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公开(公告)号：US4145555A
公开(公告)日：1979-03-20
申请号：US774828
申请日：1977-03-07
IPC分类号： A61K31/23 , A61K9/48 , A61K31/557 , A61K31/5575 , A61K31/70 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D309/12 , C08B37/00 , C08B37/16 , C07C177/00
CPC分类号： C07C405/00 , C07D309/12 , C08B37/0015
摘要： The present invention relates to prostaglandin analogues of the general formula: ##STR1## �wherein X represents cis or trans-vinylene or ethylene, Z represents ##STR2## R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom or a methyl group, R.sup.3 represents a straight- or branched-chain alkylene group containing from 1 to 7 carbon atoms and R.sup.4 represents a cycloalkyl group containing from 5 to 7 carbon atoms, a grouping of the formula: ##STR3## (wherein R.sup.5 and R.sup.6, which may be the same or different, each represent a hydrogen atom or halogen atom, a trifluoromethyl group or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms), or a grouping of the formula: ##STR4## (wherein R.sup.5 and R.sup.6 are as hereinbefore defined), or R.sup.3 and R.sup.4 together represent a straight- or branched-chain alkyl group containing from 1 to 10 carbon atoms, and (1) the double bond between C.sub.3 -C.sub.4 is trans or cis, or trans and cis, when X is cis-vinylene or ethylene, and (2) the double bond between C.sub.3 -C.sub.4 is trans, when X is trans-vinylene, and the double bond between C.sub.13 -C.sub.14 is trans! and cyclodextrin clathrates of such acids and esters, and when R.sup.1 represents a hydrogen atom, non-toxic salts thereof, which exhibit characteristic prostaglandin-like activities.
摘要翻译： 本发明涉及以下通式的前列腺素类似物：其中X表示顺式或反式亚乙烯基或亚乙基，Z表示R 1表示氢原子或含有1个或更多个的直链或支链烷基 至12个碳原子，R 2表示氢原子或甲基，R 3表示含有1至7个碳原子的直链或支链亚烷基，R 4表示含有5至7个碳原子的环烷基， 式（其中R5和R6可以相同或不同，分别表示氢原子或卤原子，三氟甲基或含有1至4个碳原子的直链或支链烷基） ，或下式的分组：其中R 5和R 6如上所定义，或者R 3和R 4一起表示含有1至10个碳原子的直链或支链烷基，和（1） C3-C4之间的双键是反式或顺式，或 反式和顺式，当X为顺式 - 亚乙烯基或亚乙基时，和（2）当X为反式亚乙烯基时，C 3 -C 4之间的双键为反式，C13-C14之间的双键为反式]和环糊精包合物 酸和酯，当R1代表氢原子时，其无毒性盐显示出特征性的前列腺素样活性。
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公开(公告)号：US4165437A
公开(公告)日：1979-08-21
申请号：US934444
申请日：1978-08-17
IPC分类号： C07C405/00 , C07D309/12 , C08B37/00 , C07C177/00
CPC分类号： C07C405/00 , C07D309/12 , C08B37/0015
摘要： The present invention relates to prostaglandin analogues of the general formula: ##STR1## [wherein X represents cis or trans-vinylene or ethylene, R represents ##STR2## R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom or a methyl group, R.sup.3 represents a straight- or branched-chain alkylene group containing from 1 to 7 carbon atoms and R.sup.4 represents a cycloalkyl group containing from 5 to 7 carbon atoms, a grouping of the formula: ##STR3## (wherein R.sup.5 and R.sup.6, which may be the same or different, each represent a hydrogen atom or halogen atom, a trifluoromethyl group or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms), or a grouping of the formula: ##STR4## (wherein R.sup.5 and R.sup.6 are as hereinbefore defined), or R.sup.3 and R.sup.4 together represent a straight- or branched-chain alkyl group containing from 1 to 10 carbon atoms, and (1) the double bond between C.sub.3 -C.sub.4 is trans or cis, or trans and cis, when X is cis-vinylene or ethylene, and (2) the double bond between C.sub.3 -C.sub.4 is trans, when X is trans-vinylene, and the double bond between C.sub.13 -C.sub.14 is trans] and cyclodextrin clathrates of such acids and esters, and when R.sup.1 represents a hydrogen atom, non-toxic salts thereof, which exhibit characteristic prostaglandin-like activities.
