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1.发明授权Production of novel condensates comprising bisphenols and aromatic aminosulfonic acids, condensates and dispersant, additive and water-reducing agent based thereon 失效生产包含双酚和芳族氨基酸的新型冷凝剂，冷凝剂和分散剂，基于其的添加剂和减水剂
公开(公告)号：US5153299A
公开(公告)日：1992-10-06
申请号：US566760
申请日：1990-08-14
IPC分类号： B01F17/52 , C04B24/22 , C08G14/073 , C08G14/12 , C09B67/46
CPC分类号： C04B24/22 , C08G14/12 , C09B67/0085 , C04B2103/302 , Y10S8/912
摘要： A production method of novel condensates comprising bisphenols and aromatic aminosulfonic acids, in particular, novel 4-aminobenzenesulfonic acid-2, 2-bis(4-hydrocyphenyl)propaneformaldehyde type condensate and said condensate itself are disclosed. Uses of condensates as a dispersant for disperse dye, additive for carbonaceous fine powder-water slurry and water-reducing agent for cement are also claimed.
摘要翻译： 公开了包含双酚和芳族氨基磺酸的新型缩合物的生产方法，特别是新的4-氨基苯磺酸-2,2-双（4-羟基苯基）丙烷甲醛型缩合物和所述缩合物本身。 还要求使用缩合物作为分散染料的分散剂，碳质细粉末 - 水浆料的添加剂和水泥的减水剂。
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2.发明授权Production of novel condensates comprising bisphenols and aromatic aminosulfonic acids, condensates and dispersant, additive and water-reducing agent based thereon 失效生产包含双酚和芳族氨基磺酸的缩合物，缩合物和分散剂，基于其的添加剂和减水剂
公开(公告)号：US5233012A
公开(公告)日：1993-08-03
申请号：US895133
申请日：1992-06-08
CPC分类号： C04B24/22 , C08G14/12 , C09B67/0085
摘要： Novel condensates comprising bisphenols and aromatic aminosulfonic acids, in particular, novel 4-aminobenzenesulfonic acid-2,2-bis (hydroxyphenyl)propaneformaldehyde condensates, and methods for their production are disclosed. The novel condensates are useful as a dispersant for disperse dyes, an additive for carbonaceous fine powder-water slurries and as a water reducing agent for cement.
摘要翻译： 包含双酚和芳族氨基磺酸的新型缩合物，特别是新的4-氨基苯磺酸-2,2-双（羟基苯基）丙烷甲醛缩合物及其生产方法。 新型缩合物可用作分散染料的分散剂，碳质细粉末 - 水浆料的添加剂和水泥的减水剂。
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公开(公告)号：US20090176693A1
公开(公告)日：2009-07-09
申请号：US12304799
申请日：2007-06-13
申请人： Hiroshi Kawakami , Nobuhiro Hanada , Susumu Imai
发明人： Hiroshi Kawakami , Nobuhiro Hanada , Susumu Imai
CPC分类号： A61Q11/00 , A23L33/19 , A23V2002/00 , A61K8/19 , A61K8/64 , A23V2200/30 , A23V2250/54248
摘要： Provided are an agent for maintaining hardness of tooth substances and a food or drink for maintaining the hardness of tooth substances, both of which include lactoferrin and iron-lactoferrin as an active ingredient. Lactoferrin and iron-lactoferrin suppress decalcification of enamel by use or ingestion thereof, and hence is effective for the prevention of dental caries.
摘要翻译： 提供了用于保持牙齿物质的硬度的药剂和用于保持牙齿物质的硬度的食品或饮料，其包括乳铁蛋白和铁 - 乳铁蛋白作为活性成分。 乳铁蛋白和铁 - 乳铁蛋白通过使用或摄取抑制釉质的脱钙，因此对于预防龋齿是有效的。
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公开(公告)号：US20070270377A1
公开(公告)日：2007-11-22
申请号：US11579600
申请日：2005-05-06
申请人： Hiroshi Kawakami , Nobuhiro Hanada , Susumu Imai
发明人： Hiroshi Kawakami , Nobuhiro Hanada , Susumu Imai
IPC分类号： A61K31/739 , A61P31/04
CPC分类号： A23K20/195 , A23K20/121 , A23L33/10 , A61K31/7028 , A61Q11/00
摘要： It is intended to provide an oral flora-improving agent capable of forming a favorable flora in the oral cavity and a food or a drink for improving the oral flora. An oral flora-improving agent containing as an active ingredient a ganglioside and a food, a drink, or a feed for improving the oral flora containing the ganglioside exhibit an antibacterial effect on harmful bacteria in the oral cavity, which are undesirable from the viewpoint of decay and diseases such as periodontal disease, and a growth-improving effect on useful bacteria to be preserved in the oral cavity. Further, the ganglioside is efficaciously used as an active ingredient in an antibacterial agent or an antibacterial drink, food, or feed, a growth promoter, or a food, a drink, or a feed for promoting growth.
