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公开(公告)号：US11181454B2
公开(公告)日：2021-11-23
申请号：US16258295
申请日：2019-01-25
Applicant: Massachusetts Institute of Technology
Inventor： Robin Singh , Anuradha M. Agarwal , Danhao Ma , Peter X. Su , Brian W. Anthony
IPC: G01N15/02 , G01N21/552 , G01N33/543 , G01N21/39 , G01N15/06 , G01N21/77 , G01N21/45 , G02B6/12 , G01N15/00 , G02B6/293
Abstract: A photonic aerosol particle sensor includes a plurality of photonic waveguide resonators each having a photonic waveguide disposed along a separate waveguide resonator path and each photonic waveguide having a lateral waveguide width different than the waveguide width of other photonic waveguide resonators in the plurality. All waveguides in the plurality of photonic waveguide resonators have a common vertical thickness and are formed of a common photonic waveguide material. An optical input connection couples light into the waveguide resonators. A particle input conveys aerosol particles toward the waveguide resonators and an aerosol particle output conveys aerosol particles away from the waveguide resonators. At least one optical output connection is optically connected to accept light out of the plurality of photonic waveguide resonators to provide a signal indicative of at least one characteristic of the aerosol particles to be analyzed.
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Patent Agency Ranking
公开(公告)号：US20180296180A1
公开(公告)日：2018-10-18
申请号：US15952999
申请日：2018-04-13
Inventor： Galit Hocsman Frydman , Alexander Tyler Jaffe , Maulik D. Majmudar , Mohamad Ali Toufic Najia , Robin Singh , Zijun Wei , Jason Yang , Brian W. Anthony , Athena Yeh Huang , Aaron Michael Zakrzewski
Abstract: Devices, systems, and methods of the present disclosure are directed to accurate and non-invasive assessments of anatomic vessels (e.g., the internal jugular vein (IJV)) of vertebrates. For example, a piezoelectric crystal may generate a signal and receive a pulse echo of the signal along an axis extending through the piezoelectric crystal and an anatomic vessel. A force sensor disposed relative to the piezoelectric crystal may measure a force exerted (e.g., along skin of the vertebrate) on the anatomic vessel along the axis. The pulse echo received by the piezoelectric crystal and the force measured by the force sensor may, in combination, non-invasively and accurately determine a force response of the anatomic vessel. In turn, the force response may be probative of any one or more of a variety of different characteristics of the anatomic vessel including, for example, location of the anatomic vessel and pressure of the anatomic vessel.
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公开(公告)号：US11378552B2
公开(公告)日：2022-07-05
申请号：US16893612
申请日：2020-06-05
Applicant: Massachusetts Institute of Technology
Inventor： Robin Singh , Anuradha M. Agarwal , Brian Anthony
Abstract: A microscale photoacoustic sensor uses the detection of ultrasound waves generated by a sample in response to incident light absorption to perform photoacoustic spectroscopy, imaging, and microscopy. The microscale photoacoustic sensor, including components to excite a sample and detect ultrasound waves, may be integrated onto a single chip. The microscale photoacoustic sensor may excite a sample using a metasurface collimator. The metasurface collimator includes an array of diffraction grooves to collimate an excitation beam uniformly out of the plane of the sensor to create a wide and homogeneous beam spot. The microscale photoacoustic sensor may detect ultrasound waves using an optical photoacoustic transducer. The optical photoacoustic transducer includes a resonator on a mechanical membrane to detect ultrasound waves with high sensitivity. The microscale photoacoustic sensor may be used in applications such as deep-tissue neural imaging or microfluidic biological screening.
