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公开(公告)号：US20080003186A1
公开(公告)日：2008-01-03
申请号：US11773240
申请日：2007-07-03
摘要： It is intended to provide an effective cariostatic material which inhibits dental plaque formation as well as onset of dental carries. A material for inhibiting enamel demineralization containing, as the active ingredient, a proanthocyanidin-like polyphenol originating in hop bract or immature apple, which effectively inhibits not only dental plaque formation but also the dental caries process including proliferation of bacteria, formation of acids by the bacteria and enamel demineralization. Also, foods, drinks and oral care goods with the use of the above substance as an enamel demineralization inhibitor are provided.
摘要翻译： 旨在提供抑制牙菌斑形成以及牙齿携带物发生的有效的抑菌材料。 用于抑制釉质脱矿质的材料，其含有起源于苞片或未成熟苹果的原花色素苷多酚作为活性成分，其不仅有效抑制牙菌斑形成，而且还有效地抑制龋齿过程，包括细菌的增殖，由 细菌和搪瓷脱矿质。 此外，提供了使用上述物质作为釉质脱矿质化抑制剂的食品，饮料和口腔护理用品。
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公开(公告)号：US20060216248A1
公开(公告)日：2006-09-28
申请号：US10554932
申请日：2004-04-30
IPC分类号： A61K36/185 , A61K8/97 , A61K36/73
摘要： It is intended to provide an effective cariostatic material which inhibits dental plaque formation as well as onset of dental carries. A material for inhibiting enamel demineralization containing, as the active ingredient, a proanthocyanidin-like polyphenol originating in hop bract or immature apple, which effectively inhibits not only dental plaque formation but also the dental caries process including proliferation of bacteria, formation of acids by the bacteria and enamel demineralization. Also, foods, drinks and oral care goods with the use of the above substance as an enamel demineralization inhibitor are provided.
摘要翻译： 旨在提供抑制牙菌斑形成以及牙齿携带物发生的有效的抑菌材料。 用于抑制釉质脱矿质的材料，其含有起源于苞片或未成熟苹果的原花色素苷多酚作为活性成分，其不仅有效抑制牙菌斑形成，而且还有效地抑制龋齿过程，包括细菌的增殖，由 细菌和搪瓷脱矿质。 此外，提供了使用上述物质作为釉质脱矿质化抑制剂的食品，饮料和口腔护理用品。
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公开(公告)号：US20060165609A1
公开(公告)日：2006-07-27
申请号：US10545412
申请日：2005-02-25
申请人： Hiroaki Inaba , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
发明人： Hiroaki Inaba , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
IPC分类号： A61K8/49 , A61K36/185
CPC分类号： A61K8/97 , A23L33/11 , A61K8/347 , A61K31/352 , A61Q11/00 , A61Q17/005 , C07D311/62
摘要： The present invention provides a protectant of periodontal membranes for inhibiting the destruction of periodontal tissues, particularly periodontal membranes by participation of Porphyromonas gingivalis. Further, it provides an agent for oral cavity or food and drinks containing the protectant of periodontal membranes having effects of prevention and therapy of diseases involving damage of periodontal membranes. A protectant of periodontal membranes is proanthocyanidins, particularly proanthocyanidins derived from apple premature fruits or hop bracts having an effect decreasing the damage to periodontal membranes caused by Porphyromonas gingivalis, and an eating and drinking product containing the protectant of periodontal membranes as an effective component.
