公开(公告)号：US4970468A

公开(公告)日：1990-11-13

申请号：US397855

申请日：1989-08-24

申请人： Masato Ishizawa ,  Hiroshi Hashimoto

发明人： Masato Ishizawa ,  Hiroshi Hashimoto

IPC分类号： G01F23/26 ,  G01N35/10

CPC分类号： G01N35/1009 ,  G01F23/263 ,  G01F23/266 ,  G01N2035/1025 ,  G01N2035/1086

摘要： Analytical equipment, in which liquid substances in sample containers and reagent containers are delivered to reaction cells by a vertically movable probe. The sample containers and the reagent containers are supported on a rotatable metal plate. The metal plate is rotated to place one of the sample containers or reagent containers at a sample or reagent pipetting position. The probe transmits a high-frequency signal to detect a change in electrostatic capacitance between itself and the metal plate at a time the probe is put in contact with a liquid substance in the sample or reagent container. A spline shaft for moving the probe in a vertical direction has a detection plate, and a control signal is generated when the detection plate reaches a predetermined position. The generation of the high-frequency signal is stopped when the probe begins to make a descending motion until the control signal is generated, to reduce the adverse effect of disturbing waves on various parts.

公开(公告)号：US08574891B2

公开(公告)日：2013-11-05

申请号：US13000579

申请日：2009-06-17

申请人： Kohshi Maeda ,  Masato Ishizawa ,  Minoru Sano ,  Hironori Kaji

发明人： Kohshi Maeda ,  Masato Ishizawa ,  Minoru Sano ,  Hironori Kaji

IPC分类号： C12M1/34 ,  C12M3/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC分类号： G01N35/025 ,  G01N2035/0463 ,  G01N2035/103

摘要： This invention relates to a nucleic acid analyzer comprising: reaction containers capable of containing nucleic-acid-containing samples and reagents; an incubation mechanism capable of controlling temperatures of reaction containers set at different levels; an analysis mechanism for analyzing the samples contained in the reaction containers; and a transport mechanism for transporting a reaction container. In accordance with the assay technique to be performed on a nucleic-acid-containing sample, the transport mechanism transports a reaction container to a given incubation mechanism in a given order. The reaction container subjected to the process of sample preparation is transported to the analysis mechanism at a given time and the sample is analyzed.

摘要翻译： 本发明涉及一种核酸分析仪，其包括：能够含有含有核酸的样品和试剂的反应容器; 能够控制设置在不同水平的反应容器的温度的孵育机构; 用于分析包含在反应容器中的样品的分析机构; 以及用于输送反应容器的输送机构。 根据对含核酸样品进行的测定技术，转运机制以给定的顺序将反应容器输送到给定的培养机制。 将经过样品制备过程的反应容器在给定时间运送到分析机构，并分析样品。

公开(公告)号：US20140193893A1

公开(公告)日：2014-07-10

申请号：US14235869

申请日：2012-05-30

申请人： Masato Ishizawa ,  Yoshiyuki Shoji

发明人： Masato Ishizawa ,  Yoshiyuki Shoji

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6844 ,  G01N35/04 ,  G01N2035/00346

摘要： There is provided a genetic test system provided with a dispensing means for dispensing a sample and a reagent to a reaction vessel and a vessel conveyance means for conveying the reaction vessel. The system further includes a plurality of nucleic acid amplification detection units, each including a temperature control means for accommodating a plurality of reaction vessels and performing temperature control for each accommodated position of the reaction vessel, a temperature monitoring means for monitoring a value of temperature to be controlled of the reaction vessel, and a light emission measurement means for measuring light emission of reaction liquid in the reaction vessel. At least one of the nucleic acid amplification detection units individually has a vessel conveyance means different from the above-mentioned vessel conveyance means.

摘要翻译： 提供了一种遗传测试系统，其具有用于将样品和试剂分配到反应容器的分配装置和用于输送反应容器的容器输送装置。 该系统还包括多个核酸扩增检测单元，每个检测单元包括温度控制装置，用于容纳多个反应容器并对反应容器的每个容纳位置进行温度控制;温度监测装置，用于监测温度值 控制反应容器，以及用于测量反应容器中的反应液的发光的发光测量装置。 至少一个核酸扩增检测单元分别具有与上述容器输送装置不同的容器输送装置。

