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公开(公告)号：US07193703B2
公开(公告)日：2007-03-20
申请号：US11322350
申请日：2006-01-03
申请人： Masashi Hakamata , Tatsuo Fujikura
发明人： Masashi Hakamata , Tatsuo Fujikura
IPC分类号： G01N1/10
CPC分类号： G01N21/553 , G01N21/05 , G01N2021/058
摘要： A surface plasmon resonance sensor unit includes a prism. A thin film has a first surface and a sensing surface. The first surface overlies the prism to constitute a thin film/prism interface. The sensing surface immobilizes a sample in sample fluid. Illuminating light is applied to the interface in a form satisfying a condition for total internal reflection, to create attenuated total reflection in the illuminating light reflected by the interface. An angle of incidence of the illuminating light upon the attenuated total reflection is changed upon (bio)chemical reaction of the sample on the sensing surface. The sensor unit includes an enclosing cover, secured to the prism, for covering the sensing surface. A lower recess is formed in the prism, and positioned at the sensing surface. The lower recess constitutes a flow channel for flow of the sample fluid on the sensing surface.
摘要翻译： 表面等离子体共振传感器单元包括棱镜。 薄膜具有第一表面和感测表面。 第一表面覆盖棱镜以构成薄膜/棱镜界面。 感测表面将样品固定在样品流体中。 照明光以满足全内反射条件的形式施加到界面，以在由界面反射的照明光中产生衰减的全反射。 减弱的全反射后的照明光的入射角随着样品在感测表面的（生物）化学反应而改变。 传感器单元包括固定到棱镜的封闭盖，用于覆盖传感表面。 在棱镜中形成下凹槽，并位于感测面上。 下凹部构成用于在感测表面上流动样品流体的流动通道。
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公开(公告)号：US20060146333A1
公开(公告)日：2006-07-06
申请号：US11322350
申请日：2006-01-03
申请人： Masashi Hakamata , Tatsuo Fujikura
发明人： Masashi Hakamata , Tatsuo Fujikura
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/05 , G01N2021/058
摘要： A surface plasmon resonance sensor unit includes a prism. A thin film has a first surface and a sensing surface. The first surface, overlies the prism to constitute a thin film/prism interface. The sensing surface immobilizes a sample in sample fluid. Illuminating light is applied to the interface in a form satisfying a condition for total internal reflection, to create attenuated total reflection in the illuminating light reflected by the interface. An angle of incidence of the illuminating light upon the attenuated total reflection is changed upon (bio)chemical reaction of the sample on the sensing surface. The sensor unit includes an enclosing cover, secured to the prism, for covering the sensing surface. A lower recess is formed in the prism, and positioned at the sensing surface. The lower recess constitutes a flow channel for flow of the sample fluid on the sensing surface.
摘要翻译： 表面等离子体共振传感器单元包括棱镜。 薄膜具有第一表面和感测表面。 第一个表面覆盖棱镜，构成薄膜/棱镜界面。 感测表面将样品固定在样品流体中。 照明光以满足全内反射条件的形式施加到界面，以在由界面反射的照明光中产生衰减的全反射。 减弱的全反射后的照明光的入射角随着样品在感测表面的（生物）化学反应而改变。 传感器单元包括固定到棱镜的封闭盖，用于覆盖传感表面。 在棱镜中形成下凹槽，并位于感测面上。 下凹部构成用于在感测表面上流动样品流体的流动通道。
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公开(公告)号：US08464438B2
公开(公告)日：2013-06-18
申请号：US13044136
申请日：2011-03-09
IPC分类号： F26B13/06
CPC分类号： B65H31/02 , B65H31/20 , B65H31/34 , B65H2301/517 , B65H2402/515 , B65H2405/1111 , B65H2405/1113 , B65H2405/115 , B65H2406/10 , B65H2406/12 , B65H2515/83 , B65H2801/27 , G03G2215/00426 , G03G2215/00586 , G03G2215/00666 , B65H2220/02
摘要： A seasoning apparatus includes: a table on which a stack of paper sheets is loaded; a ceiling plate which is arranged above the table to cover an upper side of the paper stack on the table; a front side plate and a rear side plate which are arranged to oppose to each other at front and rear sides of the paper stack on the table, at least one of the front and rear side plates being advanceable and retractable relatively to each other; a right-hand side plate and a left-hand side plate which are arranged to oppose to each other at a right-hand side and a left-hand side of the paper stack on the table, at least one of the right-hand and left-hand side plates being advanceable and retractable relatively to each other; and an air blowing device which blows air horizontally toward the paper stack on the table.
摘要翻译： 调味装置包括：装载有一叠纸张的桌子; 顶板，其布置在桌子上方以覆盖桌子上的纸叠的上侧; 前侧板和后侧板，其布置成在桌子上的纸叠的前侧和后侧彼此相对，前侧板和后侧板中的至少一个相对于彼此前进和后退; 右侧板和左侧板，其布置成在桌子的纸叠的右侧和左侧彼此相对，至少一个右侧和右侧 左侧板相对于彼此可推进和缩回; 以及将空气水平地朝向桌子上的纸叠层吹送的送风装置。
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公开(公告)号：US20070053797A1
公开(公告)日：2007-03-08
申请号：US11514885
申请日：2006-09-05
申请人： Katsuaki Muraishi , Tatsuo Fujikura , Shinya Takai
发明人： Katsuaki Muraishi , Tatsuo Fujikura , Shinya Takai
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01L2200/022 , B01L2300/0829 , G01N21/553 , G01N35/1095
摘要： A fluid dispenser for surface plasmon resonance (SPR) assay apparatus includes a first pipette device on a first pipette head, and a second pipette device on a second pipette head. In a standby state, the first pipette head is set in an upper position, a coil spring and a stopper set the second pipette head together with the first pipette head, and locate the second pipette head in a high position. While the first and second pipette devices are in an aspirating position, a driving mechanism sets the first pipette head in a lower position. A blocking mechanism sets the second pipette head in a high position against the coil spring. First, third and fifth pipette tips is positioned lower than second, fourth and sixth pipette tips, to access a well. The first to sixth pipette tips, while in an assay position, are equally lowered.