摘要翻译： 本发明提供了牙周膜保护剂，其通过参与牙龈卟啉单胞菌来抑制牙周组织，特别是牙周膜的破坏。 此外，它提供含有牙周膜保护剂的口腔或食物和饮料的药剂，其具有预防和治疗涉及牙周膜损伤的疾病的作用。 牙周膜的保护剂是原花青素，特别是源自苹果过早果实的原花青素或具有降低由牙龈卟啉单胞菌引起的牙周膜损伤作用的跳虱，以及含有牙周膜保护剂作为有效成分的饮食品。
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公开(公告)号：US20070092456A1
公开(公告)日：2007-04-26
申请号：US11640301
申请日：2006-12-18
申请人： Hiroaki Inaba , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
发明人： Hiroaki Inaba , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
IPC分类号： A61K8/49
CPC分类号： A61K8/97 , A23L33/11 , A61K8/347 , A61K31/352 , A61Q11/00 , A61Q17/005 , C07D311/62
摘要： The present invention provides a protectant of periodontal membranes for inhibiting the destruction of periodontal tissues, particularly periodontal membranes by participation of Porphyromonas gingivalis. Further, it provides an agent for oral cavity or food and drinks containing the protectant of periodontal membranes having effects of prevention and therapy of diseases involving damage of periodontal membranes. A protectant of periodontal membranes is proanthocyanidins, particularly proanthocyanidins derived from apple premature fruits or hop bracts having an effect decreasing the damage to periodontal membranes caused by Porphyromonas gingivalis, and an eating and drinking product containing the protectant of periodontal membranes as an effective component.
摘要翻译： 本发明提供了牙周膜保护剂，其通过参与牙龈卟啉单胞菌来抑制牙周组织，特别是牙周膜的破坏。 此外，它提供含有牙周膜保护剂的口腔或食物和饮料的药剂，其具有预防和治疗涉及牙周膜损伤的疾病的作用。 牙周膜的保护剂是原花青素，特别是源自苹果过早果实的原花青素或具有降低由牙龈卟啉单胞菌引起的牙周膜损伤作用的跳虱，以及含有牙周膜保护剂作为有效成分的饮食品。
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公开(公告)号：US20060251760A1
公开(公告)日：2006-11-09
申请号：US10538790
申请日：2003-12-12
申请人： Motoyuki Tagashira , Tomomasa Kanda
发明人： Motoyuki Tagashira , Tomomasa Kanda
IPC分类号： C12G1/00
CPC分类号： A61K8/97 , A61Q11/00 , C07D311/30 , C07G17/00
摘要： It is intended to provide a process for efficiently producing highly purified hop bract polyphenol using hop bract as the starting material, and foods, drinks, cosmetics and drugs with the use of the highly purified hop bract polyphenol. Namely, a process for producing hop polyphenol which comprises extracting hop bract with an aqueous alcohol solution, concentrating the extract to give a residual alcohol concentration of 0.5 to 2% and then centrifuging and/or filtering the concentrate. This polyphenol is usable in foods, drinks, cosmetics, drugs, etc.
摘要翻译： 本发明旨在提供一种利用高效提纯啤酒花苞片多酚作为起始原料的高纯度啤酒花苞多酚的方法，以及食品，饮料，化妆品和药物。 即，生产啤酒花多酚的方法，其包括用醇水溶液萃取啤酒花苞，浓缩提取物，得到残留的酒精浓度为0.5〜2％，然后离心和/或过滤浓缩物。 该多酚可用于食品，饮料，化妆品，药物等。
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6.发明申请Production method of hop preparation, hop preparation, anti-inflammatory agent, food product and beverage, and oral product 审中-公开啤酒花制备，啤酒花制备，消炎剂，食品和饮料以及口服产品的生产方法公开(公告)号：US20100179227A1
公开(公告)日：2010-07-15
申请号：US12310559
申请日：2007-08-21
申请人： Hiroaki Inaba , Daiki Honma , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
发明人： Hiroaki Inaba , Daiki Honma , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
CPC分类号： A61Q11/00 , A23L2/02 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K8/97 , A61K36/18 , A61K36/185 , A23V2200/312 , A23V2200/324 , A23V2250/032 , A23V2250/21168 , A23V2250/2132 , A23V2250/606
摘要： A method for producing a preparation that can be used in the prevention and treatment of inflammatory diseases, including periodontitis caused by P. gingivalis. Specifically, the invention provides a method for producing a hop preparation comprising the following steps (1) to (3): (1) adjusting the pH of a polyphenol-containing liquid prepared from hop bracts to 6 to 7 and passing the liquid through a gel-type synthetic resin to allow components including useful substances to be adsorbed onto the resin; (2) washing the resin obtained in the step (1) with a 30 to 60% aqueous ethanol solution to elute unwanted substances, leaving the useful substances adsorbed to the resin; and (3) washing the resin obtained in the step (2) with a 70% or higher aqueous ethanol solution or ethanol to elute the components including the useful substances and forming the preparation from the eluted fraction.
