公开(公告)号：US20250044307A1

公开(公告)日：2025-02-06

申请号：US18713411

申请日：2022-11-25

Applicant: McMaster University

Inventor： Peter Kavsak ,  Lorna Clark

IPC: G01N33/96

Abstract: A method for the preparation of a cardiac troponin quality control sample of a mammal to determine the accuracy and/or precision of a cardiac troponin assay over time is provided. The method comprises the steps of: i) preparing a cardiac troponin concentrate from a pool of biological samples obtained from a population of the mammal having a troponin concentration of greater than 75% of an upper analytical limit of the assay; ii) obtaining a cardiac troponin base material comprising whole blood, plasma or serum of the mammal which is interference-free and disease-free; and iii) combining a quantity of the troponin concentrate with the base material to yield a quality control sample having a target concentration. Quality control samples may be provided in kits which provide a set of samples having particular concentrations which essentially correspond with lower detectable limits of an assay, upper limits of normal, as well as concentrations which define risk stratification cutoffs and other diagnostic cutoffs.

公开(公告)号：US20180252724A1

公开(公告)日：2018-09-06

申请号：US15756274

申请日：2016-08-26

Applicant: McMaster University

Inventor： Peter Kavsak ,  Andrew Worster

IPC: G01N33/66 ,  G01N33/72 ,  G01N33/70

CPC classification number: G01N33/66 ,  G01N33/6887 ,  G01N33/70 ,  G01N33/723 ,  G01N33/80 ,  G01N33/92 ,  G01N2333/4712 ,  G01N2333/58 ,  G01N2333/8139 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/56

Abstract: Methods of determining the risk of an adverse cardiovascular event or death in a mammal are provided which include determining in a biological sample obtained from the mammal the level of a combination of biomarkers selected from a glucose metabolism biomarker, a heart function biomarker, a renal function biomarker and at least one biomarker of cardiac injury. A score is allotted based on the level of each biomarker, and the cumulative score is indicative of the risk of an adverse cardiovascular event.

公开(公告)号：US20170248611A1

公开(公告)日：2017-08-31

申请号：US15459463

申请日：2017-03-15

Applicant: MCMASTER UNIVERSITY ,  Yale University

Inventor： Peter Kavsak ,  Richard Whitlock ,  John Eikelboom ,  Chirag R. Parikh

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6869 ,  G01N2333/47 ,  G01N2333/5412 ,  G01N2333/5428 ,  G01N2800/347 ,  G01N2800/50

Abstract: A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of IL-6 or hFABP concentration, or the ratio of IL-6 to IL-10, in a biological sample from the mammal, either prior to cardiac surgery or within 6 hours following surgery; comparing the sample value to a corresponding reference value; and determining that the mammal is at risk of acute kidney injury following cardiac surgery if the sample value is greater than the corresponding reference value.

公开(公告)号：US11789028B2

公开(公告)日：2023-10-17

申请号：US15459463

申请日：2017-03-15

Applicant: MCMASTER UNIVERSITY ,  Yale University

Inventor： Peter Kavsak ,  Richard Whitlock ,  John Eikelboom ,  Chirag R. Parikh

IPC: G01N33/68 ,  C12Q1/6883

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  G01N33/6869 ,  C12Q2600/158 ,  G01N2333/47 ,  G01N2333/5412 ,  G01N2333/5428 ,  G01N2800/347 ,  G01N2800/50

Abstract: A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of IL-6 or hFABP concentration, or the ratio of IL-6 to IL-10, in a biological sample from the mammal, either prior to cardiac surgery or within 6 hours following surgery; comparing the sample value to a corresponding reference value; and determining that the mammal is at risk of acute kidney injury following cardiac surgery if the sample value is greater than the corresponding reference value.