公开(公告)号：US20050100456A1

公开(公告)日：2005-05-12

申请号：US10432028

申请日：2001-11-26

申请人： Masahiko Osaka ,  Hidetoshi Nishihara ,  Toshihiko Ota ,  Akihiko Kubota ,  Manabu Motegi ,  Hiroki Awashima ,  Takeshi Kojima ,  Kazuhito Noguchi ,  Ichiro Kita ,  Masahiro Kakutani

发明人： Masahiko Osaka ,  Hidetoshi Nishihara ,  Toshihiko Ota ,  Akihiko Kubota ,  Manabu Motegi ,  Hiroki Awashima ,  Takeshi Kojima ,  Kazuhito Noguchi ,  Ichiro Kita ,  Masahiro Kakutani

IPC分类号： F04B39/00 ,  F04B17/00

CPC分类号： F04B39/0055

摘要： In a hermetic compressor in a freezing refrigerating system or an air-conditioning system such as a refrigerator or a showcase, a construction is disclosed for intending to provide a low-noise hermetic compressor by effectively attenuating a pressure pulsation having occurred in a compression chamber with a suction muffler. By this construction, since a muffler cover 20 has a planar simple shape, the deformation upon molding becomes little and it can come into fully close contact with a muffler main body 19. Therefore, the pressure pulsation hardly leaks through the connecting portion between the muffler main body 19 and the muffler cover 20. The full silencing effect that the suction muffler 18 has is obtained and thereby noise can be reduced more effectively.

摘要翻译： 在冷冻冷藏系统的封闭式压缩机或冷藏库或陈列柜等空调系统中，公开了一种旨在通过有效地衰减在压缩室中产生的压力脉动来提供低噪声封闭式压缩机的结构， 吸气消声器。 通过这种结构，由于消音器盖20具有平面简单的形状，所以成型时的变形很小，并且可以与消音器主体19完全紧密接触。 因此，压力脉动几乎不会通过消音器主体19和消声器盖20之间的连接部分泄漏。 获得吸入消声器18具有的完全消音效果，从而可以更有效地降低噪音。

公开(公告)号：US07381032B2

公开(公告)日：2008-06-03

申请号：US10432028

申请日：2001-11-26

申请人： Masahiko Osaka ,  Hidetoshi Nishihara ,  Toshihiko Ota ,  Akihiko Kubota ,  Manabu Motegi ,  Hiroki Awashima ,  Takeshi Kojima ,  Kazuhito Noguchi ,  Ichiro Kita ,  Masahiro Kakutani

发明人： Masahiko Osaka ,  Hidetoshi Nishihara ,  Toshihiko Ota ,  Akihiko Kubota ,  Manabu Motegi ,  Hiroki Awashima ,  Takeshi Kojima ,  Kazuhito Noguchi ,  Ichiro Kita ,  Masahiro Kakutani

IPC分类号： F04B39/00 ,  F01N1/02 ,  F02M35/00

CPC分类号： F04B39/0055

摘要： In a hermetic compressor in a freezing refrigerating system or an air-conditioning system such as a refrigerator or a showcase, a construction is disclosed for intending to provide a low-noise hermetic compressor by effectively attenuating a pressure pulsation having occurred in a compression chamber with a suction muffler. By this construction, since a muffler cover 20 has a planar simple shape, the deformation upon molding becomes little and it can come into fully close contact with a muffler main body 19. Therefore, the pressure pulsation hardly leaks through the connecting portion between the muffler main body 19 and the muffler cover 20. The full silencing effect that the suction muffler 18 has is obtained and thereby noise can be reduced more effectively.

摘要翻译： 在冷冻冷藏系统的封闭式压缩机或冷藏库或陈列柜等空调系统中，公开了一种旨在通过有效地衰减在压缩室中产生的压力脉动来提供低噪声封闭式压缩机的结构， 吸气消声器。 通过这种结构，由于消音器盖20具有平面简单的形状，所以成型时的变形很小，并且可以与消音器主体19完全紧密接触。 因此，压力脉动几乎不会通过消音器主体19和消声器盖20之间的连接部分泄漏。 获得吸入消声器18具有的完全消音效果，从而可以更有效地降低噪音。

