链。 根据本发明获得的抗体和所述抗体的片段可用于检测试剂，诊断剂和用于保护或治疗包括ATL和/或病毒感染性疾病的癌症的药物。
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公开(公告)号：US20090053212A1
公开(公告)日：2009-02-26
申请号：US11755671
申请日：2007-05-30
申请人： Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
发明人： Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要： The present invention provides a humanized anti-human osteopontin antibody having better activities (antigen binding activity, leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, low-pH conditions, denaturants and the like) than those of conventional anti-human osteopontin antibodies.
摘要翻译： 本发明提供具有比常规的更好的活性（抗原结合活性，白细胞迁移抑制活性等）和/或稳定性（耐热，低pH条件，变性剂等）的人源化抗人骨桥蛋白抗体 抗人骨桥蛋白抗体。
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公开(公告)号：US07384633B2
公开(公告)日：2008-06-10
申请号：US10484206
申请日：2002-07-18
IPC分类号： A61K39/395
CPC分类号： C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/622 , Y10S424/805
摘要： An antibody or an antibody fragment is provided that is efficacious for treating allergic diseases in which IgE is involved. A human antibody and a fragment thereof to a receptor (FcεRI) having high affinity to Fc portion of IgE was obtained using phage antibody display technique. The human anti-IgE receptor antibody and a fragment thereof of the invention has an activity to inhibit the binding between IgE and IgE receptor and hence is expected to be useful as a medicament for treating allergic diseases caused by the binding between IgE and IgE receptor.
摘要翻译： 提供抗体或抗体片段，其对于治疗涉及IgE的过敏性疾病是有效的。 使用噬菌体抗体展示技术，获得对IgE的Fc部分具有高亲和力的受体（FcepsilonRI）的人抗体及其片段。 本发明的人抗IgE受体抗体及其片段具有抑制IgE和IgE受体之间结合的活性，因此预期可用作治疗由IgE和IgE受体结合引起的过敏性疾病的药物。
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公开(公告)号：US20060002923A1
公开(公告)日：2006-01-05
申请号：US10489866
申请日：2002-09-25
申请人： Toshimitsu Uede , Shigeyuki Kon , Nobuchika Yamamoto , Hirofumi Higuchi , Masaharu Torikai , Yoshiyuki Tokieda , Toshihiro Nakashima , Hiroaki Maeda
发明人： Toshimitsu Uede , Shigeyuki Kon , Nobuchika Yamamoto , Hirofumi Higuchi , Masaharu Torikai , Yoshiyuki Tokieda , Toshihiro Nakashima , Hiroaki Maeda
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/28 , C12N5/06
CPC分类号： C07K14/52 , A61K39/00 , A61K2039/505 , C07K16/24 , C07K16/2842 , C07K16/2848 , C07K2317/34
摘要： A recombinant antibody in which at least the constant regions in the heavy chain and the light chain have been converted into human-origin regions and which inhibits the binding of an integrin recognizing the RGD sequence to osteopontin or its fragment and inhibits the binding of an integrin recognizing the SVVYGLR sequence or a sequence corresponding thereto to osteopontin or its fragment. This antibody is useful as a remedy for autoimmune diseases and a remedy for rheumatism or rheumatoid arthritis. Thus, a method of treating autoimmune diseases, rheumatism or rheumatoid arthritis is provided. This osteopontin antibody is useful in a diagnostic for rheumatism and a method of diagnosing rheumatism too.
摘要翻译： 重组抗体，其中至少重链和轻链中的恒定区已转化为人源区，并且抑制识别RGD序列的整联蛋白与骨桥蛋白或其片段的结合并抑制整联蛋白的结合 识别SVVYGLR序列或与骨桥蛋白或其片段相应的序列。 该抗体可用作自身免疫性疾病的补救剂和风湿病或类风湿性关节炎的治疗剂。 因此，提供了治疗自身免疫疾病，风湿病或类风湿性关节炎的方法。 该骨桥蛋白抗体可用于风湿病的诊断和风湿病的诊断方法。
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公开(公告)号：US20050170451A1
公开(公告)日：2005-08-04
申请号：US10484206
申请日：2002-07-18
CPC分类号： C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/622 , Y10S424/805
摘要： An antibody or an antibody fragment is provided that is efficacious for treating allergic diseases in which IgE is involved. A human antibody and a fragment thereof to a receptor (FcεRI) having high affinity to Fc portion of IgE was obtained using phage antibody display technique. The human anti-IgE receptor antibody and a fragment thereof of the invention has an activity to inhibit the binding between IgE and IgE receptor and hence is expected to be useful as a medicament for treating allergic diseases caused by the binding between IgE and IgE receptor.
摘要翻译： 提供抗体或抗体片段，其对于治疗涉及IgE的过敏性疾病是有效的。 使用噬菌体抗体展示技术，获得对IgE的Fc部分具有高亲和力的受体（FcepsilonRI）的人抗体及其片段。 本发明的人抗IgE受体抗体及其片段具有抑制IgE和IgE受体之间结合的活性，因此预期可用作治疗由IgE和IgE受体结合引起的过敏性疾病的药物。
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公开(公告)号：US09873730B2
公开(公告)日：2018-01-23
申请号：US11815838
申请日：2006-02-07
CPC分类号： C07K16/00 , C07K16/1271 , C07K16/2818 , C07K2317/21 , C07K2317/24 , C07K2317/567 , C07K2317/94
摘要： The present invention provides for a method for improving properties of an antibody such as an expression level and stability. A method for obtaining an antibody with an improved expression level and/or stability by modifying a human antibody or a humanized antibody, characterized by that at least any one of the amino acid residues at position 8, 12, 15 or 18 (according to Kabat numbering) in a light chain variable region (hereinafter referred to as “VL chain”) of a human antibody or a humanized antibody is substituted with a different amino acid other than proline or cysteine, and a human antibody or a humanized antibody or a human antibody fragment or a humanized antibody fragment with an improved expression level and/or stability which are obtained by said method.
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公开(公告)号：US08715655B2
公开(公告)日：2014-05-06
申请号：US12810939
申请日：2008-12-26
申请人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
IPC分类号： A61K39/395 , C07K16/00 , C07K16/46 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译： 本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段， 编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗-α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎 其含有抗体或抗体片段。
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公开(公告)号：US07807161B2
公开(公告)日：2010-10-05
申请号：US11755671
申请日：2007-05-30
申请人： Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
发明人： Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
IPC分类号： A61K39/00 , A61K39/395 , C07K16/46 , C07K16/24
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要： The present invention provides a humanized anti-human osteopontin antibody having better activities (antigen binding activity, leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, low-pH conditions, denaturants and the like) than those of conventional anti-human osteopontin antibodies.
摘要翻译： 本发明提供具有比常规的更好的活性（抗原结合活性，白细胞迁移抑制活性等）和/或稳定性（耐热，低pH条件，变性剂等）的人源化抗人骨桥蛋白抗体 抗人骨桥蛋白抗体。
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