公开(公告)号：US09238688B2

公开(公告)日：2016-01-19

申请号：US13703477

申请日：2011-06-15

申请人： Masao Tanihara ,  Kana Takaichi ,  Mariko Maeda ,  Tsukasa Mitsui ,  Kazushi Yamamoto ,  Akiko Hirano

发明人： Masao Tanihara ,  Kana Takaichi ,  Mariko Maeda ,  Tsukasa Mitsui ,  Kazushi Yamamoto ,  Akiko Hirano

IPC分类号： C07K14/78 ,  A61Q19/08 ,  A61Q19/00 ,  C07K1/107 ,  A61K8/67 ,  A61K31/07 ,  A61K38/39 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/12 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/10

CPC分类号： C07K14/78 ,  A61K8/671 ,  A61K31/07 ,  A61K38/39 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/12 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10 ,  C07K1/1077

摘要： Disclosed is a compound which exhibits a higher effect of preventing wrinkle formation, a higher effect of improving wrinkles, a higher effect of making the skin beautiful, and a higher effect of improving skin quality than conventional retinol and retinol derivatives in a sustained manner. Further disclosed are a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. More specifically disclosed are retinol-modified collagen in which a dicarboxylic acid is attached to at least one hydroxyl group of collagen and retinol is attached to a carboxyl group of at least one attached dicarboxylic acid, a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient.

摘要翻译： 本发明公开了一种化合物，其具有比常规视黄醇和视黄醇衍生物持续的更好的防止皱纹形成的效果，提高皱纹的效果，使皮肤美丽的效果更高，并且提高皮肤质量的效果。 进一步公开了其制造方法，以及用于皮肤的外用组合物和各自含有活性成分的片状化妆品。 更具体地公开了视黄醇改性的胶原，其中二羧酸附着在至少一个胶原的羟基上，视黄醇与至少一个连接的二羧酸的羧基相连，其制备方法和外用组合物 对于皮肤和每个含有与活性成分相同的片状化妆品。

公开(公告)号：US20130116189A1

公开(公告)日：2013-05-09

申请号：US13703477

申请日：2011-06-15

申请人： Masao Tanihara ,  Kana Takaichi ,  Mariko Maeda ,  Tsukasa Mitsui ,  Kazushi Yamamoto ,  Akiko Hirano

发明人： Masao Tanihara ,  Kana Takaichi ,  Mariko Maeda ,  Tsukasa Mitsui ,  Kazushi Yamamoto ,  Akiko Hirano

IPC分类号： C07K14/78 ,  A61Q19/08 ,  A61Q19/00 ,  C07K1/107 ,  A61K8/67

CPC分类号： C07K14/78 ,  A61K8/671 ,  A61K31/07 ,  A61K38/39 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/12 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10 ,  C07K1/1077

摘要： Disclosed is a compound which exhibits a higher effect of preventing wrinkle formation, a higher effect of improving wrinkles, a higher effect of making the skin beautiful, and a higher effect of improving skin quality than conventional retinol and retinol derivatives in a sustained manner. Further disclosed are a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. More specifically disclosed are retinol-modified collagen in which a dicarboxylic acid is attached to at least one hydroxyl group of collagen and retinol is attached to a carboxyl group of at least one attached dicarboxylic acid, a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient.

摘要翻译： 本发明公开了一种化合物，其具有比常规视黄醇和视黄醇衍生物持续的更好的防止皱纹形成的效果，提高皱纹的效果，使皮肤美丽的效果更高，并且提高皮肤质量的效果。 进一步公开了其制造方法，以及用于皮肤的外用组合物和各自含有活性成分的片状化妆品。 更具体地公开了视黄醇改性的胶原，其中二羧酸附着在至少一个胶原的羟基上，视黄醇与至少一个连接的二羧酸的羧基相连，其制备方法和外用组合物 对于皮肤和每个含有与活性成分相同的片状化妆品。

公开(公告)号：US6027485A

公开(公告)日：2000-02-22

申请号：US856361

申请日：1997-05-14

申请人： Michiyo Matsushita ,  Akiko Hirano ,  Ikuo Akiyama

发明人： Michiyo Matsushita ,  Akiko Hirano ,  Ikuo Akiyama

IPC分类号： A61F13/49 ,  A44B18/00 ,  A61F13/56 ,  A61F13/62 ,  A61F13/15

CPC分类号： A44B18/0034 ,  A61F13/627 ,  D04B21/16 ,  Y10S2/912 ,  Y10T24/27

摘要： Medium members such as thread are provided between woven fabric sheet such as warp knitting serving as the other sheet and base member, forming linear raised portions in the woven fabric sheet. The density of woven fabric sheet at the inclined portions to either side of these raised portions becomes coarse and the gaps between fine filaments on the woven fabric sheet spread, so that retaining heads of one sheet can easily enter and so that the fine filaments easily become hooked to the base portion of the retaining heads. Consequently, the retaining of the one sheet and the other sheet in strengthened, and the peeling strength is improved.

摘要翻译： 在作为另一片的经编机织织物片和基底构件之间设置有诸如线的中等构件，在机织织物片中形成线状凸起部。 在这些凸起部分的任一侧的倾斜部分的织物片的密度变粗，并且机织织物片上细丝之间的间隙扩大，使得一片的保持头容易进入，使得细丝容易成为 钩住保持头的基部。 因此，增强了一片和另一片的保持性和剥离强度。