公开(公告)号：US11696953B2

公开(公告)日：2023-07-11

申请号：US17939528

申请日：2022-09-07

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Kevin John Kauffman ,  James C. Kaczmarek ,  Asha Kumari Patel

IPC: A61K47/18 ,  A61K9/19 ,  A61K31/7088 ,  A61K9/00 ,  C12N15/88 ,  C08G73/02 ,  A61K9/12 ,  A61K47/32 ,  A61K47/34 ,  C08G63/685 ,  A61P11/00 ,  A61K31/7105 ,  A61K31/711

CPC classification number: A61K47/183 ,  A61K9/0019 ,  A61K9/12 ,  A61K9/19 ,  A61K31/7088 ,  A61K47/32 ,  A61K47/34 ,  C08G63/6852 ,  C08G63/6856 ,  C08G63/6858 ,  C08G73/02 ,  C12N15/88 ,  A61K31/711 ,  A61K31/7105 ,  A61P11/00

Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.

公开(公告)号：US20210388196A1

公开(公告)日：2021-12-16

申请号：US17347791

申请日：2021-06-15

Applicant: Massachusetts Institute of Technology ,  Politecnico di Milano

Inventor： Umberto Capasso Palmiero ,  James C. Kaczmarek ,  Daniel Griffith Anderson ,  Davide Moscatelli

IPC: C08L33/14 ,  C08G73/02 ,  C08G63/685 ,  A61K48/00 ,  C08F20/34 ,  C12N15/87

Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

公开(公告)号：US11608412B2

公开(公告)日：2023-03-21

申请号：US16663585

申请日：2019-10-25

Applicant: Massachusetts Institute of Technology

Inventor： James C. Kaczmarek ,  Daniel Griffith Anderson ,  Luke Hyunsik Rhym ,  Kevin John Kauffman ,  Asha Kumari Patel

IPC: C08G63/685 ,  A61K47/59 ,  A61K47/54 ,  A61K47/28 ,  C08G63/56 ,  A61K31/7105

Abstract: The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.

公开(公告)号：US20190194444A1

公开(公告)日：2019-06-27

申请号：US16179698

申请日：2018-11-02

Applicant: Massachusetts Institute of Technology ,  POLITECNICO DI MILANO

Inventor： Umberto Capasso Palmiero ,  James C. Kaczmarek ,  Daniel Griffith Anderson ,  Davide Moscatelli

IPC: C08L33/14 ,  C08F20/34 ,  A61K48/00 ,  C12N15/87

CPC classification number: C08L33/14 ,  A61K48/0041 ,  C08F20/34 ,  C08G63/6852 ,  C08G73/02 ,  C08L2201/06 ,  C08L2203/02 ,  C12N15/87 ,  C12N2310/14

Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

公开(公告)号：US20230061974A1

公开(公告)日：2023-03-02

申请号：US17939528

申请日：2022-09-07

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Kevin John Kauffman ,  James C. Kaczmarek ,  Asha Kumari Patel

IPC: A61K47/18 ,  A61K9/19 ,  A61K31/7088 ,  A61K9/00 ,  C12N15/88 ,  C08G73/02 ,  A61K9/12 ,  A61K47/32 ,  A61K47/34 ,  C08G63/685

Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.

公开(公告)号：US11464860B2

公开(公告)日：2022-10-11

申请号：US16170318

申请日：2018-10-25

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Kevin John Kauffman ,  James C. Kaczmarek ,  Asha Kumari Patel

IPC: A61K47/18 ,  A61K9/19 ,  A61K31/7088 ,  A61K9/00 ,  C12N15/88 ,  C08G73/02 ,  A61K9/12 ,  A61K47/32 ,  A61K47/34 ,  C08G63/685 ,  A61P11/00 ,  A61K31/7105 ,  A61K31/711

Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.

公开(公告)号：US11041069B2

公开(公告)日：2021-06-22

申请号：US16179698

申请日：2018-11-02

Applicant: Massachusetts Institute of Technology ,  POLITECNICO DI MILANO

Inventor： Umberto Capasso Palmiero ,  James C. Kaczmarek ,  Daniel Griffith Anderson ,  Davide Moscatelli

IPC: C08L33/14 ,  C08F20/34 ,  C08G73/02 ,  C12N15/87 ,  C08G63/685 ,  A61K48/00

Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

公开(公告)号：US20200172663A1

公开(公告)日：2020-06-04

申请号：US16663585

申请日：2019-10-25

Applicant: Massachusetts Institute of Technology

Inventor： James C. Kaczmarek ,  Daniel Griffith Anderson ,  Luke Hyunsik Rhym ,  Kevin John Kauffman ,  Asha Kumari Patel

IPC: C08G63/685 ,  C08G63/56 ,  A61K47/59 ,  A61K47/54 ,  A61K47/28

Abstract: The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.

公开(公告)号：US20190125874A1

公开(公告)日：2019-05-02

申请号：US16170318

申请日：2018-10-25

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Kevin John Kauffman ,  James C. Kaczmarek ,  Asha Kumari Patel

IPC: A61K47/18 ,  A61K47/32 ,  A61K47/34 ,  C08G63/685 ,  A61K9/12

Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.