公开(公告)号：US20080161843A1

公开(公告)日：2008-07-03

申请号：US11974922

申请日：2007-10-16

申请人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Olig ,  Ana R. Menk ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Thomas P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns ,  Philip J. Haarstad

发明人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Olig ,  Ana R. Menk ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Thomas P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns ,  Philip J. Haarstad

IPC分类号： A61B17/32 ,  A61M5/00 ,  A61M31/00 ,  A61M5/178 ,  A61B19/00

CPC分类号： A61B17/32 ,  A61B17/00008 ,  A61B17/3205 ,  A61B17/32053 ,  A61B2017/320064

摘要： Embodiments of the invention provide a vessel support system and a method of vessel harvesting. The system can include a cutting device, a catheter adapted to be inserted into a section of the vessel in order to support the vessel as the cutting device is advanced over the vessel, and a cannula adapted to be coupled to the vessel and adapted to receive the catheter as the catheter is inserted into the section of the vessel. The method can include orienting a cutting device coaxially with the cannula and the catheter and advancing the cutting device over the cannula, the catheter, and the section of the vessel in order to core out the section of the vessel and a portion of the surrounding tissue.

摘要翻译： 本发明的实施例提供了一种血管支持系统和血管收集方法。 该系统可以包括切割装置，适于插入到容器的一部分中的导管，以便当切割装置前进在容器上时支撑容器，以及适于联接到容器并适于接收的套管 作为导管的导管插入血管的部分。 该方法可以包括将切割装置与套管和导管同轴定向，并将切割装置推进套管，导管和容器的部分，以便将血管的一部分和周围组织的一部分 。

公开(公告)号：US20080161841A1

公开(公告)日：2008-07-03

申请号：US11974914

申请日：2007-10-16

申请人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Olig ,  Ana R. Menk ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Thomas P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns ,  Philip J. Haarstad

发明人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Olig ,  Ana R. Menk ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Thomas P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns ,  Philip J. Haarstad

IPC分类号： A61B17/3205

CPC分类号： A61B17/32 ,  A61B17/00008 ,  A61B17/3205 ,  A61B17/32053 ,  A61B2017/320064

摘要： Embodiments of the invention provide a cutting device and method of vessel harvesting. The cutting device can include at least one tubular member, a cutting element, and a centering member. The cutting device can include at least one tubular member with a flexible section and a cutting element. The method of vessel harvesting can include spacing a cutting element of the cutting device from the vessel as the cutting element is advanced over the vessel.

摘要翻译： 本发明的实施例提供一种切割装置和容器收获方法。 切割装置可以包括至少一个管状构件，切割元件和定心构件。 切割装置可以包括具有柔性部分和切割元件的至少一个管状部件。 当切割元件在容器上前进时，容器收集的方法可以包括将切割装置的切割元件与容器间隔开。

公开(公告)号：US06837848B2

公开(公告)日：2005-01-04

申请号：US10342932

申请日：2003-01-15

申请人： Matthew D. Bonner ,  Paul A. Pignato ,  Scott E. Jahns ,  Raymond W. Usher

发明人： Matthew D. Bonner ,  Paul A. Pignato ,  Scott E. Jahns ,  Raymond W. Usher

IPC分类号： A61B18/14 ,  A61B19/00 ,  A61B19/02 ,  A61B19/08 ,  A61B19/10 ,  A61M1/00 ,  A61B1/00

CPC分类号： A61B18/1485 ,  A61B18/1402 ,  A61B46/00 ,  A61B46/23 ,  A61B50/20 ,  A61B2018/00291 ,  A61B2090/306 ,  A61B2090/3614 ,  A61B2218/007 ,  A61M1/008

摘要： A tubular suction tool for accessing an anatomic surface or anatomic space and particularly the pericardium to access pericardial space and the epicardial surface of the heart to implant cardiac leads in a minimally invasive manner are disclosed. The suction tool incorporates a suction pad concave wall defining a suction cavity, a plurality of suction ports arrayed about the concave wall, and a suction lumen, to form a bleb of tissue into the suction cavity when suction is applied. The suction cavity extends along one side of the suction pad, so that the suction pad and suction cavity can be applied tangentially against a tissue site. The suction tool can incorporate light emission and video imaging of tissue adjacent the suction pad. A working lumen terminating in a working lumen port into the suction cavity enables introduction of tools, cardiac leads, and other instruments, cells, drugs or materials into or through the tissue bleb drawn into the suction cavity.

