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公开(公告)号：US09891194B2
公开(公告)日：2018-02-13
申请号：US14931163
申请日：2015-11-03
IPC分类号： H01J49/42 , G01N27/62 , H01J49/00 , G01N33/483
CPC分类号： G01N27/622 , G01N33/483 , H01J49/0031 , H01J49/4215
摘要： The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer (“TIMS”) is used as the ion mobility separator separation device. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with up-front substance separator. TIMS with parallel accumulation provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species to improve the quality of the fragment ion spectra.
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公开(公告)号：US08410429B2
公开(公告)日：2013-04-02
申请号：US13017803
申请日：2011-01-31
CPC分类号： H01J49/4205 , H01J49/062
摘要： An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell.
摘要翻译： 具有轴的离子电池包括沿着轴线延伸并且限定内部体积的各个电极的护套。 相邻的单个电极彼此电绝缘。 各个电极各自接收DC电位和RF电压。 单个电极中的至少一些具有在轴向上变化的宽度，使得轴电位上的电效应沿离子电池的轴线变化。
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公开(公告)号：US07446312B2
公开(公告)日：2008-11-04
申请号：US11509828
申请日：2006-08-24
申请人： Oliver Räther
发明人： Oliver Räther
IPC分类号： B01D59/44
CPC分类号： H01J49/0077
摘要： Multiply-charged ions are generated from singly-charged ions of analyte substances. The singly-charged ions, which are supplied by many types of ion sources, are accelerated, together with donor ions of substances which have only a very low proton affinity, into a reaction cell. In the reaction cell, protons are transferred from the donor ions to the analyte ions to protonate the analyte ions and increase the ion charge. The multiply-charged analyte ions are subsequently fragmented by a variety of techniques and mass analyzed.
摘要翻译： 多重带电离子由分析物质的单电荷离子产生。 由许多类型的离子源提供的单电荷离子与仅具有非常低的质子亲和性的物质的供体离子一起加速到反应池中。 在反应池中，质子从供体离子转移到分析物离子，以质子化分析物离子并增加离子电荷。 随后通过多种技术碎片分析多倍体分析物离子并进行质量分析。
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4.发明授权Method for operating a time-of-flight mass spectrometer with orthogonal ion pulsing 有权用正交离子脉冲操作飞行时间质谱仪的方法公开(公告)号：US08927928B2
公开(公告)日：2015-01-06
申请号：US13465669
申请日：2012-05-07
申请人： Petra Decker , Oliver Räther
发明人： Petra Decker , Oliver Räther
CPC分类号： H01J49/0031 , H01J49/401
摘要： Methods are provided for acquiring sum spectra in a time-of-flight mass spectrometer with orthogonal pulsed acceleration, where each of the sum spectra is obtained from a plurality of summed individual spectra. The mass spectrometer has an ion storage device that collects the ions temporarily before they are transferred to an ion pulser, which pulses out the ions orthogonally. Acquisition conditions such as, for example, delay times between opening the ion storage device and the pulsed ejection in the ion pulser are varied for the individual spectra, which are added together to form the sum spectrum of ions with light masses and high masses.