公开(公告)号：US07244108B2

公开(公告)日：2007-07-17

申请号：US10432029

申请日：2001-11-26

申请人： Akihiko Kubota ,  Hidetoshi Nishihara ,  Masahiko Osaka ,  Toshihiko Ota ,  Hiroki Awashima ,  Manabu Motegi ,  Kazuhito Noguchi ,  Takeshi Kojima ,  Masahiro Kakutani

发明人： Akihiko Kubota ,  Hidetoshi Nishihara ,  Masahiko Osaka ,  Toshihiko Ota ,  Hiroki Awashima ,  Manabu Motegi ,  Kazuhito Noguchi ,  Takeshi Kojima ,  Masahiro Kakutani

IPC分类号： F04B39/00 ,  F01N1/16 ,  F02M35/00

CPC分类号： F04B39/0061 ,  F04B39/0066 ,  F04B39/0072 ,  F04B39/10 ,  Y10S181/403

摘要： This invention relates to a hermetic compressor used on a refrigerant cycle such as a refrigerator, and discloses a low noise compressor designed to attenuate a resonance sound in a compression chamber and intake pressure pulsing more operatively at a position adjacent to their sources, which intake pressure pulsing occurs at an intake valve port. In the compressor, a resonance space 38 is provided adjacent to the intake valve port 29 that is closer in distance to a noise source. As a result, noise can be reduced more operatively than muffling functions of an intake muffler 31 do. In addition, although acoustic characteristics of the intake muffler 31 amplify noises having specific frequencies, such noises can be attenuated before being amplified.

摘要翻译： 本发明涉及一种用于诸如冰箱的制冷剂循环的封闭式压缩机，并且公开了一种低噪声压缩机，其被设计成在压缩室中衰减谐振声音和进一步操作地在与其源相邻的位置处脉动的进气压力，该进气压力 脉冲发生在进气阀口。 在压缩机中，与靠近噪声源的进气阀口29相邻设置有共振空间38。 结果，与进气消声器31的消音功能相比，可以更有效地降低噪音。 此外，虽然进气消声器31的声学特性放大了具有特定频率的噪声，但是这样的噪声可以在被放大之前被衰减。

公开(公告)号：US06957951B2

公开(公告)日：2005-10-25

申请号：US10433670

申请日：2001-12-20

申请人： Toshihiko Ota ,  Hidetoshi Nishihara ,  Akihiko Kubota ,  Masahiko Osaka ,  Manabu Motegi ,  Kazuhito Noguchi ,  Takeshi Kojima

发明人： Toshihiko Ota ,  Hidetoshi Nishihara ,  Akihiko Kubota ,  Masahiko Osaka ,  Manabu Motegi ,  Kazuhito Noguchi ,  Takeshi Kojima

IPC分类号： F04B39/00

CPC分类号： F04B39/0072 ,  Y10S181/403

摘要： In a hermetic compressor for use on an air-conditioning unit as well as a refrigerating unit such as a refrigerator and a showcase, there is disclosed a constitution designed to provide a silently operated hermetic compressor that has an intake muffler readily assembled thereon. The hermetic compressor including a substantially disk-like elastic member disposed between the intake muffler at an outlet thereof and a cylinder head is provided, in which an outlet orifice of the intake muffler constantly remains pressed against an intake valve port through a gasket.

摘要翻译： 在一种用于空调装置的封闭式压缩机以及诸如冰箱和陈列柜之类的冷藏装置中，公开了一种设计成提供一种静音操作的密封式压缩机，其具有容易组装的进气消声器。 设置有设置在其出口处的进气消声器和气缸盖之间的基本盘形弹性构件的密封压缩机，其中进气消声器的出口孔通过垫圈不断地保持压靠进气阀口。

公开(公告)号：US07021425B2

公开(公告)日：2006-04-04

申请号：US10276942

申请日：2001-05-30

申请人： Kazuhito Noguchi ,  Akihiko Kubota ,  Masahiko Osaka ,  Manabu Motegi ,  Hidetoshi Nishihara

发明人： Kazuhito Noguchi ,  Akihiko Kubota ,  Masahiko Osaka ,  Manabu Motegi ,  Hidetoshi Nishihara

IPC分类号： F04C29/02

CPC分类号： F04B39/0253

摘要： A sealed electric compressor for use in, for example, an electric refrigerator, generates a little noise and can feed any moving part of its compressing element with refrigerator lubricant. An oil pickup tube is joined by insertion to the lowermost end of a crank shaft and includes a first centrifugal pumping portion and a second centrifugal pumping portion provided continuously and arranged at a smaller angle than that of the first centrifugal pumping portion. The second centrifugal pumping portion arranged at a smaller angle can spin in a pool of the refrigerator lubricant.

