公开(公告)号：US09072602B2

公开(公告)日：2015-07-07

申请号：US13676286

申请日：2012-11-14

Applicant: Medtronic, Inc.

Inventor： Daniel Glozman ,  Igor Kovalsky ,  Jason Quill

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2220/0075 ,  A61F2230/0023 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008

Abstract: A transcatheter valve prosthesis includes a self-expanding tubular stent component and a prosthetic valve disposed within and secured to the stent component. The tubular stent component has a proximal portion, a distal portion, and an intermediate portion between the proximal and distal portions. In a compressed delivery configuration, the tubular stent component has a generally circular cross-section along its length. In an expanded deployed configuration, the proximal and distal portions have a generally circular cross-section while the intermediate portion of the stent component has a generally triangular cross-section with three vertexes that are configured to project into three commissural points of a native valve when the valve prosthesis is implanted in situ. The generally triangular transverse cross-section of the valve prosthesis is formed by pulling or extending selected or particular struts of the stent component radially outwards and then applying heat to heat-set the stent component in the deployed configuration.

Abstract translation: 经导管瓣膜假体包括自扩张管状支架部件和布置在支架部件内并固定到支架部件上的人工瓣膜。 管状支架部件具有近端部分，远端部分和近端部分和远端部分之间的中间部分。 在压缩输送配置中，管状支架部件沿其长度具有大致圆形的横截面。 在扩展展开的构造中，近端部分和远端部分具有大致圆形的横截面，而支架部件的中间部分具有大致三角形的横截面，其中三个顶点被配置成投影到天然瓣膜的三个连合点， 瓣膜假体植入原位。 瓣膜假体的大致三角形的横截面通过将支架部件的选定的或特定的支柱径向向外拉动或延伸，然后施加热量以将展开部件热固定在展开构造中而形成。

公开(公告)号：US20140135908A1

公开(公告)日：2014-05-15

申请号：US13676286

申请日：2012-11-14

Applicant: MEDTRONIC, INC.

Inventor： Daniel Glozman ,  Igor Kovalsky ,  Jason Quill

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2220/0075 ,  A61F2230/0023 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008

Abstract: A transcatheter valve prosthesis includes a self-expanding tubular stent component and a prosthetic valve disposed within and secured to the stent component. The tubular stent component has a proximal portion, a distal portion, and an intermediate portion between the proximal and distal portions. In a compressed delivery configuration, the tubular stent component has a generally circular cross-section along its length. In an expanded deployed configuration, the proximal and distal portions have a generally circular cross-section while the intermediate portion of the stent component has a generally triangular cross-section with three vertexes that are configured to project into three commissural points of a native valve when the valve prosthesis is implanted in situ. The generally triangular transverse cross-section of the valve prosthesis is formed by pulling or extending selected or particular struts of the stent component radially outwards and then applying heat to heat-set the stent component in the deployed configuration.

Abstract translation: 经导管瓣膜假体包括自扩张管状支架部件和布置在支架部件内并固定到支架部件上的人工瓣膜。 管状支架部件具有近端部分，远端部分和近端部分和远端部分之间的中间部分。 在压缩输送配置中，管状支架部件沿其长度具有大致圆形的横截面。 在扩展展开的构造中，近端部分和远端部分具有大致圆形的横截面，而支架部件的中间部分具有大致三角形的横截面，其中三个顶点被配置成投影到天然瓣膜的三个连合点， 瓣膜假体植入原位。 瓣膜假体的大致三角形的横截面通过将支架部件的选定的或特定的支柱径向向外拉动或延伸，然后施加热量以将展开部件热固定在展开构造中而形成。

公开(公告)号：US20180110620A1

公开(公告)日：2018-04-26

申请号：US15831588

申请日：2017-12-05

Applicant: Medtronic, Inc.

Inventor： Igor Kovalsky ,  Jason Quill ,  Daniel Glozman ,  Ilia Hariton ,  Yossi Tuval ,  Nadav Yellin

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2230/001 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008

Abstract: In some embodiments, a valve prosthesis includes an inlet portion that is substantially s-shaped and configured to engage the floor of the outflow tract of the native heart atrium. In some embodiments, a valve prosthesis includes a chordae guiding element configured to reduce bending of the chordae to reduce stress on the chordae during the cardiac cycle. In some embodiments, a valve prosthesis includes a central portion having an hourglass shape configured to pinch a native annulus in order to provide axial fixation of the valve prosthesis within a valve site. In some embodiments, a valve prosthesis includes a frame having an outflow end that is flared to provide a gap between an outflow end of the frame and an outflow end of prosthetic leaflets when the prosthetic leaflets are fully opened.

