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公开(公告)号：US11122979B2
公开(公告)日：2021-09-21
申请号：US16289529
申请日：2019-02-28
申请人： MediBeacon Inc.
发明人： Ralf Heinrich , Johannes Pill , Sabine Neudecker , Daniel Schock-Kusch , Juergen Guenther , Stefan Koenig , Jochen Friedemann
IPC分类号： A61B5/00 , A61B5/20 , A61B5/1455
摘要： The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.
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公开(公告)号：US20180125407A1
公开(公告)日：2018-05-10
申请号：US15861299
申请日：2018-01-03
申请人： MediBeacon Inc.
发明人： Norbert Gretz , Johannes Pill , Daniel Schock-Kusch , Thomas Walter , Jürgen Hesser , Maliha Sadick , Felix Eickemeyer , Jae Hyung Hwang , Christian Schildknecht , Soichi Watanabe , Wolfgang Wach , Thomas Rose
IPC分类号： A61B5/20 , A61K49/00 , A61B5/00 , A61B5/1455 , A61B5/145
CPC分类号： A61B5/201 , A61B5/0002 , A61B5/0071 , A61B5/0082 , A61B5/145 , A61B5/14546 , A61B5/1455 , A61B5/6833 , A61B5/68335 , A61B90/39 , A61B2090/3941 , A61B2560/0219 , A61B2560/0412 , A61K49/0043 , G01N33/582 , G01N2800/065 , G01N2800/28 , G01N2800/347
摘要： A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.
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公开(公告)号：US20220022753A1
公开(公告)日：2022-01-27
申请号：US17401866
申请日：2021-08-13
申请人： MediBeacon Inc.
发明人： Ralf Heinrich , Johannes Pill , Sabine Neudecker , Daniel Schock-Kusch , Juergen Guenther , Stefan Koenig , Jochen Friedemann
IPC分类号： A61B5/00 , A61B5/20 , A61B5/1455
摘要： The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.
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公开(公告)号：US10765354B2
公开(公告)日：2020-09-08
申请号：US15267657
申请日：2016-09-16
申请人： MEDIBEACON INC.
发明人： Norbert Gretz , Johannes Pill , Daniel Schock-Kusch , Thomas Walter , Jürgen Hesser , Maliha Sadick , Felix Eickemeyer , Jae Hyung Hwang , Christian Schildknecht , Soichi Watanabe , Wolfgang Wach , Thomas Rose
摘要： A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.
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公开(公告)号：US20230132361A9
公开(公告)日：2023-04-27
申请号：US17401866
申请日：2021-08-13
申请人： MediBeacon Inc.
发明人： Ralf Heinrich , Johannes Pill , Sabine Neudecker , Daniel Schock-Kusch , Juergen Guenther , Stefan Koenig , Jochen Friedemann
IPC分类号： A61B5/00 , A61B5/20 , A61B5/1455
摘要： The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.
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公开(公告)号：US12036022B2
公开(公告)日：2024-07-16
申请号：US16995375
申请日：2020-08-17
申请人： MediBeacon Inc.
发明人： Norbert Gretz , Johannes Pill , Daniel Schock-Kusch , Thomas Walter , Jürgen Hesser , Maliha Sadick , Felix Eickemeyer , Jae Hyung Hwang , Christian Schildknecht , Soichi Watanabe , Wolfgang Wach , Thomas Rose
CPC分类号： A61B5/201 , A61B5/0071 , A61B5/0082 , A61B5/145 , A61B5/14546 , A61B5/1455 , A61B5/6833 , A61B5/68335 , A61B90/39 , A61K49/0043 , G01N33/582 , A61B5/0002 , A61B2090/3941 , A61B2560/0219 , A61B2560/0412 , G01N2800/065 , G01N2800/28 , G01N2800/347
摘要： A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.
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公开(公告)号：US20210052207A1
公开(公告)日：2021-02-25
申请号：US16995375
申请日：2020-08-17
申请人： MediBeacon Inc.
发明人： Norbert Gretz , Johannes Pill , Daniel Schock-Kusch , Thomas Walter , Jürgen Hesser , Maliha Sadick , Felix Eickemeyer , Jae Hyung Hwang , Christian Schildknecht , Soichi Watanabe , Wolfgang Wach , Thomas Rose
摘要： A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.
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公开(公告)号：US20190261862A1
公开(公告)日：2019-08-29
申请号：US16289529
申请日：2019-02-28
申请人： MediBeacon Inc.
发明人： Ralf Heinrich , Johannes Pill , Sabine Neudecker , Daniel Schock-Kusch , Juergen Guenther , Stefan Koenig , Jochen Friedemann
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/20
摘要： The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.
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公开(公告)号：US10264977B2
公开(公告)日：2019-04-23
申请号：US15030727
申请日：2014-10-20
申请人： MediBeacon, Inc.
发明人： Ralf Heinrich , Johannes Pill , Sabine Neudecker , Daniel Schock-Kusch , Juergen Guenther , Stefan Koenig , Jochen Friedmann
IPC分类号： A61B5/00 , A61B5/20 , A61B5/1455
摘要： Disclosed herein is a method for the transcutaneous determination of organ function in a subject. The method includes administering a fluorescent indicator substance to the subject, determining a first and a second concentration-time curve of the fluorescent indicator in a body fluid of the patient and fitting the concentration-time curves to a four compartment kinetic model.
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