摘要翻译： 旨在提供能够在口腔中形成有利菌群的口腔植物改良剂和用于改善口腔菌群的食品或饮料。 含有作为活性成分的神经节苷脂的口腔内植物改善剂和用于改善含有神经节苷脂的口腔菌群的食品，饮料或饲料，对口腔内的有害细菌表现出抗菌作用，从对 衰老和疾病如牙周病，以及对在口腔中保留的有用细菌的生长改善作用。 此外，神经节苷脂有效地用作抗菌剂或抗菌饮料，食品或饲料，生长促进剂或用于促进生长的食品，饮料或饲料中的活性成分。
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5.发明授权Method of administering oral flora-improving agent, antibacterial agent and growth promoter 有权口服植物改良剂，抗菌剂和生长促进剂的施用方法公开(公告)号：US08183215B2
公开(公告)日：2012-05-22
申请号：US12610896
申请日：2009-11-02
申请人： Hiroshi Kawakami , Nobuhiro Hanada , Susumu Imai
发明人： Hiroshi Kawakami , Nobuhiro Hanada , Susumu Imai
CPC分类号： A23K20/195 , A23K20/121 , A23L33/10 , A61K31/7028 , A61Q11/00
摘要： It is intended to provide an oral flora-improving agent capable of forming a favorable flora in the oral cavity and a food or a drink for improving the oral flora. An oral flora-improving agent containing as an active ingredient a ganglioside and a food, a drink, or a feed for improving the oral flora containing the ganglioside exhibit an antibacterial effect on harmful bacteria in the oral cavity, which are undesirable from the viewpoint of decay and diseases such as periodontal disease, and a growth-improving effect on useful bacteria to be preserved in the oral cavity. Further, the ganglioside is efficaciously used as an active ingredient in an antibacterial agent or an antibacterial drink, food, or feed, a growth promoter, or a food, a drink, or a feed for promoting growth.
摘要翻译： 旨在提供能够在口腔中形成有利菌群的口腔植物改良剂和用于改善口腔菌群的食品或饮料。 含有作为活性成分的神经节苷脂的口腔内植物改善剂和用于改善含有神经节苷脂的口腔菌群的食品，饮料或饲料，对口腔内的有害细菌表现出抗菌作用，从对 衰老和疾病如牙周病，以及对在口腔中保留的有用细菌的生长改善作用。 此外，神经节苷脂有效地用作抗菌剂或抗菌饮料，食品或饲料，生长促进剂或用于促进生长的食品，饮料或饲料中的活性成分。
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公开(公告)号：US20060216248A1
公开(公告)日：2006-09-28
申请号：US10554932
申请日：2004-04-30
IPC分类号： A61K36/185 , A61K8/97 , A61K36/73
摘要： It is intended to provide an effective cariostatic material which inhibits dental plaque formation as well as onset of dental carries. A material for inhibiting enamel demineralization containing, as the active ingredient, a proanthocyanidin-like polyphenol originating in hop bract or immature apple, which effectively inhibits not only dental plaque formation but also the dental caries process including proliferation of bacteria, formation of acids by the bacteria and enamel demineralization. Also, foods, drinks and oral care goods with the use of the above substance as an enamel demineralization inhibitor are provided.
摘要翻译： 旨在提供抑制牙菌斑形成以及牙齿携带物发生的有效的抑菌材料。 用于抑制釉质脱矿质的材料，其含有起源于苞片或未成熟苹果的原花色素苷多酚作为活性成分，其不仅有效抑制牙菌斑形成，而且还有效地抑制龋齿过程，包括细菌的增殖，由 细菌和搪瓷脱矿质。 此外，提供了使用上述物质作为釉质脱矿质化抑制剂的食品，饮料和口腔护理用品。
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公开(公告)号：US09730883B2
公开(公告)日：2017-08-15
申请号：US14236849
申请日：2012-08-03
申请人： Takekazu Okumura , Tomohiko Terai , Masumi Nakao , Kimiyuki Kaneko , Masahiko Ito , Kouji Miyazaki , Kazuaki Yamaji , Kaoru Tochiya , Nobuhiro Hanada , Susumu Imai , Yoshiaki Nomura , Shunsuke Baba
发明人： Takekazu Okumura , Tomohiko Terai , Masumi Nakao , Kimiyuki Kaneko , Masahiko Ito , Kouji Miyazaki , Kazuaki Yamaji , Kaoru Tochiya , Nobuhiro Hanada , Susumu Imai , Yoshiaki Nomura , Shunsuke Baba
IPC分类号： A61K39/07 , A61K8/99 , C12R1/225 , C12R1/46 , C12N1/20 , A61K35/744 , A61K35/747 , A61Q11/00 , C12Q1/68 , A23L2/52 , A61K9/20 , A23L29/00 , A23L33/135
CPC分类号： A61K8/99 , A23L2/52 , A23L29/065 , A23L33/135 , A61K9/2018 , A61K35/744 , A61K35/747 , A61Q11/00 , C12N1/20 , C12Q1/68 , C12R1/225 , C12R1/46
摘要： Provided is a novel lactic acid bacterium strain which is capable of suppressing production of volatile sulfur compounds by oral bacteria, has no cariogenicity and no causative role in infective endocarditis, and is safe in an oral cavity, and provided is an agent for preventing, improving and/or treating oral diseases and discomforts by use of the bacterial strain.An agent for preventing and/or treating an oral disease, containing, as an active ingredient, at least one lactic acid bacterium selected from Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6): (1) having no ability to produce a volatile sulfur compound (VSC); (2) having no ability to produce water-insoluble glucan; (3) having adhesiveness to a tooth surface and/or an oral cell; (4) having a growth inhibitory effect on a bad breath-causing bacterium and/or a periodontal pathogen; (5) having no causative role in infective endocarditis; and (6) having no cariogenicity.
