公开(公告)号：US20200063127A1

公开(公告)日：2020-02-27

申请号：US16485822

申请日：2018-02-14

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Fahim Farzadfard

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/62 ,  C12N9/78

Abstract: Provided herein are compositions, systems, and methods for continuous and accumulative modification of a target site.

公开(公告)号：US20200063119A1

公开(公告)日：2020-02-27

申请号：US16548143

申请日：2019-08-22

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Fahim Farzadfard

IPC: C12N15/10 ,  G16B20/00 ,  G16B40/10 ,  G16B50/20 ,  G16B50/30 ,  G16B50/40 ,  G16B50/50 ,  B01J19/00

Abstract: Provided herein are compositions, systems, and methods for information (e.g., artificial or digital information) recording and storage in nucleic acids (e.g., DNA). Information can be recorded and stored on pre-synthesized storage medium.

公开(公告)号：US20170204399A1

公开(公告)日：2017-07-20

申请号：US15324487

申请日：2015-08-13

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Fahim Farzadfard

IPC: C12N15/10 ,  C12N9/12 ,  C12N9/22 ,  C12N15/63

CPC classification number: C12N15/1024 ,  C12N9/1276 ,  C12N9/22 ,  C12N15/102 ,  C12N15/63 ,  C12N15/635 ,  C12Y207/07049

Abstract: Aspects of the present disclosure provide synthetic-biology platforms for in vivo genome editing, which enable the use of live cell genomes as “tape recorders” for long-term recording of event histories and analog memories.

公开(公告)号：US20180127759A1

公开(公告)日：2018-05-10

申请号：US15796551

申请日：2017-10-27

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Fahim Farzadfard

IPC: C12N15/113 ,  C12N9/22 ,  C12N15/70 ,  C12N9/12 ,  C12Q1/6876 ,  C12N15/74 ,  C07K16/00 ,  C12N15/90

CPC classification number: C12N15/1137 ,  C07K16/00 ,  C07K2317/14 ,  C12N9/1276 ,  C12N9/22 ,  C12N15/1024 ,  C12N15/70 ,  C12N15/74 ,  C12N15/902 ,  C12N2310/20 ,  C12Q1/6876 ,  C12Y207/07049

Abstract: Provided herein, in some embodiments, are genomic editing constructs that can achieve nearly 100% recombination efficiency within a select population of bacterial cells.

公开(公告)号：US20180119141A1

公开(公告)日：2018-05-03

申请号：US15411255

申请日：2017-01-20

Applicant: Massachusetts Institute of Technology

Inventor： Ying-Chou Chen ,  Fahim Farzadfard ,  Timothy Kuan-Ta Lu

IPC: C12N15/113 ,  G01N33/50 ,  C12N15/85

CPC classification number: C12N15/113 ,  C07K2319/00 ,  C12N15/85 ,  C12N2310/20 ,  C12N2320/12 ,  G01N33/5014

Abstract: Provided herein are methods for identifying genetic networks and methods of treating neurodegenerative disorders associated with α-synuclein dysfunction.