摘要翻译： 提供了用于在具有正交脉冲加速度的飞行时间质谱仪中获取总和光谱的方法，其中每个和光谱从多个相加的单个光谱获得。 质谱仪具有离子存储装置，其在离子脉冲发生器转移到离子脉冲发生器之前临时收集离子，从而正交地离子出离子。 对于各个光谱而言，采集条件例如打开离子存储装置之间的延迟时间和在离子脉冲发生器中的脉冲喷射之间是变化的，这些光谱被加在一起以形成具有光质量和高质量的离子的和光谱。
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公开(公告)号：US20100090102A1
公开(公告)日：2010-04-15
申请号：US12548945
申请日：2009-08-27
申请人： Oliver Räther , Gökhan Baykut , Jochen Franzen
发明人： Oliver Räther , Gökhan Baykut , Jochen Franzen
CPC分类号： H01J49/062 , G01N27/622
摘要： Ion mobilities are measured by entraining the ions in a gas and adiabatically expanding the ion-containing gas through a nozzle to form a gas jet. An electrical field barrier with variable height is located at the nozzle exit. The field barrier may be located adjacent to the nozzle exit or an ion guide may be located between the nozzle and the field barrier. If a continuous ion current is supplied, the height of the barrier is varied and the ion current of the ions passing over the barrier is measured, the ion current can be differentiated to generate a mobility spectrum. Alternatively, the ions can be temporarily stored in the ion guide so that measurement of the ion current of the ions passing over the barrier results in a direct measurement of the mobility spectrum.
摘要翻译： 通过夹带气体中的离子并通过喷嘴绝热地使含离子的气体膨胀以形成气体射流来测量离子迁移率。 具有可变高度的电场屏障位于喷嘴出口处。 场屏障可以位于喷嘴出口附近，或者离子引导件可以位于喷嘴和场屏障之间。 如果提供连续的离子电流，则屏障的高度变化，并且测量通过势垒的离子的离子电流，离子电流可以被微分以产生迁移谱。 或者，离子可以临时存储在离子导向器中，使得通过势垒的离子的离子电流的测量导致对迁移谱的直接测量。
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6.发明授权公开(公告)号：US06903332B2
公开(公告)日：2005-06-07
申请号：US10303661
申请日：2002-11-25
申请人： Gerhard Weiss , Carsten Stoermer , Oliver Räther
发明人： Gerhard Weiss , Carsten Stoermer , Oliver Räther
CPC分类号： H01J49/401 , H01J49/06
摘要： The invention relates to the construction and operation of a slit diaphragm pulser for a time-of-flight mass spectrometer with orthogonal injection of the ions to be examined. The invention includes switching three diaphragm potentials during a transition from a filling phase to an acceleration phase in order to maintain a potential along the axis of the injected ion beam at a constant level, to prevent any penetration by the accelerating fields during the filling phase and to obtain extremely high mass resolution in the acceleration phase through a lens effect.
摘要翻译： 本发明涉及正交注射待检离子的飞行时间质谱仪的狭缝隔膜脉冲发生器的结构和操作。 本发明包括在从填充阶段到加速阶段的过渡期间切换三个隔膜电位，以便沿着注入的离子束的轴线保持恒定水平的电位，以防止在填充阶段期间加速场的任何穿透;以及 通过透镜效应在加速阶段获得极高的质量分辨率。
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7.发明申请CALIBRATION FUNCTION FOR TIME-OF-FLIGHT MASS SPECTROMETERS WITH EXTREME MASS ACCURACY 有权具有超大质量精度的飞行时间质谱仪的校准功能公开(公告)号：US20120074303A1
公开(公告)日：2012-03-29
申请号：US13232204
申请日：2011-09-14
申请人： Oliver Räther
发明人： Oliver Räther
CPC分类号： H01J49/40 , H01J49/0009
摘要： A calibration function for time-of-flight mass spectrometers that converts ion times of flight into mass to charge ratios, takes into account not only the time of flight of a specific ionic species, but also the ion signal intensity of that ionic species. Use of the conversion function reduces nonsystematic deviations of the calculated mass values from the true mass values previously experienced in time of flight mass spectrometers.
