公开(公告)号：US11875876B2

公开(公告)日：2024-01-16

申请号：US16441647

申请日：2019-06-14

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Manolis Kellis ,  Jicong Cao ,  Eva Maria Novoa Pardo ,  Zhizhuo Zhang

IPC: C12N15/11 ,  G16B20/50 ,  G16B40/00 ,  C12N15/10 ,  C12N15/85

CPC classification number: G16B20/50 ,  C12N15/1089 ,  C12N15/11 ,  C12N15/85 ,  G16B40/00

Abstract: Disclosed herein are novel 5′ UTR sequences that can be used to control gene expression in various contexts. Also disclosed herein are methods of engineering 5′ UTR sequences and methods and kits for screening 5′ UTR sequences for a property of interest.

公开(公告)号：US11593512B2

公开(公告)日：2023-02-28

申请号：US16612993

申请日：2018-05-11

Applicant: Massachusetts Institute of Technology

Inventor： Zhizhuo Zhang ,  Manolis Kellis ,  Dianbo Liu ,  Anne Kim ,  Lauren Huang ,  Sandeep Nuckchady

IPC: G06F21/62 ,  G16H10/40 ,  G16H50/30 ,  G16H50/70 ,  G06F16/23 ,  G16B30/10 ,  G16B20/20 ,  G16B20/40 ,  G16B50/40 ,  G06F9/455 ,  G06F21/60 ,  G06Q50/26 ,  H04L9/30

Abstract: Described herein are a secure system for sharing private data and related systems and methods for incentivizing and validating private data sharing. In some embodiments, private data providers may register to selectively share private data under controlled sharing conditions. The private data may be cryptographically secured using encryption information corresponding to one or more secure execution environments. To demonstrate to the private data providers that the secure execution environment is secure and trustworthy, attestations demonstrating the security of the secure execution environment may be stored in a distributed ledger (e.g., a public blockchain). Private data users that want access to shared private data may publish applications for operating on the private data to a secure execution environment and publish, in a distributed ledger, an indication that the application is available to receive private data. The distributed ledger may also store sharing conditions under which the private data will be shared.

公开(公告)号：US20200066375A1

公开(公告)日：2020-02-27

申请号：US16441647

申请日：2019-06-14

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Manolis Kellis ,  Jicong Cao ,  Eva Maria Novoa Pardo ,  Zhizhuo Zhang

IPC: G16B20/50 ,  G16B40/00 ,  C12N15/10 ,  C12N15/11

Abstract: Disclosed herein are novel 5′ UTR sequences that can be used to control gene expression in various contexts. Also disclosed herein are methods of engineering 5′ UTR sequences and methods and kits for screening 5′ UTR sequences for a property of interest.

公开(公告)号：US11788135B2

公开(公告)日：2023-10-17

申请号：US16323158

申请日：2017-08-04

Applicant: THE BROAD INSTITUTE, INC. ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Yaping Liu ,  Manolis Kellis ,  Viktor Adalsteinsson ,  Zhizhuo Zhang

IPC: C12Q1/6874 ,  C12Q1/6827 ,  G16B20/00 ,  G16B40/00 ,  G16B20/10 ,  G16B40/30 ,  G16B20/20 ,  G16B30/00 ,  C12N15/10 ,  C12Q1/68

CPC classification number: C12Q1/6874 ,  C12N15/1093 ,  C12Q1/68 ,  C12Q1/6827 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B40/00 ,  G16B40/30 ,  C12Q2600/154 ,  C12Q1/6827 ,  C12Q2521/331 ,  C12Q2521/507

Abstract: As described below, disclosed herein are methods of analyzing DNA methylation in cell-free DNA (cfDNA) and genomic DNA (gDNA) from sequencing data.