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公开(公告)号：US10775388B2
公开(公告)日：2020-09-15
申请号：US15106223
申请日：2015-02-05
Applicant: MEDIMMUNE, LLC , ABBOTT LABORATORIES
Inventor： Partha S. Chowdhury , Reena Varkey , Meina Liang , Yen-Wah Lee , Katie Streicher , Koustubh Ranade , Ethan Grant , Lydia Greenlees , Yihong Yao , Melissa Parker , Gerard Davis , Nicolette Jeanblanc , Susan Brophy , Bruce Dille
IPC: G01N33/68 , C07K16/18 , A61P11/06 , A61P17/00 , A61P11/00 , A61K9/00 , A61K31/137 , A61K31/56 , A61K31/58 , A61K39/395 , C07K16/24 , C07K16/28 , A61K39/00
Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.
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公开(公告)号：US20140363429A1
公开(公告)日：2014-12-11
申请号：US14359864
申请日：2012-11-20
Applicant: MedImmune LLC
Inventor： Partha S. Chowdhury , David Tice , Zhan Xiao , Philipp Steiner , Krista Kinneer , Marlon Rebelatto
IPC: A61K39/395 , A61K45/06 , G01N33/574 , C07K16/28
CPC classification number: C07K16/2863 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , A61K2300/00
Abstract: The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
Abstract translation: 本发明涉及结合HER3受体的细胞外结构域的抗体及其抗原结合片段，并通过配体依赖性和/或配体非依赖性机制抑制各种HER3受体相关功能。 还提供了具有增加的半衰期的组合物。 此外，本发明提供用于诊断和治疗与HER3介导的信号转导相关的疾病的组合物和方法。
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公开(公告)号：US11447543B2
公开(公告)日：2022-09-20
申请号：US16925129
申请日：2020-07-09
Applicant: MedImmune, LLC
Inventor： Bret Sellman , Christine Tkaczyk , Partha S. Chowdhury , Lei Hua , Peter Pavlik , Rebecca Buonpane , Chew-Shun Chang
IPC: C07K16/12 , A61K39/40 , A61K45/06 , G01N33/569 , A61K39/00
Abstract: Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.
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公开(公告)号：US10040857B2
公开(公告)日：2018-08-07
申请号：US14947865
申请日：2015-11-20
Applicant: MedImmune, LLC
Inventor： Partha S. Chowdhury , David Tice , Zhan Xiao , Philipp Steiner , Krista Kinneer , Marlon Rebelatto
IPC: C07K16/32 , C07K16/28 , A61K39/395 , A61K45/06 , G01N33/574 , C07K16/30 , C07K16/40 , A61K39/00
Abstract: The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
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公开(公告)号：US20150291685A1
公开(公告)日：2015-10-15
申请号：US14440748
申请日：2013-11-06
Applicant: MEDIMMUNE, LLC
Inventor： Bret Sellman , Christine Tkaczyk , Partha S. Chowdhury , Lei Hua , Peter Pavlik , Rebecca Buonpane , Chew-Shun Chang
IPC: C07K16/12 , A61K45/06 , G01N33/569 , A61K39/40
CPC classification number: C07K16/1271 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/56938
Abstract: Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.
Abstract translation: 公开了针对金黄色葡萄球菌（金黄色葡萄球菌）表面决定簇抗原和分泌毒素的抗体及其抗原结合片段。 还提供了使用抗体及其抗原结合片段检测，诊断和处理金黄色葡萄球菌的方法。
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Patent Agency Ranking
公开(公告)号：US20140348839A1
公开(公告)日：2014-11-27
申请号：US14366582
申请日：2012-12-18
Applicant: MedImmune, LLC
Inventor： Partha S. Chowdhury , Vaheh Oganesyan , Yariv Mazor , Nazzareno Dimasi
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K16/248 , C07K16/2863 , C07K16/30 , C07K16/32 , C07K2317/31 , C07K2317/526 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The technology relates in part to engineered antibodies. In particular, multispecific engineered antibodies. Such antibodies can be utilized for diagnostic and therapeutic applications in some aspects.
Abstract translation: 该技术部分涉及工程抗体。 特别是多特异性工程化抗体。 这些抗体可用于某些方面的诊断和治疗应用。
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公开(公告)号：US10730934B2
公开(公告)日：2020-08-04
申请号：US15880157
申请日：2018-01-25
Applicant: MEDIMMUNE, LLC
Inventor： Bret Sellman , Christine Tkaczyk , Partha S. Chowdhury , Lei Hua , Peter Pavlik , Rebecca Buonpane , Chew-Shun Chang
IPC: C07K16/12 , G01N33/569 , A61K39/40 , A61K45/06 , A61K39/00
Abstract: Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.
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公开(公告)号：US20190040143A1
公开(公告)日：2019-02-07
申请号：US16024391
申请日：2018-06-29
Applicant: MedImmune, LLC
Inventor： Partha S. Chowdhury , David Tice , Zhan Xiao , Philipp Steiner , Krista Kinneer , Marlon Rebelatto
IPC: C07K16/28 , A61K45/06 , A61K39/395 , G01N33/574 , C07K16/30 , C07K16/40 , C07K16/32 , A61K39/00
Abstract: The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
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公开(公告)号：US09527927B2
公开(公告)日：2016-12-27
申请号：US14366582
申请日：2012-12-18
Applicant: MedImmune, LLC
Inventor： Partha S. Chowdhury , Vaheh Oganesyan , Yariv Mazor , Nazzareno Dimasi
CPC classification number: C07K16/468 , C07K16/248 , C07K16/2863 , C07K16/30 , C07K16/32 , C07K2317/31 , C07K2317/526 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The technology relates in part to engineered antibodies. In particular, multispecific engineered antibodies. Such antibodies can be utilized for diagnostic and therapeutic applications in some aspects.
Abstract translation: 该技术部分涉及工程抗体。 特别是多特异性工程化抗体。 这些抗体可用于某些方面的诊断和治疗应用。
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公开(公告)号：US11305012B2
公开(公告)日：2022-04-19
申请号：US15023858
申请日：2014-09-23
Applicant: MedImmune, LLC
Inventor： Partha S. Chowdhury , David Tice , Zhan Xiao , Philipp Steiner , Krista Kinneer , Marlon Rebelatto , Andrew Pierce
Abstract: Provided herein are antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life, as well as compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
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