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公开(公告)号：US08575318B2
公开(公告)日：2013-11-05
申请号：US13589652
申请日：2012-08-20
申请人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US20080108565A1
公开(公告)日：2008-05-08
申请号：US11757059
申请日：2007-06-01
申请人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US20110236377A1
公开(公告)日：2011-09-29
申请号：US13051474
申请日：2011-03-18
申请人： May Han , S. Kirk Wright , William M. Winston, JR. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Kirk Wright , William M. Winston, JR. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
IPC分类号： A61K39/395 , C12N5/02 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US20110229462A1
公开(公告)日：2011-09-22
申请号：US13051481
申请日：2011-03-18
申请人： William M. Winston, JR. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, JR. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
IPC分类号： A61K39/395 , A61P35/00 , C12N5/09
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US08273355B2
公开(公告)日：2012-09-25
申请号：US13051481
申请日：2011-03-18
申请人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US08268315B2
公开(公告)日：2012-09-18
申请号：US13051474
申请日：2011-03-18
申请人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US07659378B2
公开(公告)日：2010-02-09
申请号：US11757094
申请日：2007-06-01
申请人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US08580930B2
公开(公告)日：2013-11-12
申请号：US13589664
申请日：2012-08-20
申请人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US07943344B2
公开(公告)日：2011-05-17
申请号：US12632765
申请日：2009-12-07
申请人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US07935502B2
公开(公告)日：2011-05-03
申请号：US12632758
申请日：2009-12-07
申请人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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