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公开(公告)号：US20110236377A1
公开(公告)日：2011-09-29
申请号：US13051474
申请日：2011-03-18
Applicant: May Han , S. Kirk Wright , William M. Winston, JR. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
Inventor： May Han , S. Kirk Wright , William M. Winston, JR. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
IPC: A61K39/395 , C12N5/02 , A61P35/00
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
Abstract translation: 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US20110229462A1
公开(公告)日：2011-09-22
申请号：US13051481
申请日：2011-03-18
Applicant: William M. Winston, JR. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
Inventor： William M. Winston, JR. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
IPC: A61K39/395 , A61P35/00 , C12N5/09
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US20080038257A1
公开(公告)日：2008-02-14
申请号：US11757094
申请日：2007-06-01
Applicant: May Han , S. Wright , William Winston , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
Inventor： May Han , S. Wright , William Winston , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
Abstract translation: 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US08575318B2
公开(公告)日：2013-11-05
申请号：US13589652
申请日：2012-08-20
Applicant: May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
Inventor： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
Abstract translation: 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US20100173362A1
公开(公告)日：2010-07-08
申请号：US12632765
申请日：2009-12-07
Applicant: WILLIAM M. WINSTON, JR. , S. KIRK WRIGHT , MAY HAN , LYNE BREAULT , JIE LIN , BIJAN ETEMAD-GILBERTSON , CHRISTINE KNUEHL , JENO GYURIS , ARNOLD HORWITZ
Inventor： WILLIAM M. WINSTON, JR. , S. KIRK WRIGHT , MAY HAN , LYNE BREAULT , JIE LIN , BIJAN ETEMAD-GILBERTSON , CHRISTINE KNUEHL , JENO GYURIS , ARNOLD HORWITZ
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
Abstract translation: 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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Patent Agency Ranking
公开(公告)号：US20090175875A1
公开(公告)日：2009-07-09
申请号：US12263909
申请日：2008-11-03
Applicant: Bijan ETEMAD-GILBERTSON , Braydon Charles Guild , Mark Taylor Keating , Yong-In Kim , Lloyd B. Klickstein , Dmitri Mikhailov , Mariusz Milik , Michael Roguska , Igor Splawski , Kehao Zhao
Inventor： Bijan ETEMAD-GILBERTSON , Braydon Charles Guild , Mark Taylor Keating , Yong-In Kim , Lloyd B. Klickstein , Dmitri Mikhailov , Mariusz Milik , Michael Roguska , Igor Splawski , Kehao Zhao
IPC: A61K39/395 , C07K16/00 , A61P27/02
CPC classification number: C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/92
Abstract: Compositions that bind to C3b epitopes and methods of using the compositions are described herein.
Abstract translation: 本文描述了结合C3b表位的组合物和使用组合物的方法。
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公开(公告)号：US20080108565A1
公开(公告)日：2008-05-08
申请号：US11757059
申请日：2007-06-01
Applicant: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
Inventor： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US08580930B2
公开(公告)日：2013-11-12
申请号：US13589664
申请日：2012-08-20
Applicant: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
Inventor： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US07943344B2
公开(公告)日：2011-05-17
申请号：US12632765
申请日：2009-12-07
Applicant: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
Inventor： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
Abstract translation: 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US07935502B2
公开(公告)日：2011-05-03
申请号：US12632758
申请日：2009-12-07
Applicant: May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
Inventor： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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