公开(公告)号：US07504432B2

公开(公告)日：2009-03-17

申请号：US11648614

申请日：2007-01-03

申请人： Yoshio Ogino ,  Hideki Kurihara ,  Kenji Matsuda ,  Tomoshige Numazawa ,  Norikazu Otake ,  Kazuhito Noguchi

发明人： Yoshio Ogino ,  Hideki Kurihara ,  Kenji Matsuda ,  Tomoshige Numazawa ,  Norikazu Otake ,  Kazuhito Noguchi

IPC分类号： A01N43/36 ,  C07D207/00

CPC分类号： C07D207/08 ,  C07C219/10 ,  C07C219/14 ,  C07D205/04 ,  C07D207/12 ,  C07D209/52 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  C07D211/70 ,  C07D239/06 ,  C07D451/02 ,  C07D451/06 ,  C07D471/08 ,  C07D471/10 ,  C07D487/10

摘要： This invention relates to compounds which exhibit selective muscarinic M3 receptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I); [in which A signifies a group expressed by a formula (a0) or (b0); Ar signifies optionally substituted aryl or heteroaryl; B1 and B2 signify aliphatic hydrocarbon; R1 signifies fluorine-substituted cycloalkyl; R2, R3 and R4 signify lower alkyl, single bond or alkylene bonded to B1, or R2 and R3 are united to signify alkylene; R5 and R7 signify hydrogen, lower alkyl, or a single bond or alkylene bonded to B2; R6 signifies hydrogen, lower alkyl or a group expressed as —N(R8)R9; and X− signifies an anion].

摘要翻译： 本发明涉及具有选择性毒蕈碱M3受体拮抗作用，副作用小，适用于吸入治疗的化合物，并且可用作通式（I）的呼吸系统疾病的治疗剂; [其中A表示由式（a0）或（b0）表示的组; Ar表示任选取代的芳基或杂芳基; B1和B2表示脂族烃; R1表示氟取代的环烷基; R2，R3和R4表示低级烷基，单键或与B1键合的亚烷基，或者R2和R3相连，表示亚烷基; R5和R7表示氢，低级烷基或键合到B2的单键或亚烷基; R6表示氢，低级烷基或表示为-N（R8）R9的基团; 和X-表示阴离子]。

公开(公告)号：US20050065211A1

公开(公告)日：2005-03-24

申请号：US10983613

申请日：2004-11-09

申请人： Yoshio Ogino ,  Hideki Kurihara ,  Kenji Matsuda ,  Tomoshige Numazawa ,  Norikazu Otake ,  Kazuhito Noguchi

发明人： Yoshio Ogino ,  Hideki Kurihara ,  Kenji Matsuda ,  Tomoshige Numazawa ,  Norikazu Otake ,  Kazuhito Noguchi

IPC分类号： A61P11/00 ,  A61P11/06 ,  A61P27/16 ,  A61P43/00 ,  C07C219/10 ,  C07C219/14 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D209/52 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  C07D211/70 ,  C07D239/06 ,  C07D451/02 ,  C07D451/06 ,  C07D471/08 ,  C07D471/10 ,  C07D487/10 ,  C07D498/10 ,  A61K31/445 ,  A61K31/24 ,  C07C229/52

CPC分类号： C07D207/08 ,  C07C219/10 ,  C07C219/14 ,  C07D205/04 ,  C07D207/12 ,  C07D209/52 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  C07D211/70 ,  C07D239/06 ,  C07D451/02 ,  C07D451/06 ,  C07D471/08 ,  C07D471/10 ,  C07D487/10

摘要： This invention relates to compounds which exhibit selective muscarinic M3 receptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I); [in which A signifies a group expressed by a formula (a0) or (b0); Ar signifies optionally substituted aryl or heteroaryl; B1 and B2 signify aliphatic hydrocarbon; R1 signifies fluorine-substituted cycloalkyl; R2, R3 and R4 signify lower alkyl, single bond or alkylene bonded to B1, or R2 and R3 are united to signify alkylene; R5 and R7 signify hydrogen, lower alkyl, or a single bond or alkylene bonded to B2; R6 signifies hydrogen, lower alkyl or a group expressed as —N(R8)R9; and X− signifies an anion].

