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公开(公告)号：US08455001B2
公开(公告)日：2013-06-04
申请号：US12525464
申请日：2008-02-06
申请人： Masaya Ito , Hiroaki Kaneko , Yukako Fukuhira , Nobuyuki Endo
发明人： Masaya Ito , Hiroaki Kaneko , Yukako Fukuhira , Nobuyuki Endo
CPC分类号： A61K31/717 , C08B11/12 , C08B11/145
摘要： The invention provides a cellulose derivative having a repeating unit of the formula below, a composition including the cellulose derivative and a phospholipid, a method for production thereof, and an adhesion barrier including the cellulose derivative or the composition. In the formula, R1, R2, and R3 are —H, —CH2—COOH, —CH2—COOX, or —CH2CO-phosphatidylethanolamine, and X is an alkali metal or an alkali earth metal. The degree of substitution of —CH2—COOH and —CH2—COOX is 0.3 to 2.0 in total, and the degree of substitution of —CH2CO-phosphatidylethanolamine is 0.001 to 0.05.
摘要翻译： 本发明提供一种具有下式重复单元的纤维素衍生物，包含纤维素衍生物和磷脂的组合物，其制备方法和包含纤维素衍生物或组合物的粘合屏障。 在该式中，R 1，R 2和R 3是-H，-CH 2 -COOH，-CH 2 -COO x或-CH 2 CO-磷脂酰乙醇胺，X是碱金属或碱土金属。 -CH 2 -COOH和-CH 2 -COOX的取代度总计为0.3〜2.0，-CH 2 CO-磷脂酰乙醇胺的取代度为0.001〜0.05。
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公开(公告)号：US20100129452A1
公开(公告)日：2010-05-27
申请号：US12525464
申请日：2008-02-06
申请人： Masaya Ito , Hiroaki Kaneko , Yukako Fukuhira , Nobuyuki Endo
发明人： Masaya Ito , Hiroaki Kaneko , Yukako Fukuhira , Nobuyuki Endo
IPC分类号： A61K31/717 , C08B1/00 , C08B3/00 , A61K9/10 , A61P43/00
CPC分类号： A61K31/717 , C08B11/12 , C08B11/145
摘要： The invention provides a cellulose derivative having a repeating unit of the formula below, a composition including the cellulose derivative and a phospholipid, a method for production thereof, and an adhesion barrier including the cellulose derivative or the composition. In the formula, R1, R2, and R3 are —H, —CH2—COOH, —CH2—COOX, or —CH2CO-phosphatidylethanolamine, and X is an alkali metal or an alkali earth metal. The degree of substitution of —CH2—COOH and —CH2—COOX is 0.3 to 2.0 in total, and the degree of substitution of —CH2CO-phosphatidylethanolamine is 0.001 to 0.05.
摘要翻译： 本发明提供一种具有下式重复单元的纤维素衍生物，包含纤维素衍生物和磷脂的组合物，其制备方法和包含纤维素衍生物或组合物的粘合屏障。 在该式中，R 1，R 2和R 3是-H，-CH 2 -COOH，-CH 2 -COO x或-CH 2 CO-磷脂酰乙醇胺，X是碱金属或碱土金属。 -CH 2 -COOH和-CH 2 -COOX的取代度总计为0.3〜2.0，-CH 2 CO-磷脂酰乙醇胺的取代度为0.001〜0.05。
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3.发明授权Tissue regeneration substrate, complex thereof with cells, and method for its production 有权组织再生底物，与细胞的复合物及其制备方法公开(公告)号：US07915028B2
公开(公告)日：2011-03-29
申请号：US10580029
申请日：2004-11-19
申请人： Yukako Fukuhira , Masaya Ito , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
发明人： Yukako Fukuhira , Masaya Ito , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
CPC分类号： A61L27/3817 , A61L27/3852 , A61L27/446 , A61L27/50 , A61L27/56 , A61L2430/06
摘要： A tissue regeneration substrate comprising a film with a honeycomb structure composed primarily of a polymer compound and a phospholipid. A tissue regeneration complex comprising the tissue regeneration substrate and cells held in the tissue regeneration substrate. The substrate is particularly suitable for regeneration of cartilage tissue, and allows growth of cartilage tissue in a three-dimensional fashion.
摘要翻译： 一种组织再生基材，其包含主要由高分子化合物和磷脂构成的蜂窝结构体的膜。 一种组织再生复合体，其包含组织再生基质和保持在组织再生基质中的细胞。 该底物特别适用于软骨组织的再生，并允许以三维方式生长软骨组织。
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4.发明申请Tissue regeneration substrate, complex thereof with cells, and method for its production 有权组织再生底物，与细胞的复合物及其制备方法公开(公告)号：US20070112438A1
公开(公告)日：2007-05-17
申请号：US10580029
申请日：2004-11-19
申请人： Yukako Fukuhira , Masaya Ito , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
发明人： Yukako Fukuhira , Masaya Ito , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
IPC分类号： A61F2/02
CPC分类号： A61L27/3817 , A61L27/3852 , A61L27/446 , A61L27/50 , A61L27/56 , A61L2430/06
摘要： A tissue regeneration substrate comprising a film with a honeycomb structure composed primarily of a polymer compound and a phospholipid. A tissue regeneration complex comprising the tissue regeneration substrate and cells held in the tissue regeneration substrate. The substrate is particularly suitable for regeneration of cartilage tissue, and allows growth of cartilage tissue in a three-dimensional fashion.