公开(公告)号：USD638952S1

公开(公告)日：2011-05-31

申请号：US29365821

申请日：2010-07-15

申请人： Mitsuru Oonuma ,  Akira Omachi ,  Masato Ishizawa ,  Yoshiyuki Shoji

设计人： Mitsuru Oonuma ,  Akira Omachi ,  Masato Ishizawa ,  Yoshiyuki Shoji

公开(公告)号：US07903248B2

公开(公告)日：2011-03-08

申请号：US12037644

申请日：2008-02-26

申请人： Hidetsugu Tanoue ,  Masato Ishizawa ,  Yoichiro Suzuki

发明人： Hidetsugu Tanoue ,  Masato Ishizawa ,  Yoichiro Suzuki

IPC分类号： G01N21/25

CPC分类号： G01N21/645

摘要： To increase the direct light received by the detector and decrease reflections from the detection component support structures, the luminescent substance is placed as close to the detector as possible. More specifically, the apparatus is configured so as to slide out a structure shielding the detector from light and at the same time slide in the vessel containing the luminescent substance therein until the vessel comes right under the detector. The invention can detect trace luminescence from a small-volume sample by maximizing the amount of direct light received from the sample and minimizing the decay of indirect light received from the sample attributable to interactions with the vessel for containing the sample therein, the structure for collecting light, and the structure for supporting other detection components.

摘要翻译： 为了增加由检测器接收的直接光并减少来自检测部件支撑结构的反射，发光物质尽可能靠近检测器放置。 更具体地说，该装置被配置为滑出屏蔽检测器的结构，同时在其中容纳发光物质的容器中滑动，直到容器在检测器正下方。 本发明可以通过最大化从样品接收的直接光的量来最小化从样品中获得的直接光的量，并且最小化从样品接收的间接光的衰减，从而可以从小体积样品中检测到痕量的发光，归因于与容器内的样品的相互作用，用于收集样品的结构 光和支撑其他检测部件的结构。

公开(公告)号：US10512915B2

公开(公告)日：2019-12-24

申请号：US13696444

申请日：2011-04-28

申请人： Minoru Sano ,  Yoshiyuki Shoji ,  Masato Ishizawa ,  Kimikazu Sugiyama

发明人： Minoru Sano ,  Yoshiyuki Shoji ,  Masato Ishizawa ,  Kimikazu Sugiyama

IPC分类号： B01L7/00

摘要： A nucleic acid amplifier comprises a holder 3 which is provided with a plurality of temperature control blocks 10 each designed to hold at least one reaction vessel 105 storing a reaction solution. The temperature of the reaction solution in each reaction vessel 105 is controlled individually by using temperature control devices 14 and 15 arranged in each of the temperature control blocks 10. The temperature that is set in each temperature control block 10 and the timing for temperature changes are controlled independently of the temperatures of other temperature control blocks 10. This configuration makes it possible to provide a nucleic acid amplifier and a nucleic acid inspection device (employing the nucleic acid amplifier) capable of processing multiple types of samples differing in the protocol in parallel (parallel processing) and starting a process for a different sample even when there is a process in execution.

公开(公告)号：US08895296B2

公开(公告)日：2014-11-25

申请号：US13142154

申请日：2009-12-10

申请人： Minoru Sano ,  Masato Ishizawa ,  Shuhei Yamamoto

发明人： Minoru Sano ,  Masato Ishizawa ,  Shuhei Yamamoto

IPC分类号： C12M1/34 ,  C12M3/00 ,  C12Q1/68 ,  G01N21/64 ,  G01N21/66

CPC分类号： C12Q1/68 ,  B01L7/52 ,  G01N21/0332 ,  G01N21/645 ,  G01N21/6452 ,  G01N35/025 ,  G01N2035/00366

摘要： An object of the present invention relates to providing a nucleic acid analyzer capable of testing a plurality of test items in parallel, and of obtaining high efficiency of specimen processing even if the test item or a measuring object is changed. The present invention relates to an analyzer including a carousel rotatable about a rotation axis, a plurality of reaction containers held along a circumferential edge of the carousel, and at least one detector having a light source for irradiating the reaction container with excitation light and a detection element for detecting fluorescence from a reaction liquid in the reaction container. The detector is removable. By attaching a desired detector, it is possible to perform fluorescence measurement in response to the test item. According to the present invention, it is possible to test a plurality of test items in parallel, and even if the test item or the measuring object is changed, the high efficiency of specimen processing can be obtained.

摘要翻译： 本发明的目的是提供一种能够并行地测试多个测试项目的核酸分析仪，并且即使测试项目或测量对象改变也能获得高效率的样本处理。 本发明涉及一种分析仪，其包括可围绕旋转轴线旋转的圆盘传送带，沿圆盘传送带的圆周边缘保持的多个反应容器，以及至少一个检测器，具有用于向反应容器照射激发光和检测的光源 用于检测来自反应容器中的反应液体的荧光的元件。 检测器是可拆卸的。 通过附加所需的检测器，可以响应于测试项目执行荧光测量。 根据本发明，可以并行地进行多个测试项目的测试，即使测试项目或测量对象发生变化，也能够获得高效的样本处理。

公开(公告)号：US06890761B2

公开(公告)日：2005-05-10

申请号：US09940592

申请日：2001-08-29

申请人： Masato Ishizawa ,  Hideyuki Yanami

发明人： Masato Ishizawa ,  Hideyuki Yanami

IPC分类号： G01N35/10 ,  B01L3/02

CPC分类号： G01N35/1011 ,  Y10T436/115831 ,  Y10T436/2575

摘要： In order to reduce carry-over of sample liquids in an automatic analyzer by a pipeting probe and resulting contamination of sample liquids by immersing the pipeting probe into sample liquids as shallow as possible, said pipeting probe is moving down to a position which is calculated and determined according to the detected height of a container temporarily stopping said probe there, and further moving down said probe to immerse said probe into the liquid in said container.

