公开(公告)号：US20050043412A1

公开(公告)日：2005-02-24

申请号：US10503031

申请日：2003-01-28

申请人： Masaki Ichikawa ,  Fumio Nakazawa ,  Hideaki Hara

发明人： Masaki Ichikawa ,  Fumio Nakazawa ,  Hideaki Hara

IPC分类号： A61K31/551 ,  A61K31/5575 ,  A61P27/06 ,  A61K31/557

CPC分类号： A61K31/551 ,  A61K31/5575 ,  A61K2300/00

摘要： The object of the present invention is to find utility of a combination of bunazosin, having a new action mechanism, and prostaglandins as a therapeutic agent of glaucoma. The invention relates to a therapeutic agent of glaucoma, comprising bunazosin or a salt thereof and prostaglandins in combination, where bunazosin or a salt thereof and prostaglandins mutually supplement and/or enhance each action, and where bunazosin and prostaglandin may be formulated in a single preparation to be administered or may be separately administered in combination.

摘要翻译： 本发明的目的是发现具有新的作用机制的布那唑嗪和作为青光眼治疗剂的前列腺素的组合的效用。 本发明涉及青蒿素的治疗剂，其包含布那唑嗪或其盐和组合的前列腺素，其中布氮唑嗪或其盐和前列腺素相互补充和/或增强每种作用，并且其中布氮唑嗪和前列腺素可以配制成单一制剂 或者可以组合地分开施用。

公开(公告)号：US20110039891A1

公开(公告)日：2011-02-17

申请号：US12925367

申请日：2010-10-20

申请人： Masahiko Hagihara ,  Ken-ichi Komori ,  Hidetoshi Sunamoto ,  Hiroshi Nishida ,  Takeshi Matsugi ,  Tadashi Nakajima ,  Masakazu Hatano ,  Kazutaka Kido ,  Hideaki Hara

发明人： Masahiko Hagihara ,  Ken-ichi Komori ,  Hidetoshi Sunamoto ,  Hiroshi Nishida ,  Takeshi Matsugi ,  Tadashi Nakajima ,  Masakazu Hatano ,  Kazutaka Kido ,  Hideaki Hara

IPC分类号： A61K31/454 ,  A61K31/415 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/42 ,  A61P27/02 ,  A61P27/06

CPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04

摘要： A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.

摘要翻译： 一种治疗涉及Rho激酶的疾病的方法。 该方法通过向有需要的患者施用药学有效量的下式化合物或其药学上可接受的盐进行：其中环X是苯环或吡啶环; R1和R2是氢或烷基或一起形成环烯烃环; R 3是氢，取代的烷基，未取代的烯基，羧基或其酯或酰胺，氨基或氰基; R4是氢，羟基，取代或未取代的烷氧基，未取代的烯氧基，未取代的环烷基氧基取代或未取代的烷基，未取代的烯基，未取代的环烷基，氨基，取代或未取代的烷基氨基，硝基，氰基或单环杂环; R5为卤素原子或氢原子。

公开(公告)号：US07855222B2

公开(公告)日：2010-12-21

申请号：US12456652

申请日：2009-06-19

申请人： Masahiko Hagihara ,  Ken-ichi Komori ,  Hidetoshi Sunamoto ,  Hiroshi Nishida ,  Takeshi Matsugi ,  Tadashi Nakajima ,  Masakazu Hatano ,  Kazutaka Kido ,  Hideaki Hara

发明人： Masahiko Hagihara ,  Ken-ichi Komori ,  Hidetoshi Sunamoto ,  Hiroshi Nishida ,  Takeshi Matsugi ,  Tadashi Nakajima ,  Masakazu Hatano ,  Kazutaka Kido ,  Hideaki Hara

IPC分类号： A01N43/56 ,  A61K31/40 ,  C07D231/00 ,  C07D233/56

CPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04

摘要： A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.

摘要翻译： 一种治疗涉及Rho激酶的疾病的方法。 该方法通过向有需要的患者施用药学有效量的下式化合物或其药学上可接受的盐进行：其中环X是苯环或吡啶环; R1和R2是氢或烷基或一起形成环烯烃环; R 3是氢，取代的烷基，未取代的烯基，羧基或其酯或酰胺，氨基或氰基; R4是氢，羟基，取代或未取代的烷氧基，未取代的烯氧基，未取代的环烷基氧基，取代或未取代的烷基，未取代的烯基，未被取代的环烷基，氨基，取代或未取代的烷基氨基，硝基，氰基或单环杂环; R5为卤素原子或氢原子。

公开(公告)号：US20090264468A1

公开(公告)日：2009-10-22

申请号：US12456652

申请日：2009-06-19

申请人： Masahiko Hagihara ,  Ken-ichi Komori ,  Hidetoshi Sunamoto ,  Hiroshi Nishida ,  Takeshi Matsugi ,  Tadashi Nakajima ,  Masakazu Hatano ,  Kazutaka Kido ,  Hideaki Hara

发明人： Masahiko Hagihara ,  Ken-ichi Komori ,  Hidetoshi Sunamoto ,  Hiroshi Nishida ,  Takeshi Matsugi ,  Tadashi Nakajima ,  Masakazu Hatano ,  Kazutaka Kido ,  Hideaki Hara

IPC分类号： A61K31/454 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/421 ,  A61K31/42 ,  A61P9/00 ,  A61P11/00 ,  A61P35/00 ,  A61P29/00 ,  A61P15/00

CPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04

摘要： A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: , wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.

