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1.发明申请公开(公告)号：US20220288104A1
公开(公告)日：2022-09-15
申请号：US17694630
申请日：2022-03-14
Applicant: Massachusetts Institute of Technology
Inventor： Joel Blanchard , Manolis Kellis , Li-Huei Tsai , Jose Davila Velderrain , Leyla Akay , Djuna Von Maydell , Audrey Effenberger , Matheus Victor
IPC: A61K31/724 , A61P25/28
Abstract: The present disclosure provides methods of inhibiting amyloid synthesis in a subject using cyclodextrin and analogs thereof. Small molecules (cyclodextrin) reverse APOE4-associated cholesterol phenotypes and lead to significantly improved myelination both human in vitro cultures and APOE4 targeted replacement mice. This demonstrates that APOE4 alters cholesterol synthesis and transport in oligodendrocytes which impairs myelination. Collectively, this work uncovers a pathogenic role of APOE4 in oligodendrocytes and myelination and enables therapeutic opportunities for Alzheimer's Disease.
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2.发明授权公开(公告)号：US10774326B2
公开(公告)日：2020-09-15
申请号：US15539621
申请日：2015-12-23
Inventor： Manolis Kellis , Melina Christine Claussnitzer , Jan Korbel
IPC: C12N15/113 , A61K31/713 , C12N15/90
Abstract: Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rs1421085, IRX3, and IRX5. Compositions and methods for modulating the pathway in vitro and in vivo for anti-cachectic and anti-obesity effects are provided. Methods of identifying subjects at risk of developing a disorder mediated by a dysregulation of the energy consumption pathway are also provided.
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3.发明授权公开(公告)号：US12285440B2
公开(公告)日：2025-04-29
申请号：US17694630
申请日：2022-03-14
Applicant: Massachusetts Institute of Technology
Inventor： Joel Blanchard , Manolis Kellis , Li-Huei Tsai , Jose Davila Velderrain , Leyla Akay , Djuna Von Maydell , Audrey Effenberger , Matheus Victor
IPC: A61K31/724 , A61P25/28
Abstract: The present disclosure provides methods of inhibiting amyloid synthesis in a subject using cyclodextrin and analogs thereof. Small molecules (cyclodextrin) reverse APOE4-associated cholesterol phenotypes and lead to significantly improved myelination both human in vitro cultures and APOE4 targeted replacement mice. This demonstrates that APOE4 alters cholesterol synthesis and transport in oligodendrocytes which impairs myelination. Collectively, this work uncovers a pathogenic role of APOE4 in oligodendrocytes and myelination and enables therapeutic opportunities for Alzheimer's Disease.
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公开(公告)号：US11875876B2
公开(公告)日：2024-01-16
申请号：US16441647
申请日：2019-06-14
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Manolis Kellis , Jicong Cao , Eva Maria Novoa Pardo , Zhizhuo Zhang
CPC classification number: G16B20/50 , C12N15/1089 , C12N15/11 , C12N15/85 , G16B40/00
Abstract: Disclosed herein are novel 5′ UTR sequences that can be used to control gene expression in various contexts. Also disclosed herein are methods of engineering 5′ UTR sequences and methods and kits for screening 5′ UTR sequences for a property of interest.
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5.发明授权公开(公告)号：US11987790B2
公开(公告)日：2024-05-21
申请号：US16757296
申请日：2018-10-17
Inventor： Melina Claussnitzer , Liang He , Manolis Kellis , Xinchen Wang
CPC classification number: C12N15/1051 , C12N15/67 , C12N15/86 , C40B40/02 , C12N2310/20 , C12N15/1051 , C12Q2521/10 , C12Q2525/204 , C12Q2535/122
Abstract: Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.
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Patent Agency Ranking
公开(公告)号：US11593512B2
公开(公告)日：2023-02-28
申请号：US16612993
申请日：2018-05-11
Applicant: Massachusetts Institute of Technology
Inventor： Zhizhuo Zhang , Manolis Kellis , Dianbo Liu , Anne Kim , Lauren Huang , Sandeep Nuckchady
IPC: G06F21/62 , G16H10/40 , G16H50/30 , G16H50/70 , G06F16/23 , G16B30/10 , G16B20/20 , G16B20/40 , G16B50/40 , G06F9/455 , G06F21/60 , G06Q50/26 , H04L9/30
Abstract: Described herein are a secure system for sharing private data and related systems and methods for incentivizing and validating private data sharing. In some embodiments, private data providers may register to selectively share private data under controlled sharing conditions. The private data may be cryptographically secured using encryption information corresponding to one or more secure execution environments. To demonstrate to the private data providers that the secure execution environment is secure and trustworthy, attestations demonstrating the security of the secure execution environment may be stored in a distributed ledger (e.g., a public blockchain). Private data users that want access to shared private data may publish applications for operating on the private data to a secure execution environment and publish, in a distributed ledger, an indication that the application is available to receive private data. The distributed ledger may also store sharing conditions under which the private data will be shared.
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公开(公告)号：US20200066375A1
公开(公告)日：2020-02-27
申请号：US16441647
申请日：2019-06-14
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Manolis Kellis , Jicong Cao , Eva Maria Novoa Pardo , Zhizhuo Zhang
Abstract: Disclosed herein are novel 5′ UTR sequences that can be used to control gene expression in various contexts. Also disclosed herein are methods of engineering 5′ UTR sequences and methods and kits for screening 5′ UTR sequences for a property of interest.
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8.发明申请公开(公告)号：US20240384258A1
公开(公告)日：2024-11-21
申请号：US18667037
申请日：2024-05-17
Inventor： Melina Claussnitzer , Liang He , Manolis Kellis , Xinchen Wang
Abstract: Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.
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公开(公告)号：US11788135B2
公开(公告)日：2023-10-17
申请号：US16323158
申请日：2017-08-04
Inventor： Yaping Liu , Manolis Kellis , Viktor Adalsteinsson , Zhizhuo Zhang
IPC: C12Q1/6874 , C12Q1/6827 , G16B20/00 , G16B40/00 , G16B20/10 , G16B40/30 , G16B20/20 , G16B30/00 , C12N15/10 , C12Q1/68
CPC classification number: C12Q1/6874 , C12N15/1093 , C12Q1/68 , C12Q1/6827 , G16B20/00 , G16B20/10 , G16B20/20 , G16B30/00 , G16B40/00 , G16B40/30 , C12Q2600/154 , C12Q1/6827 , C12Q2521/331 , C12Q2521/507
Abstract: As described below, disclosed herein are methods of analyzing DNA methylation in cell-free DNA (cfDNA) and genomic DNA (gDNA) from sequencing data.
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10.发明申请公开(公告)号：US20190136232A1
公开(公告)日：2019-05-09
申请号：US15539621
申请日：2015-12-23
Inventor： Manolis Kellis , Melina Christine Claussnitzer , Jan Korbel
IPC: C12N15/113 , C12N15/90
Abstract: Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rs1421085, IRX3, and IRX5. Compositions and methods for modulating the pathway in vitro and in vivo for anti-cachectic and anti-obesity effects are provided. Methods of identifying subjects at risk of developing a disorder mediated by a dysregulation of the energy consumption pathway are also provided.
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