摘要翻译： 将离子飞行时间转换成质量与电荷比的飞行时间质谱仪的校准功能不仅考虑了特定离子物质的飞行时间，还考虑了该离子物质的离子信号强度。 使用转换函数可以减少计算质量值与飞行时间质谱仪以前经历的真实质量值的非系统偏差。
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公开(公告)号：US07223966B2
公开(公告)日：2007-05-29
申请号：US10316173
申请日：2002-12-10
申请人： Gerhard Weiss , Carsten Stoermer , Oliver Räther
发明人： Gerhard Weiss , Carsten Stoermer , Oliver Räther
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： The invention relates to time-of-flight mass spectrometers, equipped with ion reflector and ion detector, with orthogonal ion injection and outpulsing of a segment of the ion beam perpendicular to the direction of injection in a pulser. The invention is directed to a time-of-flight mass spectrometer in which a reflector and an ion detector each have an angular offset about an axis that is perpendicular to the respective directions of injection and deflection. This allows a large distance to be used between the pulser and detector with the highest possible utilization of ions.
摘要翻译： 本发明涉及配备有离子反射器和离子检测器的飞行时间质谱仪，其具有与脉冲发生器中的注射方向垂直的离子束的正交离子注入和脉冲。 本发明涉及一种飞行时间质谱仪，其中反射器和离子检测器各自具有围绕垂直于各个注射和偏转方向的轴线的角度偏移。 这允许在脉冲发生器和检测器之间使用较大的距离，以最大限度地利用离子。
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公开(公告)号：US06870156B2
公开(公告)日：2005-03-22
申请号：US10366578
申请日：2003-02-13
申请人： Oliver Räther
发明人： Oliver Räther
CPC分类号： H01J49/025 , H01J49/40
摘要： The invention covers a method for detecting ions in high resolution time-of-flight mass spectrometers which operate with secondary electron multiplier multichannel plates and in which many single spectra are acquired and added to produce a sum spectrum. The invention involves (a) using an analog digital converter (ADC) for converting electron currents from secondary electron multipliers, instead of a time-to-digital converter (TDC) which was previously used for highest possible signal resolution, (b) performing a separate rapid peak recognition procedure for the ion signals of each spectrum by a fast calculation method, thereby collecting flight time and intensity value pairs for the ion peaks, and (c) constructing a time-of-flight/intensity histogram, which is further processed as a composite time-of-flight spectrum. The invention retains the significantly higher measurement dynamics of an ADC and achieves the improved resolution capability of a TDC, but without showing the latter's known signal distortion due to dead times.
摘要翻译： 本发明涉及用二次电子倍增器多通道板操作的高分辨率飞行时间质谱仪中的离子检测方法，其中获得并添加许多单个光谱以产生和光谱。 本发明涉及（a）使用用于转换来自二次电子倍增器的电子电流的模拟数字转换器（ADC）而不是先前用于最高可能信号分辨率的时间 - 数字转换器（TDC），（b）执行 通过快速计算方法对每个光谱的离子信号进行单独的快速峰识别程序，从而收集离子峰的飞行时间和强度值对，（c）构建飞行时间/强度直方图，进一步处理 作为复合飞行时间谱。 本发明保留了ADC的显着更高的测量动态，并且实现了TDC的改进的分辨率能力，但是没有显示后者由于死时间而已知的信号失真。
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10.发明授权Calibration function for time-of-flight mass spectrometers with extreme mass accuracy 有权具有极高质量精度的飞行时间质谱仪的校准功能公开(公告)号：US08581183B2
公开(公告)日：2013-11-12
申请号：US13232204
申请日：2011-09-14
申请人： Oliver Räther
发明人： Oliver Räther
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/0009
摘要： A calibration function for time-of-flight mass spectrometers that converts ion times of flight into mass to charge ratios, takes into account not only the time of flight of a specific ionic species, but also the ion signal intensity of that ionic species. Use of the conversion function reduces nonsystematic deviations of the calculated mass values from the true mass values previously experienced in time of flight mass spectrometers.
摘要翻译： 将离子飞行时间转换成质量与电荷比的飞行时间质谱仪的校准功能不仅考虑了特定离子物质的飞行时间，还考虑了该离子物质的离子信号强度。 使用转换函数可以减少计算质量值与飞行时间质谱仪以前经历的真实质量值的非系统偏差。
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