摘要翻译： 一种治疗涉及Rho激酶的疾病的方法。 该方法通过向有需要的患者施用药学有效量的下式化合物或其药学上可接受的盐进行：其中环X是苯环或吡啶环; R1和R2是氢或烷基或一起形成环烯烃环; R 3是氢，取代的烷基，未取代的烯基，羧基或其酯或酰胺，氨基或氰基; R4是氢，羟基，取代或未取代的烷氧基，未取代的烯氧基，未取代的环烷基氧基，取代或未取代的烷基，未取代的烯基，未被取代的环烷基，氨基，取代或未取代的烷基氨基，硝基，氰基或单环杂环; R5为卤素原子或氢原子。

公开(公告)号：US07563906B2

公开(公告)日：2009-07-21

申请号：US10575645

申请日：2004-10-15

申请人： Masahiko Hagihara ,  Ken-ichi Komori ,  Hidetoshi Sunamoto ,  Hiroshi Nishida ,  Takeshi Matsugi ,  Tadashi Nakajima ,  Masakazu Hatano ,  Kazutaka Kido ,  Hideaki Hara

发明人： Masahiko Hagihara ,  Ken-ichi Komori ,  Hidetoshi Sunamoto ,  Hiroshi Nishida ,  Takeshi Matsugi ,  Tadashi Nakajima ,  Masakazu Hatano ,  Kazutaka Kido ,  Hideaki Hara

IPC分类号： C07D233/00

CPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04

摘要： An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.

摘要翻译： 本发明的目的是产生一种可用作药物的新型吲唑衍生物，并找到该衍生物的新药理作用。 本发明的化合物由式[I]表示，具有优异的Rho激酶抑制作用。 在该式中，环X为苯环或吡啶环; R1和R2是H或烷基; R 3和R 4是卤素，H，OH，烷氧基，烯氧基，炔氧基，环烷氧基，环烯氧基，芳氧基，烷基，烯基，炔基，环烷基，环烯基，芳基，羧基，烃基，烷基羰基等。 和R 5是卤素原子，H，OH，烷氧基，芳氧基，烷基或芳基。 每组可以替代。

公开(公告)号：US20060287246A1

公开(公告)日：2006-12-21

申请号：US10572075

申请日：2004-09-24

申请人： Shinji Yoneda ,  Rie Yamamoto ,  Hideaki Hara

发明人： Shinji Yoneda ,  Rie Yamamoto ,  Hideaki Hara

IPC分类号： A61K38/08 ,  A61K38/06

CPC分类号： A61K38/55 ,  A61K38/06 ,  A61K38/07

摘要： An object of the present invention is to search for a novel medicinal use of a compound having a secretase inhibitory activity. Because the compound having a secretase inhibitory activity has a remarkable inhibitory effect on retinal neuronal cell death, it is useful as a therapeutic agent for a retinal disease typified by retinal vessel occlusion, diabetic retinopathy, ischemic optic neuropathy, macular degeneration, retinitis pigmentosa and Leber's disease or an eye disease accompanied by an optic neuropathy such as glaucoma.

摘要翻译： 本发明的目的是寻找具有分泌酶抑制活性的化合物的新型药物用途。 由于具有分泌酶抑制活性的化合物对视网膜神经元细胞死亡具有显着的抑制作用，因此可用作视网膜病变治疗剂，以视网膜血管闭塞，糖尿病性视网膜病变，缺血性视神经病变，黄斑变性，色素性视网膜炎和Leber's 伴有视神经病如青光眼的疾病或眼病。

公开(公告)号：US06591689B2

公开(公告)日：2003-07-15

申请号：US09894907

申请日：2001-06-29

申请人： Akira Nidan ,  Takafumi Taki ,  Hideaki Hara ,  Michihiro Masuda ,  Kaname Ban ,  Kazuo Tanaka ,  Yoshifumi Murakami

发明人： Akira Nidan ,  Takafumi Taki ,  Hideaki Hara ,  Michihiro Masuda ,  Kaname Ban ,  Kazuo Tanaka ,  Yoshifumi Murakami

IPC分类号： G01L916

CPC分类号： G01L19/0084 ,  G01L9/0054 ,  G01L19/147 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2924/00014 ,  H01L2924/00

摘要： A pressure sensor has a sensor chip with a diaphragm formed therein and bumps formed thereon, and a stem with leads extending from a surface thereof to the sensor chip. The bumps and the leads are electrically connected by face down bonding so that a surface of the sensor chip faces the surface of the stem. In this manner, bonding wires are unnecessary. Therefore, an area for disposing the bonding wires in the stem can be cut down, so that the pressure sensor can be miniaturized.

