公开(公告)号：US5503744A

公开(公告)日：1996-04-02

申请号：US317397

申请日：1994-10-04

申请人： Mineo Ikematsu ,  Yukihiro Sugiyama ,  Masahiro Iseki

发明人： Mineo Ikematsu ,  Yukihiro Sugiyama ,  Masahiro Iseki

IPC分类号： G01N27/26 ,  G01J1/00 ,  G01N33/487 ,  G06G7/60 ,  G11C11/54 ,  H01L49/00 ,  B01D63/00

CPC分类号： G01N33/48728 ,  Y10S436/806

摘要： A biological oscillating device comprises a lipid-impregnated membrane which is disposed in an electrolyte solution and in which is buried an ion channel having a selectivity opposite to that of the lipid-impregnated membrane, and an electrode provided for transmitting a membrane potential of the lipid-impregnated membrane in the form of an electrical signal. When a membrane potential is caused across the lipid-impregnated membrane by the application of an electric current via an eletrode, or by the activation of the ion pump, an ion pump, an ion channel opens once the magnitude of the membrane potential reaches the active potential of the ion channel, whereby the membrane potential is accordingly eliminated. Upon the elimination of the membrane potential, the ion channel is closed to allow the membrane potential to be again raised. Then, once reaching the active potential of the ion channel, the ion channel reopens so that the membrane potential is correspondingly eliminated. Through the repetition of such procedures, an oscillating electrical signal can be generated.

摘要翻译： 一种生物振荡装置包括一种脂质浸渍的膜，其被设置在电解质溶液中，并且其中掩埋了具有与脂质浸渍的膜的选择性相反的选择性的离子通道，以及用于传递脂质的膜电位的电极 浸渍膜以电信号的形式。 当通过施加电流通过电极或通过激活离子泵离子泵来在膜浸渍的膜上引起膜电位时，离子通道打开，一旦膜电位的大小达到活性物质 离子通道的电位，从而相应地消除了膜电位。 在消除膜电位时，关闭离子通道以允许膜电位再次升高。 然后，一旦达到离子通道的有效电位，离子通道重新开放，从而相应地消除了膜电位。 通过重复这样的程序，可以产生振荡电信号。

公开(公告)号：US5608358A

公开(公告)日：1997-03-04

申请号：US534568

申请日：1995-09-27

申请人： Masahiro Iseki ,  Yukihiro Sugiyama

发明人： Masahiro Iseki ,  Yukihiro Sugiyama

IPC分类号： G01N27/26 ,  G01N27/416 ,  H03B28/00 ,  G01N27/333 ,  G01N27/40

CPC分类号： H03B28/00

摘要： To obtain a stable non-linear oscillator using polypyrrole, KCl liquid electrolyte is separated with a working electrode 14 provided with a polypyrrole film 14a. A counter electrode 16 is provided on one of the separated portions of the liquid electrolyte, and a reference electrode 12 is provided in the other separated liquid electrode portion. The counter electrode 16, working electrode 14 and reference electrode 12 are connected to a potentiostat 10. The potential on the working electrode 14 is set to be between the oxidizing and reducing potentials of polypyrrole. With oxidizing or reducing reaction of polypyrrole, an ion concentration gradient is produced in the liquid electrolyte across polypyrrole film to change the potentials on the reference and working electrodes 12 and 14, thus causing an oscillating current between the working and counter electrodes 14 and 16.

摘要翻译： 为了获得使用聚吡咯的稳定的非线性振荡器，用设置有聚吡咯膜14a的工作电极14分离KCl液体电解质。 在液体电解质的一个分离部分上设置对电极16，在另一个分离的液体电极部分中设置参考电极12。 对电极16，工作电极14和参比电极12连接到恒电位仪10.工作电极14上的电位设定在聚吡咯的氧化还原电位之间。 通过聚吡咯的氧化或还原反应，在聚吡咯膜中的液体电解质中产生离子浓度梯度，以改变参考电极12和工作电极14的电位，从而在工作电极14和反电极16之间引起振荡电流。