摘要翻译： 本发明涉及具有选择性毒蕈碱M3受体拮抗作用，副作用小，适用于吸入治疗的化合物，并且可用作通式（I）的呼吸系统疾病的治疗剂; [其中A表示由式（a0）或（b0）表示的组; Ar表示任选取代的芳基或杂芳基; B 1和B 2表示脂族烃; R 1表示氟取代的环烷基; R 2，R 3和R 4表示低级烷基，单键或与B 1键合的亚烷基，或R 2和R 3一起表示亚烷基; R 5和R 7表示氢，低级烷基或与B 2键合的单键或亚烷基; R 6表示氢，低级烷基或以-N（R 8）R 9表示的基团; 而X - 表示阴离子]。

公开(公告)号：US06846835B2

公开(公告)日：2005-01-25

申请号：US10332617

申请日：2001-07-10

申请人： Yoshio Ogino ,  Hideki Kurihara ,  Kenji Matsuda ,  Tomoshige Numazawa ,  Norikazu Otake ,  Kazuhito Noguchi

发明人： Yoshio Ogino ,  Hideki Kurihara ,  Kenji Matsuda ,  Tomoshige Numazawa ,  Norikazu Otake ,  Kazuhito Noguchi

IPC分类号： A61P11/00 ,  A61P11/06 ,  A61P27/16 ,  A61P43/00 ,  C07C219/10 ,  C07C219/14 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D209/52 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  C07D211/70 ,  C07D239/06 ,  C07D451/02 ,  C07D451/06 ,  C07D471/08 ,  C07D471/10 ,  C07D487/10 ,  C07D498/10 ,  A61K31/445 ,  A61K31/4465 ,  C07D211/04 ,  C07D221/02

CPC分类号： C07D207/08 ,  C07C219/10 ,  C07C219/14 ,  C07D205/04 ,  C07D207/12 ,  C07D209/52 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  C07D211/70 ,  C07D239/06 ,  C07D451/02 ,  C07D451/06 ,  C07D471/08 ,  C07D471/10 ,  C07D487/10

摘要： This invention relates to compounds which exhibit selective muscarinic M3 receptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I); [in which A signifies a group expressed by a formula (a0) or (b0); Ar signifies optionally substituted aryl or heteroaryl; B1 and B2 signify aliphatic hydrocarbon; R1 signifies fluorine-substituted cycloalkyl; R2, R3 and R4 signify lower alkyl, single bond or alkylene bonded to B1, or R2 and R3 are united to signify alkylene; R5 and R7 signify hydrogen, lower alkyl, or a single bond or alkylene bonded to B2; R6 signifies hydrogen, lower alkyl or a group expressed as —N(R8)R9; and X− signifies an anion].

摘要翻译： 本发明涉及具有选择性毒蕈碱性M3受体拮抗作用，副作用小，适用于吸入治疗的化合物，并且可用作通式（I）的呼吸系统疾病的治疗剂; [其中A表示一组表达 通式（a0）或（b0）; Ar表示任选取代的芳基或杂芳基; B 1和B 2表示脂族烃; R 1表示氟取代的环烷基; R 2，R 3和R 4表示低级烷基，单键或与B 1键合的亚烷基，或R 2和R 3一起表示亚烷基; R 5和R 7表示氢，低级烷基或与B 2键合的单键或亚烷基; R 6表示氢，低级烷基或以-N（R 8）R 9表示的基团; 而X - 表示阴离子]。

公开(公告)号：US20070129397A1

公开(公告)日：2007-06-07

申请号：US11648614

申请日：2007-01-03

申请人： Yoshio Ogino ,  Hideki Kurihara ,  Kenji Matsuda ,  Tomoshige Numazawa ,  Norikazu Otake ,  Kazuhito Noguchi

发明人： Yoshio Ogino ,  Hideki Kurihara ,  Kenji Matsuda ,  Tomoshige Numazawa ,  Norikazu Otake ,  Kazuhito Noguchi