摘要翻译： 本发明涉及以下通式的前列腺素类似物：其中X表示顺式或反式亚乙烯基或亚乙基，R表示R 1表示氢原子或含有1个直链或支链烷基的直链或支链烷基 至12个碳原子，R 2表示氢原子或甲基，R 3表示含有1至7个碳原子的直链或支链亚烷基，R 4表示含有5至7个碳原子的环烷基， 式（其中R5和R6可以相同或不同，分别表示氢原子或卤原子，三氟甲基或含有1至4个碳原子的直链或支链烷基） ，或下式的分组：其中R 5和R 6如上所定义，或者R 3和R 4一起表示含有1至10个碳原子的直链或支链烷基，和（1） C3-C4之间的双键是反式或顺式，或 反式和顺式，当X为顺式 - 亚乙烯基或亚乙基时，和（2）当X为反式亚乙烯基时，C 3 -C 4之间的双键为反式，C13-C14之间的双键为反式]和环糊精包合物 酸和酯，当R1代表氢原子时，其无毒性盐显示出特征性的前列腺素样活性。
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公开(公告)号：US4024174A
公开(公告)日：1977-05-17
申请号：US534509
申请日：1964-12-19
IPC分类号： C07C405/00 , C07D307/20 , C07D309/12 , C07C177/00
CPC分类号： C07D307/20 , C07C405/00 , C07D309/12 , Y10S514/825
摘要： Trans-.DELTA..sup.2 -prostaglandin compounds are disclosed of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## R.sup.1 represents an alkyl group containing from 1 to 10 carbon atoms, or an alkyl group containing from 1 to 6 carbon atoms carrying a phenyl substituent or a cycloalkyl substituent of 5 to 7 carbon atoms, R.sup.2 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, and R.sup.3.sup.' represents a hydrogen atom or an alkyl group containing from 1 to 12 carbon atoms, the double bonds in the 2- and 5-positions being in the trans- and cis-configurations respectively. These compounds are indicated in the management of conditions such as autoimmune conditions, e.g. rheumatoid arthritis.
摘要翻译： Trans-DELTA 2-前列腺素化合物公开于下列通式：其中A代表下式的基团：其中R 1表示含有1至10个碳原子的烷基，或 含有1〜6个碳原子的烷基，带有苯基取代基或5〜7个碳原子的环烷基取代基，R2表示氢原子或含1〜4个碳原子的烷基，R3'表示氢原子 或含有1至12个碳原子的烷基，2位和5位的双键分别为反式和顺式构型。 这些化合物在诸如自身免疫病症例如自身免疫病症的条件的管理中表示。 类风湿关节炎。
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公开(公告)号：US4180675A
公开(公告)日：1979-12-25
申请号：US857341
申请日：1977-12-05
申请人： Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
发明人： Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
IPC分类号： C07C405/00 , C07D309/12 , C07F9/40 , C08B37/00 , C07C177/00
CPC分类号： C08B37/0015 , C07C405/00 , C07D309/12 , C07F9/4006
摘要： The present invention relates to 15-cycloalkyl-prostaglandins of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a straight- or branched-chain alkyl group containing from 2 to 8 carbon atoms or a phenyl group unsubstituted or substituted by an alkyl group containing from 1 to 3 carbon atoms, R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and n represents 4 or 5 and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, non-toxic salts thereof.These new compounds exhibit characteristic prostaglandin-like activities.
摘要翻译： 本发明涉及下式的15-环烷基 - 前列腺素：其中A表示下式的基团：W表示亚乙基或反式亚乙烯基，X表示亚乙基或顺式亚乙烯基，Y表示亚乙基或反式亚乙烯基 - 亚乙烯基，R表示氢原子或含有1至12个碳原子的直链或支链烷基，R1表示氢原子或甲基或乙基，R2表示直链或支链烷基， 2至8个碳原子的苯基或未被取代或被含有1至3个碳原子的烷基取代的苯基，R 3表示氢原子或含有1至3个碳原子的直链或支链烷基，n 代表这些酸和酯的4或5和环糊精包合物，当R代表氢原子时，其无毒性盐。 这些新化合物表现出特征性的前列腺素样活性。
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公开(公告)号：US4087620A
公开(公告)日：1978-05-02
申请号：US703158
申请日：1976-07-07
申请人： Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
发明人： Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
IPC分类号： A61K31/557 , A61K31/19 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D309/12 , C07F9/40 , C08B37/00 , C07C177/00
CPC分类号： C07F9/4018 , C07C405/00 , C07D309/12 , C08B37/0015
摘要： The present invention relates to 15-cycloalkyl-prostaglandins of the formula: ##STR1## WHEREIN A represents a grouping of the formula: ##STR2## W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a straight- or branched-chain alkyl group containing from 2 to 8 carbon atoms or a phenyl group unsubstituted or substituted by an alkyl group containing from 1 to 3 carbon atoms, R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and n represents 4 or 5) and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, non-toxic salts thereof.These new compounds exhibit characteristic prostaglandin-like activities.