摘要翻译： 为了通过移液探头减少自动分析仪中的样品液体的残留，并通过将吸液探针浸入尽可能浅的样品液体中而导致样品液体的污染，所述吸管探针向下移动到计算的位置， 根据检测到的容器临时停止所述探针的高度确定，并且进一步向下移动所述探针以将所述探针浸入所述容器中的液体中。

公开(公告)号：US06413475B2

公开(公告)日：2002-07-02

申请号：US09181642

申请日：1998-10-29

申请人： Masato Ishizawa ,  Akira Inagaki ,  Ryuji Tao

发明人： Masato Ishizawa ,  Akira Inagaki ,  Ryuji Tao

IPC分类号： G01N2722

CPC分类号： G01N35/1009 ,  G01F23/26 ,  G01N2035/1025 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： An automatic analysis apparatus with a liquid level detection function includes a pipetting device for pipetting a liquid sample from a sample cup to a reaction container by using a pipetting probe that serves as a first capacitor electrode. A sample cup holding means serves as a second capacitor electrode having a ground potential. The conductor material is arranged along a direction in which the pipetting probe moves down for pipetting and is separate from the pipetting device. The conductor material has the same ground potential as that of the sample cup holding means and also serves as a second electrode whereby at any one time either of the sample cup holding means and the conductive material serves as a second capacitor electrode in combination with the first capacitor electrode. An a electrical detector is provided for detecting a change of electrode static capacitance between the pipetting probe and the sample cup holding means and between the pipetting probe and the conductive material as of level detection of the liquid sample. Measurement means are also provided for measuring an ingredient of the reaction container.

摘要翻译： 具有液位检测功能的自动分析装置包括：移液装置，用于通过使用用作第一电容器电极的移液探头，将液体样品从样品杯移液到反应容器。 样品杯保持装置用作具有接地电位的第二电容器电极。 导体材料沿着移液探针向下移动用于移液的方向布置，并且与吸移装置分离。 导体材料具有与样品杯保持装置相同的接地电位，并且还用作第二电极，由此在样品杯保持装置和导电材料中的任一个作为第二电容器电极与第一电极组合 电容电极。 提供了一种电检测器，用于在液体样品的液位检测时检测移液探针和样品杯保持装置之间以及移液探针和导电材料之间的电极静电容的变化。 还提供测量装置用于测量反应容器的成分。

公开(公告)号：US6107810A

公开(公告)日：2000-08-22

申请号：US971902

申请日：1997-11-17

申请人： Masato Ishizawa ,  Nobuo Suzuki

发明人： Masato Ishizawa ,  Nobuo Suzuki

IPC分类号： G01F23/26 ,  G01N35/10 ,  G01R27/26

CPC分类号： G01N35/1009 ,  G01F23/266 ,  G01N2035/1025

摘要： A liquid level detecting circuit is pattern-printed on a board. The liquid level detecting circuit has a pair of discharge elements and an electrostatic capacitance change detecting circuit. One of the discharge elements is grounded, and the other of the discharge elements is connected to a pipetting probe and the electrostatic capacitance change detecting circuit. When an extraneous noise signal such as a noise signal caused by static electricity charged on the surface of a container is input through the pipetting probe while the pipetting probe is being moved toward the container containing a liquid the liquid surface of which is to be detected, the extraneous noise signal is discharged to the ground through the pair of discharge elements to suppress the transmission of the noise signal to be transmitted to the electrostatic capacitance change detecting circuit. An inductance placed between the other discharge element and the electrostatic capacitance change detecting circuit promotes the discharge of the noise signal.

摘要翻译： 液位检测电路图案印刷在电路板上。 液位检测电路具有一对放电元件和静电电容变化检测电路。 其中一个放电元件接地，另一个放电元件连接到移液探针和静电电容变化检测电路。 当移液探头朝向容纳要液体表面被检测的液体的容器移动时，通过移液探头输入诸如由静电引起的静电引起的诸如噪声信号的外来噪声信号， 外部噪声信号通过一对放电元件放电到地面，以抑制要传输到静电电容变化检测电路的噪声信号的传输。 放置在另一个放电元件和静电电容变化检测电路之间的电感促进噪声信号的放电。