公开(公告)号：US10112045B2

公开(公告)日：2018-10-30

申请号：US13284761

申请日：2011-10-28

申请人： Thomas A. Anderson ,  Douglas D. Nippoldt ,  Richard W. Swenson, III ,  Vladimir Grubac ,  Matthew D. Bonner ,  Raymond W. Usher ,  Arshad A. Alfoqaha

发明人： Thomas A. Anderson ,  Douglas D. Nippoldt ,  Richard W. Swenson, III ,  Vladimir Grubac ,  Matthew D. Bonner ,  Raymond W. Usher ,  Arshad A. Alfoqaha

IPC分类号： A61B5/02 ,  A61N1/05 ,  A61N1/372 ,  A61N1/375 ,  A61N1/362

摘要： An assembly includes an implantable medical device (IMD) including a conductive housing, and a fixation element assembly attached to the IMD. The fixation element assembly includes a set of active fixation tines and an insulator to electrically isolate the set of active fixation tines from the conductive housing of the implantable medical device. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the implantable medical device to a hooked position in which the active fixation tines bend back towards the implantable medical device. The active fixation tines are configured to secure the implantable medical device to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.

公开(公告)号：US20120172690A1

公开(公告)日：2012-07-05

申请号：US13284761

申请日：2011-10-28

申请人： Thomas A. Anderson ,  Douglas D. Nippoldt ,  Richard W. Swenson, III ,  Vladimir Grubac ,  Matthew D. Bonner ,  Raymond W. Usher ,  Arshad A. Alfoqaha

发明人： Thomas A. Anderson ,  Douglas D. Nippoldt ,  Richard W. Swenson, III ,  Vladimir Grubac ,  Matthew D. Bonner ,  Raymond W. Usher ,  Arshad A. Alfoqaha

IPC分类号： A61B5/145 ,  A61B19/00 ,  A61N1/36 ,  A61N1/365 ,  A61B5/04 ,  A61N1/05

CPC分类号： A61N1/0573 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/37518 ,  A61N1/3756

摘要： An assembly includes an implantable medical device (IMD) including a conductive housing, and a fixation element assembly attached to the IMD. The fixation element assembly includes a set of active fixation tines and an insulator to electrically isolate the set of active fixation tines from the conductive housing of the implantable medical device. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the implantable medical device to a hooked position in which the active fixation tines bend back towards the implantable medical device. The active fixation tines are configured to secure the implantable medical device to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.

摘要翻译： 组件包括可植入医疗装置（IMD），其包括导电外壳和连接到IMD的固定元件组件。 固定元件组件包括一组主动固定齿和绝缘体，用于将一组主动固定齿与可植入医疗装置的导电外壳电隔离。 组合中的主动固定齿可从弹簧加载位置展开，其中主动固定尖端的远端尖端远离可植入医疗装置指向钩状位置，在该位置，主动固定齿可向着可植入医疗装置弯回。 主动固定齿构造成在展开时将可植入医疗装置固定到患者组织，同时活动固定齿的远端定位成与患者组织相邻。

公开(公告)号：US20100121362A1

公开(公告)日：2010-05-13

申请号：US12689357

申请日：2010-01-19

申请人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Olig ,  Ana R. Menk ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Thomas P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns ,  Philip J. Haarstad

发明人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Olig ,  Ana R. Menk ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Thomas P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns ,  Philip J. Haarstad

IPC分类号： A61B17/22 ,  A61M25/00

CPC分类号： A61B17/32 ,  A61B17/00008 ,  A61B17/3205 ,  A61B17/32053 ,  A61B2017/320064

摘要： Embodiments of the invention provide a vessel support system and a method of vessel harvesting. The system can include a cutting device, a catheter adapted to be inserted into a section of the vessel in order to support the vessel as the cutting device is advanced over the vessel, and a cannula adapted to be coupled to the vessel and adapted to receive the catheter as the catheter is inserted into the section of the vessel. The method can include orienting a cutting device coaxially with the cannula and the catheter and advancing the cutting device over the cannula, the catheter, and the section of the vessel in order to core out the section of the vessel and a portion of the surrounding tissue.

摘要翻译： 本发明的实施例提供了一种血管支持系统和血管收集方法。 该系统可以包括切割装置，适于插入到容器的一部分中的导管，以便当切割装置前进在容器上时支撑容器，以及适于联接到容器并适于接收的套管 作为导管的导管插入血管的部分。 该方法可以包括将切割装置与套管和导管同轴定向，并将切割装置推进套管，导管和容器的部分，以便将血管的一部分和周围组织的一部分 。

公开(公告)号：US07628780B2

公开(公告)日：2009-12-08

申请号：US11000798

申请日：2004-11-30

申请人： Matthew D. Bonner ,  Paul T. Rothstein ,  Prasanga D. Hiniduma-Lokuge ,  James R. Keogh ,  Raymond W. Usher ,  Scott Eric Jahns ,  Victor T. Chen

发明人： Matthew D. Bonner ,  Paul T. Rothstein ,  Prasanga D. Hiniduma-Lokuge ,  James R. Keogh ,  Raymond W. Usher ,  Scott Eric Jahns ,  Victor T. Chen