摘要翻译： 本发明涉及下式的15-环烷基 - 前列腺素：其中A表示下式的基团：W表示亚乙基或反 - 亚乙烯基，X表示亚乙基或顺式 - 亚乙烯基，Y表示亚乙基或反式 - 亚乙烯基，R表示氢原子或含有1至12个碳原子的直链或支链烷基，R1表示氢原子或甲基或乙基，R2表示直链或支链烷基， 2至8个碳原子的苯基或未被取代或被含有1至3个碳原子的烷基取代的苯基，R 3表示氢原子或含有1至3个碳原子的直链或支链烷基，n 代表4或5）和这些酸和酯的环糊精包合物，当R代表氢原子时，其无毒性盐。
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公开(公告)号：US4065632A
公开(公告)日：1977-12-27
申请号：US713941
申请日：1976-08-12
申请人： Masaki Hayashi , Seiji Kori , Hajimu Miyake , Takanori Okada
发明人： Masaki Hayashi , Seiji Kori , Hajimu Miyake , Takanori Okada
IPC分类号： A61K31/12 , A61K31/19 , A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/40 , C07C69/76
CPC分类号： C07D307/935 , C07C405/00 , C07C405/0016 , C07C405/0025 , C07C405/0033 , C07D309/12 , C07F9/4006 , Y10S514/822 , Y10S514/826 , Y10S514/869 , Y10S514/927
摘要： The present invention relates to compounds of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## B represents an oxygen or sulphur atom, R.sup.1 and R.sup.2, which may be the same or different, each represent a hydrogen or halogen atom, a trifluoromethyl group, or a straight- or branched-chain alkyl or alkoxy group containing from 1 to 4 carbon atoms, R represents a group of the formula --COOR.sup.3, in which R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, or a group of the formula --CH.sub.2 OR.sup.4, in which R.sup.4 represents a hydrogen atom or an alkylcarbonyl group containing from 2 to 5 carbon atoms and the double bonds depicted in positions C.sub.2 -C.sub.3, C.sub.5 -C.sub.6 and C.sub.13 -C.sub.14 are trans, cis and trans respectively, the cyclodextrin clathrates thereof and, when R.sup.3 in the group --COOR.sup.3 represents a hydrogen atom, non-toxic salts thereof. These compounds exhibit characteristics of prostaglandin-like activity.
摘要翻译： 本发明涉及下式的化合物：其中A表示下式的基团：IV B表示氧或硫原子，R 1和R 2可以是 相同或不同，各自表示氢或卤素原子，三氟甲基或含有1至4个碳原子的直链或支链烷基或烷氧基，R表示式-COOR 3的基团，其中R 3 表示氢原子或含有1至12个碳原子的直链或支链烷基，或式-CH 2OR 4基团，其中R 4表示氢原子或含有2至5个碳原子的烷基羰基， 位置C2-C3，C5-C6和C13-C14中所示的双键分别是反式，顺式和反式，环糊精包合，当-COOR3基团中的R3表示氢原子时，其无毒盐。 这些化合物表现出前列腺素样活性的特征。
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公开(公告)号：US4195182A
公开(公告)日：1980-03-25
申请号：US824384
申请日：1977-08-12
申请人： Masaki Hayashi , Seiji Kori , Takanori Okada
发明人： Masaki Hayashi , Seiji Kori , Takanori Okada
IPC分类号： C08B37/16 , A61K31/19 , A61K31/715 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07C177/00
CPC分类号： C07C405/00 , C07C405/0033
摘要： This invention relates to prostaglandin analogues of the formula: ##STR1## (wherein R represents a hydrogen atom or a methyl group, and the double bonds between C.sub.2 -C.sub.3 and C.sub.13 -C.sub.14 are trans) and cyclodextrin clathrates of such compounds and, when R represents a hydrogen atom, non-toxic salts thereof, which possess characteristic prostaglandin-like activity.