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公开(公告)号：US11686659B2
公开(公告)日：2023-06-27
申请号：US17507563
申请日：2021-10-21
Applicant: Massachusetts Institute of Technology
Inventor： Robin Singh , Anuradha M. Agarwal , Danhao Ma , Peter X. Su , Brian W. Anthony
IPC: G01N15/02 , G01N21/552 , G01N33/543 , G01N21/39 , G01N15/06 , G01N21/77 , G01N21/45 , G02B6/12 , G01N15/00 , G02B6/293
CPC classification number: G01N15/0205 , G01N15/06 , G01N21/39 , G01N21/45 , G01N21/552 , G01N21/7703 , G01N21/7746 , G01N33/543 , G01N33/54373 , G02B6/12004 , G02B6/12007 , G01N2015/0046 , G01N2015/03 , G01N2015/0693 , G02B6/2938 , G02B6/29338
Abstract: A photonic aerosol particle sensor includes a microfluidic sensor chamber in which is disposed a plurality of photonic waveguide resonators each having a photonic waveguide on an underlying substrate, along a separate waveguide resonator path with a lateral width different than that of other photonic waveguide resonators. All waveguides in the plurality have a common vertical thickness of a common waveguide material having a refractive index that is larger than that of the underlying substrate material. An optical input connection couples light into the waveguide resonators. An aerosol particle input fluidically connected to the microfluidic chamber fluidically conveys aerosol particles to the chamber, and an aerosol particle output fluidically connected to the microfluidic chamber fluidically conveys aerosol particles out of the chamber. At least one optical output connection accepts light out of the plurality of photonic waveguide resonators to provide a signal indicative of at least one aerosol particle characteristic.
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公开(公告)号：US20190234850A1
公开(公告)日：2019-08-01
申请号：US16258295
申请日：2019-01-25
Applicant: Massachusetts Institute of Technology
Inventor： Robin Singh , Anuradha M. Agarwal , Danhao Ma , Peter X. Su , Brian W. Anthony
CPC classification number: G01N15/0205 , G01N15/06 , G01N21/39 , G01N21/45 , G01N21/552 , G01N21/7703 , G01N21/7746 , G01N33/543 , G01N33/54373 , G01N2015/0046 , G01N2015/03 , G01N2015/0693 , G02B6/12004 , G02B6/12007 , G02B6/29338 , G02B6/2938
Abstract: A photonic aerosol particle sensor includes a plurality of photonic waveguide resonators each having a photonic waveguide disposed along a separate waveguide resonator path and each photonic waveguide having a lateral waveguide width different than the waveguide width of other photonic waveguide resonators in the plurality. All waveguides in the plurality of photonic waveguide resonators have a common vertical thickness and are formed of a common photonic waveguide material. An optical input connection couples light into the waveguide resonators. A particle input conveys aerosol particles toward the waveguide resonators and an aerosol particle output conveys aerosol particles away from the waveguide resonators. At least one optical output connection is optically connected to accept light out of the plurality of photonic waveguide resonators to provide a signal indicative of at least one characteristic of the aerosol particles to be analyzed.
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公开(公告)号：US11096654B2
公开(公告)日：2021-08-24
申请号：US15952999
申请日：2018-04-13
Inventor： Galit Hocsman Frydman , Alexander Tyler Jaffe , Maulik D. Majmudar , Mohamad Ali Toufic Najia , Robin Singh , Zijun Wei , Jason Yang , Brian W. Anthony , Athena Yeh Huang , Aaron Michael Zakrzewski
IPC: A61B8/04 , A61B8/00 , A61B8/08 , G01L17/00 , G01L1/16 , A61B5/022 , A61B90/00 , A61B5/021 , A61B5/00 , A61B5/02
Abstract: Devices, systems, and methods of the present disclosure are directed to accurate and non-invasive assessments of anatomic vessels (e.g., the internal jugular vein (IJV)) of vertebrates. For example, a piezoelectric crystal may generate a signal and receive a pulse echo of the signal along an axis extending through the piezoelectric crystal and an anatomic vessel. A force sensor disposed relative to the piezoelectric crystal may measure a force exerted (e.g., along skin of the vertebrate) on the anatomic vessel along the axis. The pulse echo received by the piezoelectric crystal and the force measured by the force sensor may, in combination, non-invasively and accurately determine a force response of the anatomic vessel. In turn, the force response may be probative of any one or more of a variety of different characteristics of the anatomic vessel including, for example, location of the anatomic vessel and pressure of the anatomic vessel.
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