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公开(公告)号：US4292272A
公开(公告)日：1981-09-29
申请号：US157737
申请日：1980-06-09
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： G01N33/525
摘要： A multilayer analysis sheet for analyzing liquid samples is described, comprising, in sequence, a light transmitting hydrophobic support having on one side thereof at least one layer containing at least one reagent in a binder and a liquid sample spreading layer made of fabric, which layers are laminated to form an integral unit together with the support, wherein said fabric has the ability to supply a liquid sample placed on the surface thereof to the reagent-containing layer at a substantially constant volume per unit area, which ability is conferred upon the fabric by rendering it hydrophilic; the multilayer analysis sheet can be economically manufactured without variations in quality, and improves the spreading capability of liquid samples.
摘要翻译： 描述了用于分析液体样品的多层分析片，其中依次包括透光性疏水性支持体，其透光性疏水性支持体的一面上具有至少一层含有粘合剂中的至少一种试剂和由织物构成的液体样品扩散层， 层叠以与支撑体一起形成整体单元，其中所述织物具有以每单位面积基本上恒定的体积供应将其表面上的液体样品供应到含有试剂的层的能力，该能力被赋予织物 通过使其亲水; 可以经济地制造多层分析片而不产生质量变化，并提高液体样品的铺展能力。
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公开(公告)号：US3951851A
公开(公告)日：1976-04-20
申请号：US364478
申请日：1973-05-29
申请人： Masao Kitajima , Asaji Kondo , Fuminori Arai
发明人： Masao Kitajima , Asaji Kondo , Fuminori Arai
CPC分类号： A61K9/5047 , A61K31/60 , A61K9/5089 , Y10T428/2989
摘要： Process of producing aspirin-containing capsules which comprises (1) dispersing aspirin particles in a solution of a cellulose derivative in an organic solvent partially miscible with water; (2) adding the dispersion to an encapsulation medium comprising water containing organic solvent(s) partially miscible with water with or without aspirin; (3) stirring the mixture to form a fine dispersion of the aspirin; and (4) evaporating off the organic solvent to deposit the cellulose derivative around the aspirin particles.
摘要翻译： 制备含阿司匹林胶囊的方法，其包括（1）将阿司匹林颗粒分散在纤维素衍生物在与水部分混溶的有机溶剂中的溶液中; （2）将分散体加入到包含含有有机溶剂的水的包封介质中，所述有机溶剂与或不与阿斯匹林部分混溶; （3）搅拌混合物形成阿司匹林的精细分散体; 和（4）蒸发掉有机溶剂以将纤维素衍生物沉积在阿司匹林颗粒周围。
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3.发明授权
公开(公告)号：US4270920A
公开(公告)日：1981-06-02
申请号：US71618
申请日：1979-08-31
申请人： Asaji Kondo , Fuminori Arai , Masao Kitajima
发明人： Asaji Kondo , Fuminori Arai , Masao Kitajima
CPC分类号： G01N31/22 , G01N33/525
摘要： An integrated material for chemical analysis comprising three or more reagent layer units on a support and a porous spreading layer, said units containing reagents for different chemical analyses and being proximately arranged on a support such that approximately equal portions thereof are within a spreading circle defined by the diffusion of a liquid sample as it passes through the porous spreading layer, and a method for analyzing blood using the same.
摘要翻译： 一种用于化学分析的综合材料，其包括在支撑体上的三个或更多个试剂层单元和多孔扩散层，所述单元包含用于不同化学分析的试剂，并且近似地布置在支撑体上，使得其大致相等的部分在由 液体样品在通过多孔扩散层时的扩散，以及使用其分析血液的方法。
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公开(公告)号：US4255384A
公开(公告)日：1981-03-10
申请号：US66363
申请日：1979-08-14
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： G01N33/525
摘要： An integral multilayered element for the chemical analysis of the blood comprising a combination of a porous spreading layer, a reagent layer, and a radiation-blocking layer, said radiation-blocking layer being water-permeable and containing at least one elemental metal or an alloy thereof.
摘要翻译： 一种用于血液化学分析的整体多层元件，包括多孔扩散层，试剂层和辐射阻挡层的组合，所述辐射阻挡层是透水性的并且包含至少一种元素金属或合金 其中。
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5.发明授权
公开(公告)号：US4248829A
公开(公告)日：1981-02-03
申请号：US101385
申请日：1979-12-07
申请人： Masao Kitajima , Asaji Kondo , Fuminori Arai
发明人： Masao Kitajima , Asaji Kondo , Fuminori Arai
CPC分类号： G01N33/525 , G01N31/22 , Y10S435/805
摘要： An integrated material for chemically analyzing a liquid sample comprising a supporting plate having provided thereon two or more different analytical units each comprising a reagent layer and a porous spreading layer or a portion of a common porous spreading layer, the units being disposed such that at least a portion of the reagent layers are in contact with or in close proximity to one another with the porous spreading layer(s) of the units being commonly covered with a liquid sample delivering patch.
摘要翻译： 一种用于化学分析液体样品的综合材料，包括其上设置有两个或更多个不同分析单元的支撑板，每个分析单元包括试剂层和多孔扩散层或共同的多孔扩散层的一部分，该单元被设置为使得至少 试剂层的一部分彼此接触或彼此靠近，单元的多孔扩散层通常被液体样品递送贴片覆盖。
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公开(公告)号：US4356149A
公开(公告)日：1982-10-26
申请号：US165444
申请日：1980-07-02
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： C12Q1/58 , G01N33/526 , Y10S435/805
摘要： A multi-layer chemical analytical material comprising a support, a reagent layer on the support and a spreading layer on the reagent layer wherein the reagent layer is composed of a hydrophilic binder and fine hydrophobic particles dispersed in the hydrophilic binder, said hydrophobic particles containing a reagent capable of directly or indirectly reacting with the component being analyzed to produce a color change.
