公开(公告)号：US6143892A

公开(公告)日：2000-11-07

申请号：US442971

申请日：1999-11-18

申请人： Matthew J. Graneto ,  Michael L. Vazquez ,  Susan J. Hartmann ,  Suzanne Metz ,  John J. Talley ,  David L. Brown ,  Richard M. Weier ,  Michael A. Stealey ,  Xiaodong C. Xu

发明人： Matthew J. Graneto ,  Michael L. Vazquez ,  Susan J. Hartmann ,  Suzanne Metz ,  John J. Talley ,  David L. Brown ,  Richard M. Weier ,  Michael A. Stealey ,  Xiaodong C. Xu

IPC分类号： C07D239/26 ,  C07D213/50 ,  C07D231/18 ,  C07D339/00 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/06 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D401/14 ,  C07D231/18 ,  C07D339/00 ,  C07D401/04 ,  C07D405/14 ,  C07D409/06

摘要： This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.

公开(公告)号：US06475953B1

公开(公告)日：2002-11-05

申请号：US09534772

申请日：2000-03-24

申请人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

发明人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

IPC分类号： A01N2530

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20 ,  Y10S514/975 ,  A01N25/08 ,  A01N25/04 ,  A01N37/48 ,  A01N37/26 ,  A01N25/02 ,  A01N2300/00

摘要： A composition is disclosed for application to a plant that comprises glyphosate, an aqueous diluent, and an excipient substance that is amphiphilic. The weight/weight ratio of the excipient substance to the exogenous chemical is between about 1:3 and about 1:100. The aqueous composition forms anisotropic aggregates on a wax layer, and the presence of the anisotropic aggregates can be detected by a test described herein. Compositions of the present invention, when applied to plants, provide enhanced biological activity per unit amount of glyphosate, as compared to otherwise similar compositions containing surfactants that do not form anisotropic aggregates. Without being bound by theory, it is presently believed that this enhanced biological activity results from the formation or enlargement of hydrophilic channels through the epicuticular wax of the plant.

摘要翻译： 公开了用于施用于包含草甘膦，水性稀释剂和两亲性赋形物质的植物的组合物。 赋形剂物质与外源性化学物质的重量/重量比为约1:3至约1:100。 水性组合物在蜡层上形成各向异性聚集体，并且各向异性聚集体的存在可以通过本文所述的测试来检测。 与应用于植物的组合物相比，含有不形成各向异性聚集体的表面活性剂的相似组合物相比，每单位量草甘膦提供增强的生物活性。 不受理论的约束，目前认为这种增强的生物活性是由于通过植物的表皮蜡形成或扩大亲水性通道而产生的。

公开(公告)号：US06992045B2

公开(公告)日：2006-01-31

申请号：US09988353

申请日：2001-11-19

申请人： Xiaodong C. Xu ,  Ronald J. Brinker ,  Tracy L. Reynolds ,  William Abraham ,  Jeffrey A. Graham

发明人： Xiaodong C. Xu ,  Ronald J. Brinker ,  Tracy L. Reynolds ,  William Abraham ,  Jeffrey A. Graham

IPC分类号： A01N25/02 ,  A01N57/02

CPC分类号： A01N37/04 ,  A01N57/20 ,  A01N25/30 ,  A01N61/00 ,  A01N2300/00

摘要： Pesticidal concentrate and spray compositions are described which exhibit enhanced efficacy due to the addition thereto of a compound which increases cell membrane permeability, suppresses oxidative burst, or increases expression of hydroxyproline-rich glycoproteins.

公开(公告)号：US06245713B1

公开(公告)日：2001-06-12

申请号：US09298136

申请日：1999-04-23

申请人： Ronald J. Brinker ,  Andrew D. Dyszlewski ,  Jane L. Gillespie ,  Claude R. Jones ,  Richard M. Kramer ,  Norman R. Pallas ,  Rodney O. Radke ,  Anthony J. I. Ward ,  Xiaodong C. Xu

发明人： Ronald J. Brinker ,  Andrew D. Dyszlewski ,  Jane L. Gillespie ,  Claude R. Jones ,  Richard M. Kramer ,  Norman R. Pallas ,  Rodney O. Radke ,  Anthony J. I. Ward ,  Xiaodong C. Xu

