利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.016 秒)

    Active transport of charged molecules into, within, and/or from charged matrices
    1.
    发明授权
    Active transport of charged molecules into, within, and/or from charged matrices 有权

    公开(公告)号：US10416116B2

    公开(公告)日：2019-09-17

    申请号：US14678660

    申请日：2015-04-03

    申请人： Massachusetts Institute of Technology

    发明人： Kwanghun Chung ,  Sung-Yon Kim ,  Kimberly Ohn ,  Evan Murray ,  Jae Hun Cho

    IPC分类号： G01N27/447

    摘要： Articles and methods for the active transport of molecules into, within, and/or from a matrix are generally described. In some embodiments, an electric field may be used to alter the position of the molecule with respect to the matrix. The electric field may be used to move the molecule to a new location within the matrix, remove the molecule from the matrix, or infuse the molecule into the matrix. For instance, the electric field may be used to move a molecule having a binding partner within the matrix into or away from the vicinity of the binding partner. In some embodiments, the position of the molecule may be altered by exposing the molecule to an electrodynamic field. In some such embodiments, the molecule exposed to the dynamic electric field may have enhanced mobility and minimal adverse matrix interactions relative to conventional molecular transport methods, and in some cases, a molecule exposed to an electrostatic field. The active transport methods and articles, described herein, may be particularly well-suited for a variety of applications including histological, biological, and pharmaceutical applications.

    ACTIVE TRANSPORT OF CHARGED MOLECULES INTO, WITHIN, AND/OR FROM CHARGED MATRICES
    2.
    发明申请
    ACTIVE TRANSPORT OF CHARGED MOLECULES INTO, WITHIN, AND/OR FROM CHARGED MATRICES 有权
    收费分类的活跃运输，收入和/或收费矩阵

    公开(公告)号：US20150285765A1

    公开(公告)日：2015-10-08

    申请号：US14678660

    申请日：2015-04-03

    申请人： Massachusetts Institute of Technology

    发明人： Kwanghun Chung ,  Sung-Yon Kim ,  Kimberly Ohn ,  Evan Murray ,  Jae Hun Cho

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44756 ,  B01L3/502 ,  B01L3/508 ,  B01L2300/0609 ,  B01L2400/0421 ,  G01N1/31 ,  G01N27/44704 ,  G01N27/44708 ,  G01N27/44713

    摘要： Articles and methods for the active transport of molecules into, within, and/or from a matrix are generally described. In some embodiments, an electric field may be used to alter the position of the molecule with respect to the matrix. The electric field may be used to move the molecule to a new location within the matrix, remove the molecule from the matrix, or infuse the molecule into the matrix. For instance, the electric field may be used to move a molecule having a binding partner within the matrix into or away from the vicinity of the binding partner. In some embodiments, the position of the molecule may be altered by exposing the molecule to an electrodynamic field. In some such embodiments, the molecule exposed to the dynamic electric field may have enhanced mobility and minimal adverse matrix interactions relative to conventional molecular transport methods, and in some cases, a molecule exposed to an electrostatic field. The active transport methods and articles, described herein, may be particularly well-suited for a variety of applications including histological, biological, and pharmaceutical applications.

    摘要翻译： 通常描述用于分子进入，内部和/或从基质主动转运分子的制品和方法。 在一些实施方案中，电场可用于改变分子相对于基质的位置。 电场可以用于将分子移动到基质内的新位置，从基质中除去分子，或将分子注入基质。 例如，电场可以用于将具有在基质内的结合配偶体的分子移动到或离开结合配偶体附近。 在一些实施方案中，可以通过将分子暴露于电动力场来改变分子的位置。 在一些这样的实施方案中，暴露于动态电场的分子可以具有相对于常规分子转运方法的增强的迁移率和最小的不利矩阵相互作用，并且在一些情况下，暴露于静电场的分子。 本文所述的活性转运方法和制品可能特别适用于各种应用，包括组织学，生物学和药物应用。