摘要翻译： 一种多层化学分析材料，包括载体，载体上的试剂层和试剂层上的扩散层，其中试剂层由亲水性粘合剂和分散在亲水性粘合剂中的细疏水性颗粒构成，所述疏水性颗粒含有 能够直接或间接地与被分析的组分反应以产生颜色变化的试剂。
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公开(公告)号：US4337222A
公开(公告)日：1982-06-29
申请号：US223062
申请日：1981-01-07
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： G01N33/525
摘要： A hemoglobin concentration-determining article comprising a water-impermeable support having integrally provided thereon, in sequence, a hydrophilic binder layer and a porous spreading layer which has a hydrophilic surface and in which the surface of the internal voids or the interior is hydrophilic and water-insoluble, said porous spreading layer being constituted so that an aqueous sample applied thereto can be spread and incorporated therein in a substantially definite volume per unit area.
摘要翻译： 一种血红蛋白浓度测定制品，其包含一体地设置在其上的不透水性支持体，依次是亲水性粘合剂层和具有亲水性表面的多孔扩散层，其中内部空隙或内部的表面是亲水性的和水 不溶性，所述多孔扩散层构成为使得施加到其上的水性样品能够以每单位面积的基本上确定的体积扩散并结合在其中。
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公开(公告)号：US4340565A
公开(公告)日：1982-07-20
申请号：US221183
申请日：1980-12-29
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： G01N33/48 , G01N33/525
摘要： A hematocrit value determining element comprising, in one embodiment, a water-impermeable planar support having integrally provided thereon a hydrophilic porous spreading layer, the porous spreading layer being such that blood spreads therethrough depending upon the viscosity of the blood and, in a second embodiment, a hematocrit value determining element as described above and a binder layer provided between the planar support and the porous spreading layer.
摘要翻译： 一种血细胞比容值确定元件，在一个实施方案中包括在其上整体设置有亲水性多孔扩散层的不透水平面支撑体，所述多孔扩散层使得血液通过其中的血液扩散，这取决于血液的粘度，并且在第二实施方案中 ，如上所述的血细胞比容值确定元件和设置在平面支撑体和多孔扩散层之间的粘合剂层。
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公开(公告)号：US5004685A
公开(公告)日：1991-04-02
申请号：US86514
申请日：1987-08-18
申请人： Fuminori Arai , Asaji Kondo
发明人： Fuminori Arai , Asaji Kondo
CPC分类号： G01N33/525 , C12Q1/26 , C12Q1/28 , C12Q2326/96 , Y10S435/805 , Y10S436/81 , Y10S436/904
摘要： A dry-type multilayer analytical element containing a color reagent composition comprising an oxidase specifically reaction with an analyte or derived therefrom to produce hydrogen peroxide, hydrogen peroxide-decomposing enzyme, an alkali metal salt of ferrocyanide and a chromogen which is separated from the hydrogen peroxide-decomposing enzyme, the chromogen being incorporated in a layer nearer to the transparent support of the analytical element than the layer containing the hydrogen peroxide-decomposing enzyme. The analytical element exhibits excellent coloration, color stability, and accuracy and the results are minimally influenced by the presence of hemoglobin in the sample.
摘要翻译： 一种干型多层分析元件，其含有显色试剂组合物，其包含氧化酶与分析物特异性反应或由其衍生产生过氧化氢，过氧化氢分解酶，亚铁氰化物碱金属盐和与过氧化氢分离的色原体 分解酶，色原子被结合在比含有过氧化氢分解酶的层更接近分析元件的透明载体的层中。 分析元素显示出优异的着色，颜色稳定性和准确性，并且结果最小程度地受样品中血红蛋白的存在的影响。
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公开(公告)号：US4783315A
公开(公告)日：1988-11-08
申请号：US758562
申请日：1985-07-23
CPC分类号： G01N33/525 , Y10T428/31736 , Y10T428/3175
摘要： An analysis material sheet is disclosed which is comprised of layers of material with strong adhesion for one another. The sheet includes a water-impermeable support having provided directly or indirectly thereon a layer of fabric. The fabric contains a hydrophobic organic polymer fiber and is physically activated on at least one surface thereof, with the physically activated surface being adhered directly or indirectly to the support. A reagent layer can be provided directly or indirectly on the liquid sample-spreading layer of fabric. By utilizing a fabric containing a hydrophobic organic polymer fiber, body fluids to be analyzed can be quickly and uniformly spread and by utilizing the physically activated surface of the fabric, strong adhesion between the layers can be obtained.
摘要翻译： 公开了一种分析材料片，其由彼此具有强粘合性的材料层组成。 片材包括直接或间接地在其上提供织物层的不透水支撑体。 织物含有疏水性有机聚合物纤维，并在其至少一个表面上物理活化，物理活化表面直接或间接地粘附到载体上。 试剂层可以直接或间接地提供在织物的液体样品铺展层上。 通过使用含有疏水性有机聚合物纤维的织物，可以快速且均匀地分散待分析的体液，并且通过利用织物的物理活化表面，可以获得层间的强粘合性。
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