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    IMMOBILIZED PROTEIN THAT IS IMMOBILIZED ONLY AT ITS AMINO TERMINUS IN ORIENTATION-CONTROLLED MANNER
    1.
    发明申请
    IMMOBILIZED PROTEIN THAT IS IMMOBILIZED ONLY AT ITS AMINO TERMINUS IN ORIENTATION-CONTROLLED MANNER 审中-公开
    固定蛋白质仅在其氨基酸终止位置受控制的人

    公开(公告)号：US20100130721A1

    公开(公告)日：2010-05-27

    申请号：US12596600

    申请日：2008-04-17

    申请人： Masahiro Iwakura ,  Kiyonori Hirota ,  Hiroyuki Sota ,  Gou Sarara ,  Hisashi Takahashi ,  Yukiko Aruga ,  Chiori Yamane

    发明人： Masahiro Iwakura ,  Kiyonori Hirota ,  Hiroyuki Sota ,  Gou Sarara ,  Hisashi Takahashi ,  Yukiko Aruga ,  Chiori Yamane

    IPC分类号： C07K17/00

    CPC分类号： C07K17/00

    摘要： This invention provides an immobilized protein bound to an immobilization carrier at a protein amino terminus via the sole α-amino group of the protein comprising an amino acid sequence containing neither lysine residues nor cysteine residues represented by the general formula S1-R1-R2, wherein: the sequences are oriented from the amino terminal side to the carboxy terminal side; the sequence of the S1 portion may be absent, but when the sequence of the S1 portion is present, the sequence of the S1 portion is a spacer sequence composed of amino acid residues other than lysine and cysteine residues; the sequence of the R1 portion is the sequence of a subject protein to be immobilized and contains neither lysine residues nor cysteine residues; and the sequence of the R2 portion may be absent, but when the sequence of the R2 portion is present, the sequence of the R2 portion is a spacer sequence composed of amino acid residues other than lysine and cysteine residues.

    摘要翻译： 本发明提供了通过蛋白质的唯一α-氨基在蛋白质氨基末端与固定化载体结合的固定化蛋白，其包含不含有由通式S1-R1-R2表示的赖氨酸残基和半胱氨酸残基的氨基酸序列，其中 ：序列从氨基末端侧到羧基末端侧; S1部分的序列可以不存在，但是当存在S1部分的序列时，S1部分的序列是由赖氨酸和半胱氨酸残基以外的氨基酸残基组成的间隔序列; R1部分的序列是待固定的主题蛋白的序列，既不含有赖氨酸残基也不含有半胱氨酸残基; 并且R2部分的序列可以不存在，但是当R2部分的序列存在时，R2部分的序列是由赖氨酸和半胱氨酸残基以外的氨基酸残基组成的间隔序列。

    Detection And Analysis System For Protein Array
    2.
    发明申请
    Detection And Analysis System For Protein Array 失效
    蛋白质阵列检测与分析系统

    公开(公告)号：US20080261827A1

    公开(公告)日：2008-10-23

    申请号：US11792095

    申请日：2005-12-02

    申请人： Masahiro Iwakura ,  Kiyonori Hirota ,  Hisashi Takahashi

    发明人： Masahiro Iwakura ,  Kiyonori Hirota ,  Hisashi Takahashi

    IPC分类号： C40B30/10 ,  C40B60/12 ,  C40B40/10

    CPC分类号： G01N33/5308 ,  G01N21/253 ,  G01N21/31 ,  G01N21/6452 ,  G01N33/54386

    摘要： To provide a method for detecting a protein by immobilizing a protein on a protein array substrate at a high density with controlled orientation, irradiating the immobilized protein with ultraviolet light, visible light, or infrared light, and measuring the light not absorbed by the protein and further analyzing an interaction between the protein on the substrate and another protein and/or a compound other than proteins, a system used for the method, and to provide a protein array suitable for the system. A system including a protein array in which a protein is immobilized in aligned position on a light-transmissive substrate at a high density, a light-irradiating means, and a light-detecting means and being for detecting or analyzing a protein on the protein array and/or a compound which is other than proteins and interacts with the immobilized protein, wherein the protein array is irradiated with light by the light-irradiating means, and the light transmitted through the protein array is measured by the light-detecting means for detecting the light absorption of the protein on the protein array and/or the compound which is other than proteins and interacts with the immobilized protein.