摘要翻译： 本发明涉及下式的前列腺素类似物：其中R表示氢原子或甲基，C2-C3和C13-C14之间的双键为反式）和这些化合物的环糊精包合物， R表示具有特征性前列腺素样活性的氢原子，无毒性盐。
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公开(公告)号：US4479966A
公开(公告)日：1984-10-30
申请号：US113502
申请日：1980-01-21
IPC分类号： A61K47/48 , C07C45/64 , C07C45/65 , C07C45/67 , C07C49/517 , C07C405/00 , C07D309/12 , C07C177/00 , C07C59/46
CPC分类号： B82Y5/00 , A61K47/48969 , C07C405/0083 , C07C45/64 , C07C45/65 , C07C45/673 , C07C49/517 , C07D309/12 , Y02P20/55
摘要： Prostaglandin I.sub.2 analogues of the formula: ##STR1## [wherein the symbol between the carbon atoms in positions 5 and 6 represents a single or double bond, Y represents ethylene or trans-vinylene, R.sup.1 represents hydrogen, alkyl of 1 to 12 carbon atoms, aralkyl of 7 to 12 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by alkyl of 1 to 4 carbon atoms, phenyl optionally substituted by chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms or phenyl, a --C.sub.m H.sub.2m COOR.sup.7 group (wherein m represents an integer of from 1 to 12 and R.sup.7 represents alkyl of 1 to 4 carbon atoms), a --C.sub.n H.sub.2n OR.sup.8 group (wherein n represents an integer of from 2 to 12 and R.sup.8 represents hydrogen or alkyl of 1 to 4 carbon atoms) or a ##STR2## group (wherein R.sup.9 and R.sup.10 each represent alkyl of 1 to 4 carbon atoms and n is as hereinbefore defined), R.sup.2 represents hydrogen or a hydroxy-protecting group, R.sup.3 represents hydrogen or a hydroxy-protecting group which is eliminated under acidic conditions, R.sup.4 represents hydrogen, methyl or ethyl, R.sup.5 represents a single bond or alkylene of 1 to 4 carbon atoms optionally substituted by a chlorine atom (provided that, when R.sup.5 is alkylene substituted by chlorine, R.sup.6 represents hydrogen or alkyl) R.sup.6 represents hydrogen, alkyl or 1 to 8 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by alkyl of 1 to 8 carbon atoms, or phenyl or phenoxy optionally substituted by cholrine, trifluoromethyl or alkyl of 1 to 4 carbon atoms, and when represents a double bond that bond is E, Z or a mixture thereof and when, represents a single bond, the absolute configuration of C.sub.6 is R, S or a mixture thereof] and, when R.sup.2 and R.sup.3 represent hydrogen, cyclodextrin clathrates of such acids and esters and, when R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, non-toxic salts thereof and, when R.sup.1 represents ##STR3## in which n, R.sup.9 and R.sup.10 are as hereinbefore defined, non-toxic acid addition salts thereof, are new compounds, possessing prostaglandin-like activity.
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公开(公告)号：US4399147A
公开(公告)日：1983-08-16
申请号：US872635
申请日：1978-01-26
申请人： Masaki Hayashi , Yoshinobu Arai , Yoshitaka Konishi , Katsuichi Shimoji , Shuichi Ohuchida , Hirohisa Wakatsuka , Hiroyuki Ito
发明人： Masaki Hayashi , Yoshinobu Arai , Yoshitaka Konishi , Katsuichi Shimoji , Shuichi Ohuchida , Hirohisa Wakatsuka , Hiroyuki Ito
IPC分类号： C07D307/935 , A61K31/34 , A61K31/343 , A61P43/00 , C07C405/00 , C07D307/937 , A61K31/557
CPC分类号： C07D307/937 , C07C405/00
摘要： Prostaglandin I.sub.2 analogues of the formula: ##STR1## [wherein X represents trans-vinylene or an ethylene group unsubstituted or substituted by a bromine atom at the C-5 position, Y represents trans-vinylene or ethylene, R.sup.1 represents hydrogen or an alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents hydrogen or methyl or ethyl, R.sup.3 represents a single bond or an alkylene group containing from 1 to 4 carbon atoms, R.sup.4 represents hydrogen, an alkyl group containing from 1 to 8 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or a phenyl or phenoxy group unsubstituted or carrying at least one substituent selected from halogen atoms, the trifluoromethyl group and alkyl groups containing from 1 to 3 carbon atoms, and the wavy line attached to the carbon atoms in positions 6, 11 and 15 depicted in the formula represents .alpha.- or .beta.-configuration or mixtures thereof] are new compounds possessing pharmacological properties typical of prostaglandins, for example PGI.sub.2, and are more stable than PGI.sub.2.
