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1.发明申请PRODUCTION OF INFECTIOUS HEPATITIS C VIRUS PARTICLES IN CELL CULTURE 审中-公开在细胞培养中生产感染性HEPATITIS C病毒颗粒公开(公告)号：US20100068698A1
公开(公告)日：2010-03-18
申请号：US12557716
申请日：2009-09-11
申请人： Matthew F. McCown , Isabel Najera
发明人： Matthew F. McCown , Isabel Najera
CPC分类号： C12N7/00 , C12N2770/24251
摘要： The present invention provides for novel methods of producing high levels of infectious HCV genotype 1 virus particles in cell culture systems. The availability of HCV genotype 1 virus (principally associated with liver disease in most regions of the world) that can undergo the complete viral cycle in cultured cells is beneficial for the discovery and development of novel therapies for the treatment of HCV.
摘要翻译： 本发明提供了在细胞培养系统中产生高水平感染性HCV基因型1病毒颗粒的新方法。 可以在培养细胞中经历完整病毒循环的HCV基因型1病毒（主要与世界大多数地区的肝病相关）的可用性有利于发现和开发用于治疗HCV的新疗法。
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公开(公告)号：US20110245328A1
公开(公告)日：2011-10-06
申请号：US13039360
申请日：2011-03-03
申请人： Hyunsoon Kang , Sophie Le Pogam , Isabel Najera
发明人： Hyunsoon Kang , Sophie Le Pogam , Isabel Najera
IPC分类号： A61K31/7105 , C12N15/63 , C12Q1/68 , A61P31/14
CPC分类号： C12N15/86 , C07K14/005 , C12N2770/24222 , C12N2770/24243 , C12Q1/703
摘要： The present invention provides for novel HCV NS5A replicon shuttle vectors useful for cloning in HCV polynucleotide sequences from samples of HCV-infected patients and testing the resulting replicons for drug susceptibility.
摘要翻译： 本发明提供了用于克隆HCV感染患者样品的HCV多核苷酸序列的新型HCV NS5A复制子穿梭载体，并测试了所得复制子的药物敏感性。
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3.发明授权4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US07915232B2
公开(公告)日：2011-03-29
申请号：US12559186
申请日：2009-09-14
申请人： Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Nobuo Shimma , Takuo Tsukuda
发明人： Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/70 , C07H19/167 , C07H19/20
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof which inhibit HCV polymerase and are useful for treating a patient suffering from a HCV infection and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式Ia核苷衍生物的用途，其中符号如说明书中所定义，及其药学上可接受的盐抑制HCV聚合酶并可用于治疗患有HCV感染的患者，以及含有 这样的化合物。
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4.发明申请4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US20100003213A1
公开(公告)日：2010-01-07
申请号：US12561097
申请日：2009-09-16
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/7068 , A61K31/7072 , A61K31/7076 , A61P31/12 , A61K38/20 , A61K38/21
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式Ia核苷衍生物的用途，其中符号如说明书中所定义，及其药学上可接受的盐以及含有这些化合物的药物组合物。
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5.发明授权4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication. 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂。公开(公告)号：US06784166B2
公开(公告)日：2004-08-31
申请号：US10167106
申请日：2002-06-11
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31776
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof; for the treatment of diseases mediated by the Hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式I的核苷衍生物的用途，其中B表示式I的9-嘌呤基残基B1或式I的1-嘧啶基残基B2，符号如说明书中所定义;及其药学上可接受的盐; 用于治疗由丙型肝炎病毒（HCV）介导的疾病，用于制备用于这种治疗的药物和含有这些化合物的药物组合物。
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6.发明申请4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION 审中-公开4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US20120034184A1
公开(公告)日：2012-02-09
申请号：US13274743
申请日：2011-10-17
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/7068 , A61K31/708 , A61K31/7076 , A61P29/00 , A61K38/21 , A61K38/19 , A61P37/02 , A61P31/14 , A61K31/7072 , A61K38/20
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof; for the treatment of diseases mediated by the Hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式I的核苷衍生物的用途，其中B表示式的9-嘌呤基残基B1或式的1-嘧啶基残基B2，其中符号如说明书中所定义，及其药学上可接受的盐; 用于治疗由丙型肝炎病毒（HCV）介导的疾病，用于制备用于这种治疗的药物和含有这些化合物的药物组合物。
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7.发明授权4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US08071567B2
公开(公告)日：2011-12-06
申请号：US12561097
申请日：2009-09-16
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/715 , A61K38/00
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式Ia核苷衍生物的用途，其中符号如说明书中所定义，及其药学上可接受的盐以及含有这些化合物的药物组合物。
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8.发明授权4′-Substituted nucleoside derivatives as inhibitors of HCV RNA replication 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US07608601B2
公开(公告)日：2009-10-27
申请号：US10891967
申请日：2004-07-15
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/675 , A61K31/522 , A61K31/52
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof; for the treatment of diseases mediated by the Hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式I的核苷衍生物的用途，其中B表示式的9-嘌呤基残基B1或式的1-嘧啶基残基B2，其中符号如说明书中所定义，及其药学上可接受的盐; 用于治疗由丙型肝炎病毒（HCV）介导的疾病，用于制备用于这种治疗的药物和含有这些化合物的药物组合物。
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9.发明申请4'-Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US20100004192A1
公开(公告)日：2010-01-07
申请号：US12559186
申请日：2009-09-14
申请人： Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Nobuo Shimma , Takuo Tsukuda
发明人： Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/7076 , C07H19/20 , C07H19/16
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式Ia核苷衍生物的用途，其中符号如说明书中所定义，及其药学上可接受的盐以及含有这些化合物的药物组合物。
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公开(公告)号：US20090004664A1
公开(公告)日：2009-01-01
申请号：US12156871
申请日：2008-06-05
申请人： Pong Kian Chua , Isabel Najera
发明人： Pong Kian Chua , Isabel Najera
CPC分类号： C12N15/86 , C12N2770/24243 , C12N2840/206
摘要： The present invention provides for novel HCV NS3 replicon shuttle vectors useful for cloning in HCV polynucleotide sequences from samples of HCV-infected patients and testing the resulting replicons for drug susceptibility.
摘要翻译： 本发明提供了可用于克隆HCV感染患者样品的HCV多核苷酸序列的新型HCV NS3复制子穿梭载体，并测试所得复制子的药物敏感性。
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