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公开(公告)号:US20140105960A1
公开(公告)日:2014-04-17
申请号:US14050320
申请日:2013-10-09
Applicant: Massachusetts Institute of Technology
Inventor: JANETA ZOLDAN , Robert S. Langer , Daniel S. Kohane , Daniel Griffith Anderson , Akihiko Kusanagi , Hila Epstein-Barash , Beata Chertok
CPC classification number: A61K38/1866 , A61K9/0024 , A61K9/127 , A61K35/44 , A61K35/545 , A61K38/1858 , A61K47/36 , A61K47/38 , A61L27/20 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2300/626
Abstract: Provided herein are hydrogels and hydrogel-forming compositions that are useful for, among others, tissue regeneration in vivo. Methods for generating such hydrogels, for example, from such hydrogel-forming compositions are also provided herein. Therapeutic methods employing hydrogels and hydrogel-forming composition, for example, for restoration of tissue perfusion in the context of acute ischemia, are also provided. The disclosure also describes kits comprising components useful for generating hydrogels as described herein.
Abstract translation: 本文提供水凝胶和形成水凝胶的组合物,其可用于组织再生体内。 本文还提供了从这种水凝胶形成组合物产生这种水凝胶的方法。 还提供了使用水凝胶和水凝胶形成组合物的治疗方法,例如用于在急性缺血的情况下恢复组织灌注。 本公开还描述了包含可用于产生如本文所述的水凝胶的组分的试剂盒。