公开(公告)号：US09867698B2

公开(公告)日：2018-01-16

申请号：US14962824

申请日：2015-12-08

Applicant: Medtronic, Inc.

Inventor： Igor Kovalsky ,  Jason Quill ,  Daniel Glozman ,  Illia Hariton ,  Yossi Tuval ,  Nadav Yellin

IPC: A61F2/06 ,  A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2230/001 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008

Abstract: In some embodiments, a valve prosthesis includes an inlet portion that is substantially s-shaped and configured to engage the floor of the outflow tract of the native heart atrium. In some embodiments, a valve prosthesis includes a chordae guiding element configured to reduce bending of the chordae to reduce stress on the chordae during the cardiac cycle. In some embodiments, a valve prosthesis includes a central portion having an hourglass shape configured to pinch a native annulus in order to provide axial fixation of the valve prosthesis within a valve site. In some embodiments, a valve prosthesis includes a frame having an outflow end that is flared to provide a gap between an outflow end of the frame and an outflow end of prosthetic leaflets when the prosthetic leaflets are fully opened.

公开(公告)号：US20160089236A1

公开(公告)日：2016-03-31

申请号：US14962824

申请日：2015-12-08

Applicant: Medtronic, Inc.

Inventor： Igor Kovalsky ,  Jason Quill ,  Daniel Glozman ,  Illia Hariton ,  Yossi Tuval ,  Nadav Yellin

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2230/001 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008

Abstract: In some embodiments, a valve prosthesis includes an inlet portion that is substantially s-shaped and configured to engage the floor of the outflow tract of the native heart atrium. In some embodiments, a valve prosthesis includes a chordae guiding element configured to reduce bending of the chordae to reduce stress on the chordae during the cardiac cycle. In some embodiments, a valve prosthesis includes a central portion having an hourglass shape configured to pinch a native annulus in order to provide axial fixation of the valve prosthesis within a valve site. In some embodiments, a valve prosthesis includes a frame having an outflow end that is flared to provide a gap between an outflow end of the frame and an outflow end of prosthetic leaflets when the prosthetic leaflets are fully opened.

Abstract translation: 在一些实施例中，瓣膜假体包括入口部分，其基本上为S形并且构造成接合天然心脏心房的流出道的底部。 在一些实施例中，瓣膜假体包括腱索引导元件，其被配置为减少腱索的弯曲以减少在心脏周期期间腱索上的应力。 在一些实施例中，瓣膜假体包括具有沙漏形状的中心部分，其构造成夹住天然环带，以便在瓣膜部位内提供瓣膜假体的轴向固定。 在一些实施例中，瓣膜假体包括具有流出端的框架，所述流出端在所述假体叶片完全打开时，所述流出端被展开以在所述框架的流出端和假体叶片的流出端之间提供间隙。

公开(公告)号：US11833038B2

公开(公告)日：2023-12-05

申请号：US17093773

申请日：2020-11-10

Applicant: MEDTRONIC, INC.

Inventor： Igor Kovalsky ,  Jason Quill ,  Daniel Glozman ,  Ilia Hariton ,  Yossi Tuval ,  Nadav Yellin

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2230/001 ,  A61F2230/005 ,  A61F2230/008 ,  A61F2230/0054 ,  A61F2230/0078

Abstract: In some embodiments, a valve prosthesis includes an inlet portion that is substantially s-shaped and configured to engage the floor of the outflow tract of the native heart atrium. In some embodiments, a valve prosthesis includes a chordae guiding element configured to reduce bending of the chordae to reduce stress on the chordae during the cardiac cycle. In some embodiments, a valve prosthesis includes a central portion having an hourglass shape configured to pinch a native annulus in order to provide axial fixation of the valve prosthesis within a valve site. In some embodiments, a valve prosthesis includes a frame having an outflow end that is flared to provide a gap between an outflow end of the frame and an outflow end of prosthetic leaflets when the prosthetic leaflets are fully opened.

公开(公告)号：US20140222142A1

公开(公告)日：2014-08-07

申请号：US14175100

申请日：2014-02-07

Applicant: Medtronic, Inc.