摘要翻译： 前列腺素I2类似物，具有下式：其中X表示反式亚乙烯基或未被取代或被C-5位上的溴原子取代的亚乙基，Y表示反式亚乙烯基或亚乙基，R 1表示氢或烷基 含有1至12个碳原子，R 2表示氢或甲基或乙基，R 3表示单键或含有1至4个碳原子的亚烷基，R 4表示氢，含有1至8个碳原子的烷基，环烷基 含有未取代或被至少一个含有1至8个碳原子的烷基取代的4至7个碳原子的基团，或未取代或携带至少一个选自卤素原子的取代基的苯基或苯氧基，三氟甲基和含有 1至3个碳原子，并且连接在式中描述的6,11和15位的碳原子上的波浪线代表α-或β-构型或其混合物] 是具有典型的前列腺素的药理学性质的新化合物，例如PGI 2，并且比PGI2更稳定。
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公开(公告)号：US4207332A
公开(公告)日：1980-06-10
申请号：US944164
申请日：1978-09-20
申请人： Masaki Hayashi , Yoshinobu Arai , Katsuichi Shimoji , Yoshitaka Konishi , Shuichi Ohuchida , Shinsuke Hashimoto
发明人： Masaki Hayashi , Yoshinobu Arai , Katsuichi Shimoji , Yoshitaka Konishi , Shuichi Ohuchida , Shinsuke Hashimoto
IPC分类号： C07D307/935 , A61K31/34 , A61K31/343 , A61P43/00 , C07C405/00 , C07D307/937 , C07D307/93
CPC分类号： C07D307/937 , C07C405/00
摘要： Prostaglandin analogues of the general formula: ##STR1## [wherein Y represents ethylene or trans-vinylene, R.sup.1 represents a group --C.sub.m H.sub.2m COOR.sup.5, --C.sub.n H.sub.2n OR.sup.6 or ##STR2## (wherein R.sup.5 represents an alkyl group containing from 1 to 4 carbon atoms, R.sup.6 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, R.sup.7 and R.sup.8, which may be the same or different, each represents an alkyl group containing from 1 to 4 carbon atoms, m represents an integer of from 1 to 12 and n represents an integer of from 2 to 12), R.sup.2 represents a hydrogen atom or a methyl or ethyl group, R.sup.3 represents a single bond, or an alkylene group containing from 1 to 4 carbon atoms, R.sup.4 represents a hydrogen atom, an alkyl group containing from 1 to 8 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms in the ring, which may be unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or represents a phenyl or phenoxy group which may be unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group or alkyl group containing from 1 to 3 carbon atoms, the wavy line attached to the carbon atoms in positions 11 and 15 represents .alpha.- or .beta.-configuration, or mixtures thereof, and the double bond between C.sub.5 -C.sub.6 is Z] and cyclodextrin clathrates thereof, and, when R.sup.1 represents a group ##STR3## in which n, R.sup.7 and R.sup.8 are as hereinbefore defined, non-toxic acid addition salts thereof, are new compounds and possess characteristic prostaglandin-like properties.
摘要翻译： 前列腺素类似物具有以下通式：其中Y表示亚乙基或反式亚乙烯基，R1表示基团-CmH2mCOOR5，-CnH2nOR6或其中R5表示含有1至4个碳原子的烷基，R6表示 含有1至4个碳原子的氢原子或烷基，可以相同或不同的R 7和R 8各自表示含有1至4个碳原子的烷基，m表示1至12的整数，m表示1至12的整数， n表示2〜12的整数），R2表示氢原子或甲基或乙基，R3表示单键或含有1〜4个碳原子的亚烷基，R4表示氢原子，烷基 含有1至8个碳原子的环烷基，环中含有4至7个碳原子的环烷基，其可以是未取代的或被至少一个含有1至8个碳原子的烷基取代，或表示苯基或苯氧基， 可以是未取代的或未取代的 由至少一个氯原子，三氟甲基或含有1至3个碳原子的烷基取代，连接到位置11和15的碳原子的波浪线表示α或β构型，或其混合物，双键 C5-C6之间是Z]和环糊精包合物，当R1代表其中n，R7和R8如上所定义的基团“IMAGE”时，其无毒的酸加成盐是新的化合物，并且具有特征性的前列腺素 - 像属性。
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