    摘要翻译： 为了提供一种通过将具有受控取向的高密度蛋白质固定在蛋白质阵列基底上的蛋白质的检测方法，用紫外光，可见光或红外光照射固定化蛋白质，并测定不被蛋白质吸收的光， 进一步分析底物上的蛋白质与另一种蛋白质和/或蛋白质以外的化合物之间的相互作用，用于该方法的系统，以及提供适用于该系统的蛋白质阵列。 一种包含蛋白质阵列的系统，其中蛋白质以高密度固定在透光基底上的对准位置，光照射装置和光检测装置，并用于检测或分析蛋白质阵列上的蛋白质 和/或不同于蛋白质并与固定化蛋白质相互作用的化合物，其中通过光照射装置用光照射蛋白质阵列，通过蛋白质阵列传输的光由用于检测的光检测装置测量 蛋白质在蛋白质阵列上的光吸收和/或不同于蛋白质并与固定化蛋白质相互作用的化合物。

    Detection and analysis system for protein array
    3.
    发明授权
    Detection and analysis system for protein array 失效
    蛋白质阵列检测与分析系统

    公开(公告)号：US08038945B2

    公开(公告)日：2011-10-18

    申请号：US11792095

    申请日：2005-12-02

    申请人： Masahiro Iwakura ,  Kiyonori Hirota ,  Hisashi Takahashi

    发明人： Masahiro Iwakura ,  Kiyonori Hirota ,  Hisashi Takahashi

    IPC分类号： G01N21/00

    CPC分类号： G01N33/5308 ,  G01N21/253 ,  G01N21/31 ,  G01N21/6452 ,  G01N33/54386

    摘要： To provide a method for detecting a protein by immobilizing a protein on a protein array substrate at a high density with controlled orientation, irradiating the immobilized protein with ultraviolet light, visible light, or infrared light, and measuring the light not absorbed by the protein and further analyzing an interaction between the protein on the substrate and another protein and/or a compound other than proteins, a system used for the method, and to provide a protein array suitable for the system. A system including a protein array in which a protein is immobilized in aligned position on a light-transmissive substrate at a high density, a light-irradiating means, and a light-detecting means and being for detecting or analyzing a protein on the protein array and/or a compound which is other than proteins and interacts with the immobilized protein, wherein the protein array is irradiated with light by the light-irradiating means, and the light transmitted through the protein array is measured by the light-detecting means for detecting the light absorption of the protein on the protein array and/or the compound which is other than proteins and interacts with the immobilized protein.

    摘要翻译： 为了提供一种通过将具有受控取向的高密度蛋白质固定在蛋白质阵列基底上的蛋白质的检测方法，用紫外光，可见光或红外光照射固定化蛋白质，并测定不被蛋白质吸收的光， 进一步分析底物上的蛋白质与另一种蛋白质和/或蛋白质以外的化合物之间的相互作用，用于该方法的系统，以及提供适用于该系统的蛋白质阵列。 一种包含蛋白质阵列的系统，其中蛋白质以高密度固定在透光基底上的对准位置，光照射装置和光检测装置，并用于检测或分析蛋白质阵列上的蛋白质 和/或不同于蛋白质并与固定化蛋白质相互作用的化合物，其中通过光照射装置用光照射蛋白质阵列，通过蛋白质阵列传输的光由用于检测的光检测装置测量 蛋白质在蛋白质阵列上的光吸收和/或不同于蛋白质并与固定化蛋白质相互作用的化合物。

    Image reconstruction device and image reconstruction method configured to perform iteratively reconstructed image using weight coefficient
    4.
    发明授权
    Image reconstruction device and image reconstruction method configured to perform iteratively reconstructed image using weight coefficient 有权
    图像重建装置和图像重建方法，配置为使用权重系数执行迭代重建图像

