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公开(公告)号:US20210121069A1
公开(公告)日:2021-04-29
申请号:US17084056
申请日:2020-10-29
Applicant: Medlumics S.L.
Abstract: A medical instrument is described that includes an optical source, an optical fiber, and a waveguide patterned upon a substrate. The optical fiber receives radiation from the optical source and includes a first segment and a second segment. The second segment is rotated about an optical axis relative to the first segment. The waveguide receives radiation from the optical source and guides a beam of radiation. The waveguide includes a first waveguide segment designed to impart a first differential group delay on the beam of radiation and a second waveguide segment designed to impart a second differential group delay on the beam of radiation. A sum of the first differential group delay and the second differential group delay is substantially zero.
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公开(公告)号:US20220280235A1
公开(公告)日:2022-09-08
申请号:US17686873
申请日:2022-03-04
Applicant: Medlumics S.L.
Inventor: Sara Mas GÓMEZ , Juan Sancho DÚRA , David GONZÁLES , Matthieu DUPERRON , Moreno Carlos SANZ , Alexandre ROMOSCANU , Jorge H. JIMÉNEZ
IPC: A61B18/24
Abstract: A catheter includes proximal and distal sections, a shaft coupled between the proximal and distal sections, and optical fibers extending through the shaft and to the distal section of the catheter. The distal section includes a support structure that includes a proximal end, a distal end, reflective elements, and a cap disposed over a portion of the distal end of the support structure. The proximal end includes alignment receptacles. Each of the optical fibers is inserted into corresponding ones of the alignment receptacles and the alignment receptacles are shaped to maintain the optical fibers straight in the support structure. The distal end includes orifices facing different directions. Each of the optical fibers is optically aligned with corresponding ones of the lenses, reflective elements, and orifices such that the optical fibers in the support structure are straight. The cap includes optical ports aligned with the orifices.
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公开(公告)号:US20230029805A1
公开(公告)日:2023-02-02
申请号:US17746798
申请日:2022-05-17
Applicant: Medlumics S.L.
Inventor: Juan SANCHO DURÁ , Sara MAS GÒMEZ , David GONZALEZ , Matthieu DUPERRON , Carlos SANZ MORENO , Jorge JIMENEZ , Alexandre ROMOSCANU
Abstract: Described herein are methods, devices, and support structures for assembling optical fibers in catheter tips and facilitating alignment and structural support. A method for assembling a plurality of optical fibers and lenses in a support structure for an ablation catheter includes providing a support structure with a proximal end, a body, and a distal end, the distal end including a plurality of alignment orifices or slits. A plurality of optical fibers are threaded through the alignment orifices or slits, such that each optical fiber is threaded through a corresponding alignment orifice or slit. An adhesive material is applied at each alignment orifice or slit to secure the optical fibers, and the plurality of optical fibers are then cleaved at the distal end to remove portions of the fibers extending out of the distal end. Finally, a lens is attached to each of the ends of the plurality of optical fibers.
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公开(公告)号:US20210212755A1
公开(公告)日:2021-07-15
申请号:US17148506
申请日:2021-01-13
Applicant: Medlumics S.L.
Inventor: Jorge JIMENEZ , David HERRANZ , James GREENE , Michael NAGY , Tyler PANIAN , Juan SANCHO , Matthieu DUPERRON
Abstract: Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.
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公开(公告)号:US20190192005A1
公开(公告)日:2019-06-27
申请号:US16222284
申请日:2018-12-17
Applicant: Medlumics S.L.
Abstract: A medical instrument is described that includes an optical source, an optical fiber, and a waveguide patterned upon a substrate. The optical fiber receives radiation from the optical source and includes a first segment and a second segment. The second segment is rotated about an optical axis relative to the first segment. The waveguide receives radiation from the optical source and guides a beam of radiation. The waveguide includes a first waveguide segment designed to impart a first differential group delay on the beam of radiation and a second waveguide segment designed to impart a second differential group delay on the beam of radiation. A sum of the first differential group delay and the second differential group delay is substantially zero.
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公开(公告)号:US20240240931A1
公开(公告)日:2024-07-18
申请号:US18391297
申请日:2023-12-20
Applicant: Medlumics S.L.