摘要翻译： 用于表面等离子体共振（SPR）测定装置的流体分配器包括在第一移液管头上的第一移液管装置和在第二移液管头上的第二移液管装置。 在待机状态下，将第一移液管头设置在上部位置，螺旋弹簧和止动器将第二移液管头与第一移液管头一起设置，并将第二移液管头定位在高位置。 当第一和第二移液管装置处于抽吸位置时，驱动机构将第一移液管头设置在较低位置。 阻塞机构将第二移液管头设置在相对于螺旋弹簧的高位置。 首先，第三和第五移液器吸头的位置比第二，第四和第六移液器吸头低，以便进入井。 在测定位置时，第一至第六移液管吸头同样降低。
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公开(公告)号：US20060197954A1
公开(公告)日：2006-09-07
申请号：US11367302
申请日：2006-03-06
申请人： Nobuhiko Ogura , Hitoshi Shimizu , Koji Kuruma , Hisashi Ohtsuka , Tatsuo Fujikura , Shu Sato
发明人： Nobuhiko Ogura , Hitoshi Shimizu , Koji Kuruma , Hisashi Ohtsuka , Tatsuo Fujikura , Shu Sato
IPC分类号： G01N21/55
CPC分类号： G01N21/05 , G01N21/553 , G01N2021/0346 , G01N2021/058
摘要： A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio)chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.
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公开(公告)号：US07858041B2
公开(公告)日：2010-12-28
申请号：US11514885
申请日：2006-09-05
申请人： Katsuaki Muraishi , Tatsuo Fujikura , Shinya Takai
发明人： Katsuaki Muraishi , Tatsuo Fujikura , Shinya Takai
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01L2200/022 , B01L2300/0829 , G01N21/553 , G01N35/1095
摘要： A fluid dispenser for surface plasmon resonance (SPR) assay apparatus includes a first pipette device on a first pipette head, and a second pipette device on a second pipette head. In a standby state, the first pipette head is set in an upper position, a coil spring and a stopper set the second pipette head together with the first pipette head, and locate the second pipette head in a high position. While the first and second pipette devices are in an aspirating position, a driving mechanism sets the first pipette head in a lower position. A blocking mechanism sets the second pipette head in a high position against the coil spring. First, third and fifth pipette tips is positioned lower than second, fourth and sixth pipette tips, to access a well. The first to sixth pipette tips, while in an assay position, are equally lowered.
摘要翻译： 用于表面等离子体共振（SPR）测定装置的流体分配器包括在第一移液管头上的第一移液管装置和在第二移液管头上的第二移液管装置。 在待机状态下，将第一移液管头设置在上部位置，螺旋弹簧和止动器将第二移液管头与第一移液管头一起设置，并将第二移液管头定位在高位置。 当第一和第二移液管装置处于抽吸位置时，驱动机构将第一移液管头设置在较低位置。 阻塞机构将第二移液管头设置在相对于螺旋弹簧的高位置。 首先，第三和第五移液器吸头的位置比第二，第四和第六移液器吸头低，以便进入井。 在测定位置时，第一至第六移液管吸头同样降低。
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公开(公告)号：USD530235S1
公开(公告)日：2006-10-17
申请号：US29237425
申请日：2005-09-01
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公开(公告)号：USD529829S1
公开(公告)日：2006-10-10
申请号：US29237422
申请日：2005-09-01
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公开(公告)号：US20060044563A1
公开(公告)日：2006-03-02
申请号：US11211602
申请日：2005-08-26
申请人： Tatsuo Fujikura
发明人： Tatsuo Fujikura
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , B01L3/502715 , B01L3/5085 , B01L2200/027 , B01L2300/0877 , B01L2300/168 , G01N21/05
摘要： A measuring unit for use in a sensor utilizing the phenomenon of attenuation in total internal reflection includes a dielectric block which is transparent to a light beam and has a flat and smooth surface on which a film layer is formed, and a flow passage member held in close contact with the film layer. The flow passage member is provided with a passage comprising a supply passage extending from an inlet of the flow passage member to a measuring portion and a discharge passage extending from the measuring portion to an outlet of the flow passage member.
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公开(公告)号：US07586615B2
公开(公告)日：2009-09-08
申请号：US11211602
申请日：2005-08-26
申请人： Tatsuo Fujikura
发明人： Tatsuo Fujikura
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , B01L3/502715 , B01L3/5085 , B01L2200/027 , B01L2300/0877 , B01L2300/168 , G01N21/05
摘要： A measuring unit for use in a sensor utilizing the phenomenon of attenuation in total internal reflection includes a dielectric block which is transparent to a light beam and has a flat and smooth surface on which a film layer is formed, and a flow passage member held in close contact with the film layer. The flow passage member is provided with a passage comprising a supply passage extending from an inlet of the flow passage member to a measuring portion and a discharge passage extending from the measuring portion to an outlet of the flow passage member.
摘要翻译： 用于利用全内反射衰减现象的传感器的测量单元包括对光束是透明的并具有平坦光滑表面的介质块，在其上形成有薄膜层，流动通道部件保持在 与胶片层紧密接触。 流路构件设置有包括从流路构件的入口延伸到测量部分的供给通道和从测量部分延伸到流动通道构件的出口的排出通道的通道。
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