    公开(公告)号：US09159146B2

    公开(公告)日：2015-10-13

    申请号：US14128769

    申请日：2012-07-05

    申请人： Hisashi Takahashi ,  Taiga Goto ,  Koichi Hirokawa

    发明人： Hisashi Takahashi ,  Taiga Goto ,  Koichi Hirokawa

    IPC分类号： G06K9/00 ,  G06T11/00

    CPC分类号： G06T11/006 ,  G06T2211/412 ,  G06T2211/424

    摘要： To provide an image reconstruction device capable of creating an image with image quality matching the operator's request when a cross-sectional image is reconstructed through a repeated calculation, the image reconstruction device which performs a repeated calculation on the basis of a difference between calculated projection data and measured projection data, the calculated projection data being obtained by performing a forward projection calculation on a reconstructed image which is reconstructed based on the measured projection data, includes an input section to which an image quality parameter which is considered to be important by an operator is input, a weight calculation section that calculates a weighting coefficient on the basis of the image quality parameter, and a repeated calculation section that performs a repeated calculation on the basis of a value obtained by weighting and adding a pixel value obtained in the previous iteration to a pixel value obtained from now using the weighting coefficient.

    摘要翻译： 为了提供一种能够通过重复计算重建横截面图像时，能够创建具有与操作者的请求相匹配的图像质量的图像重建装置，该图像重建装置基于计算出的投影数据之间的差进行重复计算 并且测量的投影数据，通过对基于测量的投影数据重建的重建图像执行前向投影计算而获得的所计算的投影数据包括输入部分，被认为对于运营商来说重要的图像质量参数 基于图像质量参数计算加权系数的权重计算部分，以及基于通过对在先前迭代中获得的像素值进行加权和相加而获得的值来执行重复计算的重复计算部分 到从现在使用的像素值 加权系数。

    Reconstruction computing device, reconstruction computing method, and X-ray CT apparatus
    6.
    发明授权
    Reconstruction computing device, reconstruction computing method, and X-ray CT apparatus 有权
    重建计算装置，重建计算方法和X射线CT装置

    公开(公告)号：US09050003B2

    公开(公告)日：2015-06-09

    申请号：US13635391

    申请日：2011-03-29

    申请人： Hisashi Takahashi ,  Taiga Goto ,  Koichi Hirokawa

    发明人： Hisashi Takahashi ,  Taiga Goto ,  Koichi Hirokawa

    IPC分类号： G06K9/00 ,  A61B6/03 ,  A61B6/00 ,  G06T11/00 ,  A61B6/06

    CPC分类号： A61B6/032 ,  A61B6/06 ,  A61B6/5205 ,  G06T11/006 ,  G06T2211/424

    摘要： In order to provide a reconstruction computing device, a reconstruction computing method, and an X-ray CT apparatus capable of improving the image quality while reducing the amount of computation when reconstructing an X-ray CT image using an iterative method, a reconstruction computing device 45 divides an initial image 50 reconstructed using an analytical method such as an FBP method into a bed region 51, an object region 52, and the other air region 53, sets reconstruction conditions including at least convergence conditions and a pixel size for each of the divided regions, updates estimation images by performing an iterative process, and fixes estimation images or forward projection data of a subset satisfying the convergence conditions until other subsets satisfy the convergence conditions.

    摘要翻译： 为了提供一种重建计算装置，重构计算方法和能够在使用迭代方法重建X射线CT图像的同时减少计算量的同时提高图像质量的X射线CT装置，重建计算装置 将使用诸如FBP方法的分析方法重构的初始图像50划分到床区域51，对象区域52和另一空气区域53中，设置至少包括收敛条件和每个像素尺寸的像素尺寸的重建条件 分割区域，通过执行迭代处理来更新估计图像，并且修正满足收敛条件的子集的估计图像或前向投影数据，直到其他子集满足收敛条件。

    Image pickup device and image pickup method for the same
    7.
    发明授权
    Image pickup device and image pickup method for the same 有权
    图像拾取装置和图像拾取方法相同

    公开(公告)号：US08866897B2

    公开(公告)日：2014-10-21

    申请号：US13184056

    申请日：2011-07-15

    申请人： Hisashi Takahashi

    发明人： Hisashi Takahashi

    IPC分类号： G01N21/88

    CPC分类号： G01N21/88

    摘要： Image pickup is executed at an image pickup timing based on reference pulses by using, as a trigger, workpiece pulses which are output at an interval synchronized with a shape portion (projecting or recess portion) which is periodically and repetitively formed on a workpiece being rotated, and the image pickup is executed at the image pickup timing based on the reference pulses PA every time only reference pulses PA whose number corresponds to a pulse number between workpiece pulses are output from the image pickup timing concerned.