IPC分类号： A61K31/46 ,  C07D451/00 ,  C07D211/34 ,  A61K31/445 ,  A61K31/40 ,  C07D207/04

CPC分类号： C07D207/08 ,  C07C219/10 ,  C07C219/14 ,  C07D205/04 ,  C07D207/12 ,  C07D209/52 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  C07D211/70 ,  C07D239/06 ,  C07D451/02 ,  C07D451/06 ,  C07D471/08 ,  C07D471/10 ,  C07D487/10

摘要： This invention relates to compounds which exhibit selective muscarinic M3 receptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I); [in which A signifies a group expressed by a formula (a0) or (b0); Ar signifies optionally substituted aryl or heteroaryl; B1 and B2 signify aliphatic hydrocarbon; R1 signifies fluorine-substituted cycloalkyl; R2, R3 and R4 signify lower alkyl, single bond or alkylene bonded to B1, or R2 and R3 are united to signify alkylene; R5 and R7 signify hydrogen, lower alkyl, or a single bond or alkylene bonded to B2; R6 signifies hydrogen, lower alkyl or a group expressed as —N(R8)R9; and X−signifies an anion].

摘要翻译： 本发明涉及具有选择性毒蕈碱M 3受体拮抗作用，副作用小，适用于吸入治疗的化合物，并且可用作通式（I）的呼吸系统疾病的治疗剂; [其中A表示由式（a 0 ）或（b 0>）表示的组; Ar表示任选取代的芳基或杂芳基; B 1和B 2表示脂族烃; R 1表示氟取代的环烷基; R 2，R 3和R 4表示低级烷基，单键或与B 1连接的亚烷基，或 R 2和R 3结合起来表示亚烷基; R 5和R 7表示氢，低级烷基或键合到B 2的单键或亚烷基; R 6表示氢，低级烷基或以-N（R 8）R 9表示的基团; 和X - 表示阴离子]。

公开(公告)号：US5380921A

公开(公告)日：1995-01-10

申请号：US55872

申请日：1993-05-04

申请人： Kiyofumi Ishikawa ,  Takehiro Fukami ,  Takashi Hayama ,  Kenji Matsuyama ,  Kazuhito Noguchi ,  Mitsuo Yano

发明人： Kiyofumi Ishikawa ,  Takehiro Fukami ,  Takashi Hayama ,  Kenji Matsuyama ,  Kazuhito Noguchi ,  Mitsuo Yano

IPC分类号： A61K31/66 ,  A61K31/675 ,  A61K38/00 ,  A61P9/08 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07F9/38 ,  C07F9/40 ,  C07K5/06 ,  C12N9/99 ,  C07F9/08

CPC分类号： C07K5/06191 ,  C07F9/3808 ,  A61K38/00

摘要： There are provided novel aminophosphonic acid derivatives of the general formula [I]: ##STR1## wherein n is an integer of 2 or 3; R.sup.1 is a phenyl, naphthyl, indolyl, benzothienyl, benzofuryl or benzoxazolyl group which may have 1 to 3 substituents selected from the group consisting of hydroxyl and lower alkyloxy groups, or a hydrogen atom; R.sup.2 is a lower alkyl group, a benzyl group, a 4-hydroxybenzyl group, a 3-indolylmethyl group or a .beta.-phenethyl group; and A is an optional residue of an amino acid selected from the group consisting of tryptophane, tyrosine, phenylalanine, homophenylalanine, naphthylalanine or N.sup..omega. -nitroarginine, and their pharmaceutically acceptable salts. The compounds according to the present invention and their pharmaceutically acceptable salts exhibit an inhibitory activity against endothelin-converting enzyme, and are expected to be useful as a drug treating various diseases with which endothelin is concerned.

摘要翻译： 提供了通式[I]的新型氨基膦酸衍生物：其中n为2或3的整数; R1是可以具有1至3个选自羟基和低级烷氧基或氢原子的取代基的苯基，萘基，吲哚基，苯并噻吩基，苯并呋喃基或苯并恶唑基; R2是低级烷基，苄基，4-羟基苄基，3-吲哚基甲基或β-苯乙基; A是任选的氨基酸残基，其选自色氨酸，酪氨酸，苯丙氨酸，高苯丙氨酸，萘丙氨酸或N，ω-硝基精氨酸，及其药学上可接受的盐。 根据本发明的化合物及其药学上可接受的盐表现出对内皮素转化酶的抑制活性，并且预期可用作治疗涉及内皮素的各种疾病的药物。