IPC分类号： A01N2530

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20 ,  A01N2300/00

摘要： A composition for application to foliage of a plant to elicit a biological effect is provided. This plant treatment composition comprises, dissolved or dispersed in water, an anionic exogenous chemical substance such as the herbicide N-phosphonomethylglycine, together with (i) one or more alkylether surfactants each having the formula R12—O—(CH2CH2O)n((CHR)2O)m—R13 wherein R12 is an aliphatic saturated or unsaturated hydrocarbyl group having about 16 to about 22 carbon atoms, n is an average number of about 5 to about 100, m is an average number of 0 to about 5, one R in each —((CHR)2O)— group is hydrogen and the other R is methyl, and R13 is a hydrogen, C1-4 alkyl or C2-4 acyl group; and (ii) one or more amine surfactants each having a molecular structure that comprises (a) a hydrophobic moiety having one or a plurality of independently saturated or unsaturated, branched or unbranched, aliphatic, alicyclic or aromatic C3-20 hydrocarbyl or hydrocarbylene groups joined together by 0 to about 7 ether linkages and having in total about 8 to about 24 carbon atoms, and (b) a hydrophilic moiety comprising an amino group that is cationic or that can be protonated to become cationic, having attached directly thereto 1 to 3 oxyethylene groups or polyoxyethylene chains, these oxyethylene groups and polyoxyethylene chains comprising on average 1 to about 50 oxyethylene units per surfactant molecule, the hydrophobic moiety being attached either to the amino group or via an ether linkage to an oxyethylene unit. The weight ratio of the alkylether surfactant(s) to the amine surfactant(s) is about 1:10 to about 10:1; and the alkylether and amine surfactants are present in total in an adjuvant amount of about 0.05 to about 0.5 parts by weight per part by weight of the anionic exogenous chemical substance, expressed as acid equivalent. Also provided are solid and liquid concentrate compositions that can be diluted, dissolved or dispersed in water to form such a plant treatment composition.

公开(公告)号：US07049270B2

公开(公告)日：2006-05-23

申请号：US09926521

申请日：2001-05-21

申请人： Patrick J. Lennon ,  Xiangyang Chen ,  Graciela B. Arhancet ,  Jeanette A. Glaenzer ,  Jane L. Gillespie ,  Jeffrey A. Graham ,  David Z. Becher ,  Daniel R. Wright ,  Henry E. Agbaje ,  Xiaodong C. Xu ,  William Abraham ,  Ronald J. Brinker ,  Norman R. Pallas ,  Al S. Wideman ,  Martin D. Mahoney ,  Susan L. Henke

发明人： Patrick J. Lennon ,  Xiangyang Chen ,  Graciela B. Arhancet ,  Jeanette A. Glaenzer ,  Jane L. Gillespie ,  Jeffrey A. Graham ,  David Z. Becher ,  Daniel R. Wright ,  Henry E. Agbaje ,  Xiaodong C. Xu ,  William Abraham ,  Ronald J. Brinker ,  Norman R. Pallas ,  Al S. Wideman ,  Martin D. Mahoney ,  Susan L. Henke

IPC分类号： A01N25/00 ,  A01N57/02

CPC分类号： A01N61/00 ,  A01N25/30 ,  A01N37/04 ,  A01N57/20 ,  A01N2300/00

摘要： A herbicidal composition is provided comprising an aqueous solution of N-phosphonomethylglycine, predominantly in the form of the potassium salt thereof, at a concentration of at least 300 g a.e./l of the composition; and a surfactant component in solution or stable suspension, emulsion, or dispersion in the water, comprising one or more surfactants in a total amount of about 20 to about 300 g/l of the composition, wherein the composition has a viscosity of less than about 250 centipoise at 0° C. or a Gardner color value less than 10.

摘要翻译： 提供除草组合物，其包含主要以其钾盐形式的N-膦酰基甲基甘氨酸的水溶液，其浓度为组合物的至少300g a.e./l; 和在水中的溶液或稳定悬浮液，乳液或分散体中的表面活性剂组分，其包含总量为组合物总量约20至约300g / l的一种或多种表面活性剂，其中所述组合物的粘度小于约 在0°C时250厘泊或加德纳颜色值小于10。

公开(公告)号：US6093681A

公开(公告)日：2000-07-25

申请号：US958149

申请日：1997-10-24

申请人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

发明人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

IPC分类号： A01N25/08 ,  A01N25/04 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/24 ,  A01N47/36 ,  A01N57/12 ,  A01N57/20 ,  G01N21/84 ,  G01N33/15 ,  G01N33/48

