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公开(公告)号：US20080287482A1
公开(公告)日：2008-11-20
申请号：US11931474
申请日：2007-10-31
IPC分类号： C07D498/18 , A61K31/436 , A61P35/00 , A61P37/00 , C12P17/14
CPC分类号： C07D498/18 , C07D405/12 , C07D471/18 , C07D487/18 , C07D493/18 , C07K14/36 , C12N15/52 , C12N15/70 , C12N15/76 , C12P17/188
摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， 制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。
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公开(公告)号：US20080039486A1
公开(公告)日：2008-02-14
申请号：US11778319
申请日：2007-07-16
申请人： Matthew Gregory , Sabine Gaisser , Hryoje Petkovic , Steven Moss
发明人： Matthew Gregory , Sabine Gaisser , Hryoje Petkovic , Steven Moss
IPC分类号： A61K31/4353 , A61K31/407 , A61P35/00
CPC分类号： C07D498/18 , C07D405/12 , C07D471/18 , C07D487/18 , C07D493/18 , C07K14/36 , C12N15/52 , C12N15/70 , C12N15/76 , C12P17/188
摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
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公开(公告)号：US07300942B2
公开(公告)日：2007-11-27
申请号：US10497135
申请日：2003-07-16
IPC分类号： C07D498/18 , A61P31/00
CPC分类号： C07D498/18 , C07D405/12 , C07D471/18 , C07D487/18 , C07D493/18 , C07K14/36 , C12N15/52 , C12N15/70 , C12N15/76 , C12P17/188
摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their,preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， ，制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。
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公开(公告)号：US07645768B2
公开(公告)日：2010-01-12
申请号：US11778319
申请日：2007-07-16
CPC分类号： C07D498/18 , C07D405/12 , C07D471/18 , C07D487/18 , C07D493/18 , C07K14/36 , C12N15/52 , C12N15/70 , C12N15/76 , C12P17/188
摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， 制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。
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公开(公告)号：US09040259B2
公开(公告)日：2015-05-26
申请号：US13046304
申请日：2011-03-11
IPC分类号： C12P19/62 , C12P17/18 , C07D471/18 , C07D487/18 , C07D493/18 , C07K14/36 , C12N15/52 , C12N15/70 , C12N15/76 , C12N1/20
CPC分类号： C07D498/18 , C07D405/12 , C07D471/18 , C07D487/18 , C07D493/18 , C07K14/36 , C12N15/52 , C12N15/70 , C12N15/76 , C12P17/188
摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogs and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogs and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogs, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在用途。 本发明特别涉及用于产生FKBP类似物和重组细胞的菌株的有效转化的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， 制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。
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公开(公告)号：US20110165633A1
公开(公告)日：2011-07-07
申请号：US13046304
申请日：2011-03-11
IPC分类号： C12P17/18
CPC分类号： C07D498/18 , C07D405/12 , C07D471/18 , C07D487/18 , C07D493/18 , C07K14/36 , C12N15/52 , C12N15/70 , C12N15/76 , C12P17/188
摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， 制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。
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公开(公告)号：US07390895B2
公开(公告)日：2008-06-24
申请号：US11778264
申请日：2007-07-16
IPC分类号： C07D498/18
CPC分类号： C07D498/18 , C07D405/12 , C07D471/18 , C07D487/18 , C07D493/18 , C07K14/36 , C12N15/52 , C12N15/70 , C12N15/76 , C12P17/188
摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， 制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。
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8.发明申请公开(公告)号：US20110160175A1
公开(公告)日：2011-06-30
申请号：US12513983
申请日：2007-11-09
申请人： Christine Martin , Ming Zhang , Nigel Coates , William Vousden , Steven Moss , Sabine Gaisser
发明人： Christine Martin , Ming Zhang , Nigel Coates , William Vousden , Steven Moss , Sabine Gaisser
IPC分类号： A61K31/395 , C07D225/06 , A61P35/00 , A61P31/00 , A61P25/28 , C12P17/10 , C12N1/00
CPC分类号： C07D225/06 , C12N9/0073 , C12N15/52 , C12P17/10
摘要： The present invention relates to macbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds involving incorporation of non-natural starter units and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
摘要翻译： 本发明涉及可用的例如麦克风类似物。 在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫性疾病和/或作为癌症的预防性预处理。 本发明还提供生产这些化合物的方法，其涉及非天然起始单元的并入及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤。
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9.发明申请公开(公告)号：US20090253667A1
公开(公告)日：2009-10-08
申请号：US12296542
申请日：2007-05-09
申请人： Christine Martin , Ming Zhang , Nigel Coates , William Vousden , Steven Moss , Sabine Gaisser
发明人： Christine Martin , Ming Zhang , Nigel Coates , William Vousden , Steven Moss , Sabine Gaisser
IPC分类号： A61K31/395 , C12P17/10 , C12N1/00 , C07D225/06
CPC分类号： C07D225/06
摘要： The present invention relates to 18,21-didesoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
摘要翻译： 本发明涉及有用的18,21-二氧杂氧化锍类似物。 在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫性疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。
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公开(公告)号：US20080021211A1
公开(公告)日：2008-01-24
申请号：US11778264
申请日：2007-07-16
申请人： Matthew Gregory , Sabine Gaisser , Hrvoje Petkovic , Steven Moss
发明人： Matthew Gregory , Sabine Gaisser , Hrvoje Petkovic , Steven Moss
IPC分类号： C07D273/00
CPC分类号： C07D498/18 , C07D405/12 , C07D471/18 , C07D487/18 , C07D493/18 , C07K14/36 , C12N15/52 , C12N15/70 , C12N15/76 , C12P17/188
摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， 制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。
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