公开(公告)号：US5378342A

公开(公告)日：1995-01-03

申请号：US37030

申请日：1993-03-25

申请人： Mineo Ikematsu ,  Yukihiro Sugiyama ,  Masahiro Iseki

发明人： Mineo Ikematsu ,  Yukihiro Sugiyama ,  Masahiro Iseki

IPC分类号： G06G7/60 ,  G01J1/00 ,  G01N33/487 ,  G11C11/54 ,  G01N27/26

CPC分类号： G01N33/48728 ,  Y10S436/806

摘要： A neural modeling device comprising an electrolyte, a lipid or lipid-impregnated membrane which is situated in the electrolyte and in which an ion pump and an ion channel are buried, and an electrode for transmitting a potential of the lipid or lipid-impregnated membrane as an electrical signal. The ion pump actively transports selected ions in the electrolyte through the membrane from one side to the other side in response to an external stimulus such as light irradiation. When the difference in potential between the opposite sides of the membrane reaches a threshold, the ion channel opens to passively transport selected ions in a direction reverse to the ion transporting direction of the ion pump. When this device is exposed to light, the ion pump actively transports ions to generate a potential in the lipid or lipid-impregnated membrane. Upon detection of this potential, the ion channel opens to eliminate the potential, and then another potential will be generated again by the active transportation of the ion pump. Thus it is possible to generate an oscillating electrical signal by an external stimulus such as light irradiation.

摘要翻译： 一种神经建模装置，包括位于电解质中并且其中埋置有离子泵和离子通道的电解质，脂质或脂质浸渍的膜，以及用于将脂质或脂质浸渍的膜的电位传递为 电信号。 响应于诸如光照射的外部刺激，离子泵主动地将电解质中的选定离子从膜的一侧输送到另一侧。 当膜的相对侧之间的电位差达到阈值时，离子通道打开以与离子泵的离子传输方向相反的方向被动离子输送选定的离子。 当该装置暴露于光时，离子泵主动地输送离子以在脂质或脂质浸渍的膜中产生电位。 当检测到该电位时，离子通道打开以消除电位，然后通过离子泵的主动输送再次产生另一个电位。 因此，可以通过诸如光照射的外部刺激来产生振荡电信号。

公开(公告)号：US5770038A

公开(公告)日：1998-06-23

申请号：US650404

申请日：1996-05-20

申请人： Akifumi Iwama ,  Masahiro Iseki ,  Azusa Nakagawa ,  Yukihiro Sugiyama

发明人： Akifumi Iwama ,  Masahiro Iseki ,  Azusa Nakagawa ,  Yukihiro Sugiyama

IPC分类号： G01N27/416 ,  G01N33/00 ,  G01N33/02 ,  G01N33/12 ,  G01N27/26

CPC分类号： G01N33/02 ,  G01N27/4162 ,  G01N33/0011 ,  G01N33/12

摘要： A method for detecting and identifying a chemical substance in various phases such as a vapor phase and a liquid phase. The chemical substance being measured is diffused into a predetermined phase. Then, an electric state at an electrode existing in the predetermined phase is detected as a change with time based on the diffusion and absorption of the chemical substance on the electrode. A pattern of the change of the electric state with time is prepared. A fitting function based on the pattern is set and parameters of the chemical substance being measured are found. A distance between the parameters of the chemical substance being measured and parameters of the reference substance which is detected is determined. In the case of a detection of a chemical substance in a liquid phase, before detecting the electric state at the electrode existing in the liquid phase, a predetermined electrolytic solution is supplied around the electrode to stabilize the electric state of the electrode and then the liquid phase containing the chemical substance being measured is supplied to the electrode.

摘要翻译： 一种用于检测和鉴定诸如气相和液相的各个相中的化学物质的方法。 被测量的化学物质扩散到预定的相位。 然后，基于电极上的化学物质的扩散和吸收，检测存在于预定相位的电极处的电状态随时间的变化。 准备电状态随时间变化的模式。 设定基于该图案的拟合函数，并且求出待测化学物质的参数。 确定待测化学物质的参数与检测到的参考物质的参数之间的距离。 在检测液相中的化学物质的情况下，在检测到存在于液相中的电极的电状态之前，在电极周围提供预定的电解液以稳定电极的电状态，然后液体 将含有被测量的化学物质的相位提供给电极。

公开(公告)号：US20050271648A1

公开(公告)日：2005-12-08

申请号：US11123170

申请日：2005-05-06

申请人： Yukihiro Sugiyama

发明人： Yukihiro Sugiyama

IPC分类号： A61K33/44 ,  A61K38/17 ,  C01B31/02

CPC分类号： B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C01B2202/06 ,  C01B2202/30 ,  C01B2202/36

摘要： Modified molecules (119) and carbon nanotubes (105) are dispersed in a dispersion medium (121). The resulting dispersion solution is spread over the surface of a subphase (125) in a Langmuir trough (113) to obtain carbon nanotube structures (131) comprising the carbon nanotubes (105) and the modified molecules (129) covering the sidewall of the carbon nanotubes (105).