摘要翻译： 一种可用于预防和治疗由牙龈卟啉菌引起的牙周炎的炎性疾病的制剂的制备方法。 具体地说，本发明提供一种制备包含以下步骤（1）至（3）的啤酒花制备方法：（1）将由跳虱制备的含多酚液体的pH调节至6至7，并使液体通过 凝胶型合成树脂，使包含有用物质的成分吸附在树脂上; （2）用30〜60％乙醇水溶液洗涤工序（1）得到的树脂，洗脱不需要的物质，留下有用物质吸附在树脂上; 和（3）用70％或更高的乙醇水溶液或乙醇洗涤步骤（2）中得到的树脂，以洗脱含有有用物质的组分并从洗脱级分形成制剂。
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公开(公告)号：US20090053384A1
公开(公告)日：2009-02-26
申请号：US11887777
申请日：2006-03-16
申请人： Takehiro Watanabe , Rumi Fujita , Motoyuki Tagashira , Tomomasa Kanda , Seiichi Higuchi , Masayuki Tanabe
发明人： Takehiro Watanabe , Rumi Fujita , Motoyuki Tagashira , Tomomasa Kanda , Seiichi Higuchi , Masayuki Tanabe
CPC分类号： C07G17/00 , A23L33/105 , C12F3/06
摘要： It is intended to develop a technique for producing a water-soluble polyphenol at high purity and with high efficiency in a short time from hop bract or the like which is a by-product in the beer brewing. A method for preparation of a purified plant extract comprising steps of treating a plant extract with a clay mineral such as bentonite and removing any divalent cations from the resulting product; a method for producing a polyphenol comprising steps of passing the purified plant extract through a column to adsorb polyphenols onto the column and passing a solvent though the column to elute a water-soluble polyphenol from the column; and a method for producing a water-soluble hop bract polyphenol comprising steps of adding bentonite to a hop bract extract and allowing the resulting mixture to stand under acidic conditions, performing solid-liquid separation to produce a supernatant, purifying the supernatant through a column to give a pholyphenol-containing fraction, cooling the fraction and allowing the cooled fraction to stand to cause the precipitation of water-insoluble ingredients and performing solid-liquid separation to give the desired water-soluble hop bract polyphenol.
摘要翻译： 旨在开发一种在啤酒酿造中作为副产物的啤酒花苞等在高纯度和高效率的短时间内生产水溶性多酚的技术。 一种纯化植物提取物的制备方法，其包括用粘土矿物如膨润土处理植物提取物并从所得产物中除去任何二价阳离子的步骤; 一种生产多酚的方法包括以下步骤：使纯化的植物提取物通过柱，以将多酚吸附到柱上并使溶剂通过柱，以从柱中洗脱水溶性多酚; 以及制造水溶性跳苞片多酚的方法，其特征在于，包括以下步骤：将膨润土加入到鞭毛提取物中，使所得混合物在酸性条件下放置，进行固液分离，制成上清液，通过柱纯化上清液至 得到含苯酚的级分，冷却该级分并使冷却的级分静置以引起水不溶性成分的沉淀并进行固液分离，得到所需的水溶性鞭毛多酚。
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8.发明授权Method of determining falling state of falling body for viscometer of falling body type, falling-body velocity measuring sensor, and viscometer of falling body type including same 有权下降体型粘度计下落体下落状态的方法，下降体速度测量传感器，以及包括其的坠体类型的粘度计公开(公告)号：US08485018B2
公开(公告)日：2013-07-16
申请号：US13499565
申请日：2010-05-21
申请人： Kimito Kawamura , Motoyuki Tagashira , Eiji Tamura
发明人： Kimito Kawamura , Motoyuki Tagashira , Eiji Tamura
IPC分类号： G01M7/00
CPC分类号： G01N11/12
摘要： A technique used to determine a falling state of a falling body, such as whether the falling body reaches a falling termination speed and falls uniformly or falls with a change in the speed is provided. In particular, a method of determining a falling state of a falling body passing through a measured substance inserted into a measuring container is provided, the method including: measuring a first elapsed time which is a time interval between extreme values of two potentials generated in a first coil pair when the falling body passes through the first coil pair and a second elapsed time which is a time interval between extreme values of two potentials generated in a second coil pair when the falling body passes through the second coil pair; and determining the falling state of the falling body by comparing the first elapsed time with the second elapsed time.