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公开(公告)号：US20140178313A1
公开(公告)日：2014-06-26
申请号：US14236849
申请日：2012-08-03
申请人： Takekazu Okumura , Tomohiko Terai , Masumi Nakao , Kimiyuki Kaneko , Masahiko Ito , Kouji Miyazaki , Kazuaki Yamaji , Kaoru Tochiya , Nobuhiro Hanada , Susumu Imai , Yoshiaki Nomura , Shunsuke Baba
发明人： Takekazu Okumura , Tomohiko Terai , Masumi Nakao , Kimiyuki Kaneko , Masahiko Ito , Kouji Miyazaki , Kazuaki Yamaji , Kaoru Tochiya , Nobuhiro Hanada , Susumu Imai , Yoshiaki Nomura , Shunsuke Baba
CPC分类号： A61K8/99 , A23L2/52 , A23L29/065 , A23L33/135 , A61K9/2018 , A61K35/744 , A61K35/747 , A61Q11/00 , C12N1/20 , C12Q1/68 , C12R1/225 , C12R1/46
摘要： Provided is a novel lactic acid bacterium strain which is capable of suppressing production of volatile sulfur compounds by oral bacteria, has no cariogenicity and no causative role in infective endocarditis, and is safe in an oral cavity, and provided is an agent for preventing, improving and/or treating oral diseases and discomforts by use of the bacterial strain.An agent for preventing and/or treating an oral disease, containing, as an active ingredient, at least one lactic acid bacterium selected from Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6): (1) having no ability to produce a volatile sulfur compound (VSC); (2) having no ability to produce water-insoluble glucan; (3) having adhesiveness to a tooth surface and/or an oral cell; (4) having a growth inhibitory effect on a bad breath-causing bacterium and/or a periodontal pathogen; (5) having no causative role in infective endocarditis; and (6) having no cariogenicity.
摘要翻译： 本发明提供能够抑制口腔细菌产生挥发性硫化合物的新型乳酸菌株，在感染性心内膜炎中不具有致龋性，无致病作用，并且在口腔中是安全的，作为预防，改善 和/或通过使用细菌菌株治疗口腔疾病和不适。 用于预防和/或治疗口腔疾病的药剂，其含有至少一种选自干酪乳杆菌，发酵乳杆菌，加氏乳杆菌和链球菌的至少一种乳酸菌，并具有以下所有性质（1）至 （6）：（1）不具有产生挥发性硫化合物（VSC）的能力; （2）不具有产生水不溶性葡聚糖的能力; （3）对牙齿表面和/或口腔具有粘附性; （4）对不良呼吸细菌和/或牙周病原体具有生长抑制作用; （5）感染性心内膜炎无致病作用; 和（6）没有致龋性。
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公开(公告)号：US20080003186A1
公开(公告)日：2008-01-03
申请号：US11773240
申请日：2007-07-03
摘要： It is intended to provide an effective cariostatic material which inhibits dental plaque formation as well as onset of dental carries. A material for inhibiting enamel demineralization containing, as the active ingredient, a proanthocyanidin-like polyphenol originating in hop bract or immature apple, which effectively inhibits not only dental plaque formation but also the dental caries process including proliferation of bacteria, formation of acids by the bacteria and enamel demineralization. Also, foods, drinks and oral care goods with the use of the above substance as an enamel demineralization inhibitor are provided.
摘要翻译： 旨在提供抑制牙菌斑形成以及牙齿携带物发生的有效的抑菌材料。 用于抑制釉质脱矿质的材料，其含有起源于苞片或未成熟苹果的原花色素苷多酚作为活性成分，其不仅有效抑制牙菌斑形成，而且还有效地抑制龋齿过程，包括细菌的增殖，由 细菌和搪瓷脱矿质。 此外，提供了使用上述物质作为釉质脱矿质化抑制剂的食品，饮料和口腔护理用品。
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