Inventor： Igor Kovalsky ,  Cathleen Bergin ,  Marian Creaven ,  Joshua Dwork ,  Kshitija Garde ,  Daniel Glozman ,  Ilia Hariton ,  Pham Lo ,  Jason Quill ,  Jeffrey Sandstrom ,  Padraig Savage ,  Michael Schendel ,  Elizabeth Schotzko ,  Yossi Tuval ,  Nadav Yellin

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2457 ,  A61F2210/0004 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0036 ,  A61F2250/0071

Abstract: Heart valve prosthesis are disclosed that include a frame or support structure having an inflow portion, a valve-retaining tubular or central portion and a pair of support arms. The inflow portion radially extends from a first end of the valve-retaining tubular portion and the pair of support arms are circumferentially spaced apart and radially extend from an opposing second end of the valve-retaining tubular portion.

Abstract translation: 公开了包括具有流入部分，阀保持管状或中心部分和一对支撑臂的框架或支撑结构的心脏瓣膜假体。 流入部分从阀保持管状部分的第一端径向延伸，并且一对支撑臂沿圆周间隔开并且从阀保持管状部分的相对的第二端径向延伸。

公开(公告)号：US20140194982A1

公开(公告)日：2014-07-10

申请号：US13736460

申请日：2013-01-08

Applicant: MEDTRONIC, INC.

Inventor： Igor Kovalsky ,  Jason Quill ,  Daniel Glozman ,  Ilia Hariton ,  Yossi Tuval ,  Nadav Yellin

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2230/001 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008

Abstract: In some embodiments, a valve prosthesis includes an inlet portion that is substantially s-shaped and configured to engage the floor of the outflow tract of the native heart atrium. In some embodiments, a valve prosthesis includes a chordae guiding element configured to reduce bending of the chordae to reduce stress on the chordae during the cardiac cycle. In some embodiments, a valve prosthesis includes a central portion having an hourglass shape configured to pinch a native annulus in order to provide axial fixation of the valve prosthesis within a valve site. In some embodiments, a valve prosthesis includes a frame having an outflow end that is flared to provide a gap between an outflow end of the frame and an outflow end of prosthetic leaflets when the prosthetic leaflets are fully opened.

Abstract translation: 在一些实施例中，瓣膜假体包括入口部分，其基本上为S形并且构造成接合天然心脏心房的流出道的底部。 在一些实施例中，瓣膜假体包括腱索引导元件，其被配置为减少腱索的弯曲以减少在心脏周期期间腱索上的应力。 在一些实施例中，瓣膜假体包括具有沙漏形状的中心部分，其构造成夹住天然环带，以便在瓣膜部位内提供瓣膜假体的轴向固定。 在一些实施例中，瓣膜假体包括具有流出端的框架，所述流出端在所述假体叶片完全打开时，所述流出端被展开以在所述框架的流出端和假体叶片的流出端之间提供间隙。

公开(公告)号：US09232995B2

公开(公告)日：2016-01-12

申请号：US13736460

申请日：2013-01-08

Applicant: Medtronic, Inc.

Inventor： Igor Kovalsky ,  Jason Quill ,  Daniel Glozman ,  Ilia Hariton ,  Yossi Tuval ,  Nadav Yellin

IPC: A61F2/06 ,  A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2230/001 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008

Abstract: In some embodiments, a valve prosthesis includes an inlet portion that is substantially s-shaped and configured to engage the floor of the outflow tract of the native heart atrium. In some embodiments, a valve prosthesis includes a chordae guiding element configured to reduce bending of the chordae to reduce stress on the chordae during the cardiac cycle. In some embodiments, a valve prosthesis includes a central portion having an hourglass shape configured to pinch a native annulus in order to provide axial fixation of the valve prosthesis within a valve site. In some embodiments, a valve prosthesis includes a frame having an outflow end that is flared to provide a gap between an outflow end of the frame and an outflow end of prosthetic leaflets when the prosthetic leaflets are fully opened.

Abstract translation: 在一些实施例中，瓣膜假体包括入口部分，其基本上为S形并且构造成接合天然心脏心房的流出道的底部。 在一些实施例中，瓣膜假体包括腱索引导元件，其被配置为减少腱索的弯曲以减少在心脏周期期间腱索上的应力。 在一些实施例中，瓣膜假体包括具有沙漏形状的中心部分，其构造成夹住天然环带，以便在瓣膜部位内提供瓣膜假体的轴向固定。 在一些实施例中，瓣膜假体包括具有流出端的框架，所述流出端在所述假体叶片完全打开时，所述流出端被展开以在所述框架的流出端和假体叶片的流出端之间提供间隙。