摘要翻译： 提供了一种用于确定下降体的下降状态的技术，例如下降的身体是否达到下降的终止速度并且一致地下降或随着速度的变化而下降。 特别地，提供了一种确定通过插入到测量容器中的测量物质的下降体的下降状态的方法，所述方法包括：测量作为在测量容器中产生的两个电位的极值之间的时间间隔的第一经过时间 当下降体通过第一线圈对时，第一线圈对和第二经过时间是当下降体通过第二线圈对时在第二线圈对中产生的两个电位的极值之间的时间间隔; 以及通过将第一经过时间与第二经过时间进行比较来确定下降体的下降状态。
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公开(公告)号：US20080275109A1
公开(公告)日：2008-11-06
申请号：US12041550
申请日：2008-03-03
IPC分类号： A61K31/353 , C07D311/04
CPC分类号： C07D311/62 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/73 , A23V2250/2104
摘要： A drug, quasi drug, food or drink product containing a proanthocyanidine derived from hop, hop bract or apple has the effect of neutralizing or attenuating a vacuolacting toxin produced by Helicobacter pylori, thus preventing, preventing recurrence or treating digestive diseases in which Helicobacter pylori participates, as well as killing Helicobacter pylori, while providing few side effects and being free of risk of the occurrence of a tolerant strain.
摘要翻译： 含有源自啤酒花，啤酒花苞或苹果的原花青素的药物，准药物，食品或饮料产品具有中和或减弱由幽门螺杆菌产生的空泡活化毒素的作用，从而预防，预防复发或治疗幽门螺杆菌参与的消化系统疾病 ，以及杀死幽门螺杆菌，同时提供很少的副作用，并且没有发生耐受性菌株的风险。
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10.发明授权Falling speed measuring sensor for falling body viscometer and falling speed measuring method 有权下降速度测量传感器用于下降体粘度计和下落速度测量方法公开(公告)号：US08555706B2
公开(公告)日：2013-10-15
申请号：US13120978
申请日：2009-09-14
申请人： Kimito Kawamura , Motoyuki Tagashira , Eiji Tamura
发明人： Kimito Kawamura , Motoyuki Tagashira , Eiji Tamura
IPC分类号： G01N11/00
CPC分类号： G01N11/12
摘要： A novel configuration for a falling body viscometer using an electromagnetic induction sensor, wherein the time at which a falling body passes through the electromagnetic induction sensor can be specified with enhanced accuracy. This enables the falling speed of the falling body and in turn the viscosity of a fluid to be measured with increased accuracy. A falling body viscometer is provided with a first pair of coils located at the outer periphery of a measuring container so as to be separated from each other in the vertical direction, and also with a second pair of coils located at the outer periphery of the measuring container so as to be separated from each other in the vertical direction and to be located below the first coil pair, a specified distance away therefrom.
摘要翻译： 使用电磁感应传感器的坠体粘度计的新颖结构，其中下降体通过电磁感应传感器的时间可以提高精度。 这使得能够以更高的精度实现下降体的下降速度，并且进而使待测流体的粘度。 下降体粘度计设置有位于测量容器的外周处的第一对线圈，以便在垂直方向上彼此分离，并且还具有位于测量装置外周的第二对线圈 容器，以便在垂直方向上彼此分离并且位于第一线圈对下方，距离其指定距离。
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