公开(公告)号：US06407799B2

公开(公告)日：2002-06-18

申请号：US09358395

申请日：1999-07-22

申请人： Hideaki Hara

发明人： Hideaki Hara

IPC分类号： G03B2742

CPC分类号： G01B9/02027 ,  G01B9/02021 ,  G01B9/02052 ,  G03F7/70716 ,  G03F7/70866 ,  G03F7/70875 ,  G03F7/70891

摘要： A jacket is provided to surround coils in a stationary member of a linear motor. An inlet of the jacket is directed toward the optical path of a laser beam from a laser interferometer, and a temperature-controlled fluid is circulated through the jacket. Temperature sensors are provided at the outlet and inlet, respectively, of a temperature controller. The temperature of the fluid supplied to the stationary member is controlled so as to become equal to the temperature around the optical path of the laser beam on the basis of the values of temperature measured by the temperature sensors, thereby suppressing fluctuations of air in the optical path of the laser beam. An exhaust groove is provided in a guide bar transport member so as to surround a bearing surface around a gas outlet, and partition walls flush with the bearing surface are provided outside the exhaust groove. The discharge opening of the exhaust groove is provided on the leeward of an environmental air stream, and a temperature sensor is provided at the discharge opening. The temperature of compressed air supplied to the gas outlet is controlled such that the temperature measured by the temperature sensor becomes equal to the temperature of the environmental air stream.

摘要翻译： 提供外套来围绕线性马达的固定件中的线圈。 护套的入口被引导到来自激光干涉仪的激光束的光路，并且温度控制的流体循环通过护套。 温度传感器分别设置在温度控制器的出口和入口处。 基于由温度传感器测量的温度值，控制提供给静止部件的流体的温度使其等于激光束的光路周围的温度，从而抑制光学部件中的空气的波动 激光束的路径。 排气槽设置在导杆传送构件中，以便围绕气体出口围绕轴承表面，并且在排气槽的外侧设置有与支承表面齐平的分隔壁。 排气槽的排出口设置在环境空气流的背风上，在排出口设有温度传感器。 控制供给到气体出口的压缩空气的温度，使得由温度传感器测量的温度等于环境空气流的温度。

公开(公告)号：US06387910B1

公开(公告)日：2002-05-14

申请号：US09601231

申请日：2000-10-02

申请人： Hideaki Hara ,  Masamitsu Shimazawa ,  Yasushi Iwakura ,  Tetsuya Sugiyama

发明人： Hideaki Hara ,  Masamitsu Shimazawa ,  Yasushi Iwakura ,  Tetsuya Sugiyama

IPC分类号： A61K31495

CPC分类号： C07D295/096 ,  A61K31/495 ,  Y10S514/912 ,  Y10S514/913

摘要： A novel drug for improving the circulation in the optic nerve head, which comprises as an active ingredient Lomerizine (I): or a pharmaceutically acceptable acid addition salt. The optic nerve head circulation improving drug of this invention can increase the blood flow in the optic nerve head with no or little systemic side effects such as hypotensive activity or heart rate increasing activity and is useful particularly for the treatment of normal tension glaucoma.

摘要翻译： 一种用于改善视神经头循环的新型药物，其包含作为活性成分的洛美利嗪（I）或其药学上可接受的酸加成盐。 本发明的视神经乳头循环改善药物可以增加视神经头部的血流量，没有或少量全身副作用，如降血压活性或心率增加活性，并且特别适用于治疗正常的紧张性青光眼。

公开(公告)号：US5839324A

公开(公告)日：1998-11-24

申请号：US623008

申请日：1996-03-28

申请人： Hideaki Hara

发明人： Hideaki Hara

IPC分类号： G12B5/00 ,  G03F7/20 ,  H01L21/027 ,  H01L21/68 ,  H01L21/683

CPC分类号： G03F7/70691 ,  H01L21/68 ,  H01L21/6838 ,  Y10T74/20201 ,  Y10T74/20354

摘要： A stage apparatus comprises a pedestal, an X axis guide bar which is fixed on the pedestal, an X stage which is movable along an upper surface of the pedestal and the guide bar, and a Y stage which is placed over the X stage and movable along the pedestal in a direction of the Y axis. Vacuum-pre-loadable static pressure air bearings, in which pressures of vacuum ports are independently controllable, are provided on a surface of the X stage opposing to the pedestal and on another surface of the X stage opposing to the X axis guide bar. By using the stage apparatus, the electric power consumption of driving means for movable units can be reduced, the amount of heat generation can be reduced, and the bearing gap, can be adjusted highly accurately after assembling.

摘要翻译： 舞台装置包括基座，固定在基座上的X轴导杆，可沿着底座和导杆的上表面移动的X平台，以及放置在X台上并可移动的Y平台 沿Y轴的方向沿基座。 真空预加载的静压空气轴承，其中真空端口的压力是可独立控制的，设置在与基座相对的X台的表面上，在与X轴导杆相对的X台的另一个表面上。 通过使用平台装置，可以减少可动单元的驱动装置的电力消耗，能够减少发热量，并且可以在组装后高精度地调整轴承间隙。