摘要翻译： 一种组织再生基材，其包含主要由高分子化合物和磷脂构成的蜂窝结构体的膜。 一种组织再生复合体，其包含组织再生基质和保持在组织再生基质中的细胞。 该底物特别适用于软骨组织的再生，并允许以三维方式生长软骨组织。
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5.发明申请Composite of support matrix and collagen, and process for producing support substrate and composite 审中-公开复合支撑基质和胶原蛋白，以及生产支撑底物和复合材料的方法公开(公告)号：US20060216320A1
公开(公告)日：2006-09-28
申请号：US10551192
申请日：2004-03-31
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2210/0004 , A61L27/34 , C08L89/06
摘要： A cylindrical body is produced which is composed of a fiber structure with a basis weight of 1-50 g/m2 and having a diameter of 0.5-50 mm and a bellows-shaped section, wherein the crest-to-crest spacing of the bellows-shaped section is no greater than 2 mm and the crest-to-valley depth of the bellows-shaped section is 0.01-1 mm; collagen is added to the cylindrical body to produce a composite comprising the cylindrical body and collagen.
摘要翻译： 制造圆筒体，其由基重为1-50g / m 2的纤维结构体构成，直径为0.5〜50mm，波纹状部分为波纹状， 波纹管形截面的波峰间距不大于2mm，波纹管形截面的波谷深度为0.01-1mm; 将胶原蛋白加入到圆柱体中以产生包含圆柱体和胶原的复合物。
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6.发明授权Composite of support matrix and collagen, and method for production of support matrix and composite 有权支撑基质和胶原的复合物，以及支撑基质和复合材料的生产方法公开(公告)号：US08263187B2
公开(公告)日：2012-09-11
申请号：US13031934
申请日：2011-02-22
CPC分类号： A61F2/06 , A61F2210/0004 , A61L27/34 , C08L89/06
摘要： A cylindrical body is produced which is composed of a fiber structure with a basis weight of 1-50 g/m2 and having a diameter of 0.5-50 mm and a bellows-shaped section, wherein the crest-to-crest spacing of the bellows-shaped section is no greater than 2 mm and the crest-to-valley depth of the bellows-shaped section is 0.01-1 mm; collagen is added to the cylindrical body to produce a composite including the cylindrical body and collagen.
摘要翻译： 制造圆筒体，其由基重为1-50g / m 2且直径为0.5-50mm的纤维结构和波纹管状部分组成，其中波纹管的峰间距 形状截面不大于2mm，波纹状截面的波谷深度为0.01-1mm; 将胶原蛋白加入到圆柱体中以产生包括圆柱体和胶原蛋白的复合物。
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公开(公告)号：US08097273B2
公开(公告)日：2012-01-17
申请号：US10552685
申请日：2004-04-08
申请人： Yukako Fukuhira , Eiichi Kitazono , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
发明人： Yukako Fukuhira , Eiichi Kitazono , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
摘要： The invention relates to a honeycomb film made of a biodegradable polymer which has biodegradation properties as an anti-adhesion membrane for preventing adhesion after an operation, is excellent in handling properties, and exhibits a satisfactory adhesion preventive effect stably over a desired period of time, and to a production process of the same. Above all, the invention provides an anti-adhesion membrane of a honeycomb film made of polylactic acid as a biodegradable polymer and a phospholipid and a production process of the same.
摘要翻译： 本发明涉及一种由生物降解性聚合物制成的蜂窝膜，其具有生物降解性，作为防止粘合后的防粘膜，操作性优异，并且在期望的时间段内稳定地表现出令人满意的粘合防止效果， 以及其生产过程。 其中，本发明提供了由聚乳酸作为生物降解性聚合物和磷脂制成的蜂窝膜的防粘膜及其制造方法。
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公开(公告)号：US20060189911A1
公开(公告)日：2006-08-24
申请号：US10552685
申请日：2004-04-08
申请人： Yukako Fukuhira , Eiichi Kitazono , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
发明人： Yukako Fukuhira , Eiichi Kitazono , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
摘要： The invention relates to a honeycomb film made of a biodegradable polymer which has biodegradation properties as an anti-adhesion membrane for preventing adhesion after an operation, is excellent in handling properties, and exhibits a satisfactory adhesion preventive effect stably over a desired period of time, and to a production process of the same. Above all, the invention provides an anti-adhesion membrane of a honeycomb film made of polylactic acid as a biodegradable polymer and a phospholipid and a production process of the same.
摘要翻译： 本发明涉及一种由生物降解性聚合物制成的蜂窝膜，其具有生物降解性，作为防止粘合后的防粘膜，操作性优异，并且在期望的时间段内稳定地表现出令人满意的粘合防止效果， 以及其生产过程。 其中，本发明提供了由聚乳酸作为生物降解性聚合物和磷脂制成的蜂窝膜的防粘膜及其制造方法。
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