IPC分类号： A61M31/00 ,  A61B17/32

CPC分类号： A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/2926 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M25/0084

摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

摘要翻译： 将生物制剂注入组织的装置和方法。 设备具有细长轴和远端注射头，用于将针驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以转换成针驱动力。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

公开(公告)号：US20130184727A1

公开(公告)日：2013-07-18

申请号：US12445919

申请日：2007-10-16

申请人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Jolly ,  Ana R. Menk ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Thomas P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns ,  Philip J. Haarstad

发明人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Jolly ,  Ana R. Menk ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Thomas P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns ,  Philip J. Haarstad

IPC分类号： A61B17/32

CPC分类号： A61B17/32 ,  A61B17/00008 ,  A61B17/3205 ,  A61B17/32053 ,  A61B2017/320064

摘要： Embodiments of the invention provide a vessel support system and a method of vessel harvesting. The system can include a cutting device, a catheter adapted to be inserted into a section of the vessel in order to support the vessel as the cutting device is advanced over the vessel, and a cannula adapted to be coupled to the vessel and adapted to receive the catheter as the catheter is inserted into the section of the vessel. The method can include orienting a cutting device coaxially with the cannula and the catheter and advancing the cutting device over the cannula, the catheter, and the section of the vessel in order to core out the section of the vessel and a portion of the surrounding tissue.

摘要翻译： 本发明的实施例提供了一种血管支持系统和血管收集方法。 该系统可以包括切割装置，适于插入到容器的一部分中的导管，以便当切割装置前进在容器上时支撑容器，以及适于联接到容器并适于接收的套管 作为导管的导管插入血管的部分。 该方法可以包括将切割装置与套管和导管同轴定向，并将切割装置推进套管，导管和容器的部分，以便将血管的一部分和周围组织的一部分 。

公开(公告)号：US08480696B2

公开(公告)日：2013-07-09

申请号：US11155533

申请日：2005-06-16

申请人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Jolly ,  Ana R. Buhr ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Tom P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns

发明人： Cynthia T. Clague ,  Michael J. Hobday ,  Raymond W. Usher ,  Roderick E. Briscoe ,  Katherine S. Jolly ,  Ana R. Buhr ,  Christopher P. Olig ,  Eric A. Meyer ,  Steven C. Christian ,  Tom P. Daigle ,  Robert H. Reetz ,  Jeffrey D. Sandstrom ,  James R. Keogh ,  Matthew D. Bonner ,  Scott E. Jahns

IPC分类号： A61B17/22

CPC分类号： A61B17/22 ,  A61B17/00008 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/32053 ,  A61B2017/00557 ,  A61B2017/00778 ,  A61B2017/22062 ,  A61B2017/22068

摘要： The invention provides a system and method for harvesting a vessel section. The system comprises a vessel support member, a handle, and a tubular cutting device. The vessel support member is introduced into the vessel section to be harvested. The tubular cutting device may comprise an outer tubular member or an outer and an inner tubular member. The outer tubular member carries at least one cutting element. The tubular member or members are advanced over the vessel section and vessel support member to core out the vessel section and tissue adjoining the vessel section.

摘要翻译： 本发明提供了一种收集血管部分的系统和方法。 该系统包括容器支撑构件，手柄和管状切割装置。 将容器支撑构件引入待收获的容器部分。 管状切割装置可以包括外部管状构件或外部管状构件和内部管状构件。 外部管状构件承载至少一个切割元件。 管状构件在容器部分和容器支撑构件上前进，以将与容器部分相邻的容器部分和组织芯出。

公开(公告)号：US20120109149A1

公开(公告)日：2012-05-03

申请号：US12915859

申请日：2010-10-29

申请人： Matthew D. Bonner ,  Raymond W. Usher

发明人： Matthew D. Bonner ,  Raymond W. Usher

IPC分类号： A61B17/00

CPC分类号： A61N1/057 ,  A61N1/372 ,  A61N1/37205 ,  A61N1/3756 ,  A61N2001/0578 ,  A61N2001/058

摘要： System and method for implanting an implantable medical device. A catheter has a lumen and a distal portion configured for insertion in proximity of tissue of a patient. An implantable medical device has a fixation member operatively coupled to the housing having an unengaged state when in the lumen of the catheter and an engaged state configured to engage tissue of a patient when outside of the lumen of the catheter, the medical device being magnetically attractable. A magnetic element is configured to magnetically engage the implantable medical device and to pass through the lumen of the catheter.

摘要翻译： 用于植入可植入医疗装置的系统和方法。 导管具有被配置用于插入患者组织附近的内腔和远端部分。 可植入医疗装置具有可操作地联接到壳体的固定构件，其在导管的内腔中具有未接合状态，并且被配置为在导管内腔外部接合患者的组织的接合状态，医疗装置是磁性吸引的 。 磁性元件构造成磁性接合可植入医疗装置并穿过导管的内腔。