    摘要翻译： 通过使用与被旋转的工件周期性地重复地形成的形状部（突出部或凹部）同步的间隔输出的工件脉冲作为基准脉冲，基于基准脉冲进行图像拾取。 ，并且每次只有从相关的图像拾取时序输出数量对应于工件脉冲之间的脉冲数的参考脉冲PA，基于参考脉冲PA，在图像拾取定时执行图像拾取。

    X-RAY CT APPARATUS AND IMAGE RECONSTRUCTION METHOD
    8.
    发明申请
    X-RAY CT APPARATUS AND IMAGE RECONSTRUCTION METHOD 有权
    X射线CT设备和图像重建方法

    公开(公告)号：US20130177132A1

    公开(公告)日：2013-07-11

    申请号：US13824697

    申请日：2011-10-13

    申请人： Hisashi Takahashi ,  Taiga Goto ,  Koichi Hirokawa

    发明人： Hisashi Takahashi ,  Taiga Goto ,  Koichi Hirokawa

    IPC分类号： G06T11/00 ,  G01N23/04

    CPC分类号： G06T11/006 ,  A61B6/032 ,  A61B6/5205 ,  A61B6/5264 ,  G06T2211/424

    摘要： In order to provide an X-ray CT apparatus and the like that reconstruct an image using an iterative approximation method which ensures stable convergence and can be executed at high speed, a computation device 5 of an X-ray CT apparatus 1 calculates matrices A, B, D, R, and R′ on the basis of the scanning conditions input through an input device 6 (step 1). Then, the computation device 5 calculates each element of a matrix I−α(SBTDA+βSR) (step 2). Then, the computation device 5 calculates the operator norm ∥I−α(SBTDA+βSR)∥ of the matrix I−α(SBTDA+βSR) (step 3). Then, the computation device 5 determines a relaxation coefficient α such that a predetermined conditional expression is satisfied (step 4).

    摘要翻译： 为了提供使用确保稳定收敛并且可以高速执行的迭代逼近方法来重建图像的X射线CT装置等，X射线CT装置1的计算装置5计算矩阵A， 基于通过输入装置6输入的扫描条件（步骤1），B，D，R和R'。 然后，计算装置5计算矩阵I-α（SBTDA +βSR）的每个元素（步骤2）。 然后，计算装置5计算矩阵I-α（SBTDA +βSR）的运算符范数‖I-α（SBTDA +βSR）‖（步骤3）。 然后，计算装置5确定满足预定条件表达式的松弛系数α（步骤4）。

    Frequency synthesizer
    10.
    发明授权
    Frequency synthesizer 失效
    频率合成器

    公开(公告)号：US07391841B2

    公开(公告)日：2008-06-24

    申请号：US11041888

    申请日：2005-01-25

    申请人： Hisashi Takahashi

    发明人： Hisashi Takahashi

    IPC分类号： H03D3/24 ,  H03L7/00

    CPC分类号： H03L7/0898 ,  H03L7/099 ,  H03L7/18

    摘要： A plurality of voltage controlled oscillators and a plurality of dividers are provided corresponding to a plurality of frequency bands, respectively, and a phase comparator, a charge pump, and a low pass filter are used in common for the plurality of frequency bands. A switch which selects any one of the plurality of voltage controlled oscillators, and a switch which selects any one of the plurality of dividers are provided. A controller which performs a gain control of a frequency synthesizer loop is further provided so that a gain characteristic of the frequency synthesizer loop comprised of a selected voltage controlled oscillator, selected divider, phase comparator, charge pump, and low pass filter becomes constant regardless of a selection change of the plurality of voltage controlled oscillators and the plurality of dividers.

    摘要翻译： 分别对应于多个频带设置多个压控振荡器和多个分频器，并且对于多个频带使用相位比较器，电荷泵和低通滤波器。 提供选择多个压控振荡器中的任何一个的开关，以及选择多个分频器中的任何一个的开关。 还提供执行频率合成器环路的增益控制的控制器，使得由选定的压控振荡器，选择的分频器，相位比较器，电荷泵和低通滤波器构成的频率合成器回路的增益特性变得恒定，而不管 多个压控振荡器和多个分频器的选择变化。