摘要翻译： 改性分子（119）和碳纳米管（105）分散在分散介质（121）中。 将得到的分散溶液分布在Langmuir槽（113）中的相位（125）的表面上，以获得包含碳纳米管（105）和覆盖碳侧壁的改性分子（129）的碳纳米管结构（131） 纳米管（105）。

公开(公告)号：US07244499B2

公开(公告)日：2007-07-17

申请号：US10751524

申请日：2004-01-06

申请人： Yukihiro Sugiyama ,  Yasuhiro Oue

发明人： Yukihiro Sugiyama ,  Yasuhiro Oue

IPC分类号： B32B5/16

CPC分类号： H01G4/228 ,  B82Y10/00 ,  B82Y30/00 ,  H01L21/2007 ,  H01L51/0048 ,  H01L51/0049 ,  H01L51/0595 ,  Y10S977/745 ,  Y10S977/746 ,  Y10S977/748 ,  Y10T428/25 ,  Y10T428/2991 ,  Y10T428/2998

摘要： A technique of stably bonding a structure including a carbon nanotube with another structure is to be provided. Also, a nano-device that offers excellent performance and high production efficiency is to be provided.A polymer and a carbon nanotube are dispersed in a dispersion medium and on a filled liquid in a Langmuir trough, to obtain a carbon nanotube-based structure constituted of a carbon nanotube and the polymer wound around its rounded surface. The carbon nanotube-based structure is adhered to a substrate, and a ligand is immobilized on a side chain of the polymer. A receptor is immobilized on another carbon nanotube-based structure, and the both carbon nanotube-based structures are joined because of a specific interaction between the ligand and the receptor.

摘要翻译： 提供一种稳定地结合包含其他结构的碳纳米管的结构的技术。 此外，提供了提供优异的性能和高生产效率的纳米器件。 将聚合物和碳纳米管分散在Langmuir槽中的分散介质和填充液中，得到由碳纳米管和缠绕在其圆形表面上的聚合物构成的碳纳米管基结构。 将碳纳米管基结构粘附到基底上，并将配体固定在聚合物的侧链上。 受体被固定在另一个基于碳纳米管的结构上，由于配体和受体之间的特异性相互作用，两个碳纳米管基结构都被连接在一起。

公开(公告)号：US20050093425A1

公开(公告)日：2005-05-05

申请号：US11003355

申请日：2004-12-06

申请人： Yukihiro Sugiyama

发明人： Yukihiro Sugiyama

IPC分类号： H01J1/62 ,  H01J63/04

CPC分类号： H01L51/428 ,  B82Y10/00 ,  Y02E10/549

摘要： In an optical sensor provided with an optically polarizable molecule, a pair of source electrode and drain electrode is electrically connected via a carbon nanotube. When a photosensitive molecule constituting the light sensitively polarizable layer polarizes upon receiving a light, conductance of the carbon nanotube varies. Since the variation of the conductance of the carbon nanotube incurs a variation of current value between the source electrode and the drain electrode, such variation is to be detected. Also, by forming a layer including the aligned, efficient connection with the source electrode and the drain electrode can be simply achieved. A small-sized optical sensor capable of performing with high precision and high sensitivity, manufacturing and driving method of such optical sensor, and method of light intensity detection are accomplished.

摘要翻译： 在具有光学可极化分子的光学传感器中，一对源电极和漏电极经由碳纳米管电连接。 当构成光敏极化层的光敏分子在受到光时极化，碳纳米管的电导率变化。 由于碳纳米管的电导率的变化引起源电极和漏电极之间的电流值的变化，因此将检测这种变化。 此外，通过形成包括与源电极和漏电极对准的有效连接的层可以简单地实现。 实现了能够以高精度和高灵敏度执行的小尺寸光学传感器，这种光学传感器的制造和驱动方法以及光强度检测方法。