公开(公告)号：US09883851B2

公开(公告)日：2018-02-06

申请号：US14663866

申请日：2015-03-20

申请人： Matthew W. Urban ,  Alireza Nabavizadehrafsanjani ,  Pengfei Song ,  Shigao Chen ,  James F. Greenleaf

发明人： Matthew W. Urban ,  Alireza Nabavizadehrafsanjani ,  Pengfei Song ,  Shigao Chen ,  James F. Greenleaf

IPC分类号： A61B8/00 ,  A61B8/08 ,  G01S7/52 ,  G01S15/89

CPC分类号： A61B8/485 ,  A61B8/4494 ,  A61B8/54 ,  G01S7/52022 ,  G01S7/52042 ,  G01S15/8915 ,  G01S15/8927

摘要： A system and method for performing a steered push beam (SPB) technique to create multiple foci generated by the interference of different ultrasound push beams to create shear waves and, based thereon, generate a report indicating mechanical properties about an object.

公开(公告)号：US20150265249A1

公开(公告)日：2015-09-24

申请号：US14663866

申请日：2015-03-20

申请人： Matthew W. Urban ,  Alireza Nabavizadehrafsanjani ,  Pengfei Song ,  Shigao Chen ,  James F. Greenleaf

发明人： Matthew W. Urban ,  Alireza Nabavizadehrafsanjani ,  Pengfei Song ,  Shigao Chen ,  James F. Greenleaf

IPC分类号： A61B8/08 ,  A61B8/00

CPC分类号： A61B8/485 ,  A61B8/4494 ,  A61B8/54 ,  G01S7/52022 ,  G01S7/52042 ,  G01S15/8915 ,  G01S15/8927

摘要： A system and method for performing a steered push beam (SPB) technique to create multiple foci generated by the interference of different ultrasound push beams to create shear waves and, based thereon, generate a report indicating mechanical properties about an object.

摘要翻译： 一种用于执行转向推波束（SPB）技术的系统和方法，用于产生由不同的超声推波束的干涉产生的多个焦点以产生剪切波，并且基于此产生指示关于物体的机械特性的报告。

公开(公告)号：US20140046173A1

公开(公告)日：2014-02-13

申请号：US14001604

申请日：2012-02-27

申请人： James F. Greenleaf ,  Shigao Chen ,  Armando Manduca ,  Pengfei Song

发明人： James F. Greenleaf ,  Shigao Chen ,  Armando Manduca ,  Pengfei Song

IPC分类号： A61B8/08 ,  A61B5/00 ,  A61B8/00 ,  G01R33/48

CPC分类号： A61B8/485 ,  A61B5/0059 ,  A61B8/461 ,  A61B8/5223 ,  G01N21/17 ,  G01N29/075 ,  G01N29/221 ,  G01N29/2456 ,  G01N2291/02475 ,  G01N2291/02827 ,  G01N2291/0422 ,  G01R33/4814 ,  G01S7/52042 ,  G01S15/8927

摘要： Methods for measuring mechanical properties of an object or subject under examination with an ultrasound system and using unfocused ultrasound energy are provided. Shear waves that propagate in the object or subject are produced by applying unfocused ultrasound energy to the object or subject, and measurement data is acquired by applying focused or unfocused ultrasound energy to at least one location in the object or subject at which shear waves are present Mechanical properties are then calculated from the acquired measurement data.

摘要翻译： 提供了使用超声系统测量被检查物体或受试者的机械性能并使用未聚焦的超声能量的方法。 通过对物体或被摄体施加未聚焦的超声能量来产生在物体或被摄体中传播的剪切波，并且通过将聚焦或未聚焦的超声能量应用于存在剪切波的物体或对象中的至少一个位置来获取测量数据 然后从获取的测量数据计算机械性能。

公开(公告)号：US11172910B2

公开(公告)日：2021-11-16

申请号：US14001604

申请日：2012-02-27

申请人： James F. Greenleaf ,  Shigao Chen ,  Armando Manduca ,  Pengfei Song

发明人： James F. Greenleaf ,  Shigao Chen ,  Armando Manduca ,  Pengfei Song

IPC分类号： A61B8/08 ,  G01N29/07 ,  G01N21/17 ,  G01N29/24 ,  G01N29/22 ,  G01S7/52 ,  A61B5/00 ,  G01R33/48 ,  G01S15/89 ,  A61B8/00

摘要： Methods for measuring mechanical properties of an object or subject under examination with an ultrasound system and using unfocused ultrasound energy are provided. Shear waves that propagate in the object or subject are produced by applying unfocused ultrasound energy to the object or subject, and measurement data is acquired by applying focused or unfocused ultrasound energy to at least one location in the object or subject at which shear waves are present Mechanical properties are then calculated from the acquired measurement data.

公开(公告)号：US07018816B2

公开(公告)日：2006-03-28

申请号：US10809757

申请日：2004-03-25

申请人： Charles R. Yates ,  Duane Miller ,  Dick Gourley ,  Pengfei Song

发明人： Charles R. Yates ,  Duane Miller ,  Dick Gourley ,  Pengfei Song

IPC分类号： C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The present invention provides fluorescence-based real-time PCR assays for the rapid detection of single nucleotide polymorphisms (SNPs). The genotyping assay can be used to detect SNPs of a number of genes of interest that include, but are not limited to, the human multidrug resistance gene (MDR1) single nucleotide polymorphisms C3435T and G2677T, and cytochrome P-450 3A5 single nucleotide polymorphisms CYP3A5*3 (A22893G) and CYP3A5*6 (G30597A).

公开(公告)号：US20060134689A1

公开(公告)日：2006-06-22

申请号：US11358570

申请日：2006-02-21

申请人： Charles Yates ,  Duane Miller ,  Dick Gourley ,  Pengfei Song

发明人： Charles Yates ,  Duane Miller ,  Dick Gourley ,  Pengfei Song

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The present invention provides fluorescence-based real-time PCR assays for the rapid detection of single nucleotide polymorphisms (SNPs). The genotyping assay can be used to detect SNPs of a number of genes of interest that include, but are not limited to, the human multidrug resistance gene (MDR1) single nucleotide polymorphisms C3435T and G2677T, and cytochrome P-450 3A5 single nucleotide polymorphisms CYP3A5*3 (A22893G) and CYP3A5*6 (G30597A).

摘要翻译： 本发明提供用于快速检测单核苷酸多态性（SNP）的基于荧光的实时PCR测定。 基因分型检测可用于检测感兴趣的多个基因的SNP，包括但不限于人多药耐药基因（MDR1）单核苷酸多态性C3435T和G2677T，以及细胞色素P-450 3A5单核苷酸多态性CYP3A5 * 3（A22893G）和CYP3A5 * 6（G30597A）。