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20 ,  Y10S514/975

摘要： A composition is disclosed for application to a plant that comprises an exogenous chemical (for example, a postemergent herbicide), an aqueous diluent, and a first excipient substance that is amphiphilic. The weight/weight ratio of the first excipient substance to the exogenous chemical is between about 1:3 and about 1:100. The aqueous composition forms anisotropic aggregates on a wax layer, and the presence of the anisotropic aggregates can be detected by a test described herein. Compositions of the present invention, when applied to plants, provide enhanced biological activity per unit amount of exogenous chemical, as compared to otherwise similar compositions containing surfactants that do not form anisotropic aggregates. Without being bound by theory, it is presently believed that this enhanced biological activity results from the formation or enlargement of hydrophilic channels through the epicuticular wax of the plant.

摘要翻译： 公开了一种用于植物的组合物，其包含外源化学物质（例如，出芽后除草剂），水性稀释剂和两亲性的第一赋形物质。 第一赋形物质与外源性化学物质的重量/重量比为约1:3至约1:100。 水性组合物在蜡层上形成各向异性聚集体，并且各向异性聚集体的存在可以通过本文所述的测试来检测。 与其它相似的含有不形成各向异性聚集体的表面活性剂的组合物相比，本发明的组合物当应用于植物时，提供每单位量外源化学品的增强的生物活性。 不受理论的束缚，目前认为这种增强的生物活性是由于通过植物的表皮蜡形成或增加亲水性通道而产生的。

公开(公告)号：US20110034332A1

公开(公告)日：2011-02-10

申请号：US12802395

申请日：2010-06-04

申请人： David Z. Becher ,  Henry E. Agbaje ,  Jeffrey N. Travers ,  Ronald J. Brinker ,  Xiaodong C. Xu ,  Timothy S. Ottens

发明人： David Z. Becher ,  Henry E. Agbaje ,  Jeffrey N. Travers ,  Ronald J. Brinker ,  Xiaodong C. Xu ,  Timothy S. Ottens

IPC分类号： A01N57/12 ,  A01P13/00

CPC分类号： A01N57/20 ,  A01N25/30 ,  A01N37/38 ,  A01N37/40 ,  A01N2300/00 ,  A01N43/42 ,  A01N43/40 ,  A01N39/04 ,  A01N39/02

摘要： Herbicidal compositions are provided which cause rapid symptomology while delivering long term control of regrowth of plants. The herbicidal concentrate compositions comprise N-phosphonomethylglycine or a herbicidal derivative thereof, an auxin herbicide or a herbicidal derivative thereof, and at least one surfactant. Also provided is a method for killing or controlling the growth of certain plants by contacting the foliage of the plants with the diluted concentrate composition.

摘要翻译： 提供除草剂组合物，其引起快速症状，同时长期控制植物的再生长。 除草浓缩物组合物包含N-膦酰甲基甘氨酸或其除草衍生物，生长素除草剂或其除草衍生物和至少一种表面活性剂。 还提供了通过使植物的叶子与稀释的浓缩物组合物接触来杀死或控制某些植物的生长的方法。

公开(公告)号：US06479434B1

公开(公告)日：2002-11-12

申请号：US09493446

申请日：2000-01-28

申请人： Jane L. Gillespie ,  Ronald J. Brinker ,  Anthony J. I. Ward ,  Xiaodong C. Xu

发明人： Jane L. Gillespie ,  Ronald J. Brinker ,  Anthony J. I. Ward ,  Xiaodong C. Xu

IPC分类号： A01N2530

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20 ,  Y10S514/975 ,  A01N25/08 ,  A01N25/04 ,  A01N37/48 ,  A01N37/26 ,  A01N25/02 ,  A01N2300/00

摘要： Methods and compositions are disclosed wherein exogenous chemicals are applied to plants to generate a desired biological response. One embodiment of the present invention is a plant treatment composition that comprises (a) an exogenous chemical; (b) a first excipient substance which is a compound or mixture of compounds having the formula R14—CO—A—R15 wherein R14 is a hydrocarbyl group having about 5 to about 21 carbon atoms, R15 is a hydrocarbyl group having 1 to about 14 carbon atoms, the total number of carbon atoms in R14 and R15 is about 11 to about 27, and A is O or NH; and (c) a second excipient substance which is an amphiphilic substance having a critical packing parameter greater than ⅓.

