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1.发明授权Hyaluronic acid gel composition, process for producing the same, and medical material containing the same 失效透明质酸凝胶组合物，其制造方法以及含有该透明质酸凝胶组合物的医用材料公开(公告)号：US06638538B1
公开(公告)日：2003-10-28
申请号：US09913718
申请日：2001-09-27
申请人： Masamichi Hashimoto , Toshihiko Umeda , Kazuhiko Arai , Yoshiaki Miyata , Osamu Yamamoto , Yasukazu Himeda
发明人： Masamichi Hashimoto , Toshihiko Umeda , Kazuhiko Arai , Yoshiaki Miyata , Osamu Yamamoto , Yasukazu Himeda
IPC分类号： A61K3534
CPC分类号： A61L31/042 , A61L26/0023 , A61L26/008 , A61L27/20 , A61L27/52 , C08B37/0072 , C08L1/286 , C08L5/08 , C08L29/04 , C08L1/26 , C08L2666/02
摘要： A hyaluronic acid gel composition comprising hyaluronic acid and a polymer, which is substantially unmodified with a chemical cross-linking agent or a chemical modifying agent and which has a percentage dissolution of hyaluronic acid of 50% or lower in 12 hours in a neutral aqueous solution of 37° C.
摘要翻译： 一种透明质酸凝胶组合物，其包含透明质酸和聚合物，其基本上用化学交联剂或化学改性剂未改性，并且在中性水溶液中在12小时内透明质酸溶解百分率为50％或更低 的37℃
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公开(公告)号：US20060135469A1
公开(公告)日：2006-06-22
申请号：US10524785
申请日：2002-08-16
IPC分类号： A61K31/728
CPC分类号： A61K31/728 , A61K9/0024 , A61K9/08 , A61K47/36 , A61L24/0031 , A61L24/08 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2400/06 , C08B37/0072 , C08L5/08
摘要： A separate type medical material containing a hyaluronic acid ester derivative, which satisfies the storage stability of a hyaluronic acid ester derivative and avoidance of irritation and pain at the time of injecting a therapeutic agent for joints, is provided. A separate type medical material comprising liquid (A) which is an aqueous solution containing a hyaluronic acid ester derivative and buffered to a pH of from 4.5 to 6.5, and liquid (B) which is an aqueous solution having such a buffering power that when it is mixed with the liquid (A), the mixed liquid has a pH within a range of from 6.8 to 7.8, kept separately from each other.
摘要翻译： 提供了含有透明质酸酯衍生物的分离型药物，其满足透明质酸酯衍生物的保存稳定性，并且在注射用于关节的治疗剂时避免刺激和疼痛。 包含作为含有透明质酸酯衍生物并且缓冲至4.5至6.5的pH的水溶液的液体（A）的单独类型的医用材料和作为具有缓冲能力的水溶液的液体（B） 与液体（A）混合，混合液体的pH值在6.8〜7.8的范围内，彼此分开。
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公开(公告)号：US07807657B2
公开(公告)日：2010-10-05
申请号：US12027365
申请日：2008-02-07
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： A61K31/728 , A61K9/0024 , A61K9/08 , A61K47/36 , A61L24/0031 , A61L24/08 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2400/06 , C08B37/0072 , C08L5/08
摘要： A separate type medical material containing a hyaluronic acid ester derivative, which satisfies the storage stability of a hyaluronic acid ester derivative and avoidance of irritation and pain at the time of injecting a therapeutic agent for joints, is provided. A separate type medical material comprising liquid (A) which is an aqueous solution containing a hyaluronic acid ester derivative and buffered to a pH of from 4.5 to 6.5, and liquid (B) which is an aqueous solution having such a buffering power that when it is mixed with the liquid (A), the mixed liquid has a pH within a range of from 6.8 to 7.8, kept separately from each other.
摘要翻译： 提供了含有透明质酸酯衍生物的分离型药物，其满足透明质酸酯衍生物的保存稳定性，并且在注射用于关节的治疗剂时避免刺激和疼痛。 包含作为含有透明质酸酯衍生物并且缓冲至4.5至6.5的pH的水溶液的液体（A）的单独类型的医用材料和作为具有缓冲能力的水溶液的液体（B） 与液体（A）混合，混合液体的pH值在6.8〜7.8的范围内，彼此分开。
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公开(公告)号：US20080132585A1
公开(公告)日：2008-06-05
申请号：US12027365
申请日：2008-02-07
CPC分类号： A61K31/728 , A61K9/0024 , A61K9/08 , A61K47/36 , A61L24/0031 , A61L24/08 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2400/06 , C08B37/0072 , C08L5/08
摘要： A separate type medical material containing a hyaluronic acid ester derivative, which satisfies the storage stability of a hyaluronic acid ester derivative and avoidance of irritation and pain at the time of injecting a therapeutic agent for joints, is provided.A separate type medical material comprising liquid (A) which is an aqueous solution containing a hyaluronic acid ester derivative and buffered to a pH of from 4.5 to 6.5, and liquid (B) which is an aqueous solution having such a buffering power that when it is mixed with the liquid (A), the mixed liquid has a pH within a range of from 6.8 to 7.8, kept separately from each other.
摘要翻译： 提供了含有透明质酸酯衍生物的分离型药物，其满足透明质酸酯衍生物的保存稳定性，并且在注射用于关节的治疗剂时避免刺激和疼痛。 包含作为含有透明质酸酯衍生物并且缓冲至4.5至6.5的pH的水溶液的液体（A）的单独类型的医用材料和作为具有缓冲能力的水溶液的液体（B） 与液体（A）混合，混合液体的pH值在6.8〜7.8的范围内，彼此分开。
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5.发明授权公开(公告)号：US07514097B1
公开(公告)日：2009-04-07
申请号：US10129751
申请日：2000-08-18
申请人： Yasukazu Himeda , Toshihiko Umeda
发明人： Yasukazu Himeda , Toshihiko Umeda
IPC分类号： A61K31/715 , A61K31/075 , A61L15/16 , A61L15/00 , A01N43/04 , A01N31/14
CPC分类号： A61L27/20 , A61L15/28 , A61L31/042 , C08L1/02 , C08L1/28
摘要： (1) A tissue-covering medical material which comprises a soluble cellulose derivative having been made hardly soluble in water, which is used with a purpose of being embedded in the body or applied to the tissue, and (2) a method for producing the tissue-covering medical material as defined in (1), which comprises, as a method to make a soluble cellulose derivative hardly soluble in water, freezing and thawing an acidic solution of the soluble cellulose derivative, are provided.
摘要翻译： （1）一种组织覆盖医用材料，其特征在于，其包含难溶于水的可溶性纤维素衍生物，其以嵌入体内或施用于组织为目的使用，以及（2） 提供（1）中定义的组织覆盖医用材料，其包括作为使可溶性纤维素衍生物难溶于水的方法，使可溶性纤维素衍生物的酸性溶液冷冻融化。
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