Inventor: Matthieu DUPERRON , Juan SANCHO , Abel ROIGÉ , Sara MAS
IPC: G01B9/02091 , A61B17/00 , A61B18/00 , A61B18/20 , A61B90/00 , G01B9/02 , G01B9/02001
CPC classification number: G01B9/02091 , A61B18/20 , G01B9/02007 , G01B9/02083 , A61B2017/00057 , A61B2018/00577 , A61B2018/00904 , A61B2090/3735
Abstract: Described herein are systems and methods for optical coherence tomography with a centimetric range of scan depth and a high tolerance of a precision of lengths among different optical components. A system includes a long coherent light source, an optical interferometer with multiple optical components, an optical detector with a wide bandwidth, a data acquisition unit with high sampling rate, and a data processing unit to process information of interest.
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公开(公告)号:US20240207013A1
公开(公告)日:2024-06-27
申请号:US18392268
申请日:2023-12-21
Applicant: Medlumics S.L.
Inventor: Juan SANCHO DURÁ , David HERRANZ ARAGONCILLO , Christopher BAILLEUL , James L. GREENE , Matthieu DUPERRON , Abel ROIGÉ
IPC: A61B90/00
CPC classification number: A61B90/37 , A61B2090/373
Abstract: Described herein are systems and methods for performing optical signal analysis for tissue ablation using a catheter having viewports. A method includes transmitting illumination toward a target tissue via the viewport. The method also includes receiving, at a first viewport, a first scattered illumination from the target tissue and generating a first measurement signal based on the first scattered illumination. The method also includes receiving, at the first viewport, a second scattered illumination from the target tissue after the receiving of the first scattered illumination and generating a second measurement signal based on the second scattered illumination. The method also includes determining whether the viewport is in contact with the target tissue based on a first difference among the plurality of optical measurements meeting or crossing a first threshold value, wherein the first difference comprises a difference between the first and second measurement signals.
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8.
公开(公告)号:US20230320592A1
公开(公告)日:2023-10-12
申请号:US18079667
申请日:2022-12-12
Applicant: Medlumics S.L.
Inventor: Juan SANCHO DURÁ , Sara MAS GÓMEZ , David GONZALEZ , Matthieu DUPERRON , Carlos SANZ MORENO , Jorge JIMENEZ , Alexandre ROMOSCANU , David HERRANZ ARAGONCILLO
CPC classification number: A61B5/0084 , A61B5/0066 , A61B18/02 , A61B18/1492 , A61B18/20 , A61B18/24 , A61B2090/309
Abstract: Described herein are systems and methods for performing optical signal analysis and lesion predictions in ablations. A system includes a catheter coupled to a plurality of optical fibers via a connector that interfaces with a computing device. The computing device includes a memory and a processor configured to receive optical measurement data of a portion of tissue from the catheter. The processor identifies one or more optical properties of the portion of tissue by analyzing the optical measurement data and determines a time of denaturation of the portion of tissue based on the one or more optical properties. A model is created to represent a correlation between lesion depths and ablation times using the time of denaturation, the one or more optical properties, and the predetermined period of time. A predicted lesion depth for a predetermined ablation time is generated using the model.
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公开(公告)号:US20210212569A1
公开(公告)日:2021-07-15
申请号:US17148480
申请日:2021-01-13
Applicant: Medlumics S.L.
Inventor: Juan SANCHO DURÁ , Sara MAS GÓMEZ , David GONZALEZ , Matthieu DUPERRON , Carlos SANZ MORENO , Jorge JIMENEZ , Alexandre ROMOSCANU
Abstract: Described herein are systems and methods for performing optical signal analysis and lesion predictions in ablations. A system includes a catheter coupled to a plurality of optical fibers via a connector that interfaces with a computing device. The computing device includes a memory and a processor configured to receive optical measurement data of a portion of tissue from the catheter. The processor identifies one or more optical properties of the portion of tissue by analyzing the optical measurement data and determines a time of denaturation of the portion of tissue based on the one or more optical properties. A model is created to represent a correlation between lesion depths and ablation times using the time of denaturation, the one or more optical properties, and the predetermined period of time. A predicted lesion depth for a predetermined ablation time is generated using the model.
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