摘要翻译： 公开了将外源性化学品施用于植物以产生期望的生物反应的方法和组合物。 本发明的一个实施方案是植物处理组合物，其包含（a）外源化学品; （b）第一赋形剂物质，其是具有式R 14的化合物或化合物的混合物是具有约5至约21个碳原子的烃基，R 15是具有1至约14个碳原子的烃基，碳总数 R14和R15中的原子为约11至约27，A为O或NH; 和（c）作为临界包装参数大于1/3的两亲物质的第二赋形剂物质。

公开(公告)号：US06407042B1

公开(公告)日：2002-06-18

申请号：US09534560

申请日：2000-03-24

申请人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

发明人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

IPC分类号： A01N2500

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20 ,  Y10S514/975 ,  A01N25/08 ,  A01N25/04 ,  A01N37/48 ,  A01N37/26 ,  A01N25/02 ,  A01N2300/00

摘要： A composition is disclosed for application to a plant that comprises an exogenous chemical (for example, a postemergent herbicide), an aqueous diluent, and a first excipient substance that is amphiphilic. The weight/weight ratio of the first excipient substance to the exogenous chemical is between about 1:3 and about 1:100. The aqueous composition forms anisotropic aggregates on a wax layer, and the presence of the anisotropic aggregates can be detected by a test described herein. Compositions of the present invention, when applied to plants, provide enhanced biological activity per unit amount of exogenous chemical, as compared to otherwise similar compositions containing surfactants that do not form anisotropic aggregates. Without being bound by theory, it is presently believed that this enhanced biological activity results from the formation or enlargement of hydrophilic channels through the epicuticular wax of the plant.

摘要翻译： 公开了一种用于植物的组合物，其包含外源化学物质（例如，出芽后除草剂），水性稀释剂和两亲性的第一赋形物质。 第一赋形物质与外源性化学物质的重量/重量比为约1:3至约1:100。 水性组合物在蜡层上形成各向异性聚集体，并且各向异性聚集体的存在可以通过本文所述的测试来检测。 与其它相似的含有不形成各向异性聚集体的表面活性剂的组合物相比，本发明的组合物当应用于植物时，提供每单位量外源化学品的增强的生物活性。 不受理论的约束，目前认为这种增强的生物活性是由于通过植物的表皮蜡形成或扩大亲水性通道而产生的。

公开(公告)号：US6093680A

公开(公告)日：2000-07-25

申请号：US957764

申请日：1997-10-24

申请人： Jane L. Gillespie ,  Ronald J. Brinker ,  Anthony J. I. Ward ,  Xiaodong C. Xu

发明人： Jane L. Gillespie ,  Ronald J. Brinker ,  Anthony J. I. Ward ,  Xiaodong C. Xu

IPC分类号： A01N25/08 ,  A01N25/04 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/24 ,  A01N47/36 ,  A01N57/12 ,  A01N57/20 ,  G01N21/84 ,  G01N33/15 ,  G01N33/48

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20 ,  Y10S514/975

摘要： Methods and compositions are disclosed wherein exogenous chemicals are applied to plants to generate a desired biological response. One embodiment of the present invention is a plant treatment composition that comprises (a) an exogenous chemical; (b) a first excipient substance which is a compound or mixture of compounds having the formulaR.sup.14 --CO--A--R.sup.15wherein R.sup.14 is a hydrocarbyl group having about 5 to about 21 carbon atoms, R.sup.15 is a hydrocarbyl group having 1 to about 14 carbon atoms, the total number of carbon atoms in R.sup.14 and R.sup.15 is about 11 to about 27, and A is O or NH; and (c) a second excipient substance which is an amphiphilic substance having a critical packing parameter greater than 1/3.

摘要翻译： 公开了将外源性化学品施用于植物以产生期望的生物反应的方法和组合物。 本发明的一个实施方案是植物处理组合物，其包含（a）外源化学品; （b）第一赋形剂物质，其为化合物或具有式R14-CO-A-R15的化合物的混合物，R14为具有约5至约21个碳原子的烃基，R 15为具有1至约14个碳原子的烃基 R14和R15中的碳原子总数为约11至约27，A为O或NH; 和（c）第二赋形物质，其是具有大于+ E的临界包装参数的两亲物质，1/3 + EE。