公开(公告)号：US20230321230A1

公开(公告)日：2023-10-12

申请号：US18190068

申请日：2023-03-24

申请人： Massachusetts Institute of Technology

发明人： Bowen Li ,  Allen Jiang ,  Robert S. Langer ,  Daniel G. Anderson

IPC分类号： A61K39/215 ,  C07K14/47 ,  A61K39/39 ,  C07K14/005

CPC分类号： A61K39/39 ,  A61K39/215 ,  C07K14/005 ,  C07K14/472 ,  A61K2039/53

摘要： Provided herein are, in various embodiments, methods and compositions comprising polynucleotides (e.g., mRNA) for eliciting an immune response. In certain embodiments, the disclosure provides for methods and compositions for enhancing efficacy of infectious disease treatment (e.g., mRNA vaccines). In still further embodiments, the disclosure provides methods and compositions for enhancing one or more vaccines, such as SARS-CoV-2 mRNA vaccines.

公开(公告)号：US20230183168A1

公开(公告)日：2023-06-15

申请号：US18080299

申请日：2022-12-13

申请人： Massachusetts Institute of Technology

发明人： Daniel Griffith Anderson ,  Luke Hyunsik Rhym ,  Allen Jiang ,  Jacob Witten ,  Idris Raji

IPC分类号： C07C237/16 ,  C07D211/86 ,  C07D211/82 ,  C07D207/12 ,  C07D207/09 ,  C07D231/12

CPC分类号： C07C237/16 ,  C07D211/86 ,  C07D211/82 ,  C07D207/12 ,  C07D207/09 ,  C07D231/12

摘要： Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).